Wood dust and formaldehyde: this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 11 - 18 Ocober 1994
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Lyon
Internat. Agency for Research on Cancer
1995
|
| Schriftenreihe: | Centre International de Recherche sur le Cancer <Lyon>: IARC monographs on the evaluation of carcinogenic risks to humans
62 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VIII, 405 S. Ill., graph. Darst. |
| ISBN: | 9283212622 |
Internformat
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| 245 | 1 | 0 | |a Wood dust and formaldehyde |b this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 11 - 18 Ocober 1994 |
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Datensatz im Suchindex
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|---|---|
| adam_text | CONTENTS
NOTE TO THE READER 1
LIST OF PARTICIPANTS 3
PREAMBLE 9
Background 9
Objective and Scope 9
Selection of Topics for Monographs 10
Data for Monographs 11
The Working Group 11
Working Procedures 11
Exposure Data 12
Studies of Cancer in Humans 14
Studies of Cancer in Experimental Animals 17
Other Data Relevant to an Evaluation of Carcinogenicity and Its Mechanisms 20
Summary of Data Reported 21
Evaluation 23
References 27
GENERAL REMARKS 31
THE MONOGRAPHS
Wood dust 35
1. Exposure data 35
1.1 Composition of wood 35
1.1.1 Classification and nomenclature 35
1.1.2 Anatomical features 38
1.1.3 Cell wall structure and distribution of components of wood 41
1.1.4 Chemical components 41
(a) Macromolecular components 48
(b) Low relative molecular mass components 48
1.2 Wood related industries and occupations 51
1.2.1 Major woodworking processes 53
(a) Debarking 53
(b) Sawing 54
(c) Sanding 55
iii
iv IARC MONOGRAPHS VOLUME 62
(d) Planing, jointing, moulding and shaping 55
(e) Turning (lathing) 55
(f) Boring (drilling), routing and carving 55
(g) Mortising and tenoning 56
(h) Veneer cutting 56
(i) Chipping, flaking, hogging and grinding 56
(j) Mechanical defibrating 57
1.2.2 Sawmilling 57
1.2.3 Manufacture of plywood and other boards 59
(a) Plywood manufacture 59
(b) Manufacture of particle board and related boards 60
(c) Fibre board manufacture 60
1.2.4 Wooden furniture manufacture and cabinet making 61
1.2.5 Manufacture of other wood products 63
1.2.6 Construction, carpentry and other wood related occupations 63
(a) The construction industry 63
(b) Maintenance and repair 64
(c) Pattern and model making 65
(d) Wood shop teachers and artists 65
1.3 Analytical methods 65
1.3.1 Characterization and measurement of wood dust 65
(a) Type of wood 66
(b) Airborne dust concentrations 66
(c) Particle size distribution 67
(d) Other characteristics of wood dust 68
1.3.2 Chemical analysis of wood constituents 68
(a) Extractives 68
(b) Inorganic compounds in ash 69
(c) Polysaccharides 69
(d) Lignin 70
1.4 Exposure to wood dust and other agents in the workplace 70
1.4.1 General influences on occupational exposure to wood dust 70
1.4.2 Extent of exposure to wood dust 71
1.4.3 Exposure during sawmilling 72
1.4.4 Exposure during the manufacture of plywood and other boards 74
1.4.5 Exposure during wooden furniture manufacture and cabinet making 78
1.4.6 Exposure during the manufacture of other wood products 82
1.4.7 Exposure in other wood related occupations 86
1.4.8 Particle size distribution of wood dust in workroom air 88
1.5 Regulations and guidelines 93
CONTENTS v
2. Studies of cancer in humans 94
2.1 Case reports 94
2.2 Descriptive studies 95
2.3 Cohort studies 101
2.4 Case control studies 102
2.4.1 Cancer of the nasal cavity andparanasal sinuses 102
(a) Exposure to wood dust 102
(b) Occupational group 111
2.4.2 Cancers of other parts of the respiratory system 127
(a) Nasopharyngeal cancer 127
(b) Pharyngeal cancer other than cancer of the nasopharynx 129
(c) Laryngeal cancer 132
(d) Lung cancer 136
2.4.3 Cancers of the lymphatic and haematopoeitic system 146
(a) Non Hodgkin s lymphoma 146
(b) Hodgkin s disease 152
(c) Multiple myeloma 154
(d) Leukaemia 156
2.4.4 Cancers of the digestive tract 158
(a) Exposure to wood dust 158
(b) Occupational group 164
3. Studies of cancer in experimental animals 165
3.1 Inhalation 165
3.1.1 Rat 165
3.1.2 Hamster 169
3.2 Intraperitoneal injection 169
3.3 Administration with known carcinogens or other modifying factors 169
3.3.1 Rat 169
3.3.2 Hamster 170
3.4 Skin application of wood dust extracts 171
3.5 Experimental data on wood shavings 173
4. Other data relevant to an evaluation of carcinogenicity and its mechanisms 173
4.1 Deposition and clearance 173
4.1.1 Humans 173
4.1.2 Experimental systems 173
4.2 Toxic effects 173
4.2.1 Humans 173
(a) Effects on the nose 173
(b) Effects on the lung 177
(c) Other effects 183
4.2.2 Experimental systems 184
vi IARC MONOGRAPHS VOLUME 62
4.3 Genetic and related effects 185
4.3.1 Humans 185
4.3.2 Experimental systems 185
5. Summary of data reported and evaluation 191
5.1 Exposure data 191
5.2 Human carcinogenicity data 192
5.3 Animal carcinogenicity data 193
5.4 Other relevant data 193
5.5 Evaluation 194
6. References 194
Formaldehyde 217
1. Exposure data 217
1.1 Chemical and physical data 217
1.1.1 Nomenclature 217
1.1.2 Structural and molecular formulae and relative molecular mass 217
1.1.3 Chemical and physical properties of the pure substance 217
1.1.4 Technical products and impurities 218
1.1.5 Analysis 218
1.2 Production and use 219
1.2.1 Production 219
1.2.2 Use 221
1.3 Occurrence 223
1.3.1 Natural occurrence 223
1.3.2 Occupational exposure 224
(a) Extent of exposure 224
(b) Manufacture of formaldehyde, formaldehyde based resins and
other chemical products 224
(c) Manufacture of wood products and paper 225
(d) Manufacture of textiles and garments 231
(e) Manufacture of metal products, mineral wool and other products 232
(f) Mortuaries, hospitals and laboratories 237
(g) Building, agriculture, forestry and other activities 240
1.3.3 Ambient air 242
1.3.4 Residential indoor air 242
1.3.5 Other exposures 243
1.4 Regulations and guidelines 243
2. Studies of cancer in humans 246
2.1 Case reports 246
2.2 Descriptive studies 246
2.3 Cohort studies 246
2.3.1 Professional groups 247
2.3.2 Industrial groups 251
CONTENTS vii
2.4 Case control studies 262
2.4.1 Cancers of the nasal cavity, paranasal sinuses, nasopharynx,
oropharynx and pharynx (unclassified) 262
2.4.2 Cancers of the lung and larynx..... 272
2.4.3 Cancers at other sites 275
2.5 Meta analyses 282
3. Studies of cancer in experimental animals 282
3.1 Inhalation 282
3.1.1 Mouse 282
3.1.2 Rat 284
3.1.3 Hamster 289
3.2 Oral administration 289
3.3 Skin application 292
3.4 Subcutaneous injection 292
3.5 Administration with known carcinogens and other modifying factors 292
3.5.1 Mouse 292
3.5.2 Rat 293
3.5.3 Hamster 293
4. Other data relevant to an evaluation of carcinogenicity and its mechanisms 294
4.1 Absorption, distribution, metabolism and excretion 294
4.1.1 Humans 294
4.1.2 Experimental systems 295
4.2 Toxic effects 301
4.2.1 Humans 302
(a) Acute effects 302
(b) Chronic effects 304
(c) Allergy 308
4.2.2 Experimental systems 308
(a) Acute effects 309
(b) Chronic effects 315
(c) Immunotoxicity 319
4.3 Reproductive and developmental effects 319
4.3.1 Humans 319
4.3.2 Experimental systems 320
4.4 Genetic and related effects 321
4.4.1 Humans 321
(a) DNA protein cross links 321
(b) Mutation and allied effects 321
(c) Sperm abnormalities 322
(d) Urinary mutagenicity 323
viii IARC MONOGRAPHS VOLUME 62
4.4.2 Experimental systems 323
(a) DNA protein cross links 323
(b) Mutation and allied effects 323
(c) Mutational spectra 330
5. Summary of data reported and evaluation 332
5.1 Exposure data 332
5.2 Human carcinogenicity data 333
5.3 Animal carcinogenicity data 334
5.4 Other relevant data 334
5.5 Evaluation 335
6. References 335
APPENDIX 1. SUMMARY TABLE OF GENETIC AND RELATED EFFECTS 365
APPENDIX 2. ACTIVITY PROFILE FOR GENETIC AND RELATED EFFECTS 369
CUMULATIVE INDEX TO THE MONOGRAPHS SERIES 377
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| series2 | Centre International de Recherche sur le Cancer <Lyon>: IARC monographs on the evaluation of carcinogenic risks to humans |
| spelling | Wood dust and formaldehyde this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 11 - 18 Ocober 1994 Lyon Internat. Agency for Research on Cancer 1995 VIII, 405 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Centre International de Recherche sur le Cancer <Lyon>: IARC monographs on the evaluation of carcinogenic risks to humans 62 Formaldehyd (DE-588)4017845-6 gnd rswk-swf Carcinogenität (DE-588)4206051-5 gnd rswk-swf Holzstaub (DE-588)4460536-5 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1994 Lyon gnd-content Holzstaub (DE-588)4460536-5 s Carcinogenität (DE-588)4206051-5 s DE-604 Formaldehyd (DE-588)4017845-6 s International Agency for Research on Cancer Working Group on the Evaluation of the Carcinogenic Risks to Humans Sonstige (DE-588)670543-1 oth Centre International de Recherche sur le Cancer <Lyon>: IARC monographs on the evaluation of carcinogenic risks to humans 62 (DE-604)BV000878150 62 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006893943&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wood dust and formaldehyde this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 11 - 18 Ocober 1994 Centre International de Recherche sur le Cancer <Lyon>: IARC monographs on the evaluation of carcinogenic risks to humans Formaldehyd (DE-588)4017845-6 gnd Carcinogenität (DE-588)4206051-5 gnd Holzstaub (DE-588)4460536-5 gnd |
| subject_GND | (DE-588)4017845-6 (DE-588)4206051-5 (DE-588)4460536-5 (DE-588)1071861417 |
| title | Wood dust and formaldehyde this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 11 - 18 Ocober 1994 |
| title_auth | Wood dust and formaldehyde this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 11 - 18 Ocober 1994 |
| title_exact_search | Wood dust and formaldehyde this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 11 - 18 Ocober 1994 |
| title_full | Wood dust and formaldehyde this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 11 - 18 Ocober 1994 |
| title_fullStr | Wood dust and formaldehyde this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 11 - 18 Ocober 1994 |
| title_full_unstemmed | Wood dust and formaldehyde this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 11 - 18 Ocober 1994 |
| title_short | Wood dust and formaldehyde |
| title_sort | wood dust and formaldehyde this publication represents the views and expert opinions of an iarc working group on the evaluation of carcinogenic risks to humans which met in lyon 11 18 ocober 1994 |
| title_sub | this publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 11 - 18 Ocober 1994 |
| topic | Formaldehyd (DE-588)4017845-6 gnd Carcinogenität (DE-588)4206051-5 gnd Holzstaub (DE-588)4460536-5 gnd |
| topic_facet | Formaldehyd Carcinogenität Holzstaub Konferenzschrift 1994 Lyon |
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| volume_link | (DE-604)BV000878150 |
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