The peroxisome: a vital organelle
Gespeichert in:
Hauptverfasser: | , |
---|---|
Format: | Buch |
Sprache: | English |
Veröffentlicht: |
Cambridge u.a.
Cambridge Univ. Press
1995
|
Ausgabe: | 1. publ. |
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | XVII, 286 S. Ill., graph. Darst. |
ISBN: | 0521482127 |
Internformat
MARC
LEADER | 00000nam a2200000 c 4500 | ||
---|---|---|---|
001 | BV010324533 | ||
003 | DE-604 | ||
005 | 00000000000000.0 | ||
007 | t | ||
008 | 950802s1995 ad|| |||| 00||| engod | ||
020 | |a 0521482127 |9 0-521-48212-7 | ||
035 | |a (OCoLC)31409467 | ||
035 | |a (DE-599)BVBBV010324533 | ||
040 | |a DE-604 |b ger |e rakddb | ||
041 | 0 | |a eng | |
049 | |a DE-355 |a DE-29 |a DE-703 |a DE-11 |a DE-188 | ||
050 | 0 | |a QH603.P47 | |
082 | 0 | |a 574.87/4 |2 20 | |
084 | |a WE 3500 |0 (DE-625)148282: |2 rvk | ||
100 | 1 | |a Masters, Colin J. |e Verfasser |4 aut | |
245 | 1 | 0 | |a The peroxisome |b a vital organelle |c Colin Masters and Denis Crane |
250 | |a 1. publ. | ||
264 | 1 | |a Cambridge u.a. |b Cambridge Univ. Press |c 1995 | |
300 | |a XVII, 286 S. |b Ill., graph. Darst. | ||
336 | |b txt |2 rdacontent | ||
337 | |b n |2 rdamedia | ||
338 | |b nc |2 rdacarrier | ||
650 | 7 | |a Peroxysomen |2 gtt | |
650 | 4 | |a Microbodies | |
650 | 4 | |a Peroxisomes | |
650 | 0 | 7 | |a Peroxisom |0 (DE-588)4128263-2 |2 gnd |9 rswk-swf |
689 | 0 | 0 | |a Peroxisom |0 (DE-588)4128263-2 |D s |
689 | 0 | |5 DE-604 | |
700 | 1 | |a Crane, Denis |e Verfasser |4 aut | |
856 | 4 | 2 | |m HEBIS Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006870646&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
999 | |a oai:aleph.bib-bvb.de:BVB01-006870646 |
Datensatz im Suchindex
_version_ | 1804124744479408128 |
---|---|
adam_text | THE PEROXISOME:
A VITAL ORGANELLE
COLIN_MASTERS AND DENIS CRANE
Faculty of Science and Technology Griffith University, Brisbane
i CAMBRIDGE
UNIVERSITY PRESS
Contents
rejace
1 Introduction
Outline of the metabolic role
Biochemical definition
Morphology
Microperoxisomes, hydrogenosomes and glycosomes
Phylogenetic distribution
Summary
Further reading
2 Enzymology
Introduction
Catalase
L-a-Hydroxyacid oxidase
D-Amino acid oxidase
Urate oxidase
^-Oxidation enzymes
Acyl-CoA oxidases
Enoyl-CoA hydratase and 3-hydroxyacyl-CoA
dehydrogenase
3-Ketoacyl-CoA thiolase
Oxidation of unsaturated fatty acids
Palmitoyl-CoA and lignoceroyl-CoA ligase
Carnitine octanoyltransferase
Isocitrate dehydrogenase
Alanine: glyoxylate aminotransferase
Glycerol 3-phosphate dehydrogenase
Aldehyde dehydrogenase
page xv
IX
x Contents
Pipecolic acid oxidase 43
Polyamine oxidase 44
Other peroxisomal enzymes 44
Summary 44
Further reading 46
3 Intraparticulate organization of peroxisomal proteins -
methodology and topology 47
Introduction 47
Centrifugal fractionation 47
Use of detergents 50
Electron immunocytochemistry 53
Enzymes of glycerolipid synthesis 55
Perturbations of enzyme localization 58
Peroxisomal enzymes in the cytoplasm 61
The peroxisomal membrane 63
Summary 68
Further reading 70
4 The phenotypic characteristics, genetics and ontogeny of
peroxisomal proteins 71
Introduction 71
Catalase - the genetics of turnover and multiplicity 71
Chromosomal mapping of peroxisomal genes 77
Cloning and structural analysis of peroxisomal genes 79
Peroxisomal ontogeny in mammals 84
The involvement of the peroxisome in the ageing process 88
Catalase development in plants 89
Peroxisome-glyoxysome transitions in plants 90
Concluding comments - 93
Summary 93
Further reading 95
5 Peroxisomal metabolism - lipids 96
Scope of metabolism 96
P-Oxidation of long chain fatty acids 97
The p-oxidation cycle 99
P -Oxidation of common fatty acids in the peroxisome 101
P -Oxidation of unsaturated fatty acids 101
P-Oxidation of very long chain fatty acids 106
Contents xi
Branched chain fatty acids
Peroxisomal oxidation of dicarboxylic acids
Metabolism of bile acids
Prostaglandins and related compounds
Metabolism of xenobiotics
Fatty acid binding proteins
Anabolic roles in lipid metabolism
Synthesis of ether lipids
Synthesis of cholesterol
Dolichol metabolism
Summary
Further reading
6 Further metabolic involvements of the peroxisome
Introduction
The metabolism of amino acids and related compounds
Gluconeogenesis
Glyoxylate metabolism
Glyoxylate adducts
Hydroxyacid metabolism
Purine metabolism
Further oxidations
Respiration
The subcellular disposal of hydrogen peroxide and
superoxide radicals
Peroxisomal metabolism in protozoa, yeasts and plants
Summary
Further reading
7 Regulatory factors in peroxisomal metabolism
Introduction
Energetics
Factors influencing peroxisomal metabolism
The diversity of metabolism within the peroxisome
Regulatory shuttles
Metabolic interactions between peroxisomes and other
organdies
Metabolic flux and its implications in regulation
Substrate turnover in vivo
Intertissue communication
xii Contents
Concluding comments 172
Summary 172
Further reading 173
8 Peroxisomal biogenesis and turnover 174
Overview 174
Biogenesis of individual peroxisomal proteins 177
Catalase 178
Thiolase 179
Topogenic signals 180
Universality of the topogenic signal? 181
Membrane translocation of peroxisomal proteins 183
Biogenesis of peroxisomal membranes 185
Ultrastructural aspects of peroxisomal biogenesis 186
Peroxisome assembly in yeasts and Chinese hamster ovary
cells 187
Summarizing model 189
Elements in the turnover of peroxisomal proteins 191
Synthesis and degradation of peroxisomal proteins 193
Organelle turnover 196
Summary 199
Further reading 201
9 Peroxisome proliferators 202
Introduction 202
Induction of peroxisomal enzymes 205
Induction in other cellular compartments 207
Mechanisms of peroxisome proliferation 208
Enzyme activities, membrane permeability and metabolic
shifts • 209
Substrate overload 212
Receptor mechanisms 213
Commentary on mechanistic models 219
Peroxisome proliferators and carcinogenesis 220
Summary 223
Further reading 224
10 Peroxisomes and human disease 225
Introduction 225
Categories of peroxisomal disorders 225
Contents xiii
Clinical and biochemical features of peroxisomal disorders 227
Molecular mechanisms of peroxisomal pathology 234
Nature of the molecular defects in the Zellweger syndrome
and in other generalized peroxisomal disorders 235
Turnover of peroxisomes 242
Genetic relationships between peroxisomal disorders 242
Summary 244
Further reading 245
11 Concluding comments 246
Recent developments 246
Prospectives in education and science 248
Peroxisomal diseases and community interactions 250
Lorenzo s oil - a journalistic account 252
Bibliography 255
Index 284
|
any_adam_object | 1 |
author | Masters, Colin J. Crane, Denis |
author_facet | Masters, Colin J. Crane, Denis |
author_role | aut aut |
author_sort | Masters, Colin J. |
author_variant | c j m cj cjm d c dc |
building | Verbundindex |
bvnumber | BV010324533 |
callnumber-first | Q - Science |
callnumber-label | QH603 |
callnumber-raw | QH603.P47 |
callnumber-search | QH603.P47 |
callnumber-sort | QH 3603 P47 |
callnumber-subject | QH - Natural History and Biology |
classification_rvk | WE 3500 |
ctrlnum | (OCoLC)31409467 (DE-599)BVBBV010324533 |
dewey-full | 574.87/4 |
dewey-hundreds | 500 - Natural sciences and mathematics |
dewey-ones | 574 - [Unassigned] |
dewey-raw | 574.87/4 |
dewey-search | 574.87/4 |
dewey-sort | 3574.87 14 |
dewey-tens | 570 - Biology |
discipline | Biologie |
edition | 1. publ. |
format | Book |
fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01414nam a2200397 c 4500</leader><controlfield tag="001">BV010324533</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">950802s1995 ad|| |||| 00||| engod</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0521482127</subfield><subfield code="9">0-521-48212-7</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)31409467</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV010324533</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-29</subfield><subfield code="a">DE-703</subfield><subfield code="a">DE-11</subfield><subfield code="a">DE-188</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH603.P47</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">574.87/4</subfield><subfield code="2">20</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WE 3500</subfield><subfield code="0">(DE-625)148282:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Masters, Colin J.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The peroxisome</subfield><subfield code="b">a vital organelle</subfield><subfield code="c">Colin Masters and Denis Crane</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">1. publ.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Cambridge u.a.</subfield><subfield code="b">Cambridge Univ. Press</subfield><subfield code="c">1995</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XVII, 286 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Peroxysomen</subfield><subfield code="2">gtt</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Microbodies</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Peroxisomes</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Peroxisom</subfield><subfield code="0">(DE-588)4128263-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Peroxisom</subfield><subfield code="0">(DE-588)4128263-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Crane, Denis</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HEBIS Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006870646&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-006870646</subfield></datafield></record></collection> |
id | DE-604.BV010324533 |
illustrated | Illustrated |
indexdate | 2024-07-09T17:50:32Z |
institution | BVB |
isbn | 0521482127 |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006870646 |
oclc_num | 31409467 |
open_access_boolean | |
owner | DE-355 DE-BY-UBR DE-29 DE-703 DE-11 DE-188 |
owner_facet | DE-355 DE-BY-UBR DE-29 DE-703 DE-11 DE-188 |
physical | XVII, 286 S. Ill., graph. Darst. |
publishDate | 1995 |
publishDateSearch | 1995 |
publishDateSort | 1995 |
publisher | Cambridge Univ. Press |
record_format | marc |
spelling | Masters, Colin J. Verfasser aut The peroxisome a vital organelle Colin Masters and Denis Crane 1. publ. Cambridge u.a. Cambridge Univ. Press 1995 XVII, 286 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Peroxysomen gtt Microbodies Peroxisomes Peroxisom (DE-588)4128263-2 gnd rswk-swf Peroxisom (DE-588)4128263-2 s DE-604 Crane, Denis Verfasser aut HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006870646&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Masters, Colin J. Crane, Denis The peroxisome a vital organelle Peroxysomen gtt Microbodies Peroxisomes Peroxisom (DE-588)4128263-2 gnd |
subject_GND | (DE-588)4128263-2 |
title | The peroxisome a vital organelle |
title_auth | The peroxisome a vital organelle |
title_exact_search | The peroxisome a vital organelle |
title_full | The peroxisome a vital organelle Colin Masters and Denis Crane |
title_fullStr | The peroxisome a vital organelle Colin Masters and Denis Crane |
title_full_unstemmed | The peroxisome a vital organelle Colin Masters and Denis Crane |
title_short | The peroxisome |
title_sort | the peroxisome a vital organelle |
title_sub | a vital organelle |
topic | Peroxysomen gtt Microbodies Peroxisomes Peroxisom (DE-588)4128263-2 gnd |
topic_facet | Peroxysomen Microbodies Peroxisomes Peroxisom |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006870646&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
work_keys_str_mv | AT masterscolinj theperoxisomeavitalorganelle AT cranedenis theperoxisomeavitalorganelle |