Basic biology for the thoracic surgeon:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia u.a.
Saunders
1995
|
| Schriftenreihe: | Chest surgery clinics of North America
5,1 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VIII, 176 S. Ill., graph. Darst. |
Internformat
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| 245 | 1 | 0 | |a Basic biology for the thoracic surgeon |c Michael R. Johnston, guest ed. |
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Datensatz im Suchindex
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I BASIC BIOLOGY FOR THE THORACIC SURGEON
CONTENTS
Preface xi
Michael R. Johnston
Why Should Thoracic Surgeons Understand Basic Biology? 1
Robert B. Wagner and Michael R. Johnston
Thoracic surgery is undergoing major changes. In addition to the
well publicized political and economic upheavals, our patients
and the diseases targeted are rapidly evolving. Much of the
change is driven by an explosion of new biology that many in
the field have little or no familiarity with. As molecular biology,
immunology, and information about cytokines pervade our litera¬
ture and practices, it is imperative that thoracic surgeons develop
a basic understanding of these and other unique concepts. The
best link between our clinical practice and the new biology is
thoracic surgical scientists who are exposed to current informa¬
tion.
The Training and Preservation of Thoracic Surgeon Scientists 7
Jack A. Roth
The practice of thoracic surgery presents unique opportunities
for research; however, the changing climate of medical practice
and research funding threatens to undermine careers in research
for the surgeon. Strategies for training future surgical scientists
and developing academic environments conducive to research
are discussed. In addition, funding strategies and research philos¬
ophy are presented.
I CHEST SURGERY CLINICS OF NORTH AMERICA
VOLUME 5 • NUMBER 1 • FEBRUARY 1995 V
Genetic Modulation in the Pathogenesis and Treatment
of Cancer 17
Alan G. Casson and J. Andrea McCart
Recent advances in molecular biology have improved our under¬
standing of the pathogenesis of cancer. Molecular genetic alter¬
ations have been characterized in lung and esophageal malig¬
nancies and may have potential clinical application in tumor
diagnosis, staging, prevention and treatment.
Molecular Biologic Features of Non Small Cell Lung Cancer:
Clinical Implications 39
Valerie W. Rusch and Ethan Dmitrovsky
A fuller understanding of the fundamental mechanisms involved
in tumor initiation, growth, and metastasis will enable us to
develop innovative approaches to detection and treatment that
will improve the poor survival of patients with lung cancer.
Current information suggests that certain individuals may be
predisposed to developing lung cancer and that lung cancers,
like other solid tumors, are characterized by the activation of
oncogenes, the expression of growth factor loops, and the inacti
vation of tumor suppressor genes. Within the next decade, it is
likely that genetic abnormalities will be used to identify individu¬
als at risk for lung cancer, to select patients for adjuvant therapy,
and to develop novel forms of treatment.
Immunoreactivity in Lung Cancer 57
Steven J. Mentzer
Lung cancer has been associated with suppression of the cellular
immune system. Recent experimental evidence suggests that rec¬
ognition of HLA class I molecules by cytolytic T lymphocytes is
important for tumor resistance. Augmentation of this interaction
may soon play a role in cancer therapy.
The Macrophage, TNF, and Other Cytokines 73
Harvey I. Pass, Daphne Mew, Helen A. Pass, and
Barbara K. Temeck
A complex interplay of peptides known as the cytokines may
have a tremendous influence over a number of inflammatory
related conditions. Tumor necrosis factor occupies an early and
central role in the initiation of cascades that ultimately influences
a number of cell types involved in tissue inflammation, tissue
rejection, cancer, and injuries from ischemia reperfusion. Only
now are the cascades being defined and therapies being designed
to interrupt the toxic effects of these cytokines and to treat malig¬
nancy.
vi CONTENTS
Lung Preservation and Lung Injury 91
Helmut W. Unruh
Lung preservation and injury associated with lung transplanta¬
tion are presented in four temporal phases. The first phase is
lung injury that is present in the donor prior to any preservation
intervention. The second phase occurs with the organ procure¬
ment procedure. The third phase is the storage time prior to
transplantation. The fourth phase encompasses the ischemia re
perfusion event with its attendant free radical mediated injury.
Immunologic Consequences of Transplantation 107
Robert J. Keenan and Adriana Zeevi
Since the first clinical heart lung transplant performed in 1982,
more than 2000 pulmonary transplants have been performed
worldwide with increasing success rates. Rejection (both acute
and chronic) remains an important cause of morbidity and mor¬
tality despite our increasingly sophisticated approaches to treat¬
ing this problem. Obliterative bronchiolitis (OB), a progressive
obstructive ventilatory disease, is the most significant long term
complication following pulmonary transplantation. The purpose
of this review is to describe some of the known host immune
responses associated with pulmonary rejection.
Photodynamic Therapy: Biology and Clinical Application 121
Steven M. Keller
The absorption of light by chemical compounds has been ex¬
ploited for both cancer detection and therapy. Techniques em¬
ploying fluorescence are now available for detection of early
mucosal tumors that are not visible with conventional fiberoptics.
Photodynamic therapy using a light activated hematoporhyrin
derivative Photofrin II has proven tumoricidal against a variety
of neoplasms in both the laboratory and clinical settings.
Lung Perfusion and Other Methods of Targeting Therapy
to Lung Tumors 139
Michael R. Johnston
A variety of drugs and biologic agents are available or under
development for treating cancer and other diseases of the chest.
Understanding the process by which these agents are directed
preferentially toward disease tissue may allow for their improved
clinical efficacy. The basic targeting concepts are outlined along
with various biophysical targeting techniques. An in depth re¬
view of regional infusion and isolated perfusion is presented with
emphasis on their relevance to thoracic surgery.
CONTENTS Vii
Neuronal Control of Esophageal Function 157
William G. Richards and David J. Sugarbaker
Esophageal peristalsis and sphincter function are controlled by
the autonomic nervous system. The nature of neuronal control
varies because of regional differences in muscular anatomy. In
addition to cholinergic and adrenergic mechanisms, neurons uti¬
lizing a number of neuropeptides and nitric oxide contribute to
coordination of esophageal function.
Index 173
Subscription Information Inside back cover
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| physical | VIII, 176 S. Ill., graph. Darst. |
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| spelling | Basic biology for the thoracic surgeon Michael R. Johnston, guest ed. Philadelphia u.a. Saunders 1995 VIII, 176 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Chest surgery clinics of North America 5,1 Biologie Chirurgie thoracique Thorax Biology Krankheit (DE-588)4032844-2 gnd rswk-swf Brustorgan (DE-588)4194536-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Brustorgan (DE-588)4194536-0 s Krankheit (DE-588)4032844-2 s DE-604 Johnston, Michael R. Sonstige oth Chest surgery clinics of North America 5,1 (DE-604)BV005455558 5,1 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006734944&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Basic biology for the thoracic surgeon |
| title_auth | Basic biology for the thoracic surgeon |
| title_exact_search | Basic biology for the thoracic surgeon |
| title_full | Basic biology for the thoracic surgeon Michael R. Johnston, guest ed. |
| title_fullStr | Basic biology for the thoracic surgeon Michael R. Johnston, guest ed. |
| title_full_unstemmed | Basic biology for the thoracic surgeon Michael R. Johnston, guest ed. |
| title_short | Basic biology for the thoracic surgeon |
| title_sort | basic biology for the thoracic surgeon |
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