Overexpression and knockout of cytokines in transgenic mice:
Cytokines are a steadily growing family of molecules which play a major role in intercellular communication. Key questions for the cytokine researcher today include 'which cytokines are involved in the pathophysiology of a disease or immune response', 'when do these cytokines function...
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London u.a.
Acad. Press
1994
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | Cytokines are a steadily growing family of molecules which play a major role in intercellular communication. Key questions for the cytokine researcher today include 'which cytokines are involved in the pathophysiology of a disease or immune response', 'when do these cytokines function' and 'which of their many activities are relevant in vivo' The intricate ways in which they act, often with the exhibition of pleiotropic or synergistic effects, make the study of cytokine biology complicated, and the results potentially ambiguous using conventional systems. As a consequence, many investigators are now utilizing the powerful tools of transgenic technology to address some of these questions Written by the leading authorities in the field, this book describes the achievements realized so far, and clearly demonstrates the feasibility of using this approach to study the expression of this group of biologically important substances |
| Beschreibung: | XIII, 191 S. Ill., graph. Darst. |
| ISBN: | 0123784506 |
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| 245 | 1 | 0 | |a Overexpression and knockout of cytokines in transgenic mice |c ed. by Chaim O. Jacob |
| 264 | 1 | |a London u.a. |b Acad. Press |c 1994 | |
| 300 | |a XIII, 191 S. |b Ill., graph. Darst. | ||
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| 520 | 3 | |a Cytokines are a steadily growing family of molecules which play a major role in intercellular communication. Key questions for the cytokine researcher today include 'which cytokines are involved in the pathophysiology of a disease or immune response', 'when do these cytokines function' and 'which of their many activities are relevant in vivo' | |
| 520 | |a The intricate ways in which they act, often with the exhibition of pleiotropic or synergistic effects, make the study of cytokine biology complicated, and the results potentially ambiguous using conventional systems. As a consequence, many investigators are now utilizing the powerful tools of transgenic technology to address some of these questions | ||
| 520 | |a Written by the leading authorities in the field, this book describes the achievements realized so far, and clearly demonstrates the feasibility of using this approach to study the expression of this group of biologically important substances | ||
| 650 | 7 | |a Cytokinen |2 gtt | |
| 650 | 7 | |a Genexpressie |2 gtt | |
| 650 | 7 | |a Muizen |2 gtt | |
| 650 | 7 | |a Transgene organismen |2 gtt | |
| 650 | 4 | |a Cellular immunity | |
| 650 | 4 | |a Cytokines | |
| 650 | 4 | |a Disease Models, Animal | |
| 650 | 4 | |a Gene Expression | |
| 650 | 4 | |a Genetic engineering | |
| 650 | 4 | |a Interleukins |x genetics | |
| 650 | 4 | |a Interleukins |x immunology | |
| 650 | 4 | |a Mice, Knockout | |
| 650 | 4 | |a Mice, Transgenic | |
| 650 | 4 | |a T-Lymphocytes |x immunology | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-006679435 | ||
Datensatz im Suchindex
| _version_ | 1804124451857498112 |
|---|---|
| adam_text | jDyerexpression and Knockout
of Cytokines in Transgenic
Mice
Edited by
Chaim O Jacob
University of Southern California School of Medicine,
Los Angeles, CA, USA
ACADEMIC PRESS
Harcourt Brace amp;? Company, Publishers
London San Diego New York
Boston Sydney Tokyo Toronto
Contents
Contributors vii
Introduction ix
CO Jacob
1 Strategies for modulation of interleuldn-l in vivo:
knockout and transgenics 1
F F Csaikl, U M Csaikl and S K Durum
2 In situ production of interleukin-2 and its role in
autoimmunity 15
/ Allison, W R Heath andJ FAP Miller
3 Interleukin-2 overexpression and deprivation:
consequences for lymphopoiesis and T cell function 31
A Schimpl and T Hiinig
4 Interleukin-4 expressing transgenic mice: in vivo models
for studying the actions of a cytokine 47
H J Burstein, R I Tepper and A K Abbas
5 Interleukin-5 activity in vivo 61
C J Sanderson and M Strath
6 Interleukin-6 transgenic mouse: a model of chronic
inflammatory proliferative disease 73
T Hirano
7 Leukemia inhibitory factor and mammalian development 85
C L Stewart
8 Lymphopoiesis in mice homozygous for an interleukin-7
transgene: in vivo interactions with abnormal
interleukin-4 or c-Kit receptor expression 97
R Palacios and J Samaridis
9 Expression and knockout of interferons in transgenic mice 111
CO Jacob
vi Contents
10 Human erythropoietin gene expression in transgenic mice 125
G L Semenza
11 The importance of transforming growth factor-pi in
immunological homeostasis as revealed by gene ablation
in mice 135
M M Shull, A B Kier, R J Diebold, M Yin and T Doetschman
12 Granulocyte-macrophage colony stimulating factor
transgenic mice 161
D Metcalf
Index 187
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| bvnumber | BV010065975 |
| callnumber-first | Q - Science |
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| callnumber-search | QH450 |
| callnumber-sort | QH 3450 |
| callnumber-subject | QH - Natural History and Biology |
| classification_rvk | XD 3211 |
| ctrlnum | (OCoLC)31191307 (DE-599)BVBBV010065975 |
| discipline | Medizin |
| format | Book |
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| id | DE-604.BV010065975 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:45:53Z |
| institution | BVB |
| isbn | 0123784506 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006679435 |
| oclc_num | 31191307 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XIII, 191 S. Ill., graph. Darst. |
| publishDate | 1994 |
| publishDateSearch | 1994 |
| publishDateSort | 1994 |
| publisher | Acad. Press |
| record_format | marc |
| spelling | Overexpression and knockout of cytokines in transgenic mice ed. by Chaim O. Jacob London u.a. Acad. Press 1994 XIII, 191 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cytokines are a steadily growing family of molecules which play a major role in intercellular communication. Key questions for the cytokine researcher today include 'which cytokines are involved in the pathophysiology of a disease or immune response', 'when do these cytokines function' and 'which of their many activities are relevant in vivo' The intricate ways in which they act, often with the exhibition of pleiotropic or synergistic effects, make the study of cytokine biology complicated, and the results potentially ambiguous using conventional systems. As a consequence, many investigators are now utilizing the powerful tools of transgenic technology to address some of these questions Written by the leading authorities in the field, this book describes the achievements realized so far, and clearly demonstrates the feasibility of using this approach to study the expression of this group of biologically important substances Cytokinen gtt Genexpressie gtt Muizen gtt Transgene organismen gtt Cellular immunity Cytokines Disease Models, Animal Gene Expression Genetic engineering Interleukins genetics Interleukins immunology Mice, Knockout Mice, Transgenic T-Lymphocytes immunology Cytokine (DE-588)4205701-2 gnd rswk-swf Transgene Tiere (DE-588)4279021-9 gnd rswk-swf Cytokine (DE-588)4205701-2 s Transgene Tiere (DE-588)4279021-9 s DE-604 Jacob, Chaim O. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006679435&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Overexpression and knockout of cytokines in transgenic mice Cytokinen gtt Genexpressie gtt Muizen gtt Transgene organismen gtt Cellular immunity Cytokines Disease Models, Animal Gene Expression Genetic engineering Interleukins genetics Interleukins immunology Mice, Knockout Mice, Transgenic T-Lymphocytes immunology Cytokine (DE-588)4205701-2 gnd Transgene Tiere (DE-588)4279021-9 gnd |
| subject_GND | (DE-588)4205701-2 (DE-588)4279021-9 |
| title | Overexpression and knockout of cytokines in transgenic mice |
| title_auth | Overexpression and knockout of cytokines in transgenic mice |
| title_exact_search | Overexpression and knockout of cytokines in transgenic mice |
| title_full | Overexpression and knockout of cytokines in transgenic mice ed. by Chaim O. Jacob |
| title_fullStr | Overexpression and knockout of cytokines in transgenic mice ed. by Chaim O. Jacob |
| title_full_unstemmed | Overexpression and knockout of cytokines in transgenic mice ed. by Chaim O. Jacob |
| title_short | Overexpression and knockout of cytokines in transgenic mice |
| title_sort | overexpression and knockout of cytokines in transgenic mice |
| topic | Cytokinen gtt Genexpressie gtt Muizen gtt Transgene organismen gtt Cellular immunity Cytokines Disease Models, Animal Gene Expression Genetic engineering Interleukins genetics Interleukins immunology Mice, Knockout Mice, Transgenic T-Lymphocytes immunology Cytokine (DE-588)4205701-2 gnd Transgene Tiere (DE-588)4279021-9 gnd |
| topic_facet | Cytokinen Genexpressie Muizen Transgene organismen Cellular immunity Cytokines Disease Models, Animal Gene Expression Genetic engineering Interleukins genetics Interleukins immunology Mice, Knockout Mice, Transgenic T-Lymphocytes immunology Cytokine Transgene Tiere |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006679435&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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