Biopharmaceutics of orally administered drugs:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London, Munich u.a.
Horwood
1995
|
| Schriftenreihe: | Ellis Horwood Series in pharmaceutical technology
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VIII, 281 S. Ill., zahlr. graph. Darst. |
| ISBN: | 0131080938 |
Internformat
MARC
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| 650 | 4 | |a Oral medication | |
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Datensatz im Suchindex
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| adam_text | O BIOPHARMACEUTICS OF ORALLY ADMINISTERED DRUGS P. MACHERAS, C. REPPAS
AND J.B. DRESSMAN ELLIS HORWOOD LONDON NEW YORK TORONTO SYDNEY TOKYO
SINGAPORE MADRID MEXICO CITY MUNICH TABLE OF CONTENTS PREFACE VII 1.
INTRODUCTION 1 PARTI 2. RATE PARAMETERS AND PHYSICAL PROCESSES RELEVANT
TO DRUG ABSORPTION .. 7 2.1 BASIC KINETICS RELEVANT TO DRUG TRANSPORT
.... 7 2.2 CHARACTERISTIC TIMES: APPLICATION TO FIRST- AND ZERO-ORDER
PROCESSES.. 12 2.3 MECHANISMS OF DRUG TRANSPORT 14 PARTH 3.
BIOAVAILABILITY 25 3.1 INTRODUCTION TO BIOAVAILABILITY 25 3.2 PROCESSES
THAT AFFECT THE BIOAVAILABILITY OF DRUGS AFTER ORAL ADMINISTRATION 28
3.3 METHODS OF ASSESSING AND PARAMETERS USED TO CHARACTERIZE
BIOAVAILABILITY 30 4. SUPPLY OF THE GASTROINTESTINAL FLUIDS WITH DRUG 35
4.1 PROCESSES WHICH TRANSFER DRUG TO THE GASTROINTESTINAL FLUIDS AND
THEIR IMPACT ON ABSORPTION 38 4.2 RELEASE OF THE DRUG FROM A SOLID
IMMEDIATE-RELEASE DOSAGE FORMULATION 40 4.3 DRUG RELEASE FROM AN
EXTENDED-RELEASE SYSTEM 74 4.4 ASSESSING DRUG DISSOLUTION AND RELEASE IN
VITRO 79 5. DELIVERY OF THE DRUG TO AND REMOVAL OF DRUG FROM UPTAKE
SITES 89 5.1 PROCESSES INVOLVED IN THE DELIVERY OF DRUG TO AND REMOVAL
OF DRUG FROM UPTAKE SITES 89 VI TABLE OF CONTENTS 5.2 REVIEW OF THE
ANATOMY AND PHYSIOLOGY OF THE GASTROINTESTINAL TRACT.. 99 5.3 TRANSIT OF
THE DOSAGE FORM AND THE DRUG THROUGH THE GASTROINTESTINAL TRACT 110 6.
UPTAKE OF DRUG BY THE GASTROINTESTINAL MUCOSA 125 6.1 TRANSFER OF THE
DRUG FROM THE GASTROINTESTINAL FLUIDS TO THE INTERIOR OF THE EPITHELIAL
CELL 127 6.2 TRANSFER OF THE DRUG FROM THE INTERIOR OF THE EPITHELIAL
CELL INTO THE BLOOD 143 6.3 METHODS OF ENHANCING THE PERMEATION OF DRUGS
THROUGH THE GASTRO- INTESTINAL MUCOSA 149 6.4 METHODS OF STUDYING UPTAKE
151 PART III 7. PROTEIN BINDING 163 7.1 STRUCTURE OF THE MOST IMPORTANT
PLASMA PROTEINS 164 7.2 DRUG-PROTEIN BINDING 169 7.3 TECHNIQUES USED IN
PROTEIN BINDING STUDIES 184 8. DISTRIBUTION OF DRUGS IN THE BODY 189 8.1
APPARENT VOLUME OF DISTRIBUTION 189 8.2 TRANSPORT OF DRUGS THROUGH
SPECIFIC MEMBRANES 201 8.3 EXCRETION OF DRUGS IN BREAST MILK AND SALIVA
206 9. RENAL AND HEPATIC CLEARANCE 211 9.1 THE CONCEPT OF CLEARANCE 211
9.2 RENAL CLEARANCE 214 9.3 HEPATIC CLEARANCE 225 9.4 FIRST-PASS EFFECT
250 PART IV 10. STATISTICAL TREATMENT OF EXPERIMENTAL DATA 259 10.1
TESTING FOR THE EQUIVALENCE OF MEANS 259 10.2 SIMPLE LINEAR REGRESSION
ANALYSIS 268 10.3 CORRELATION 274 INDEX 279
|
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| dewey-ones | 615 - Pharmacology and therapeutics |
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| dewey-sort | 3615 17 |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T17:47:49Z |
| institution | BVB |
| isbn | 0131080938 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006759023 |
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| physical | VIII, 281 S. Ill., zahlr. graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Horwood |
| record_format | marc |
| series2 | Ellis Horwood Series in pharmaceutical technology |
| spelling | Macheras, Panos Verfasser aut Biopharmaceutics of orally administered drugs P. Macheras, C. Reppas and J. B. Dressman London, Munich u.a. Horwood 1995 VIII, 281 S. Ill., zahlr. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Ellis Horwood Series in pharmaceutical technology Administration, Oral Biopharmaceutics Digestive System metabolism Oral medication Pharmacokinetics Orales Arzneimittel (DE-588)4274444-1 gnd rswk-swf Wirkstofffreisetzung (DE-588)4190018-2 gnd rswk-swf Orales Arzneimittel (DE-588)4274444-1 s Wirkstofffreisetzung (DE-588)4190018-2 s DE-604 Reppas, Christos Verfasser aut Dressman, Jennifer B. Verfasser aut GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006759023&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Macheras, Panos Reppas, Christos Dressman, Jennifer B. Biopharmaceutics of orally administered drugs Administration, Oral Biopharmaceutics Digestive System metabolism Oral medication Pharmacokinetics Orales Arzneimittel (DE-588)4274444-1 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd |
| subject_GND | (DE-588)4274444-1 (DE-588)4190018-2 |
| title | Biopharmaceutics of orally administered drugs |
| title_auth | Biopharmaceutics of orally administered drugs |
| title_exact_search | Biopharmaceutics of orally administered drugs |
| title_full | Biopharmaceutics of orally administered drugs P. Macheras, C. Reppas and J. B. Dressman |
| title_fullStr | Biopharmaceutics of orally administered drugs P. Macheras, C. Reppas and J. B. Dressman |
| title_full_unstemmed | Biopharmaceutics of orally administered drugs P. Macheras, C. Reppas and J. B. Dressman |
| title_short | Biopharmaceutics of orally administered drugs |
| title_sort | biopharmaceutics of orally administered drugs |
| topic | Administration, Oral Biopharmaceutics Digestive System metabolism Oral medication Pharmacokinetics Orales Arzneimittel (DE-588)4274444-1 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd |
| topic_facet | Administration, Oral Biopharmaceutics Digestive System metabolism Oral medication Pharmacokinetics Orales Arzneimittel Wirkstofffreisetzung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006759023&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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