Immune reactions: headlines, overviews, tables and graphics
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1995
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturverz. S. [465] - 581 |
| Beschreibung: | XIII, 581 S. Ill., graph. Darst. |
| ISBN: | 3540589570 |
Internformat
MARC
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| 245 | 1 | 0 | |a Immune reactions |b headlines, overviews, tables and graphics |c H.-Harald Sedlacek ; Tarik Möröy |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1995 | |
| 300 | |a XIII, 581 S. |b Ill., graph. Darst. | ||
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| 500 | |a Literaturverz. S. [465] - 581 | ||
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-006887872 | ||
Datensatz im Suchindex
| _version_ | 1804124770238726144 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
1 CYTOKINES, GROWTH FACTORS, CHEMOKINES AND THEIR RECEPTORS 1 1.1
OVERVIEW 1
1.1.1 CYTOKINES IN HEMATOPOIESIS 1
1.1.2 CLASSIFICATION OF GROWTH FACTORS 4
1.1.3 RECEPTORS FOR CYTOKINES 6
1.1.4 RECEPTORS FOR GROWTH FACTORS 7
1.1.5 CHARACTERISTICS OF CHEMOKINES 8
1.1.6 NEUTROPHIL-ACTIVATING PEPTIDES 9
1.2 CHARACTERISTICS OF MEDIATORS, RECEPTORS 10
1.2.1 SCF, IL-1, IL-1 RA 10
1.2.2 1L-2 15
1.2.3 IL-3, IL-4, IL-5, IL-6 21
1.2.4 LIF, IL-7, IL-8 29
1.2.5 IL-10, IL-11, IL-12, IL-13 32
1.2.6 GM-CSF, G-CSF, M-CSF, ERYTHROPOIETIN, THROMBOPOIETIN, IFN GAMMA 35
1.2.7 IGF, TNF, TGF, PDGF, EGF, FGF 43
1.2.8 ONCOSTATIN, CNTF 51
1.2.9 APPROACHES TO INHIBIT THE BIOLOGICAL EFFECT OF GROWTH FACTORS ..
53
2 CELL-ADHESION MOLECULES 55
2.1 OVERVIEW 55
2.1.1 CLASSIFICATION 55
2.1.2 FUNCTION 56
2.2 CHARACTERISTICS 56
2.2.1 IMMUNOGLOBULIN GENE SUPERFAMILY TYPE 57
2.2.2 INTEGRIN TYPE 58
2.2.3 CELL DISTRIBUTION 63
2.2.4 BINDING PARTNERS 64
2.2.5 MODULATION OF EXPRESSION AND FUNCTION 65
2.2.6 STRUCTURE AND FUNCTION OF CD44 65
2.2.7 STRUCTURE AND FUNCTION OF CADHERINS 66
3 ANTIGEN PRESENTATION 67
3.1 OVERVIEW 67
3.2 DETAILS 68
IMAGE 2
VIII CONTENTS
3.2.1 DENDRITIC CELLS 68
3.2.2 ANTIGEN-BINDING MOLECULES 70
3.2.3 MHC GENES 73
3.2.4 REGULATION OF MHC GENE EXPRESSION 75
3.2.5 LOADING OF ANTIGEN-PRESENTING MOLECULES 76
3.2.6 ANTIGEN PRESENTATION BY B-CELLS 80
3.2.7 EXPRESSION OF MHC MOLECULES 81
3.2.8 MODULATION OF EXPRESSION OF MHC MOLECULES 83
4 DIFFERENTIATION OF T-CELLS 85
4.1 OVERVIEW 85
4.2 DETAILS 86
4.2.1 T-CELL DEVELOPMENT 86
4.2.2 THE T-CELL RECEPTOR 89
4.2.3 THE CD4 MOLECULE 92
4.2.4 THE CD8 MOLECULE 92
4.2.5 ACTIVATION OF T-CELLS BY ANTIGEN-PRESENTING CELLS 93
4.2.6 SIGNAL TRANSDUCTION AFTER ACTIVATION OF THE TCR COMPLEX 95 4.2.7
ACTIVATION OF T-CELLS 98
4.2.8 ACTIVATION OF MEMORY T-CELLS 103
4.2.9 PHARMACOLOGICAL INTERVENTION OF T-CELL ACTIVATION 105
5 SUPERANTIGENS 107
5.1 OVERVIEW 107
5.1.1 COMPARISON BETWEEN CONVENTIONAL ANTIGENS AND SUPERANTIGENS 108
5.1.2 FUNCTION 109
5.2 DETAILS 110
5.2.1 FOREIGN SUPERANTIGENS 110
5.2.2 SELF-SUPERANTIGENS OF MOUSE MAMMARY TUMOR VIRUS (MMTV) . ILL
6 DIFFERENTIATION OF B-CELLS 113
6. 1 OVERVIEW 113
6.2 DETAILS 113
6.2.1 B-CELL DEVELOPMENT 113
6.2.2 THE B-CELL RECEPTOR 114
6.2.3 TRANSCRIPTIONAL CONTROL OF IG HEAVY-AND IG LIGHT-CHAIN GENES . 119
7 ANTIBODY FORMATION 123
7.1 OVERVIEW 123
7.2 DETAILS 124
7.2.1 VDJ RECOMBINATION 124
7.2.2 COOPERATION OF B-CELLS WITH T-CELLS 126
7.2.3 B-CELL DIFFERENTIATION IN LYMPH NODES 129
7.2.4 MAIN CYTOKINES INVOLVED IN DIFFERENTIATION TO PLASMA CELLS . . ..
136
8 FC RECEPTORS AND ANTIBODY INTERACTION 137
8. 1 OVERVIEW 137
IMAGE 3
CONTENTS IX
8.2 DETAILS 138
8.2.1 PROPERTIES OF MURINE FC RECEPTORS 138
8.2.2 HUMAN FC RECEPTORS 139
8.2.3 MODULATION BY CYTOKINES 146
8.2.4 RELEASE OF IMMUNOGLOBULIN BINDING PROTEINS (IBFS) AND ITS
MODULATION 147
8.2.5 BLOCKAGE OF ANTIBODY PRODUCTION 148
9 GENERATION OF THE IGA RESPONSE 151
9.1 OVERVIEW 151
9.2 DETAILS 152
9.2.1 PROPERTIES OF SECRETORY AND SERUM IGA 152
9.2.2 CIRCULATION AND METABOLIZATION OF IGA 153
9.2.3 ENTERAL IGA RESPONSE 153
9.2.4 SECRETORY IMMUNOGLOBULIN A (SLGA) IN TEARS 157
10 COMPLEMENT ACTIVATION AND INHIBITION 159
10.1 OVERVIEW 159
10.1.1 CLASSIFICATION 160
10.1.2 ACTIVATION 160
10.1.3 BLOCKAGE OF COMLEMENT MEDIATED LYSIS BY NUCLEATED CELLS . . ..
161 10.2 DETAILS 162
10.2.1 FUNCTION OF COMPLEMENT INHIBITORS 162
10.2.2 ACTIVITY OF COMPLEMENT SPLIT PRODUCTS ON CELLS 164
10.2.3 COMPLEMENT RECEPTORS 165
10.2.4 INTERACTIONS BETWEEN COMPLEMENT COMPONENTS AND PLATELETS . .. 170
10.2.5 RESISTANCE OF NUCLEATED CELLS (NC) TO LYSIS BY MEMBRANE ATTACKING
COMPLEX (MAC) OF COMPLEMENT 173
10.2.6 ACTIVATION OF NUCLEATED CELLS BY MEMBRANE ATTACKING COMPLEX 174
10.2.7 DISEASES ASSOCIATED WITH INHERITED OR ACQUIRED DEFICIENCY OF
COMPLEMENT COMPONENTS 176
10.2.8 APPROACHES FOR IMMUNOTHERAPY WITH REGULATORS OF COMPLEMENT
ACTIVATION 172
11 CELL-MEDIATED CYTOTOXICITY 179
11.1 OVERVIEW 179
11.2 DETAILS 179
11.2.1 CYTOTOXICITY BY T-LYMPHOCYTES 179
11.2.2 CELLULAR CYTOTOXICITY VIA MECHANISMS NOT INVOLVING RECOGNITION OF
ANTIGENS PRESENTED BY MHC-1 184
12 IMMUNE-MEDIATED INFLAMMATORY REACTION 187
12.1 OVERVIEW 187
12.1.1 CASCADES OF THE INFLAMMATORY RESPONSE 188
12.1.2 CENTRAL ROLE OF THE HAGEMAN FACTOR 189
12.1.3 COMPLEXITY OF INTERACTIONS (CELLS, CYTOKINES, MEDIATORS) 190 12.2
DETAILS 191
IMAGE 4
CONTENTS
12.2.1 ACTIVATION AND ACTION OF KININS 191
12.2.2 BIOLOGICAL ACTION OF MEDIATORS OF THE ARACHIDONIC ACID PATHWAY
192 12.2.3 DISEASES ASSOCIATED WITH PROMINENT NEUTROPHIL INFILTRATES 196
12.2.4 METABOLIC CHANGES INDUCED BY CYTOKINES 197
12.2.5 PUTATIVE MECHANISM OF THE DELAYED-TYPE HYPERSENSITIVITY REACTION
198
12.2.6 APPROACHES FOR THE THERAPY OF INFLAMMATORY REACTIONS 199
13 INTERACTIONS WITH ENDOTHELIAL CELLS 205
13. 1 OVERVIEW 205
13.1.1 GRANULOCYTES AND ENDOTHELIAL CELLS 205
13.1.2 LYMPHOCYTES AND ENDOTHELIAL CELLS 206
13.2 DETAILS 209
13.2.1 ACTIVATION OF ENDOTHELIAL CELLS 209
13.2.2 ENDOTHELIUM-DERIVED RELAXING FACTORS (EDRF) 212
13.2.3 ENDOTHELIUM-DERIVED CONTRACTING FACTORS (EDCF) 214 13.2.4
IMMUNOLOGICAL ASPECTS OF ARTHERIOSCLEROSIS 215
14 INVOLVEMENT OF THE CLOTTING SYSTEM AND PLATELETS 219
14.1 OVERVIEW 219
14.2 DETAILS 220
14.2.1 INHIBITION OF COAGULATION IN NORMAL EPITHELIUM 220
14.2.2 EFFECT OF GROWTH FACTORS AND CYTOKINES ON PLASMINOGEN ACTIVATOR
SECRETION 221
14.2.3 ACTIVATION AND AGGREGATION OF PLATELETS 222
14.2.4 ROLE OF TRANSFORMING GROWTH FACTOR-P 229
14.2.5 ARACHIDONIC ACID METABOLISM IN PLATELETS 230
14.2.6 INHIBITORS OF PLATELET AGGREGATION 231
14.2.7 MODULATION OF PLATELET AGGREGATION IN VIVO 232
14.2.8 CYTOKINES THAT STIMULATE MEGAKARYOCYTOPOIESIS 233
15 ENZYMATIC DEGRADATION OF EXTRACELLULAR MATRIX 235
15.1 OVERVIEW 235
15.1.1 DESTRUCTION OF EXTRACELLULAR MATRIX 235
15.1.2 INTERACTION OF PROTEASES 236
15.2 DETAILS 237
15.2.1 MATRIX METALLOPROTEINASES (MMP) 237
15.2.2 CELLULAR PROTEASES 238
15.2.3 MODULATION OF SECRETION OF CELLULAR PROTEASES 244
16 ANGIOGENESIS 245
16.1 OVERVIEW 245
16.2 DETAILS 248
16.2.1 ANGIOGENIC OR MITOGENIC PEPTIDES 248
16.2.2 VASCULAR ENDOTHELIAL GROWTH FACTOR 252
16.2.3 BALANCE BETWEEN UPA/PAT-1 AND FGFZTGF-* 253
16.2.4 INHIBITORS OF ANGIOGENESIS 254
IMAGE 5
CONTENTS XI
17 SYSTEMIC IMFLAMMATORY REACTION SYNDROME 255
17.1 OVERVIEW 255
17.2 DETAILS 256
17.2.1 PATHOPHYSIOLOGICAL PATHWAYS 256
17.2.2 ROLE OF LBS BINDING PROTEIN 262
17.2.3 ROLE OF COMPLEMENT AND NEUTROPHILS 263
17.2.4 APPROACHES TO INFLUENCING SIRS 264
18 IMMUNE COMPLEX MEDIATED DISEASES 271
1 8. 1 OVERVIEW 271
18.2 DETAILS 272
18.2.1 CONFORMATIONAL CHANGE OF ANTIBODY 272
18.2.2 EFFECTOR FUNCTION OF IMMUNOGLOBULINS 274
18.2.3 SIZE OF IMMUNE COMPLEXES 279
18.2.4 INHIBITION/SOLUBILIZATION OF 1C BY COMPLEMENT 282
18.2.5 ELIMINATION OF 1C 283
18.2.6 1C DISEASES ASSOCIATED WITH CHANGES IN THE EXPRESSION OF
CR-L,CR-2, CR-3, C-IA(INH) 289
18.2.7 APPROACHES FOR THERAPY OF 1C DISEASES 291
19 ALLERGIC DISEASES 295
19.1 OVERVIEW 295
19.2 DETAILS 298
19.2.1 MODULATION OF IGE SECRETION BY CYTOKINES 298
19.2.2 ALLERGIC INFLAMMATION 301
19.2.3 ROLE OF LANGERHANS CELLS 304
19.2.4 ROLE OF FEE RII (CD23) 304
19.2.5 HISTAMINE-RELEASING FACTORS (HRF) 305
19.2.6 TREATMENT OF ALLERGIC DISEASES 307
20 AUTOIMMUNE DISEASES 311
20. 1 OVERVIEW 311
20.1.1 REASONS FOR AUTOIMMUNE REACTIONS 311
20.1.2 AUTOANTIBODIES IN NORMAL PERSONS 311
20.1.3 ROLE OF B-CELLS AND T-HELPER CELLS IN AUTOIMMUNE DISEASES . ..
312 20.2 DETAILS 313
20.2.1 SPECIFICITY OF HUMAN AUTOANTIBODIES 313
20.2.2 RELATIONSHIP TO EXPOSURE TO XENOBIOTICS 319
20.2.3 APPROACHES TO TREAT AUTOIMMUNE DISEASES 320
21 IMMUNE SUPPRESSION 333
21.1 OVERVIEW 333
21.1.1 THERAPEUTIC ACTIVITY AND TOXICITY OF IMMUNE SUPPRESSIVES . . ..
333 21.1.2 MODE OF ACTION OF IMMUNE SUPPRESSIVE DRUGS 334
21.2 DETAILS 335
21.2.1 MODE OF ACTION OF SPECIFIC AGENTS 335
21.2.2 MONOCLONAL ANTIBODIES 341
IMAGE 6
XII CONTENTS
22 IMMUNE REACTION IN NEOPLASIA 345
22.1 OVERVIEW 345
22.2 DETAILS 347
22.2.1 HUMAN TUMOR ANTIGENS DETECTED BY IMMUNE RESPONSE 347 22.2.2
VIRUSES ASSOCIATED WITH CANCER 349
22.2.3 VACCINES FOR PROPHYLAXIS OF VIRUS-INDUCED TUMORS 350
22.2.4 TUMORS AND INFILTRATING MACROPHAGES 351
22.2.5 TUMORS AND INFILTRATING LYMPHOCYTES 352
22.2.6 TUMOR THERAPY WITH CYTOKINES 353
22.2.7 ACTIVE SPECIFIC THERAPY WITH TUMOR VACCINES 360
22.2.8 MECHANISMS BY WHICH TUMOR CELLS BECOME IMMUNE RESISTANT 370
22.2.9 TUMOR THERAPY WITH ANTIBODY PREPARATIONS 375
22.2.10 TARGETING OF DRUGS WITH MONOCLONAL ANTIBODIES TO MALIGNANT CELLS
377
22.2.11 REASONS FOR THE LIMITED SUCCESS OF ANTIBODIES 380
22.2.12 PHARMACOKINETIC PARAMETERS FOR ANTIBODIES 386
22.2.13 ANTIBODY-DEPENDENT ENZYME-MEDIATED PRODRUG THERAPY 391 22.2.14
ANTIBODY ENGINEERING 397
23 CNS AND IMMUNE REACTIONS 401
23.1 OVERVIEW 401
23.2 DETAILS 403
23.2.1 MODULATION OF THE IMMUNE SYSTEM BY NEUROPEPTIDES 403 23.2.2 IL-1
AS A NEUROPEPTIDE 405
23.2.3 CYTOKINES AND CYTOKINE RECEPTORS EXPRESSED BY CELLS OF THE CNS
AND ENDOCRINE ORGANS 407
23.2.4 COMMUNICATION OF THE CNS WITH THE IMMUNE SYSTEM 408 23.2.5
MODULATION OF THE ENDOCRINE SYSTEM BY IMMUNE MEDIATORS . . .. 409 23.2.6
HORMONAL INFLUENCE ON ANTIBODIES IN MUCOSAL TISSUES 411 23.2.7 IMMUNE
RESPONSE AND EPILEPSY 412
24 GENETIC BACKGROUND OF APOPTOSIS AND MALIGNANT LYMPHOCYTE GROWTH 415
24.1 APOPTOSIS AND MALIGNANT LYMPHOCYTE GROWTH 415
24.2 MECHANISMS OF TUMORIGENESIS 419
25 SOMATIC GENE THERAPY 423
25.1 OVERVIEW 423
25.1.1 OPPORTUNITIES AND RISKS 423
25.1.2 PRECONDITIONS 425
25.1.3 METHODS 426
25.2 DETAILS 429
25.2.1 VIRAL TRANSFER OF GENES 429
IMAGE 7
CONTENTS
XIII
25.2.2 LIPOSOMAL TRANSFER OF GENES 436
25.2.3 RECEPTOR MEDIATED TRANSFER OF GENES 438
25.2.4 EXPERIMENTAL THERAPEUTIC APPROACHES 439
25.2.5 IMMUNIZATION WITH POLYNUCLEOTIDES 450
26 CD TERMINOLOGY 453
REFERENCES 465
|
| any_adam_object | 1 |
| author | Sedlacek, Hans-Harald 1943- Möröy, Tarik |
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| discipline | Biologie Medizin |
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| id | DE-604.BV010347250 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:50:56Z |
| institution | BVB |
| isbn | 3540589570 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006887872 |
| oclc_num | 634072578 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-188 DE-19 DE-BY-UBM |
| owner_facet | DE-355 DE-BY-UBR DE-188 DE-19 DE-BY-UBM |
| physical | XIII, 581 S. Ill., graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Springer |
| record_format | marc |
| spelling | Sedlacek, Hans-Harald 1943- Verfasser (DE-588)1029511926 aut Immune reactions headlines, overviews, tables and graphics H.-Harald Sedlacek ; Tarik Möröy Berlin [u.a.] Springer 1995 XIII, 581 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturverz. S. [465] - 581 Immune Response cabt Immunreaktion (DE-588)4133841-8 gnd rswk-swf Immunreaktion (DE-588)4133841-8 s DE-604 Möröy, Tarik Verfasser aut SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006887872&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sedlacek, Hans-Harald 1943- Möröy, Tarik Immune reactions headlines, overviews, tables and graphics Immune Response cabt Immunreaktion (DE-588)4133841-8 gnd |
| subject_GND | (DE-588)4133841-8 |
| title | Immune reactions headlines, overviews, tables and graphics |
| title_auth | Immune reactions headlines, overviews, tables and graphics |
| title_exact_search | Immune reactions headlines, overviews, tables and graphics |
| title_full | Immune reactions headlines, overviews, tables and graphics H.-Harald Sedlacek ; Tarik Möröy |
| title_fullStr | Immune reactions headlines, overviews, tables and graphics H.-Harald Sedlacek ; Tarik Möröy |
| title_full_unstemmed | Immune reactions headlines, overviews, tables and graphics H.-Harald Sedlacek ; Tarik Möröy |
| title_short | Immune reactions |
| title_sort | immune reactions headlines overviews tables and graphics |
| title_sub | headlines, overviews, tables and graphics |
| topic | Immune Response cabt Immunreaktion (DE-588)4133841-8 gnd |
| topic_facet | Immune Response Immunreaktion |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006887872&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT sedlacekhansharald immunereactionsheadlinesoverviewstablesandgraphics AT moroytarik immunereactionsheadlinesoverviewstablesandgraphics |