PRE mRNA processing:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer [u.a.]
1995
|
| Schriftenreihe: | Molecular biology intelligence unit
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 217 S. Ill., graph. Darst. |
| ISBN: | 3540590811 1570592268 |
Internformat
MARC
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| 001 | BV010215235 | ||
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| 008 | 950608s1995 ad|| |||| 00||| engod | ||
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| 100 | 1 | |a Lamond, Angus I. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a PRE mRNA processing |c Angus I. Lamond |
| 264 | 1 | |a New York [u.a.] |b Springer [u.a.] |c 1995 | |
| 300 | |a 217 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Molecular biology intelligence unit | |
| 650 | 2 | |a ARN messager - Métabolisme | |
| 650 | 7 | |a ARN messagers |2 ram | |
| 650 | 7 | |a Biologia molecular e macromolecular |2 larpcal | |
| 650 | 2 | |a Modification post-transcriptionnelle des ARN | |
| 650 | 4 | |a Messenger RNA | |
| 650 | 4 | |a RNA Processing, Post-Transcriptional | |
| 650 | 4 | |a RNA, Messenger |x metabolism | |
| 650 | 0 | 7 | |a RNS-Spleißen |0 (DE-588)4201877-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Messenger-RNS |0 (DE-588)4169499-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Prozessierung |0 (DE-588)4318417-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Präkursor |0 (DE-588)4300438-6 |2 gnd |9 rswk-swf |
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| 689 | 2 | |5 DE-604 | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006788229&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-006788229 | |
Datensatz im Suchindex
| _version_ | 1808137510982778880 |
|---|---|
| adam_text |
CONTENTS
1.
RNA
STRUCTURE
AND
INTERACTIONS
WITH
PROTEINS
.
1
DAVID
M.J.
LILLEY
INTRODUCTION
.
1
RNA
STRUCTURE
.
1
SEQUENCE
SPECIFIC
RECOGNITION
OF
NUCLEIC
ACIDS:
INTERACTION
WITH
THE
MAJOR
GROOVE
.
5
GROOVE
ACCESS
IN
RNA
IS
A
SPECIAL
PROBLEM
.
5
POSSIBLE
SOLUTIONS
TO
THE
RNA
RECOGNITION
PROBLEM
.
6
THE
TAT-TAR
INTERACTION
.
7
REV-RRE
INTERACTION
.
7
THE
UI
A
SNRNP
.
7
SUMMARY
.
9
2.
FUNCTIONS
OF
NUCLEAR
PRE-MRNA/MRNA
BINDING
PROTEINS
.
17
MAURICE
S.
SWANSON
INTRODUCTION
.
17
WHAT
ARE
HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEINS?
AN
EVOLVING
DEFINITION
.
19
HNRNP
NOMENCLATURE
.
19
HNRNP
STRUCTURE
AND
SEQUENCE-SPECIFIC
RNA
BINDING
.
21
SUBNUCLEAR
DISTRIBUTION
OF
HNRNPS
.
21
HNRNPS
ARE
NOT
EXCLUSIVELY
NUCLEAR
.
23
A
DIVERSITY
OF
CELLULAR
FUNCTIONS
FOR
HNRNPS
.
23
SINGLE-STRANDED
RNA/DNA
BINDING PROTEINS
AND
ANNEALING
FACTORS
.
25
NASCENT
TRANSCRIPT
PACKAGING
.
26
CONSTITUTIVE
AND
ALTERNATIVE
PRE-MRNA
SPLICING
.
27
3
'-END
CLEAVAGE
AND
POLYADENYLATION
.
28
NUCLEOCYTOPLASMIC
TRANSPORT
OF
MRNAS
.
28
POSSIBLE
INVOLVEMENT
OF
HNRNPS
IN
DNA
REPLICATION
AND
TRANSCRIPTION
.
29
CONCLUSION
.
29
3.
THE
BIOCHEMISTRY
OF
PRE-MRNA
SPLICING
.
35
ANGELA
KRAMER
INTRODUCTION
.
35
THE
SPLICING
MECHANISMS
.
36
SNRNPS
.
38
THE
SPLICEOSOME
CYCLE
.
39
RNA-RNA
INTERACTIONS
IN
THE
SPLICEOSOME
.
42
PROTEIN
FACTORS
ESSENTIAL
FOR
SPLICING
.
45
THE
SR
FAMILY
OF
SPLICING
FACTORS
.
46
POLYPYRIMIDINE
TRACT-BINDING
PROTEINS
.
50
SNRNP-ASSOCIATED
SPLICING
ACTIVITIES
.
52
OTHER
SPLICING
ACTIVITIES
.
55
CONCLUDING
REMARKS
.
55
4.
PRE-MRNA
SPLICING
IN
PLANTS
.
65
WITOLD
FILIPOWICZ,
MAREK
GNIADKOWSKI,
UELI
KLAHRE
AND
HONG-XIANG
LIU
INTRODUCTION
.65
STRUCTURAL
FEATURES
OF
PLANT
INTRONS
.65
SPLICING
FACTORS
.
66
REGULATION
OF
SPLICING
IN
PLANTS
.
72
5.
YEAST
SPLICING
FACTORS
AND
GENETIC
STRATEGIES
FOR
THEIR
ANALYSIS
.
79
JEAN
D.
BEGGS
INTRODUCTION
.
79
RANDOM
ISOLATION
OF
MUTANTS
CAUSING
SPLICING
DEFECTS
.80
CLONING
GENES
ENCODING
SNRNAS
AND
SNRNP
PROTEINS
.
80
DIRECTED
METHODS
.82
SUPPRESSORS
OF
CIS-ACTING
RNA
MUTATIONS
.
83
SUPPRESSORS
OF
DEFECTS
IN
TRANS-ACTING
SPLICING
FACTORS
.
84
SYNTHETIC
LETHAL
MUTATIONS
.
87
TWO-HYBRID
INTERACTIONS
.
88
DOMINANT
NEGATIVE
MUTATIONS
.
88
CONCLUSIONS
.
89
6.
MECHANISMS
OF
REGULATED
PRE-MRNA
SPLICING
.
97
JUAN
VALCDRCEL,
RAVINDER
SINGH
AND
MICHAEL
R.
GREEN
INTRODUCTION
.
97
TO
SPLICE
OR
NOT
TO
SPLICE:
A
UL-5'
SPLICE
SITE
RECOGNITION
DILEMMA
.
99
CHOOSING
BETWEEN
TWO?
LOOK
FOR
THE
RS
LABEL
.
101
HARMONY
IN
COORDINATED
CHOICES
.
107
FUTURE
.
108
7.
3'-END
CLEAVAGE
AND
POLYADENYLATION
OF
NUCLEAR
MESSENGER
RNA
PRECURSORS
.
113
WALTER
KELLER
INTRODUCTION
.
113
RNA
SEQUENCES
REQUIRED
FOR
3'-PROCESSING
.
114
3'-END
PROCESSING
IN
VITRO
.
114
FRACTIONATION
OF
MAMMALIAN
3'-PROCESSING
FACTORS
.
115
POLY(A)
POLYMERASE
.
116
CLEAVAGE
AND
POLYADENYLATION
SPECIFICITY
FACTOR
(CPSF)
.
118
CLEAVAGE
FACTORS
.
119
POLY(A)
BINDING
PROTEIN
II
.
120
REACTION
MECHANISM
.
121
PRE-MRNA
3'-END
FORMATION
IN
YEAST
.
123
COUPLING
OF
SPLICING
AND
3'-END
FORMATION
.
127
RELATIONSHIP
BETWEEN
3
-END
PROCESSING
AND
TRANSCRIPTION
TERMINATION
.
128
8.
STRATEGIES
FOR
REGULATING
NUCLEAR
PRE-MRNA
POLYADENYLATION
.135
ANDERS
VIRTANEN
INTRODUCTION
.
135
GENERAL
CONSIDERATIONS
.
136
REGULATION
OF
POLYADENYLATION,
EXAMPLES
AND
POSSIBILITIES:
REGULATION
THROUGH
ESSENTIAL
POLYADENYLATION
FACTORS
.
136
REGULATION
THROUGH
NONESSENTIAL
POLYADENYLATION
FACTORS
.
139
REGULATION
THROUGH
ENVIRONMENTAL
FACTORS
.
141
SUMMARY
AND
PERSPECTIVES
.
144
9.
RNA
EDITING
.
151
JAMES
SCOTT
INTRODUCTION
.
151
EDITING
OF
RNA
IN
MITOCHONDRIA
.
152
EDITING
OF
RNA
IN
THE
NUCLEUS
.
155
PERSPECTIVE
.
157
10.
NUCLEAR
ORGANIZATION
OF
SNRNPS
AND
SPLICING
FACTORS
.
163
MARIA
CARMO-FONSECA
AND
JOAO
FERREIRA
INTRODUCTION
.
163
SNRNPS
ASSOCIATE
WITH
DISTINCT
STRUCTURES
IN
THE
NUCLEUS
.
163
PROTEIN
SPLICING
FACTORS
CO-LOCALIZE
WITH
SNRNPS
IN
DISTINCT
NUCLEAR
STRUCTURES
.
165
SNRNPS
AND
SPLICING
FACTORS
ARE
PRESENT
AT
SITES
OF
PRE-MRNA
SYNTHESIS
.
166
POSSIBLE
ROLES
FOR
SNRNPS
IN
COILED
BODIES
AND
INTERCHROMATIN
GRANULES
.
167
11.
EXPORT
OF
MRNA
THROUGH
THE
NUCLEAR
PORE
COMPLEX
.173
WILBERT
C.
BOELENS,
CATHERINE
DARGEMONT
AND
IAIN
W.
MATTAJ
INTRODUCTION
.
173
THE
NUCLEAR
PORE
COMPLEX
.
174
RNA
PROCESSING
AND
TRANSPORT
.
176
PROTEINS
INVOLVED
IN
RNA
EXPORT
.
178
GENETIC
IDENTIFICATION
OF
FACTORS
INVOLVED
IN
EXPORT
OF
POLYADENYLATED
RNA
.
179
TRANSPORT
OF
SNRNAS
.
181
NUCLEAR
EXPORT
OF
U
SNRNAS
.
181
CONCLUSIONS
.
183
12.
CLINICAL
DEFECTS
IN
PRE-MRNA
PROCESSING
.
187
MICHAEL
ANTONIOU
INTRODUCTION
.
187
SPLICE
SITE
ELEMENTS
AND
SPLICING
REACTIONS
.
187
SPLICING
MUTANTS
.
188
MUTANTS
OF
THE
SPLICE
DONOR
AND
ACCEPTOR
SITES
.
190
ACTIVATION
OF
CRYPTIC
SPLICE
SITES
.
193
THE
LARIAT
BRANCH
POINT
REGION
.
194
THE
STUDY
OF
0-THALASSEMIA
SPLICE
MUTANTS
IN
TISSUE
CULTURE
.
195
13.
VIRAL
STRATEGIES
AFFECTING
RNA
PROCESSING
IN
MAMMALIAN
CELLS
.
203
J.
BARKLIE
CLEMENTS
AND
ANNE
PHELAN
INTRODUCTION
.
203
HERPES
SIMPLEX
VIRUS
(HSV)
.
204
ADENOVIRUSES
.
206
HUMAN
IMMUNODEFICIENCY
VIRUS
(HIV-1)
.
209
INFLUENZA
A
VIRUS
.
210
INDEX
.
215 |
| any_adam_object | 1 |
| author | Lamond, Angus I. |
| author_facet | Lamond, Angus I. |
| author_role | aut |
| author_sort | Lamond, Angus I. |
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| callnumber-first | Q - Science |
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| callnumber-search | QP623.5.M47 |
| callnumber-sort | QP 3623.5 M47 |
| callnumber-subject | QP - Physiology |
| classification_rvk | WD 5355 WG 1800 |
| ctrlnum | (OCoLC)31971331 (DE-599)BVBBV010215235 |
| dewey-full | 574.87/3283 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 574 - [Unassigned] |
| dewey-raw | 574.87/3283 |
| dewey-search | 574.87/3283 |
| dewey-sort | 3574.87 43283 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Book |
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| id | DE-604.BV010215235 |
| illustrated | Illustrated |
| indexdate | 2024-08-23T00:51:42Z |
| institution | BVB |
| isbn | 3540590811 1570592268 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006788229 |
| oclc_num | 31971331 |
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| owner | DE-355 DE-BY-UBR DE-703 DE-11 |
| owner_facet | DE-355 DE-BY-UBR DE-703 DE-11 |
| physical | 217 S. Ill., graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Lamond, Angus I. Verfasser aut PRE mRNA processing Angus I. Lamond New York [u.a.] Springer [u.a.] 1995 217 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit ARN messager - Métabolisme ARN messagers ram Biologia molecular e macromolecular larpcal Modification post-transcriptionnelle des ARN Messenger RNA RNA Processing, Post-Transcriptional RNA, Messenger metabolism RNS-Spleißen (DE-588)4201877-8 gnd rswk-swf Messenger-RNS (DE-588)4169499-5 gnd rswk-swf Prozessierung (DE-588)4318417-0 gnd rswk-swf Präkursor (DE-588)4300438-6 gnd rswk-swf Messenger-RNS (DE-588)4169499-5 s Präkursor (DE-588)4300438-6 s DE-604 Prozessierung (DE-588)4318417-0 s RNS-Spleißen (DE-588)4201877-8 s DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006788229&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lamond, Angus I. PRE mRNA processing ARN messager - Métabolisme ARN messagers ram Biologia molecular e macromolecular larpcal Modification post-transcriptionnelle des ARN Messenger RNA RNA Processing, Post-Transcriptional RNA, Messenger metabolism RNS-Spleißen (DE-588)4201877-8 gnd Messenger-RNS (DE-588)4169499-5 gnd Prozessierung (DE-588)4318417-0 gnd Präkursor (DE-588)4300438-6 gnd |
| subject_GND | (DE-588)4201877-8 (DE-588)4169499-5 (DE-588)4318417-0 (DE-588)4300438-6 |
| title | PRE mRNA processing |
| title_auth | PRE mRNA processing |
| title_exact_search | PRE mRNA processing |
| title_full | PRE mRNA processing Angus I. Lamond |
| title_fullStr | PRE mRNA processing Angus I. Lamond |
| title_full_unstemmed | PRE mRNA processing Angus I. Lamond |
| title_short | PRE mRNA processing |
| title_sort | pre mrna processing |
| topic | ARN messager - Métabolisme ARN messagers ram Biologia molecular e macromolecular larpcal Modification post-transcriptionnelle des ARN Messenger RNA RNA Processing, Post-Transcriptional RNA, Messenger metabolism RNS-Spleißen (DE-588)4201877-8 gnd Messenger-RNS (DE-588)4169499-5 gnd Prozessierung (DE-588)4318417-0 gnd Präkursor (DE-588)4300438-6 gnd |
| topic_facet | ARN messager - Métabolisme ARN messagers Biologia molecular e macromolecular Modification post-transcriptionnelle des ARN Messenger RNA RNA Processing, Post-Transcriptional RNA, Messenger metabolism RNS-Spleißen Messenger-RNS Prozessierung Präkursor |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006788229&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT lamondangusi premrnaprocessing |