Verfügbarkeit: Toxicology of metals

Toxicology of metals: biochemical aspects ; [with 17 tables]

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Bibliographische Detailangaben
Format:	Buch
Sprache:	English
Veröffentlicht:	Berlin [u.a.] Springer 1995
Schriftenreihe:	Handbook of experimental pharmacology 115
Schlagworte:	Metals Toxicity Maximum Permissible Exposure Level Metalen Métaux - Toxicologie Toxicologia Toxicologie Maximum Allowable Concentration Metals > Toxicology Metals > toxicity Physiologische Chemie Toxizität Biochemie Toxikologie Metall
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XXII, 467 S. Ill., graph. Darst.
ISBN:	3540582819 0387582819

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Datensatz im Suchindex

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adam_text	TOXICOLOGY OF METAL S BIOCHEMICAL ASPECT S CONTRIBUTORS N. BALLATORI, M.G. CHERIAN, D.C . DAWSON, M. DELNOMDEDIEU P. DRUET , B.R. FISHER, P. GOERING, R.A . GOYER, S. HIMENO N. IMURA, E.H . JEFFREY, M.M. JONES, J.H.R . KAGI, S. KAWANISHI CD . KLAASSEN, J. KOROPATNICK, J.S . LAZO, M.E.I . LEIBBRANDT K. MIURA, A . NAGANUMA, E.J . O FLAHERTY, L. PELLETIER T.G . ROSSMAN, S. SILVER, M. STYBLO, D.M. TEMPLETON, D.J . THOMAS M.P. WAALKES, M. WALDERHAUG, J.S . WOODS, J. ZENG EDITOR S ROBER T A . GOYER AND M. GEORGE CHERIAN SPRINGER- VERLAG BERLIN HEIDELBERG NEW YORK LONDON PARIS TOKYO HONG KONG BARCELONA BUDAPEST CONTENTS CHAPTER 1 TRANSPLACENTAL TRANSFER OF LEAD AND CADMIUM R.A . GOYER. WITH 2 FIGURES 1 A . INTRODUCTION 1 I. COMPARISON OF HUMAN AND RODENT FETAL-MATERNAL BLOOD BARRIERS 2 II . METHODS FOR SAMPLING THE HUMAN PLACENTA 3 B. PLACENTAL TRANSFER OF LEAD 3 I. MECHANISM OF PLACENTAL TRANSFER OF LEAD 3 II . MATERNAL BLOOD LEAD LEVELS DURING PREGNANCY 5 III. EFFECT OF MATERNAL LEAD ON BIRTH OUTCOMES 6 IV. EFFECT OF LEAD ON NEUROBEHAVIORAL AND COGNITIVE DEVELOPMENT IN UTERO 6 V. MECHANISMS FOR THE NEUROTOXICITY OF LEAD 7 C. PLACENTAL TRANSFER OF CADMIUM 8 I. CADMIUM LEVELS IN HUMAN PLACENTA 9 II . CADMIUM EFFECTS ON PLACENTA AND FETUS 10 III. INTERACTIONS IN PLACENTA BETWEEN CADMIUM, ZINC AND COPPER, AND METALLOTHIONEIN 11 D . SUMMARY 13 REFERENCES 13 CHAPTER 2 PORPHYRIN METABOLISM AS INDICATOR OF METAL EXPOSURE AND TOXICITY J.S. WOODS. WITH 8 FIGURES 19 A . INTRODUCTION 19 B. HEME BIOSYNTHESIS AND PORPHYRIN METABOLISM 19 C. MECHANISTIC BASIS OF METAL-INDUCED PORPHYRIA (PORPHYRINURIA) . . 23 I. METAL EFFECTS ON SPECIFIC STEPS OF THE HEME BIOSYNTHETIC PATHWAY 23 II . METAL-INDUCED OXIDATION OF REDUCED PORPHYRINS 25 XII CONTENTS D . METAL- AND METALLOID-INDUCED PORPHYRINOPATHIES AND PORPHYRINURIAS 27 I. LEAD 27 1. ERYTHROCYTE ALA DEHYDRATASE 28 2. ERYTHROCYTE ZINC-PROTOPORPHYRIN 30 3 . URINARY COPROPORPHYRIN 33 II . MERCURY 36 1. MERCURY-DIRECTED ALTERATION OF RENAL COPROPORPHYRINOGEN METABOLISM 36 2. MERCURY-FACILITATED PORPHYRINOGEN OXIDATION 38 III. ARSENIC 39 IV. OTHER METALS 41 1. CADMIUM 41 2. PLATINUM 41 3. ALUMINUM 42 4. METAL INTERACTIONS 43 E . PERSPECTIVES ON THE USE OF PORPHYRINS AS BIOMARKERS OF METAL EXPOSURE IN HUMAN STUDIES 43 REFERENCES 46 CHAPTER 3 MEMBRANE TRANSPORTERS AS SITES OF ACTION AND ROUTES OF ENTRY FOR TOXIC METALS D.C . DAWSON AND N. BALLATORI. WITH 4 FIGURES 53 A . INTRODUCTION: METALS AND MEMBRANES 53 B. CHEMICAL PROPERTIES OF METALS IN SOLUTIONS 54 C. MODEL SYSTEMS 59 D . MERCURY INHIBITION OF NACL COTRANSPORT: AN EXAMPLE PROBLEM WITH A MODEL SYSTEM 62 E . METAL ENTRY INTO CELLS 63 F. PERMEATION IN A LIPID-SOLUBLE FORM 63 G. PERMEATION AS A CATION 64 H. PERMEATION AS AN ANION 67 I. TRANSPORT OF ORGANIC COMPLEXES 69 J. PHYSIOLOGICAL SIGNIFICANCE OF METAL PERMEATION PATHWAYS 71 REFERENCES 72 CONTENTS XIII CHAPTER 4 IMMUNOTOXICOLOGY OF METALS L. PELLETIER AND P. DRUET 77 A . INTRODUCTION 77 B . BASIS OF THE IMMUNE RESPONSE 78 C. HYPERSENSITIVITY REACTIONS 80 D . EXPERIMENTAL MODELS OF METAL-INDUCED AUTOIMMUNITY 81 I . DESCRIPTION OF THE MODELS 81 1. HGCL 2 -INDUCED AUTOIMMUNITY IN RATS 81 2. HGCL 2 -INDUCED AUTOIMMUNITY IN OTHER SPECIES 83 3. GOLD-INDUCED AUTOIMMUNITY 83 II . MECHANISMS OF INDUCTION 83 III . AUTOREGULATION 86 E . NONANTIGEN-SPECIFIC IMMUNOSUPPRESSION INDUCED BY HGCL 2 86 F. CONCLUSIONS 87 REFERENCES 87 CHAPTER 5 EFFECTS OF METALS ON GENE EXPRESSION J. KOROPATNICK AND M.E.I . LEIBBRANDT 93 A. INTRODUCTION 93 B . MOLECULAR CONTROL OF GENE EXPRESSION 95 C. EUKARYOTIC STRATEGIES OF SIGNAL TRANSFER 95 I. MULTIPLE FACTOR SIGNAL TRANSDUCTION SYSTEMS 96 II . SINGLE FACTOR SIGNAL TRANSDUCTION SYSTEMS 96 D . TRANSDUCTION OF METAL SIGNALS IN EUKARYOTES 98 I. ENTRY , BINDING, AND STORAGE OF ESSENTIAL METALS 98 1. IRON 98 2. COPPER 100 II . ESSENTIAL METALS AS REGULATORS OF METABOLISM 102 1. IRON 102 2. COPPER 103 III . METALLOTHIONEIN AND OTHER GENES AS MODELS FOR METAL REGULATION 103 1. METAL REGULATION IN YEAST 104 2. METAL REGULATION IN MAMMALS 104 IV. METAL BIOAVAILABILITY AND SEQUESTRATION 107 E. OTHER METAL-REGULATED GENES 109 I. PLASTOCYANIN AND CYT C6 109 II . SUPEROXIDE DISMUTASE 109 III . HEAT SHOCK PROTEINS IL L IV. ACUTE PHASE PROTEINS, HEME OXYGENASE, AND ONCOGENES . . IL L XIV CONTENTS F. METAL-INDUCED CHANGES IN CHROMATIN STRUCTURE 112 G. SUMMARY 113 REFERENCES 113 CHAPTER 6 METALLOTHIONEIN AND ITS INTERACTION WITH METALS M.G. CHERIAN 121 A . INTRODUCTION 121 B . METAL BINDING AND DYNAMIC ASPECTS OF METALLOTHIONEIN STRUCTURE 122 C. INDUCTION OF METALLOTHIONEIN AND EXCRETION OF METALS 123 D . DETOXIFICATION OF METALS 125 E . REGULATION OF ZINC AND COPPER METABOLISM 127 F . LIPID PEROXIDATION AND OXIDATIVE STRESS 130 G. SUMMARY 131 REFERENCES 132 CHAPTER 7 BIOCHEMICAL MECHANISMS OF ALUMINUM TOXICITY E.H . JEFFERY 139 A . INTRODUCTION 139 B . ALUMINUM SPECIES IN BIOLOGICAL SYSTEMS 141 C. BIOAVAILABILITY OF ALUMINUM 142 I . EXPOSURE 142 II . GASTROINTESTINAL ABSORPTION 143 III. TRANSCELLULAR UPTAKE 144 IV. PARACELLULAR UPTAKE 145 V. SYSTEMIC TRANSPORT 146 VI. ACCUMULATION IN ERYTHROCYTES 146 VII . CELLULAR UPTAKE 147 VIII. ALUMINUM INTERACTIONS WITH DESFERRIOXAMINE 147 D . ALUMINUM-RELATED ANEMIA 148 E . ALUMINUM-RELATED BONE DISEASE 149 F. ALUMINUM NEUROTOXICITY 151 G. ALUMINUM AND SECOND MESSENGER SYSTEMS 153 I . FLUOROALUMINATE STIMULATION OF G-PROTEIN SYSTEMS 153 II . FLUORIDE STIMULATION OF SECOND MESSENGER SYSTEMS 154 III . ALUMINUM STIMULATION OF SECOND MESSENGER SYSTEMS 155 IV. GTP INTERACTION WITH ALUMINUM 155 REFERENCES 156 CONTENTS XV CHAPTE R 8 MERCURY TOXICITY K. MIURA, A . NAGANUMA, S. HIMENO, AND N. IMURA 163 A . INTRODUCTION 163 B . ORGANIC MERCURY 163 I . METHYLMERCURY 164 1. MECHANISM OF UPTAKE AND EXCRETION 164 2. MECHANISM OF TOXICITY 166 C. INORGANIC MERCURY 171 I. MERCURIC MERCURY 171 1. TISSUE ACCUMULATION AND EXCRETION 171 2. TOXICITY 172 3. MECHANISM OF RENAL TOXICITY 173 II . ELEMENTAL MERCURY 175 1. EXPOSURE TO ELEMENTAL MERCURY 175 2. METABOLISM 176 3. BIOTRANSFORMATION 177 4. TOXICITY 179 5. MECHANISM OF TOXICITY 179 REFERENCES 180 CHAPTE R 9 TOXICOLOGY OF CADMIUM P.L. GOERING, M.P . WAALKES, AND CD . KLAASSEN 189 A . INTRODUCTION 189 I. PRODUCTION AND USES 189 II . EXPOSURE TO CADMIUM 190 III . METABOLISM 190 B . MOLECULAR AND CELLULAR EFFECTS 191 I. CALMODULIN-CALCIUM-CADMIUM INTERACTIONS 191 II . OTHER EFFECTS 193 C. TARGET ORGAN TOXICITY 194 I. ACUTE TOXICITIES 194 II . CHRONIC TOXICITIES 194 1. LUNG 194 2. KIDNEY 195 3. LIVER 195 4. DEVELOPMENTAL EFFECTS 196 5. REPRODUCTIVE EFFECTS 196 6. BONE 197 7. IMMUNE EFFECTS 198 XVI CONTENTS D . CARCINOGENESIS 199 I. HUMAN STUDIES 199 II . ANIMAL STUDIES 200 1. LUNG , 200 2. PROSTATE 201 3. TESTES 201 4. INJECTION SITE 201 5. HEMATOPOIETIC 202 6. METAL-METAL INTERACTIONS 202 7. SYNERGISM AND ANTAGONISM 202 E . ROLES OF METALLOTHIONEIN AND GLUTATHIONE IN CADMIUM TOXICITY. . 203 I. METALLOTHIONEIN 203 II. GLUTATHIONE 204 F . CONCLUSION 204 REFERENCES 205 CHAPTE R 10 CHROMIUM TOXICOKINETICS E.J . O FLAHERTY 215 A . INTRODUCTION 215 B . CHROMIUM ACTIONS AND KINETICS 215 I . LOCAL AND SYSTEMIC TOXICITY 215 II . ESSENTIALITY OF CR(III) 216 III . CARCINOGENICITY OF CR(VI) 217 C. KEY FEATURES OF CHROMIUM KINETICS 218 I . SOLUBILITY 218 II. MEMBRANE PERMEABILITY AND CHROMIUM ABSORPTION 219 1. GASTROINTESTINAL ABSORPTION 219 2. PULMONARY ABSORPTION 220 III. REDUCTION OF CR(VI) TO CR(III) 221 IV. GENERAL CHROMIUM DISPOSITION 221 V. CHROMIUM IN THE RED CELL 222 VI. CHROMIUM IN BONE 225 VII. CHROMIUM IN OTHER TISSUES 225 VIII. EXCRETION 222 D . UNCERTAINTIES AND RESEARCH NEEDS 223 REFERENCES 226 CONTENTS XVII CHAPTER 11 METALS AND STRESS PROTEINS P.L. GOERING AND B.J. FISHER. WITH 1 FIGURE 229 A . INTRODUCTION 229 B. STRESS PROTEINS AND THEIR FUNCTIONS 230 C. METALS AND THEIR EFFECTS ON EXPRESSION OF STRESS PROTEINS 233 I. GENERAL 233 II. ARSENIC 235 III. CADMIUM 239 IV. MERCURY 240 V. COPPER 240 VI. ZINC 241 VII. LEAD 241 VIII. IRON 242 IX. GOLD 242 D . TOLERANCE INDUCTION AND STRESS PROTEINS 243 E. HEME OXYGENASE IS A STRESS PROTEIN 245 F . IS METALLOTHIONEIN A STRESS PROTEIN? 247 I. EVOLUTIONARY CONSERVATION 248 II . COMMON INDUCERS 248 III. PROTECTIVE ROLES AND CROSS-TOLERANCE 248 IV. GENE REGULATION 250 V. INCREASED EXPRESSION IN NEOPLASMS AND OTHER DISEASES .. . 250 VI. ADJUNCTS TO CHEMOTHERAPY 251 G. STRESS PROTEINS AS BIOMARKERS OF METAL EXPOSURE AND TOXICITY .. . 251 I. RATIONALE AND CRITERIA 252 II. EXPOSURE AND TOXICITY 252 III. TOXICITY SCREENING ASSAYS 254 IV. ENVIRONMENTAL MONITORING 256 V. HUMAN APPLICATIONS 257 REFERENCES 257 CHAPTER 12 METALS AND ANTICANCER DRUG RESISTANCE J.S. LAZO. WITH 1 FIGURE 267 A . INTRODUCTION 267 B. METAL-BINDING AND METAL-BASED ANTICANCER AGENTS 267 I. BLEOMYCIN 268 II. DOXORUBICIN 268 III. CISPLATIN AND CARBOPLATIN 268 C. METAL-INDUCED ANTICANCER DRUG RESISTANCE IN CELL CULTURE 269 I. CADMIUM 269 XVIII CONTENTS II . ZINC 270 D . METALLOTHIONEIN AND ANTICANCER DRUG RESISTANCE 270 I. IN VITRO METALLOTHIONEIN-DRUG INTERACTIONS 270 II . METALLOTHIONEIN IN DRUG-RESISTANT CELLS 271 III. NONMETAL INDUCTION OF METALLOTHIONEIN 272 IV. METALLOTHIONEIN GENE TRANSFER 273 V. HUMAN TUMOR EXPRESSION OF METALLOTHIONEIN AND DRUG SENSITIVITY 274 E . METAL-MEDIATED CHANGES IN DRUG SENSITIVITY IN VIVO 274 I. ZINC 274 II . BISMUTH 275 F . SUMMARY 276 REFERENCES 276 CHAPTER 13 CHEMISTRY OF CHELATION: CHELATING AGENT ANTAGONISTS FOR TOXIC METALS M.M. JONES. WITH 9 FIGURES 279 A . CHELATION: ITS BASIC CHEMISTRY AND ADVANTAGES AS A METAL COMPLEXATION PROCESS 279 B . CHEMISTRY OF CHELATION IN BIOLOGICAL SYSTEMS 280 C. TOXIC METAL EXCRETION AND ITS ACCELERATION 286 I. TOXIC METAL HALF-LIVES, ORGAN DISTRIBUTION, AND NORMAL RATES OF EXCRETION 286 II . ACCELERATION OF RATES OF EXCRETION OF TOXIC METAL IONS SUBSEQUENT TO CHELATION 287 1. LEAD INTOXICATION 287 D . ALTERATION OF METAL REACTIVITY, TOXICITY, AND DISTRIBUTION BY CHELATION 289 E . STABILITY CONSTANTS OF CLINICAL CHELATING AGENTS WITH TOXIC METAL IONS 289 I. CONDITIONAL OR EFFECTIVE STABILITY CONSTANTS 290 F . DEVELOPMENT OF CHELATING AGENTS FOR CLINICAL USE 290 I. BAL AND ITS DERIVATIVES 291 II. EDTA AND ITS ANALOGS 292 III. D-PENICILLAMINE AND TRIETHYLENETETRAMINE DIHYDROCHLORIDE 292 IV. DEFEROXAMINE AND HYDROXYPYRID INONES 292 V. SODIUM DIETHYLDITHIOCARBAMATE 293 G. TOXICITY AND ADVERSE EFFECTS OF CLINICALLY USED CHELATING AGENTS 293 H. CURRENT CLINICAL TREATMENTS FOR COMMON METAL INTOXICATIONS AND THEIR UNDERLYING CHEMISTRY 293 I. LEAD 293 CONTENTS XIX 1. D-PENICILLAMINE 295 II . ARSENIC 295 III . MERCURY 297 IV. COPPER 298 V. OTHER TOXIC METALS 298 I. UNSOLVED PROBLEMS AND FUTURE PROSPECTS 299 REFERENCES 299 CHAPTER 14 THERAPEUTIC USE OF CHELATING AGENTS IN IRON OVERLOAD D.M. TEMPLETON. WITH 2 FIGURES 305 A. TRANSPORT, STORAGE, AND TOXICITY OF IRON 305 B. CHRONIC IRON OVERLOAD AND THE CLINICAL NEED FOR IRON CHELATORS 307 I. INTAKE 307 II . ABSORPTION 307 HI. TRANSFUSION 308 C. OTHER APPLICATIONS OF IRON CHELATION 309 D . STRUCTURAL CONSIDERATIONS FOR IRON-SPECIFIC CHELATORS 310 E . BIOLOGICAL CONSIDERATIONS FOR IRON REMOVAL 314 F. CRITERIA FOR THE SAFE CHELATION OF IRON 317 G. CLINICALLY USEFUL IRON CHELATORS 319 I. NATURAL SIDEROPHORES 320 1. DESFERRIOXAMINE B 320 2. OTHER SIDEROPHORES 321 II . SYNTHETIC CHELATORS 321 1. DEFERIPRONE B 321 2. OTHER SYNTHETIC CHELATORS 323 H. SUMMARY 324 REFERENCES 324 CHAPTER 15 ZINC FINGERS AND METALLOTHIONEIN IN GENE EXPRESSION J. ZENG AND J.H.R . KAGI. WITH 7 FIGURES 333 A. INTRODUCTION 333 B. ZINC FINGER PROTEINS IN GENE EXPRESSION 333 C. MODULATION OF ZINC FINGER-DEPENDENT GENE EXPRESSION BY PZN : . . 336 D . EFFECTS OF THIONEIN ON ZINC FINGER-DEPENDENT GENE EXPRESSION 338 E. IMPLICATIONS AND SPECULATION 343 XX CONTENTS F . SUMMARY 344 REFERENCES 345 CHAPTE R 16 ROLE OF ACTIVE OXYGEN SPECIES IN METAL-INDUCED DNA DAMAGE S. KAWANISHI. WITH 1 FIGURE 349 A . INTRODUCTION 349 B . CHROMIUM 351 C. IRON COMPLEX 354 D . NICKEL 356 E . COBALT 358 F . COPPER 360 G. MANGANESE 362 H . ARSENIC, LEAD , AND CADMIUM 363 I. ROLE OF ACTIVE OXYGEN SPECIES IN CARCINOGENESIS 364 REFERENCES 365 CHAPTE R 17 METAL MUTAGENESIS T.G . ROSSMAN 373 A . INTRODUCTION 373 B . MUTAGENESIS BY OXJDATIVE REACTIONS 375 C. CONFOUNDING FACTORS IN METAL MUTAGENESIS 376 D . MUTAGENIC EFFECTS OF HUMAN CARCINOGENS 377 I . ARSENIC 377 II . BERYLLIUM 378 III . CADMIUM 380 IV. CHROMIUM 383 V. NICKEL 386 E . MULTAGENIC EFFECTS OF OTHE R METALS 389 I. LEAD 389 II . MERCURY 391 III . OTHE R METALS 392 REFERENCES 395 CONTENTS XXI CHAPTER 18 BIOLOGICAL MECHANISMS AND TOXICOLOGICAL CONSEQUENCES OF THE METHYLATION OF ARSENIC M. STYBLO, M. DELNOMDEDIEU, AND D.J. THOMAS 407 A . INTRODUCTION 407 B . BIOLOGICAL METHYLATION OF ARSENIC 408 I. ROLE OF METHYLATION IN ARSENIC METABOLISM 408 II . DETERMINANTS OF INTERINDIVIDUAL VARIATION IN METHYLATION CAPACITY 409 1. SATURABLE CAPACITY FOR ARSENIC METHYLATION 409 2. INFLUENCE OF NUTRITIONAL STATUS 410 3 . GENETICALLY DETERMINED CAPACITY FOR ARSENIC METHYLATION 411 III. ENZYMOLOGY OF ARSENIC METHYLATION 412 1. CHARACTERISTICS OF ARSENIC METHYLTRANSFERASES 412 2. ROLE OF GSH IN ARSENIC REDUCTION, BINDING, AND METHYLATION 412 C. COMPARATIVE METABOLISM, KINETICS, AND TOXICITY 413 I. METHYLATION IN PROKARYOTES 413 II . METHYLATION IN EUKARYOTES 414 1. METHYLATION IN NONHUMAN SPECIES 414 2. ARSENIC METHYLATION IN HUMANS 421 D . CONCLUSIONS AND FUTURE RESEARCH DIRECTIONS 425 REFERENCES 427 CHAPTER 19 BACTERIAL PLASMID-MEDIATED RESISTANCES TO MERCURY, CADMIUM, AND COPPER S. SILVER AND M. WALDERHAUG. WITH 10 FIGURES 435 A . INTRODUCTION AND OVERVIEW: GENERALITIES 435 B. MERCURY AND ORGANOMERCURIAL RESISTANCE 436 I. INTRODUCTION 436 II . GENETIC ORGANIZATION AND MOLECULAR BIOLOGY 436 1. OPERON STRUCTURE IN GRAM-NEGATIVE BACTERIA ; . . 437 2. THE SPECIAL CASE OF THIOBACILLUS 441 3. OPERON STRUCTURE IN GRAM-POSITIVE BACTERIA 441 C. CADMIUM AND ZINC RESISTANCE 442 I. CADA CD 2 + ATPASE IN STAPHYLOCOCCUS AND BACILLUS 442 II . CZC (CD 2+ , ZN 2+ , AND CO 2+ ) AND CNR (CO 2 + AND NI 2+ ) RESISTANCE SYSTEMS OF ALCALIGENES 447 D . RELATIONSHIP BETWEEN HUMAN MENKES AND WILSON S ATPASES AND BACTERIAL P-TYPE ATPASES 449 XXII CONTENTS E . COPPER TRANSPORT AND RESISTANCE IN BACTERIA 452 F . SUMMARY AND CONCLUSIONS 455 REFERENCES 456 SUBJECT INDEX 459
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id	DE-604.BV009965712
illustrated	Illustrated
indexdate	2024-07-09T17:44:05Z
institution	BVB
isbn	3540582819 0387582819
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-006605205
oclc_num	30776864
open_access_boolean
owner	DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-12 DE-29 DE-20 DE-11 DE-188 DE-578
owner_facet	DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-12 DE-29 DE-20 DE-11 DE-188 DE-578
physical	XXII, 467 S. Ill., graph. Darst.
publishDate	1995
publishDateSearch	1995
publishDateSort	1995
publisher	Springer
record_format	marc
series	Handbook of experimental pharmacology
series2	Handbook of experimental pharmacology
spelling	Toxicology of metals biochemical aspects ; [with 17 tables] contributors N. Ballatori ... Ed. Robert A. Goyer ... Berlin [u.a.] Springer 1995 XXII, 467 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 115 Metals cabt Toxicity cabt Maximum Permissible Exposure Level cabt Metalen gtt Métaux - Toxicologie Toxicologia larpcal Toxicologie gtt Maximum Allowable Concentration Metals Toxicology Metals toxicity Physiologische Chemie (DE-588)4076124-1 gnd rswk-swf Toxizität (DE-588)4078372-8 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Toxikologie (DE-588)4060538-3 gnd rswk-swf Metall (DE-588)4038860-8 gnd rswk-swf Metall (DE-588)4038860-8 s Toxizität (DE-588)4078372-8 s DE-604 Toxikologie (DE-588)4060538-3 s Physiologische Chemie (DE-588)4076124-1 s Biochemie (DE-588)4006777-4 s Goyer, Robert A. Sonstige oth Ballatori, Nazzareno Sonstige oth Handbook of experimental pharmacology 115 (DE-604)BV002390716 115 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006605205&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Toxicology of metals biochemical aspects ; [with 17 tables] Handbook of experimental pharmacology Metals cabt Toxicity cabt Maximum Permissible Exposure Level cabt Metalen gtt Métaux - Toxicologie Toxicologia larpcal Toxicologie gtt Maximum Allowable Concentration Metals Toxicology Metals toxicity Physiologische Chemie (DE-588)4076124-1 gnd Toxizität (DE-588)4078372-8 gnd Biochemie (DE-588)4006777-4 gnd Toxikologie (DE-588)4060538-3 gnd Metall (DE-588)4038860-8 gnd
subject_GND	(DE-588)4076124-1 (DE-588)4078372-8 (DE-588)4006777-4 (DE-588)4060538-3 (DE-588)4038860-8
title	Toxicology of metals biochemical aspects ; [with 17 tables]
title_auth	Toxicology of metals biochemical aspects ; [with 17 tables]
title_exact_search	Toxicology of metals biochemical aspects ; [with 17 tables]
title_full	Toxicology of metals biochemical aspects ; [with 17 tables] contributors N. Ballatori ... Ed. Robert A. Goyer ...
title_fullStr	Toxicology of metals biochemical aspects ; [with 17 tables] contributors N. Ballatori ... Ed. Robert A. Goyer ...
title_full_unstemmed	Toxicology of metals biochemical aspects ; [with 17 tables] contributors N. Ballatori ... Ed. Robert A. Goyer ...
title_short	Toxicology of metals
title_sort	toxicology of metals biochemical aspects with 17 tables
title_sub	biochemical aspects ; [with 17 tables]
topic	Metals cabt Toxicity cabt Maximum Permissible Exposure Level cabt Metalen gtt Métaux - Toxicologie Toxicologia larpcal Toxicologie gtt Maximum Allowable Concentration Metals Toxicology Metals toxicity Physiologische Chemie (DE-588)4076124-1 gnd Toxizität (DE-588)4078372-8 gnd Biochemie (DE-588)4006777-4 gnd Toxikologie (DE-588)4060538-3 gnd Metall (DE-588)4038860-8 gnd
topic_facet	Metals Toxicity Maximum Permissible Exposure Level Metalen Métaux - Toxicologie Toxicologia Toxicologie Maximum Allowable Concentration Metals Toxicology Metals toxicity Physiologische Chemie Toxizität Biochemie Toxikologie Metall
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006605205&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
volume_link	(DE-604)BV002390716
work_keys_str_mv	AT goyerroberta toxicologyofmetalsbiochemicalaspectswith17tables AT ballatorinazzareno toxicologyofmetalsbiochemicalaspectswith17tables

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