Cannabinoid receptors:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | Undetermined |
| Veröffentlicht: |
London u.a.
Acad. Press
1995
|
| Schriftenreihe: | Neuroscience perspectives
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 264 S. graph. Darst. |
| ISBN: | 0125514603 |
Internformat
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Datensatz im Suchindex
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| adam_text | CANNABINOID RECEPTORS EDITED BY R. G. PERTWEE DEPARTMENT OF BIOMEDICAL
SCIENCES MARISCHAL COLLEGE, UNIVERSITY OF ABERDEEN ABERDEEN, SCOTLAND
ACADEMIC PRESS HARCOURT BRACE & COMPANY, PUBLISHERS LONDON SAN DIEGO NEW
YORK BOSTON SYDNEY TOKYO TORONTO CONTENTS CONTRIBUTORS IX SERIES PREFACE
XI PREFACE XIII 1 PHARMACOLOGICAL, PHYSIOLOGICAL AND CLINICAL
IMPLICATIONS OF THE DISCOVERY OF CANNABINOID RECEPTORS: AN OVERVIEW 1
R.G. PERTWEE 1.1 INTRODUCTION 2 1.2 PHARMACOLOGICAL IMPLICATIONS OF THE
DISCOVERY OF THE ANANDAMIDE SYSTEM 10 1.3 PHYSIOLOGICAL IMPLICATIONS OF
THE DISCOVERY OF THE ANANDAMIDE SYSTEM 18 1.4 CLINICAL IMPLICATIONS OF
THE DISCOVERY OF THE ANANDAMIDE SYSTEM 21 REFERENCES 29 2 STRUCTURAL
REQUIREMENTS FOR CANNABINOID RECEPTOR PROBES 35 BILLY R. MARTIN, BRIAN
F. THOMAS AND RAJ K. RAZDAN 2.1 INTRODUCTION 36 2.2 CRITICAL DESCRIPTION
OF IN VIVO AND IN VITRO ASSAY SYSTEMS 36 2.3 PHARMACOLOGICAL ACTIVITY IN
LABORATORY ANIMALS 54 2.4 PHARMACOLOGICAL ACTIVITY IN HUMANS 64 2.5
MOLECULAR MODELLING OF THE CANNABINOID PHARMACOPHORE 65 2.6 EVIDENCE FOR
AND AGAINST RECEPTOR SUBTYPES 70 2.7 STRATEGIES FOR DEVELOPING
ANTAGONISTS 72 2.8 PROMISING LEADS 76 2.9 SUMMARY 77 ACKNOWLEDGEMENTS 79
REFERENCES 79 3 THE ROLE OF CELL MEMBRANES IN CANNABINOID ACTIVITY 87
ALEXANDROS MAKRIYANNIS 3.1 INTRODUCTION 88 3.2 MEMBRANE-BASED
CANNABINOID ACTIVITY 89 CONTENTS 3.3 CONCLUSION 109 REFERENCES 111
MOLECULAR BIOLOGY OF THE CANNABINOID RECEPTOR 117 LA. MATSUDA AND T.I.
BANNER 4.1 INTRODUCTION 117 4.2 THE CLONED CANNABINOID RECEPTOR 119 4.3
THE RECEPTOR GENE AND ITS EXPRESSION 129 4.4 UNRESOLVED ISSUES AND
RESEARCH IMPLICATIONS 136 4.5 SUMMARY 139 REFERENCES 140 LOCALIZATION OF
CANNABINOID RECEPTORS IN BRAIN AND PERIPHERY 145 MILES HERKENHAM 5.1
INTRODUCTION 145 5.2 LOCALIZATION OF CANNABINOID BINDING SITES 147 5.3
LOCALIZATION OF CANNABINOID RECEPTOR MRNA 156 5.4 CONCLUSIONS 159
REFERENCES 161 CANNABINOID COMPOUNDS AND SIGNAL TRANSDUCTION MECHANISMS
167 ALLYN C. HOWLETT * 6.1 CELLULAR MECHANISMS FOR CANNABINOID COMPOUNDS
168 6.2 SIGNAL TRANSDUCTION VIA THE CB! RECEPTOR AS A G PROTEIN-COUPLED
RECEPTOR 174 6.3 PHOSPHOLIPASE C 189 6.4 CANNABINOID COMPOUNDS AND
EICOSANOIDS 190 6.5 PROTEIN KINASE C 195 6.6 IMPLICATIONS AND FUTURE
DIRECTIONS 196 REFERENCES 197 FUNCTIONAL SIGNIFICANCE OF CANNABINOID
RECEPTORS IN BRAIN 205 SAM A. DEADWYLER, ROBERT E. HAMPSON AND STEVEN R.
CHILDERS 7.1 INTRODUCTION 206 7.2 CELLULAR ACTIONS OF CANNABINOIDS 206
7.3 CANNABINOID EFFECTS ON SYNAPTIC MECHANISMS 214 7.4 ENDOGENOUS
CANNABINOID SUBSTANCES IN BRAIN 214 7.5 CANNABINOID ACTIONS IN
CEREBELLUM 216 7.6 RECEPTOR CONVERGENCE IN CEREBELLAR GRANULE CELLS 218
7.7 FUNCTIONAL CONSEQUENCES OF CANNABINOID RECEPTOR ACTIVATION 220 VI
CONTENTS 7.8 PROMISING LEADS - POTENTIAL ROLE OF CANNABINOID RECEPTORS
IN HIPPOCAMPUS 222 7.9 SUMMARY 226 ACKNOWLEDGEMENTS 226 REFERENCES 227
THE UNPAVED ROAD TO THE ENDOGENOUS BRAIN CANNABINOID LIGANDS, THE
ANANDAMIDES 223 R. MECHOULAM AND E. FRIDE 8.1 8.2 8.3 8.4 8.5 8.6 8.7
INTRODUCTION TECHNICAL AND CONCEPTUAL PROBLEMS MYELIN BASIC PROTEIN - A
POTENTIAL CANNABINOID LIGAND STEREOSELECTIVITY OF CANNABIMIMETIC ACTION
VARIOUS APPROACHES TOWARDS DIE IDENTIFICATION OF ENDOGENOUS CANNABINOIDS
ANANDAMIDE CONCLUSION ACKNOWLEDGEMENTS REFERENCES 233 234 236 237 241
242 254 255 255 INDEX 259 VII
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T17:48:03Z |
| institution | BVB |
| isbn | 0125514603 |
| language | Undetermined |
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| physical | XIV, 264 S. graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Acad. Press |
| record_format | marc |
| series2 | Neuroscience perspectives |
| spelling | Cannabinoid receptors ed. by R. G. Pertwee London u.a. Acad. Press 1995 XIV, 264 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Neuroscience perspectives Rezeptor (DE-588)4049722-7 gnd rswk-swf Cannabinoide (DE-588)4069839-7 gnd rswk-swf Rezeptor (DE-588)4049722-7 s Cannabinoide (DE-588)4069839-7 s DE-604 Pertwee, Roger Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006767962&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cannabinoid receptors Rezeptor (DE-588)4049722-7 gnd Cannabinoide (DE-588)4069839-7 gnd |
| subject_GND | (DE-588)4049722-7 (DE-588)4069839-7 |
| title | Cannabinoid receptors |
| title_auth | Cannabinoid receptors |
| title_exact_search | Cannabinoid receptors |
| title_full | Cannabinoid receptors ed. by R. G. Pertwee |
| title_fullStr | Cannabinoid receptors ed. by R. G. Pertwee |
| title_full_unstemmed | Cannabinoid receptors ed. by R. G. Pertwee |
| title_short | Cannabinoid receptors |
| title_sort | cannabinoid receptors |
| topic | Rezeptor (DE-588)4049722-7 gnd Cannabinoide (DE-588)4069839-7 gnd |
| topic_facet | Rezeptor Cannabinoide |
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| work_keys_str_mv | AT pertweeroger cannabinoidreceptors |