Selective immunosuppression: basic concepts and clinical applications ; 7 tables
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Basel [u.a.]
Karger
1995
|
| Schriftenreihe: | Chemical immunology
60 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | X, 165 S. Ill., graph. Darst. |
| ISBN: | 3805560346 |
Internformat
MARC
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| 001 | BV009970511 | ||
| 003 | DE-604 | ||
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| 007 | t | ||
| 008 | 950102s1995 ad|| |||| 00||| eng d | ||
| 016 | 7 | |a 943273137 |2 DE-101 | |
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| 084 | |a MED 450f |2 stub | ||
| 245 | 1 | 0 | |a Selective immunosuppression |b basic concepts and clinical applications ; 7 tables |c vol. ed. L. Adorini |
| 264 | 1 | |a Basel [u.a.] |b Karger |c 1995 | |
| 300 | |a X, 165 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Chemical immunology |v 60 | |
| 500 | |a Literaturangaben | ||
| 650 | 7 | |a Immunosuppressie |2 gtt | |
| 650 | 7 | |a Imunoquimica |2 larpcal | |
| 650 | 4 | |a Immunosuppression | |
| 650 | 0 | 7 | |a Immunsuppression |0 (DE-588)4026641-2 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Immunsuppression |0 (DE-588)4026641-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Adorini, Luciano |d 1949- |e Sonstige |0 (DE-588)1055780742 |4 oth | |
| 830 | 0 | |a Chemical immunology |v 60 |w (DE-604)BV002307222 |9 60 | |
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Datensatz im Suchindex
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CONTENTS
SELECTIVE
IMMUNOSUPPRESSION:
WHERE
ARE
WE
NOW,
AND
WHERE
ARE
WE
GOING?
A
PREFACE
.
IX
SELF-DETERMINANT
SELECTION
AND
SELECTIVE
REGULATION
*
V.
KUMAR,
E.
SERCARZ,
LOS
ANGELES,
CALIF.
.
1
INTRODUCTORY
COMMENTS
.
1
SELF
DETERMINANTS,
SELF
REPERTOIRE
AND
TOLERANCE
.
2
ONLY
A
FEW
SELF
ANTIGENS
AND
THEIR
DETERMINANTS
MAY
BE
INVOLVED
IN
AUTOIMMUNE
PATHOLOGY
.
2
CONSERVED
STRESS
PROTEINS
MIGHT
BE
AN
IMPORTANT
TARGET
IN
AUTOIMMUNE
PATHOLOGY
.
3
SELF-REACTIVE
T
CELIS
UTILIZE
A
LIMITED
SET
OF
TCR
VARIABLE
GENES
.
4
THE
RECRUITMENT
OF
A
T-CELL
REPERTOIRE
TO
OTHER
DETERMINANTS
ON
THE
SAME
ANTIGEN
AS
WELL
AS
ON
OTHER
ANTIGENS
.
4
T
CELIS
WITH
HIGHER
AFFINITY
RECEPTORS
MAY
BE
ALREADY
TOLERIZED
.
5
REGULATORY
T
CELIS
.
5
AN
EQUILIBRIUM
BETWEEN
EFFECTORS
AND
REGULATORS
MAY
BE
IMPORTANT
IN
AUTOIMMUNITY
.
5
TCR-BASED
REGULATION
OF
EAE
.
6
ANTIGEN-CENTERED
REGULATION
.
10
GENETIC
UNRESPONSIVENESS
.
11
LACK
OF
BINDING
TO
THE
MHC
.
11
PROCESSING
DEFECT
MAY
LEAD
TO
NON-RESPONSIVENESS
.
12
ABSENCE
OF
CRITICAL
RESIDUES
WITHIN
CDR3
CONSTRAINS
T-CELL
RECOGNITION
OF
A
SELF
ANTIGEN
.
12
SUSCEPTIBILITY
TO
MBP-INDUCED
EAE
MAY
CORRELATE
WITH
THE
BALANCE
BETWEEN
THL
AND
TH2
CELIS
.
13
THL
AND
TH2
BALANCE
MAY
BE
CRUCIAL
FOR
AUTOIMMUNITY
.
13
REFERENCES
.
15
SELECTIVE
TARGETS
FOR
IMMUNOTHERAPY
IN
AUTOIMMUNE
DISEASE
X.-D.
YANG,
R.
TISCH,
H.O.
MCDEVITT,
STANFORD,
CALIF.
.
20
T-CELL
TOLERANCE
.
20
CENTRAL
TOLERANCE
.
20
PERIPHERAL
TOLERANCE
.
21
IMMUNE
REGULATION
/
SUPPRESSION
.
22
SELECTIVE
TARGETS
FOR
IMMUNOINTERVENTION
.
23
CELL
ADHESION
MOLECULES
.
23
CYTOKINES
AND
CYTOKINE
RECEPTORS
.
25
T-CELL
RECEPTORS
.
26
ANTIGEN-SPECIFIC
INTERVENTION
.
27
COSTIMULATORY
MOLECULES
.
28
CONCLUDING
REMARKS
.
28
REFERENCES
.
29
IMMUNOSUPPRESSION
IN
INSULIN-DEPENDENT
DIABETES
MELLITUS:
FROM
CELLULAR
SELECTIVITY
TOWARDS
AUTOANTIGEN
SPECIFICITY
J.-F.
BACH,
L.
CHATENOUD,
PARIS
.
32
NONSPECIFIC
APPROACHES
.
33
IMMUNE
MODULATION
.
33
NONSPECIFIC
IMMUNOSUPPRESSION
.
35
T-CELL
SELECTIVE
IMMUNOSUPPRESSION
.
35
CYCLOSPORIN
A
.
35
FK506,
RAPAMYCIN
.
36
ANTILYMPHOCYTE
ANTIBODIES
.
36
IMMUNOTOXINS
.
37
MHC-BASED
THERAPY
.
37
MHC
TRANSGENIC
MICE
.
37
ANTI-MHC
MONOCLONAL
ANTIBODIES
.
38
BLOCKING
PEPTIDES
.
39
T-CELL
RECEPTOR-BASED
IMMUNOINTERVENTION
.
39
ANTI-TCR
AND
ANTI-CD3
MONOCLONAL
ANTIBODIES
.
39
T-CELL
VACCINATION
.
40
VSS
INHIBITION
.
40
AUTOANTIGEN-SPECIFIC
THERAPY
.
41
MISCELLANEOUS
APPROACHES
.
42
CONCLUSIONS
.
42
REFERENCES
.
42
SELECTIVE
IMMUNOSUPPRESSION
OF
TUMOUR
NECROSIS
FACTOR-ALPHA
IN
RHEUMATOID
ARTHRITIS
F.
M.
BRENNAN,
A.P.
COPE,
P.
KATSIKIS,
D.L.
GIBBONS,
R.N.
MAINI,
M.
FELDMANN,
LONDON
.
48
CYTOKINE
PRODUCTION
IN
RHEUMATOID
ARTHRITIS
.
48
CYTOKINE
INHIBITORS
.
52
VI
IMMUNOREGULATORY
CYTOKINES
IN
RHEUMATOID
ARTHRITIS
.
53
INTERLEUKIN-10
.
53
INTERLEUKIN-4
.
54
TRANSFORMING
GROWTH
FACTOR-BETA
.
56
CHRONIC
EXPOSURE
OF
T
CELIS
TO
TUMOUR
NECROSIS
FACTOR
.
57
CONCLUDING
REMARKS
.
57
REFERENCES
.
58
MHC
BLOCKING
PEPTIDES
AND
T-CELL
RECEPTOR
ANTAGONISTS:
NOVEL
PATHS
TO
SELECTIVE
IMMUNOSUPPRESSION?
J.
RUPPERT,
A.
FRANCO,
J.
ALEXANDER,
K.
SNOKE,
G.Y.
ISHIOKA,
SAN
DIEGO,
CALIF.;
D.M.
PAGE,
S.M.
HEDRICK,
LA
JOLLA,
CALIF.;
L.
ADORINI,
MILAN;
H.M.
GREY,
A.
SETTE,
SAN
DIEGO,
CALIF.
.
61
THERAPEUTIC
POTENTIAL
OF
MHC
BLOCKING
PEPTIDES
.
62
TCR
ANTAGONISM:
A
PROMISING
ALTERNATIVE
.
64
ANTAGONISM
VERSUS
TOLERANCE
OR
ANERGY
.
66
TCR
ANTAGONISM:
SUGGESTION
OF
A
MODEL
.
67
TCR
ANTAGONIST
PEPTIDES
INHIBIT
DIFFERENT
T-CELL
LINES
.
69
EAE:
IN
VIVO
APPLICATION
OF
TCR
ANTAGONISTS
.
71
TCR
ANTAGONISTS
AS
A
TOOL
TO
STUDY
NEGATIVE
SELECTION
.
73
CONCLUSION
.
74
REFERENCES
.
V
74
MODIFIED
T-CELL
RECEPTOR
LIGANDS:
MOVING
BEYOND
A
STRICT
OCCUPANCY
MODEL
FOR
T-CELL
ACTIVATION
BY
ANTIGEN
L.
RACIOPPI,
NAPLES;
R.N.
GERMAIN,
BETHESDA,
MD
.
79
THE
MOLECULAR
BASIS
OF
T-CELL
RECOGNITION
.
79
T-CELL
SIGNAL
TRANSDUCTION
AND
COSTIMULATION
.
81
NEW
CLASSES
OF
T-CELL
RECEPTOR
LIGANDS
.
82
A
MODEL
FOR
TCR-LIGAND
INTERACTIONS
.
84
BIOLOGICAL
EFFECTS
OF
MODIFIED
TCR
LIGANDS
.
92
POTENTIAL
THERAPEUTIC
APPLICATIONS
OF
MODIFIED
TCR
LIGANDS
.
94
CONCLUSION
.
95
REFERENCES
.
96
IDIOTYPIC
REGULATION
DIRECTED
AT
T-CELL
RECEPTOR
DETERMINANTS
A.A.
VANDENBARK,
PORTLAND,
OREG.;
G.
A.
HASHIM,
NEW
YORK,
N.Y.;
H.
OFFNER,
PORTLAND,
OREG
.
100
THE
PATHOGENIC
PROCESSES
IN
EAE
AND
MS
.
101
CLINICAL
AND
HISTOPATHOLOGICAL
FEATURES
.
101
CHARACTERISTICS
OF
ENCEPHALITOGENIC
T
CELIS
.
103
FREQUENCY
.
103
PHENOTYPE
AND
SPECIFICITY
.
106
IMMUNOREGULATION
USING
TCR
PEPTIDES
.
112
CHOICE
AND
ADMINISTRATION
OF
TCR
PEPTIDES
.
113
VH
BIOLOGICAL
EFFECTS
IN
VIVO
.
114
WORKING
HYPOTHESIS
.
120
CONCLUSIONS
AND
FUTURE
CHALLENGES
.
120
ACKNOWLEDGEMENTS
.
121
REFERENCES
.
121
ANTIGEN-SPECIFIC
IMMUNOSUPPRESSION:
ORAL
TOLERANCE
FOR
THE
TREATMENT
OF
AUTOIMMUNE
DISEASE
D.A.
HAFTER,
H.L.
WEINER,
BOSTON,
MASS
.
126
THE
ETIOLOGY
OF
MULTIPLE
SCLEROSIS
.
126
MYELIN
ANTIGENS
AS
TARGETS
FOR
T
CELIS
.
127
AUTOREACTIVE
T
CELIS
IN
MS
.
127
T-CELL
RECEPTOR
CHARACTERIZATION
IN
MS
.
130
ACTIVATION
OF
AUTOREACTIVE
T
CELIS
.
130
ANTIGEN-SPECIFIC
IMMUNOTHERAPY
.
132
OVERVIEW
OF
ANTIGEN-SPECIFIC
IMMUNOTHERAPY
.
132
ORAL
TOLERANCE
.
133
MECHANISM
OF
ORAL
TOLERANCE
(SCHEMA)
.
134
ACTIVE
SUPPRESSION
.
136
ANTIGEN-DRIVEN
BYSTANDER
SUPPRESSION
.
137
ANERGY
.
137
TREATMENT
OF
ORGAN-SPECIFIC
AUTOIMMUNE
DISEASES
IN
ANIMAIS
.
138
EAE
.
139
COLLAGEN
AND
ADJUVANT
ARTHRITIS
.
141
UVEITIS
.
141
DIABETES
.
142
TREATMENT
OF
AUTOIMMUNE
DISEASES
IN
HUMANS
.
142
MULTIPLE
SCLEROSIS
.
143
RHEUMATOID
ARTHRITIS
.
143
UVEITIS
.
144
FUTURE
DIRECTIONS
.
144
REFERENCES
.
145
TREATMENT
OF
AUTOIMMUNE
DISEASE:
TO
ACTIVATE
OR
TO
DEACTIVATE?
I.R.
COHEN,
REHOVOT
.
150
CLONAL
SELECTION
.
151
THE
COGNITIVE
PARADIGM
.
151
THE
INTERNAL
PHYSICIAN
AND
THE
PROBLEM
OF
AMBIGUITY
.
152
DIAGNOSTIC
INTERPRETATION
.
153
IMAGES
OF
SELF
.
153
IMAGES
OF
INFECTIONS
.
156
IMMUNE
INTERPRETATION:
STRINGS
OF
INFORMATION
.
156
AUTOIMMUNE
DISEASE:
A
MISINTERPRETATION
.
158
REFERENCES
.
159
SUBJECT
INDEX
.
161
VIII |
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV009970511 |
| illustrated | Illustrated |
| indexdate | 2024-08-16T01:32:23Z |
| institution | BVB |
| isbn | 3805560346 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006606418 |
| oclc_num | 31723744 |
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| owner_facet | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-12 DE-20 DE-91 DE-BY-TUM |
| physical | X, 165 S. Ill., graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Karger |
| record_format | marc |
| series | Chemical immunology |
| series2 | Chemical immunology |
| spelling | Selective immunosuppression basic concepts and clinical applications ; 7 tables vol. ed. L. Adorini Basel [u.a.] Karger 1995 X, 165 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Chemical immunology 60 Literaturangaben Immunosuppressie gtt Imunoquimica larpcal Immunosuppression Immunsuppression (DE-588)4026641-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Immunsuppression (DE-588)4026641-2 s DE-604 Adorini, Luciano 1949- Sonstige (DE-588)1055780742 oth Chemical immunology 60 (DE-604)BV002307222 60 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006606418&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Selective immunosuppression basic concepts and clinical applications ; 7 tables Chemical immunology Immunosuppressie gtt Imunoquimica larpcal Immunosuppression Immunsuppression (DE-588)4026641-2 gnd |
| subject_GND | (DE-588)4026641-2 (DE-588)4143413-4 |
| title | Selective immunosuppression basic concepts and clinical applications ; 7 tables |
| title_auth | Selective immunosuppression basic concepts and clinical applications ; 7 tables |
| title_exact_search | Selective immunosuppression basic concepts and clinical applications ; 7 tables |
| title_full | Selective immunosuppression basic concepts and clinical applications ; 7 tables vol. ed. L. Adorini |
| title_fullStr | Selective immunosuppression basic concepts and clinical applications ; 7 tables vol. ed. L. Adorini |
| title_full_unstemmed | Selective immunosuppression basic concepts and clinical applications ; 7 tables vol. ed. L. Adorini |
| title_short | Selective immunosuppression |
| title_sort | selective immunosuppression basic concepts and clinical applications 7 tables |
| title_sub | basic concepts and clinical applications ; 7 tables |
| topic | Immunosuppressie gtt Imunoquimica larpcal Immunosuppression Immunsuppression (DE-588)4026641-2 gnd |
| topic_facet | Immunosuppressie Imunoquimica Immunosuppression Immunsuppression Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006606418&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002307222 |
| work_keys_str_mv | AT adoriniluciano selectiveimmunosuppressionbasicconceptsandclinicalapplications7tables |