Diabetic retinopathy: haemodynamic and clinical factors in the pathogenesis
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | German |
| Published: |
Bergisch Gladbach u.a.
Eul
1995
|
| Series: | Medizinische Forschung
8 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Zugl.: London, Univ., Diss., 1994 |
| Physical Description: | 275 S. Ill., graph. Darst. |
| ISBN: | 3890124321 |
Staff View
MARC
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| 008 | 950130s1995 gw ad|| m||| 00||| ger d | ||
| 016 | 7 | |a 943354668 |2 DE-101 | |
| 020 | |a 3890124321 |c kart. : DM 69.00, sfr 69.00, S 532.00 |9 3-89012-432-1 | ||
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| 035 | |a (DE-599)BVBBV010029092 | ||
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| 100 | 1 | |a Patel, Vinod |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Diabetic retinopathy |b haemodynamic and clinical factors in the pathogenesis |c Vinod Patel |
| 264 | 1 | |a Bergisch Gladbach u.a. |b Eul |c 1995 | |
| 300 | |a 275 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Medizinische Forschung |v 8 | |
| 500 | |a Zugl.: London, Univ., Diss., 1994 | ||
| 650 | 4 | |a Diabetic Retinopathy |x pathology | |
| 650 | 4 | |a Hemodynamics | |
| 650 | 4 | |a Retinal Vessels |x pathology | |
| 650 | 0 | 7 | |a Pathogenese |0 (DE-588)4115512-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Retinopathia diabetica |0 (DE-588)4177904-6 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Retinopathia diabetica |0 (DE-588)4177904-6 |D s |
| 689 | 0 | 1 | |a Pathogenese |0 (DE-588)4115512-9 |D s |
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Record in the Search Index
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CONTENTS
PAGE
ABSTRACT
2
LIST
OF
FIGURES
10
LIST
OF
TABLES
13
STATEMENT
BY
THE
AUTHOR
15
ACKNOWLEDGEMENTS
16
DEDICATION
17
CHAPTER
1
INTRODUCTION
AND
LITERATURE
REVIEW
1.1
INTRODUCTION
20
1.2
HISTORICAL
PERSPECTIVES
20
1.2.1
HAEMODYNAMICS
20
1.2.2
DIABETIC
RETINOPATHY
20
1.2.3
HAEMODYNAMICS
OF
DIABETIC
RETINOPATHY
20
1.3
ANATOMY
OF
THE
RETINAL
CIRCULATION
23
1.4
REGULATION
OF
RETINAL
BLOOD
FLOW
25
1.4.1
AUTONOMIE
NERVOUS
SYSTEM
25
1.4.2
AUTOREGULATION
26
1.4.3
MECHANISM
OF
RETINAL
AUTOREGULATION
29
1.5
QUANTIFICATION
OF
RETINAL
BLOOD
FLOW
32
1.5.1
MEAN
TRANSIT
TIME
OF
FLUORESCEIN
AND
32
FLUORESCEIN-FRONT
ADVANCE
TIMING
1.5.2
RADIO-LABELLED
MICROSPHERES
33
1.5.3
BLUE
LIGHT
ENTOPTIC
PHENOMENON
33
1.5.4
SCANNING
LASER
OPHTHALMOSCOPY
34
1.5.5
TARGETED
DYE
DELIVERY
34
1.5.6
LASER
DOPPLER
VELOCIMETRY
35
1.6
DIABETIC
RETINOPATHY:CIASSIFICATION
AND
CLINICAL
FINDINGS
35
1.7
EPIDEMIOLOGY
OF
DIABETIC
RETINOPATHY
36
1.8
PATHOGENIC
MECHANISMS
IN
DIABETIC
RETINOPATHY
38
1.8.1
BIOCHEMICAL
HYPOTHESES
38
1.8.2
ENDOCRINE
FACTORS
39
1.8.3
HAEMODYNAMIC
ALTERATIONS
40
1.9
TREATMENT
OF
DIABETIC
RETINOPATHY
41
CHAPTER
2
AIM
AND
SCOPE
OF
THE
THESIS
48
CHAPTER
3
THE
APPLICATION
OF
HAEMODYNAMIC
PRINCIPLES
TO
THE
PATHOPHYSIOLOGY
OF
THE
RETINAL
CIRCULATION
3.1
LAMINAR
FLOW
AND
POISEUILLE
'
S
LAW
51
3.2
VISCOSITY
52
3.3
DERIVATION
OF
DISTRIBUTION
OF
VELOCITIES
IN
54
LAMINAR
FLOW
3.4
DERIVATION
OF
POISEUILLE
'
S
LAW
56
3.5
DERIVATION
OF
VMAX
TO
VMEAN
RATIO
57
3.6
LIMITATIONS
OF
POISEUILLE
'
S
LAW
IN
RETINAL
58
HAEMODYNAMICS
3.6.1
PURE
NEWTONIAN
FLUID
58
3.6.2
LAMINAR
FLOW
AND
TURBULENCE
58
3.6.3
STEADY
FLOW
59
3.6.4
CYLINDRICAL
SHAPE
59
3.7
BERNOUILLI
'
S
PRINCIPLE
60
3.8
LAPLACE
'
S
LAW
AND
CIRCUMFERENTIAL STRESS
60
3.9
VESSEL
WALL
SHEAR
STRESS
62
3.10
BRANCHING
IN
THE
MICROCIRCULATION
64
3.11
RESISTANCE
AND
CONDUCTANCE
67
3.12
RETINAL
PERFUSION
PRESSURE
68
3.13
THE
INTER-RELATIONSHIP
OF
THE
MAP,
IOP
AND
69
RETINAL
PERFUSION
PRESSURE
3.14
COEFFICIENT
OF
AUTOREGULATION
69
CHAPTER
4
METHODOLOGY
I
LASER
DOPPLER
VELOCIMETRY
4.1
LASER
DOPPLER
VELOCIMETRY
77
4.2
COMPONENTS
OF
THE
BIDIRECTIONAL
LASER
DOPPLER
VELOCIMETER
77
4.2.1
LASER
DELIVERY
SYSTEM
77
4.2.2
COLLECTION
OF
THE
DOPPLER-SHIFTED
LASER
78
LIGHT
4.2.3
COMPUTER
ANALYSIS
AND
DETERMINATION
OF
VMAX
79
4.3
PRINCIPLES
OF
LDV
OPERATION
84
5
4.4
THE
CHOICE
OF
RETINAL
VEIN
FOR
VMAX
MEASUREMENT
86
4.5
REPRODUCIBILITY
OF
THE
LDV
87
4.6
MODE
OF
OPERATION
OF
LDV
88
4.7
CALCULATION
OF
THE
MEAN
RED
CELL
VELOCITY
89
4.8
LIMITATIONS
OF
THE
LDV
89
CHAPTER
5
METHODOLOGY
II
MEASUREMENT
OF
RETINAL
VESSEL
DIAMETER
5.1
INTRODUCTION
92
5.2
RETINAL
VESSEL
PHOTOGRAPHY
93
5.3
COMPUTER-ASSISTED
RETINAL
VESSEL
DIAMETER
MEASUREMENT
93
5.4
RETINAL
FUNDUS
CAMERA
MAGNIFICATION
94
5.5
CALCULATION
OF
THE
RETINAL
VESSEL
CROSS-SECTION
95
5.6
LIMITATIONS
OF
THE
RETINAL
VESSEL
DIAMETER
TECHNIQUE
96
YY
CHAPTER
6
A
NEW
CONCEPT
IN
RETINAL
VESSEL
DIAMETER
MEASUREMENT
6.1
INTRODUCTION
100
6.2
METHODS
101
6.2.1
MATHEMATICAL
MODEL
101
6.2.2
EXPERIMENTAL
MODEL
105
6.2.3
IN-VIVO
MEASUREMENTS
106
6.3
STATISTICAL
ANALYSIS
106
6.4
RESULTS
107
6.4.1
EXPERIMENTAL
MODEL
107
6.4.2
HUMAN
RETINAL
PHOTOGRAPHS
107
6.5
DISCUSSION
116
CHAPTER
7
RETINAL
BLOOD
FLOW
IN
DIABETIC
RETINOPATHY
7.1
INTRODUCTION
122
7.2
SUBJECTS
AND
METHODS
123
7.2.1
SUBJECTS
123
7.2.2
EXPERIMENTAL
PROCEDURE
124
7.2.3
MEASUREMENT
OF
RETINAL
BLOOD
FLOW
124
6
7.2.4
CALCULATIONS
125
7.3
STATISTICAL
METHODS
126
7.4
RESULTS
127
7.4.1
CLINICAL
DATA
127
7.4.2
RETINAL
HAEMODYNAMIC
DATA
127
7.4.3
CONDUCTANCE
AND
RESISTANCE
DATA
129
7.5
DISCUSSION
136
CHAPTER
8
RETINAL
AUTOREGULATION
TO
EXPERIMENTAL
HYPERTENSION
IN
DIABETIC
AND
CONTROL
SUBJECTS
8.1
INTRODUCTION
144
8.2
SUBJECTS
AND
METHODS
145
8.2.1
ACTION
OF
TYRAMINE
145
8.2.2
SUBJECTS
AND
STUDY
DESIGN
146
8.2.3
MEASUREMENT
OF
RETINAL
BLOOD
FLOW
147
8.2.4
CALCULATION
OF
MAP
AND
RETINAL
PERFUSION
PRESSURE
148
8.2.5
COEFFICIENT
OF
AUTOREGULATION
148
8.3
STATISTICAL
ANALYSIS
148
8.4
RESULTS
149
8.4.1
CLINICAL
DATA
149
8.4.2
TYRAMINE
INFUSION
149
8.4.3
HAEMODYNAMIC
PARAMETERS
150
*
8.4.4
COEFFICIENT
OF
AUTOREGULATION
151
8.4.5
SIDE-EFFECTS
OF
TYRAMINE
152
8.5
DISCUSSION
166
CHAPTER
9
RETINAL
AUTOREGULATION
TO
HYPEROXIA:
THE
EFFECT
OF
HYPERTENSION
AND
HYPERGLYCAEMIA
9.1
INTRODUCTION
172
9.2
SUBJECTS
AND
METHODS
173
9.2.1
SUBJECTS
173
9.2.2
OXYGEN
REACTIVITY
174
9.2.3
STUDY
PROTOCOL
175
9.3
STATISTICAL
ANALYSIS
176
9.4
RESULTS
177
9.4.1
CLINICAL
DATA
177
7
9.4.2
BASIC
RETINAL
HAEMODYNAMICS
178
9.4.3
OXYGEN
REACTIVITY
179
9.4.4
OXYGEN
REACTIVITY
CORRELATIONS
179
9.4.5
COEFFICIENT
OF
AUTOREGULATION
180
9.4.6
CUTANEOUS
OXYGEN
AND
CARBON
DIOXIDE
181
CONCENTRATION
WITH
OXYGEN
9.5
DISCUSSION
194
9.5.1
THE
PHENOMENON
OF
OXYGEN
REACTIVITY
194
9.5.2
RETINAL
VESSEL
RESPONSES
TO
OXYGEN
196
9.5.3
COEFFICIENT
OF
AUTOREGULATION
198
CHAPTER
10
HAEMODYNAMIC
AND
CLINICAL
RISK
FACTORS
IN
THE
PROGRESSION
OF
DIABETIC
RETINOPATHY
10.1
INTRODUCTION
201
10.2
SUBJECTS
AND
METHODS
202
10.2.1
SUBJECTS 202
10.2.2
MEDICAL
DATA
202
10.2.3
OPHTHALMOLOGICAL
DATA
203
10.3
STATISTICAL
ANALYSIS 203
10.4
RESULTS 204
10.4.1
OPHTHALMOLOGICAL
DATA
204
10.4.2
CLINICAL
RISK
FACTORS
FOR
SIGHT-THREATENING
RETINOPATHY
205
10.4.3
ANALYSES
OF
RELATIVE
RISK
206
10.4.4
RELATIVE
RISKS
OF
HAEMODYNAMIC
FACTORS
207
10.4.5
RELATIVE
RISKS
OF
BIOCHEMICAL
FACTORS
208
10.5
DISCUSSION 220
10.5.1
DURATION
OF
DIABETES
MELLITUS
221
10.5.2
GLYCAEMIC
CONTROL
222
10.5.3
CHOLESTEROL
LEVEL
223
10.5.4
HYPERTENSION
224
10.5.5
OTHER
CLINICAL
RISK
FACTORS
225
10.5.6
CONCLUDING
REMARKS
226
CHAPTER
11
HAEMODYNAMIC
FACTORS
IN
THE
PATHOGENESIS
OF
DIABETIC
RETINOPATHY:
A
CONCLUSION
11.1
A
HAEMODYNAMIC
MODEL
229
11.2
CLINICAL
EVIDENCE
FOR
THE
HAEMODYNAMIC
MODEL
230
8
11.3
HYPERTENSIVE
RETINOPATHY
AND
DIABETIC
RETINOPATHY
11.4
FUTURE
RESEARCH
232
233
CHAPTER
12
REFERENCES
237
APPENDIX
I
PUBLICATIONS
AND
PRESENTATIONS
ARISING
FROM
THE
THESIS
WORK
271
MICRODENSITOMETRY
PLOTS
273
ABBREVIATIONS
274
NORMAL
VALUES
AND
METHODS
OF
MEASUREMENT
OF
275
BIOCHEMICAL
PARAMETERS
53
9 |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV010029092 |
| illustrated | Illustrated |
| indexdate | 2024-08-18T00:44:56Z |
| institution | BVB |
| isbn | 3890124321 |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006650630 |
| oclc_num | 32627448 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 275 S. Ill., graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Eul |
| record_format | marc |
| series | Medizinische Forschung |
| series2 | Medizinische Forschung |
| spelling | Patel, Vinod Verfasser aut Diabetic retinopathy haemodynamic and clinical factors in the pathogenesis Vinod Patel Bergisch Gladbach u.a. Eul 1995 275 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Medizinische Forschung 8 Zugl.: London, Univ., Diss., 1994 Diabetic Retinopathy pathology Hemodynamics Retinal Vessels pathology Pathogenese (DE-588)4115512-9 gnd rswk-swf Retinopathia diabetica (DE-588)4177904-6 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Retinopathia diabetica (DE-588)4177904-6 s Pathogenese (DE-588)4115512-9 s DE-604 Medizinische Forschung 8 (DE-604)BV000015686 8 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006650630&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Patel, Vinod Diabetic retinopathy haemodynamic and clinical factors in the pathogenesis Medizinische Forschung Diabetic Retinopathy pathology Hemodynamics Retinal Vessels pathology Pathogenese (DE-588)4115512-9 gnd Retinopathia diabetica (DE-588)4177904-6 gnd |
| subject_GND | (DE-588)4115512-9 (DE-588)4177904-6 (DE-588)4113937-9 |
| title | Diabetic retinopathy haemodynamic and clinical factors in the pathogenesis |
| title_auth | Diabetic retinopathy haemodynamic and clinical factors in the pathogenesis |
| title_exact_search | Diabetic retinopathy haemodynamic and clinical factors in the pathogenesis |
| title_full | Diabetic retinopathy haemodynamic and clinical factors in the pathogenesis Vinod Patel |
| title_fullStr | Diabetic retinopathy haemodynamic and clinical factors in the pathogenesis Vinod Patel |
| title_full_unstemmed | Diabetic retinopathy haemodynamic and clinical factors in the pathogenesis Vinod Patel |
| title_short | Diabetic retinopathy |
| title_sort | diabetic retinopathy haemodynamic and clinical factors in the pathogenesis |
| title_sub | haemodynamic and clinical factors in the pathogenesis |
| topic | Diabetic Retinopathy pathology Hemodynamics Retinal Vessels pathology Pathogenese (DE-588)4115512-9 gnd Retinopathia diabetica (DE-588)4177904-6 gnd |
| topic_facet | Diabetic Retinopathy pathology Hemodynamics Retinal Vessels pathology Pathogenese Retinopathia diabetica Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006650630&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000015686 |
| work_keys_str_mv | AT patelvinod diabeticretinopathyhaemodynamicandclinicalfactorsinthepathogenesis |