The pharmacology of alcohol abuse:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1995
|
| Schriftenreihe: | Handbook of experimental pharmacology
114 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XXVI, 548 S. Ill., graph. Darst. |
| ISBN: | 3540571256 0387571256 |
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| adam_text | THE PHARMACOLOGY OF ALCOHOL ABUSE CONTRIBUTORS R.F. ANTON, H.C. BECKER,
B.J. BERG, M.J. BOHN, K.E. BREMNER D.A. CIRAULO, R.K. FULLER, J.
GELERNTER, K.A. GRANT, D. HERSH G.A. HIGGINS, P.L. HOFFMAN, CM. KNAPP,
H.R. KRANZLER A. DZUNG LE, S.W. LESLIE, R.Z. LITTEN, J. LITTLETON, P.
MANU A.T. MCLELLAN, A.K. MEHTA, J. MORING, C. MIILLER, C.A. NARANJO M.K.
ROMACH, H. ROMMELSPACHER, H.H. SAMSON, B.F. SANDS E.M. SELLERS, W.J.
SHOEMAKER, M.K. TICKU, D.M. TOMKINS J.R. VOLPICELLI, N.T. WATSON, T.M.
WORNER EDITOR HENRY R. KRANZLER SPRINGER-VERLAG BERLIN HEIDELBERG NEW
YORK LONDON PARIS TOKYO HONG KONG BARCELONA BUDAPEST CONTENTS CHAPTER 1
THE PHARMACOLOGY OF ALCOHOL ABUSE: AN INTRODUCTION H.R. KRANZLER 1
REFERENCES 10 CHAPTER 2 ALCOHOL-INDUCED CHANGES IN NEURONAL MEMBRANES J.
MORING AND W.J. SHOEMAKER. WITH 1 FIGURE 11 A. INTRODUCTION 11 B.
HISTORICAL OVERVIEW 11 I. THE MEYER-OVERTON HYPOTHESIS 11 II. MEMBRANE
DISORDER 14 C. MEMBRANE LIPID EFFECTS 15 I. DISORDERING OF MEMBRANES BY
ACUTE ETHANOL 15 II. PARTITIONING OF ETHANOL INTO MEMBRANES 17 III.
PRESSURE REVERSAL OF ACUTE EFFECTS OF ETHANOL 19 IV. MEMBRANE LIPID
COMPOSITION CHANGES DUE TO CHRONIC ETHANOL EXPOSURE 20 1. PHOSPHOLIPIDS
20 2. CHOLESTEROL 21 3. ACYL CHAIN COMPOSITION 22 4. DO LIPID
COMPOSITION CHANGES CAUSE TOLERANCE OR CHANGE MEMBRANE FUNCTION? 23 V.
EFFECTS OF ETHANOL ON MEMBRANE LIPID DOMAINS 24 1. LIPID CLASSES 24 2.
TRANSBILAYER LIPID DISTRIBUTION 25 3. ANNULAR LIPIDS 26 4. LATERAL
MEMBRANE DOMAINS 27 VI. ETHANOL-INDUCED HYPOTHERMIA 27 VII. LIPID
EFFECTS ON PROTEINS 28 D. MEMBRANE PROTEIN EFFECTS 29 I. DIRECT EFFECTS
OF ACUTE ETHANOL ON PROTEINS 29 XIV CONTENTS 1. FIREFLY LUCIFERASE 29 2.
THE GABA A RECEPTOR 30 II. PROTEIN MODEL OF THE ANESTHETIC CUTOFF EFFECT
31 III. EFFECTS OF ETHANOL ON CALCIUM CHANNELS 32 IV. EFFECTS OF ETHANOL
ON INTRACELLULAR CALCIUM 34 V. EFFECTS OF ETHANOL ON G-PROTEIN-RELATED
SYSTEMS 35 1. ACUTE EFFECTS ON PROTEIN KINASE C 36 2. THE ADENYLYL
CYCLASE SYSTEM 37 3. CHRONIC EFFECTS 37 VI. EFFECTS OF CHRONIC ETHANOL
ON RECEPTOR SUBUNIT EXPRESSION 39 1. THE GABA A RECEPTOR 40 2. ORIGIN OF
MRNA EFFECTS 41 E. CONCLUSIONS 41 REFERENCES 43 CHAPTER 3 EFFECTS OF
ETHANOL ON VOLTAGE-DEPENDENT CALCIUM CHANNEL FUNCTION S.W. LESLIE 55 A.
VOLTAGE-DEPENDENT CALCIUM CHANNELS 55 I. INTRODUCTION 55 II. L TYPE
CHANNELS 55 III. N, P, AND T TYPE CHANNELS 58 1. CONCLUSIONS 60 B.
EFFECTS OF ETHANOL AND OTHER SEDATIVE-HYPNOTIC DRUGS ON
VOLTAGE-DEPENDENT CALCIUM CHANNELS 60 I. ETHANOL EFFECTS ON ION CHANNELS
60 II. ETHANOL EFFECTS ON DIFFERENT TYPES OF CALCIUM CHANNEL. 62 III.
BRAIN REGIONAL DIFFERENCES IN THE EFFECTS OF ETHANOL... 64 IV. CHRONIC
ETHANOL EFFECTS ON CALCIUM CHANNELS 65 V. CALCIUM CHANNEL BLOCKERS AND
ETHANOL PREFERENCE .... 66 VI. CONCLUSIONS 67 C. EFFECTS OF BARBITURATES
AND BENZODIAZEPINES ON CALCIUM CHANNELS 67 I. CONCLUSIONS 69 REFERENCES
69 CHAPTER 4 EFFECTS OF ALCOHOL ON EXCITATORY AMINO ACID RECEPTOR
FUNCTION P.L. HOFFMAN 75 A. INTRODUCTION 75 I. SITE OF ACTION OF
ETHANOL: PROTEIN VERSUS LIPID 75 CONTENTS XV B. ETHANOL AND EXCITATORY
AMINO ACID RECEPTORS 76 I. CHARACTERISTICS OF GLUTAMATE RECEPTORS 76 II.
ETHANOL AND NMD A RECEPTOR FUNCTION: ACUTE EFFECTS . 79 1. MECHANISM OF
ACTION OF ETHANOL 81 2. EFFECTS OF ANESTHETICS AND SEDATIVE HYPNOTICS 81
3. ETHANOL AND THE NMD A RECEPTOR IN VIVO 83 4. ETHANOL AND THE NMD A
RECEPTOR IN DEVELOPMENT 85 III. ETHANOL AND NMD A RECEPTOR FUNCTION:
CHRONIC EFFECTS 86 1. ROLE OF NMDA RECEPTORS IN ETHANOL WITHDRAWAL
(PHYSICAL DEPENDENCE) 88 2. ROLE OF NMDA RECEPTORS IN ETHANOL
TOLERANCE.... 91 3. ROLE OF NMDA RECEPTORS IN OPIATE TOLERANCE AND
DEPENDENCE 94 C. SUMMARY: ETHANOL AND THE NMDA RECEPTOR 95 REFERENCES 96
CHAPTER 5 EFFECTS OF ALCOHOL ON GABA-MEDIATED NEUROTRANSMISSION - *,
M.K. TICKU AND A.K. MEHTA A. INTRODUCTION 103 B. BEHAVIORAL STUDIES 104
C. BINDING STUDIES 105 D. FUNCTIONAL STUDIES 106 I. ELECTROPHYSIOLOGICAL
STUDIES 106 II. CHLORIDE FLUX 107 E. ROL5-4513: ETHANOL ANTAGONIST 108
F. MOLECULAR BIOLOGICAL STUDIES 110 G. CHRONIC ETHANOL TREATMENT AND
GABA RECEPTOR GENE EXPRESSION 112 H. CONCLUSIONS 112 REFERENCES 113
CHAPTER 6 INVOLVEMENT OF CNS CATECHOLAMINES IN ALCOHOL
SELF-ADMINISTRATION, TOLERANCE, AND DEPENDENCE: PRECLINICAL STUDIES H.A.
SAMSON AND P.L. HOFFMAN 121 A. INTRODUCTION 121 B. ACUTE EFFECTS OF
INVESTIGATOR-ADMINISTERED ETHANOL: POTENTIAL FOR CATECHOLAMINE
INVOLVEMENT IN ETHANOL REINFORCEMENT 121 XVI CONTENTS I. NOREPINEPHRINE
121 II. DOPAMINE 123 C. ORAL ETHANOL SELF-ADMINISTRATION IN NONOPERANT
SITUATIONS 124 I. LIMITED ACCESS ETHANOL DRINKING SITUATIONS 124 1.
NOREPINEPHRINE 124 2. DOPAMINE 124 II. CONTINUOUS ACCESS ETHANOL
DRINKING SITUATIONS 125 1. NOREPINEPHRINE 125 2. DOPAMINE 125 III.
OPERANT PARADIGMS OF ORAL ETHANOL SELF-ADMINISTRATION 126 1.
NOREPINEPHRINE 126 2. DOPAMINE 126 D. CHRONIC EFFECTS OF ETHANOL ON
NORADRENERGIC AND DOPAMINERGIC ACTIVITY 127 I. NOREPINEPHRINE 127 II.
DOPAMINE 129 E. ROLE OF CATECHOLAMINES IN ETHANOL TOLERANCE AND PHYSICAL
DEPENDENCE 130 I. TOLERANCE 130 II. PHYSICAL DEPENDENCE 131 F. SUMMARY
132 REFERENCES 133 CHAPTER 7 5-HT MEDIATION OF ALCOHOL
SELF-ADMINISTRATION, TOLERANCE, AND DEPENDENCE: PRE-CLINICAL STUDIES
G.A. HIGGINS, A.D. LE, AND E.M. SELLERS. WITH 3 FIGURES 139 A.
INTRODUCTION 139 B. OVERVIEW OF THE 5-HT SYSTEM: MORPHOLOGY AND
RECEPTORS 139 C. 5-HT AND ALCOHOL SELF-ADMINISTRATION 141 I. INCREASING
5-HT FUNCTION 141 1. INDIRECT 5-HT AGONISTS AND ALCOHOL
SELF-ADMINISTRATION 141 2. 5-HT RECEPTOR AGONISTS AND ALCOHOL
SELF-ADMINISTRATION 143 3. TREATMENTS THAT ENHANCE 5-HT FUNCTION AND
OTHER CONSUMMATORY BEHAVIOURS 145 4. TREATMENTS THAT ENHANCE 5-HT
FUNCTION AND OTHER DRUG-REINFORCED BEHAVIOUR 147 II. REDUCING 5-HT
FUNCTION 147 1. 5-HT RECEPTOR ANTAGONISTS AND ALCOHOL
SELF-ADMINISTRATION 147 2. 5-HT LESIONS AND ALCOHOL SELF-ADMINISTRATION
149 CONTENTS XVII 3. TREATMENTS THAT REDUCE 5-HT FUNCTION AND OTHER
CONSUMMATORY BEHAVIOURS 150 4. TREATMENTS THAT REDUCE 5-HT FUNCTION AND
OTHER DRUG-REINFORCED BEHAVIOUR 150 III. BIOCHEMICAL FACTORS 151 IV.
SUMMARY 152 D. 5-HT, ALCOHOL TOLERANCE, AND PHYSICAL DEPENDENCE 155 I.
GENERAL ASPECTS OF ALCOHOL TOLERANCE 155 1. DEFINITION AND
CLASSIFICATION 155 2. FEATURES OF ETHANOL TOLERANCE 156 II. ROLE OF 5-HT
IN ETHANOL TOLERANCE/DEPENDENCE 156 III. DIFFERENCES IN 5-HT REGULATION
OF ETHANOL DRINKING AND ETHANOL TOLERANCE 157 IV. 5-HT AND ETHANOL
DEPENDENCE 158 E. EFFECTS OF CHRONIC ETHANOL ADMINISTRATION ON 5-HT
RECEPTORS .. 158 I. INTOXICATION 158 F. INTERACTION OF 5-HT AND OPIOIDS
159 G. GENERAL SUMMARY 159 REFERENCES 160 CHAPTER 8 OPIOID MEDIATION OF
ALCOHOL SELF-ADMINISTRATION: PRE-CLINICAL STUDIES J.R. VOLPICELLI, B.J.
BERG, AND N.T. WATSON 169 A. INTRODUCTION 169 B. ALCOHOL DRINKING
ENHANCES OPIOID SYSTEM ACTIVITY 169 I. OPIOID PEPTIDES ARE PRODUCED IN
THE METABOLISM OF ALCOHOL (TIQ ALKALOID HYPOTHESIS) 169 II. ALCOHOL
DRINKING LEADS TO CHANGES IN OPIOID RECEPTOR SENSITIVITY 170 III.
ALCOHOL DRINKING LEADS TO THE RELEASE OF ENDOGENOUS OPIOIDS 171 C.
GENETIC SUSCEPTIBILITY TO ALCOHOL ABUSE 171 D. MODULATING OPIATE
RECEPTOR ACTIVITY INFLUENCES ALCOHOL DRINKING 172 I. LOW DOSES OF
OPIOIDS INCREASE ALCOHOL DRINKING 173 II. MODERATE TO HIGH DOSES OF
OPIOIDS SUPPRESS ALCOHOL DRINKING 174 III. ALCOHOL DRINKING INCREASES
DURING OPIATE WITHDRAWAL . 175 E. UNCONTROLLABLE STRESS AND ALCOHOL
ABUSE 175 I. POST-STRESS ALCOHOL DRINKING 176 F. OPIATE ANTAGONISTS
ATTENUATE ALCOHOL DRINKING 176 I. WHY DO ORGANISMS ABUSE ALCOHOL? 178 G.
SUMMARY 180 REFERENCES 181 XVIII CONTENTS CHAPTER 9 ANIMAL MODELS OF THE
ALCOHOL ADDICTION PROCESS K.A. GRANT 185 A. INTRODUCTION 185 B.
ALCOHOL-SEEKING BEHAVIOR 186 C. INITIATION 188 I. MODELS TO ASSESS
ENVIRONMENTAL EFFECTS IN THE INITIATION OF ALCOHOL-SEEKING 189 II.
MODELS TO ASSESS THE GENETIC BASIS OF INITIATION OF ALCOHOL-SEEKING 192
III. MODELS TO ASSESS THE PSYCHOPHARMACOLOGICAL BASIS OF INITIATION OF
ALCOHOL-SEEKING 195 D. TRANSITION TO ABUSE AND DEPENDENCE (MAINTENANCE)
201 I. ROLE OF TOLERANCE IN THE MAINTENANCE OF EXCESSIVE ALCOHOL-SEEKING
202 II. ROLE OF SENSITIZATION IN THE MAINTENANCE OF EXCESSIVE
ALCOHOL-SEEKING 204 III. ROLE OF DEPENDENCE IN THE MAINTENANCE OF
EXCESSIVE ALCOHOL-SEEKING 206 IV. ROLE OF ENVIRONMENTAL INTERACTIONS IN
THE MAINTENANCE OF EXCESSIVE ALCOHOL-SEEKING BEHAVIOR 208 V. ROLE OF
CONDITIONED EFFECTS IN THE MAINTENANCE OF EXCESSIVE ALCOHOL-SEEKING
BEHAVIOR 211 E. REMISSION/TREATMENT 212 I. NONPHARMACOLOGICAL TREATMENTS
TO REDUCE ALCOHOL CONSUMPTION 213 II. PHARMACOLOGICAL TREATMENTS TO
REDUCE ALCOHOL CONSUMPTION 213 F. RELAPSE 215 I. ROLE OF CONDITIONED
WITHDRAWAL IN THE RELAPSE PROCESS 215 II. ROLE OF CONDITIONED DRUG-LIKE
EFFECTS IN THE RELAPSE PROCESS 216 G. SUMMARY 218 REFERENCES 218 CHAPTER
10 ETHANOL AND NEUROHORMONAL REGULATION J. LITTLETON 231 A. EFFECTS OF
ETHANOL ON NEUROHORMONES 231 I. HYPOTHALAMIC-PITUITARY-GONADAL AXIS 233
1. GONADOTROPIN-RELEASING HORMONE SECRETION 234 CONTENTS XIX 2.
GONADOTROPIN SECRETION 234 3. GONADAL ENDOCRINE SECRETION 235 4. GONADAL
STEROID METABOLISM 236 5. CONSEQUENCES OF ALTERATIONS IN THE HPG AXIS
237 6. HYPOTHALAMIC-PITUITARY-GONADAL AXIS AND FETAL DEVELOPMENT 237 7.
CONCLUSIONS 239 II. HYPOTHALAMIC-PITUITARY-ADRENAL AXIS 239 1.
CORTICOTROPIN-RELEASING HORMONE SECRETION 240 2. ADRENOCORTICOTROPIC
HORMONE SECRETION 240 3. ADRENAL STEROIDS 241 4. CONSEQUENCES OF
ALTERATIONS IN THE HP A AXIS 242 5. HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
AND FETAL DEVELOPMENT 243 6. CONCLUSIONS 244 III.
HYPOTHALAMIC-PITUITARY-THYROID AXIS 244 1. THYROTROPIN-RELEASING HORMONE
AND TSH SECRETION 244 2. THYROID HORMONES 245 3. CONSEQUENCES OF
ALTERATIONS IN THE HPT AXIS 246 4. CONCLUSIONS 246 IV. OTHER
NEUROHORMONAL SYSTEMS 246 1. GROWTH HORMONE 247 B. ROLE OF NEUROHORMONAL
ALTERATIONS IN ETHANOL CONSUMPTION.... 248 I. OPIOID PEPTIDES 249 II.
HYPOTHALAMIC-PITUITARY-ADRENAL AXIS 250 III. APPETITIVE SYSTEMS 252 C.
OVERALL CONCLUSIONS 253 REFERENCES 254 CHAPTER 11 CLINICAL APPLICATION
OF FINDINGS FROM ANIMAL RESEARCH ON ALCOHOL SELF-ADMINISTRATION AND
DEPENDENCE M.K. ROMACH AND D.M. TOMKINS 261 A. OVERVIEW 261 B. ALCOHOL
CONSUMPTION 261 I. CLINICAL ASPECTS OF ALCOHOLISM 261 II. ANIMAL MODELS
OF ALCOHOLISM 265 1. SELF-ADMINISTRATION 266 2. DRUG DISCRIMINATION 267
3. GENETIC STRAINS 268 III. PRECLINICAL STUDIES 268 1. SEROTONIN 268 XX
CONTENTS 2. OPIOIDS 270 3. DOPAMINE 271 IV. CLINICAL STUDIES 272 1.
SEROTONIN 272 2. OPIOIDS 275 3. DOPAMINE 277 C. ALCOHOL WITHDRAWAL 277
I. PRECLINICAL STUDIES 277 II. CLINICAL STUDIES 279 D. COMORBIDITY 281
I. OVERVIEW 281 II. ANIMAL MODELS 282 III. CLINICAL STUDIES 283 1.
DEPRESSION 283 2. ANXIETY 284 E. CONCLUSIONS 285 REFERENCES 287 CHAPTER
12 GENETIC FACTORS IN ALCOHOLISM: EVIDENCE AND IMPLICATIONS J. GELERNTER
297 A. INTRODUCTION 297 B. CLINICAL STUDIES: FAMILIAL PATTERNS IN
ALCOHOL USE 298 I. ADOPTION STUDIES 298 II. TWIN STUDIES 301 III. OTHER
CLINICAL DATA BEARING ON GENETICS 303 IV. TRAIT MARKERS AND DIFFERENCES
BETWEEN FAMILIAL AND NONFAMILIAL ALCOHOLISM 303 C. LABORATORY STUDIES:
SEARCH FOR A MOLECULAR BASIS FOR A COMPLEX BEHAVIOR 303 I. LINKAGE
STUDIES 304 II. ASSOCIATION STUDIES 304 1. ALCOHOL-METABOLIZING ENZYMES
305 2. D 2 DOPAMINE RECEPTOR GENE 306 D. CONCLUSIONS 308 REFERENCES 309
CHAPTER 13 PHARMACOTHERAPY AND PATHOPHYSIOLOGY OF ALCOHOL WITHDRAWAL
R.F. ANTON AND H.C. BECKER. WITH 3 FIGURES 315 A. INTRODUCTION 315
CONTENTS XXI B. CLINICAL SYNDROME 316 I. PHENOMENOLOGY AND DESCRIPTION
316 II. DRINKING VARIABLES RELATED TO THE ALCOHOL WITHDRAWAL SYNDROME
318 III. PROTRACTED ALCOHOL WITHDRAWAL 319 IV. PSYCHIATRIC COMORBIDITY
AND ALCOHOL WITHDRAWAL 320 C. PATHOPHYSIOLOGY OF ALCOHOL DEPENDENCE AND
WITHDRAWAL 322 I. GABA-A RECEPTOR SYSTEM 322 II. NMDA RECEPTOR SYSTEM
325 III. VOLTAGE-OPERATED CALCIUM CHANNELS 326 IV. MONOAMINE SYSTEMS 328
V. SECOND MESSENGER SYSTEMS AND ADENOSINE 330 VI. SUMMARY 331 D.
REPEATED EPISODES OF ALCOHOL WITHDRAWAL: THE KINDLING HYPOTHESIS 332
E. TREATMENT OF ALCOHOL WITHDRAWAL 337 F. MEASUREMENT OF THE ALCOHOL
WITHDRAWAL SYNDROME 337 G. NONPHARMACOLOGIC TREATMENT OF ALCOHOL
WITHDRAWAL 338 H. PHARMACOLOGIC TREATMENT 339 I. COMPLICATED ALCOHOL
WITHDRAWAL 339 II. UNCOMPLICATED ALCOHOL WITHDRAWAL 341 III.
BENZODIAZAPINES 341 IV. ALPHA- AND BETA-ADRENERGIC BLOCKERS 347 V.
ANTICONVULSANTS 348 VI. MISCELLANEOUS TREATMENTS 349 I. TREATMENT OF
ALCOHOL WITHDRAWAL SEIZURES 350 J. BIOLOGIC ASPECTS OF ALCOHOL
WITHDRAWAL IN MAN 352 REFERENCES 354 CHAPTER 14 DRUGS TO DECREASE ALCHOL
CONSUMPTION IN HUMANS: AVERSIVE AGENTS R.K. FULLER AND R.Z. LITTEN 369
A. INTRODUCTION 369 B. ABSORPTION, METABOLISM, AND EXCRETION 370 C.
PHARMACOKINETICS 370 D. MECHANISM OF DISULFIRAM: ETHANOL REACTION 371 E.
CLINICAL USE 371 F. EFFICACY 372 G. ENHANCING DISULFIRAM COMPLIANCE 374
H. TOXICITY 377 I. CONTRAINDICATIONS TO DISULFIRAM TREATMENT 378 J.
CALCIUM CARBAMIDE 378 K. FUTURE RESEARCH DIRECTIONS 379 REFERENCES 379
XXII CONTENTS CHAPTER 15 DRUGS ATTENUATING ALCOHOL CONSUMPTION IN HUMANS
THROUGH EFFECTS ON VARIOUS NEUROTRANSMITTER SYSTEMS C. A. NARANJO AND K.
E. BREMNER 383 A. INTRODUCTION 383 B. SEROTONIN 383 C. DOPAMINE 388 D.
OPIOIDS 388 E. MEDICATIONS ACTING ON OTHER NEUROTRANSMITTER SYSTEMS 389
F. CONCLUSIONS 390 REFERENCES 391 CHAPTER 16 PHARMACOLOGY OF
GASTROINTESTINAL COMORBIDITY IN ALCOHOLICS T.M. WORNER AND P. MANU 395
A. INTRODUCTION 395 B. DRUG THERAPY FOR ALCOHOL-INDUCED LIVER DISEASE
396 I. STEATOSIS 396 II. ALCOHOLIC HEPATITIS 396 1. INSULIN AND GLUCAGON
397 2. CORTICOSTEROIDS 397 3. ANABOLIC STEROIDS 398 4. COLCHICINE 398 5.
PROPYLTHIOURACIL 398 III. CIRRHOSIS 399 1. ASCITES 400 2. ENCEPHALOPATHY
400 3. ESOPHAGEAL VARICES 402 IV. LIVER TRANSPLANTATION 403 C. DRUG
THERAPY OF ACUTE ALCOHOLIC PANCREATITIS 403 1. CIMETIDINE 403 2.
SOMATOSTATIN 404 3. PIRENZEPINE 405 D. DRUG THERAPY OF CHRONIC ALCOHOLIC
GASTRITIS 406 E. SUMMARY 407 REFERENCES 407 CHAPTER 17 DRUGS FOR THE
TREATMENT OF PSYCHIATRIC COMORBIDITY IN ALCOHOLICS: RECENT DEVELOPMENTS
M.J. BOHN AND D. HERSH 415 CONTENTS XXIII A. INTRODUCTION 415 B.
DEPRESSION 416 I. ASSESSMENT 419 II. TREATMENT 419 III. PHARMACOTHERAPY
420 1. CYCLIC ANTIDEPRESSANTS 421 2. MONOAMINE OXIDASE INHIBITORS 423 3.
SEROTONIN UPTAKE INHIBITORS 424 4. LITHIUM 424 C. ANXIETY DISORDERS 425
I. ASSESSMENT 427 II. TREATMENT 427 III. PHARMACOTHERAPY 427 D. BIPOLAR
AFFECTIVE DISORDER 429 I. ASSESSMENT 430 II. TREATMENT 431 III.
PHARMACOTHERAPY 431 E. SCHIZOPHRENIA 433 I. ASSESSMENT 434 II. TREATMENT
435 III. PHARMACOLOGIC TREATMENT 435 F. CONCLUSIONS 436 REFERENCES 437
CHAPTER 18 CLINICAL MARKERS OF ALCOHOL ABUSE H. ROMMELSPACHER AND C.
MULLER 443 A. INTRODUCTION 443 I. DEFINITION OF THE TERM MARKER 443 B.
ETHANOL, ACETALDEHYDE, AND ACETATE 445 I. ETHANOL 445 II. ACETALDEHYDE
446 III. ACETALDEHYDE-HEMOGLOBIN ADDUCT 446 IV. ACETATE 448 C. MONOAMINE
OXIDASE 448 I. REGULATION OF ENZYME ACTIVITY 448 II. IN VITRO EFFECTS OF
ETHANOL 449 III. ENZYME ACTIVITY IN ALCOHOLICS AND NONALCOHOLICS 449 IV.
IN VITRO STUDIES OF PLATELETS FROM ALCOHOLICS 451 D. GUANINE NUCLEOTIDE
BINDING PROTEINS AND ADENYLYLCYCLASE 451 I. ACUTE EFFECTS OF ETHANOL 452
II. CHRONIC EFFECTS OF ETHANOL 452 E. SERUM ENZYMES 453 I.
Y-GLUTAMYLTRANSFERASE 454 XXIV CONTENTS II. ASPARTATE AMINOTRANSFERASE
454 III. OTHER ENZYMES, INDICES, AND TEST COMBINATIONS 455 F.
TETRAHYDROISOQUINOLINES AND /?-CARBOLINES 455 I. TETRAHYDROISOQUINOLINES
456 II. /?-CARBOLINES 457 G. IMMUNE SYSTEM 458 I. BLOOD GROUPS 458 II.
IMMUNOGLOBULINS 458 III. HUMAN LEUKOCYTE ANTIGENS 458 IV. CELL-MEDIATED
IMMUNE FUNCTION 459 H. ALCOHOL INTAKE AND SERUM TRACE ELEMENTS 459 I.
TRACE ELEMENTS AND ELECTROLYTES 459 II. THIAMINE (VITAMIN BI) 459 I.
CARBOHYDRATE-DEFICIENT TRANSFERRIN 460 I. BIOCHEMISTRY 460 II.
METHODOLOGICAL APPROACHES 461 III. PERFORMANCE: SENSITIVITY AND
SPECIFICITY 462 J. CONCLUSION 463 REFERENCES 464 CHAPTER 19 INTERACTION
OF ALCOHOL WITH THERAPEUTIC DRUGS AND DRUGS OF ABUSE B.F. SANDS, CM.
KNAPP, AND D.A. CIRAULO 475 A. INTRODUCTION 475 B. PHARMACOKINETIC
MECHANISMS 476 I. BIOAVAILABILITY AND ABSORPTION 476 II. DISTRIBUTION
477 III. METABOLISM 478 C. PHARMACODYNAMIC MECHANISMS 480 D. INDIVIDUAL
DRUGS 484 I. ACETAMINOPHEN 484 II. ANGIOTENSIN-CONVERTING ENZYME
INHIBITORS 484 1. ENALAPRIL 484 III. ANTICONVULSANTS 484 1. PHENYTOIN
484 IV. ANTIDEPRESSANTS 485 1. AMITRIPTYLINE 485 2. IMIPRAMINE 485 3.
CLOMIPRAMINE 486 4. DESIPRAMINE 486 5. DOXEPIN 486 6. NORTRIPTYLINE 486
V. SEROTONIN SELECTIVE REUPTAKE INHIBITORS 487 CONTENTS XXV VI.
ANTIPYRINE 487 VII. ASCORBIC ACID 487 VIII. BARBITURATES 488 1.
PHENOBARBITAL 488 2. PENTOBARBITAL 488 IX. BENZODIAZEPINES 488 1.
CHLORDIAZEPOXIDE 488 2. DIAZEPAM 488 3. FLURAZEPAM 490 4. LORAZEPAM 490
5. TRIAZOLAM 490 X. BROMOCRIPTINE 491 XL CA 2+ BLOCKERS 491 1.
NIFEDIPINE 491 2. NIMODIPINE 491 3. VERAPAMIL 491 XII. CANNABIS 492
XIII. COCAINE 492 XIV. SODIUM WARFARIN 494 XV. CROMOGLYCATE 494 XVI.
DISULFIRAM 494 XVII. H 2 BLOCKERS 495 1. CIMETIDINE 495 2. FAMOTIDINE
495 3. RANITIDINE 495 XVIIII. LITHIUM CARBONATE 496 XIX. METHYLXANTHINES
496 1. CAFFEINE 496 2. THEOPHYLLINE 496 XX. METOCLOPRAMIDE 497 XXI.
NEUROLEPTICS 497 1. CHLORPROMAZINE 497 2. REMOXIPRIDE 497 3.
THIORIDAZINE 497 XXII. NITRATES 498 1. NITROGLYCERIN 498 XXIII. OPIOIDS
498 1. METHADONE 499 2. PROPOXYPHENE 499 XXIV. ORAL CONTRACEPTIVES 499
XXV. ORAL HYPOGLYCEMICS 500 1. CHLORPROPRAMIDE 500 2. TOLBUTAMIDE 500
XXVI. SEDATIVE-HYPNOTICS 500 1. CHLORAL HYDRATE 500 XXVI CONTENTS 2.
GLUTETHIMIDE 501 3. MEPROBAMATE 501 XXVII. SALICYLATES 501 XXVIII.
TOBACCO 501 REFERENCES 502 CHAPTER 20 PHARMACOTHERAPIES FOR ALCOHOLISM:
THEORETICAL AND METHODOLOGICAL PERSPECTIVES H.R. KRANZLER, A.T.
MCLELLAN, AND M.J. BOHN 513 A. PHARMACOLOGIC APPROACHES TO RELAPSE
PREVENTION IN ALCOHOLICS 513 B. TREATMENT MATCHING 514 I. MATCHING BASED
UPON COMORBID PSYCHOPATHOLOGY .... 514 1. ANXIETY AND ALCOHOLISM 515 2.
DEPRESSION AND ALCOHOLISM 515 II. MATCHING BASED UPON OTHER PATIENT
CHARACTERISTICS . .. 516 1. CLONINGER S TYPOLOGY 517 2. THE TYPE A/TYPE
B DISTINCTION OF BABOR AND COLLEAGUES 518 C. METHODOLOGIC ISSUES IN
CLINICAL TRIALS WITH ALCOHOLICS 520 I. PATIENT ASSESSMENT AND OUTCOME
MEASUREMENT: FOR WHOM IS ONE DRINK TOO MANY? 522 II. TREATMENT
RETENTION AND HOW MUCH ADDITIONAL TREATMENT IS TOO MUCH TREATMENT? 524
1. PREVENTING ATTRITION 525 2. ANALYSIS OF OUTCOMES WHEN ATTRITION
OCCURS 527 III. MAXIMIZING COMPLIANCE AND DETERMINING HOW WELL YOU VE
DONE 527 IV. HOW LONG TO TREAT? THEN WHAT? 530 D. WHAT MAY THE FUTURE
HOLD? 531 REFERENCES 532 SUBJECT INDEX 539
|
| any_adam_object | 1 |
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| bvnumber | BV009945161 |
| callnumber-first | Q - Science |
| callnumber-label | QP905 |
| callnumber-raw | QP905 |
| callnumber-search | QP905 |
| callnumber-sort | QP 3905 |
| callnumber-subject | QP - Physiology |
| classification_rvk | XI 1701 YH 2900 |
| classification_tum | MED 612f MED 941f |
| ctrlnum | (OCoLC)30780211 (DE-599)BVBBV009945161 |
| dewey-full | 615/.1 615/.7828 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.1 615/.7828 |
| dewey-search | 615/.1 615/.7828 |
| dewey-sort | 3615 11 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
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| id | DE-604.BV009945161 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:43:42Z |
| institution | BVB |
| isbn | 3540571256 0387571256 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006589880 |
| oclc_num | 30780211 |
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| owner | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-29 DE-12 DE-20 DE-11 DE-188 DE-578 |
| owner_facet | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-29 DE-12 DE-20 DE-11 DE-188 DE-578 |
| physical | XXVI, 548 S. Ill., graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | The pharmacology of alcohol abuse contributors R. F. Anton ... Ed. Henry R. Kranzler Berlin [u.a.] Springer 1995 XXVI, 548 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 114 Literaturangaben Ethanol cabt Metabolism cabt Alcoholism cabt Drug Therapy cabt Alcohol gtt Alcoholisme gtt Stofwisseling gtt Alcohol Physiological effect Alcoholism drug therapy Alcoholism metabolism Disease Models, Animal Ethanol pharmacology Physiologie (DE-588)4045981-0 gnd rswk-swf Ethanol (DE-588)4125880-0 gnd rswk-swf Alkoholmissbrauch (DE-588)4068547-0 gnd rswk-swf Alkoholismus (DE-588)4001220-7 gnd rswk-swf Alkohol (DE-588)4001210-4 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf Sekundärkrankheit (DE-588)4131705-1 gnd rswk-swf Alkoholmissbrauch (DE-588)4068547-0 s Pharmakologie (DE-588)4045687-0 s DE-604 Ethanol (DE-588)4125880-0 s Physiologie (DE-588)4045981-0 s Alkohol (DE-588)4001210-4 s Alkoholismus (DE-588)4001220-7 s Sekundärkrankheit (DE-588)4131705-1 s Kranzler, Henry R. 1950- Sonstige (DE-588)172810655 oth Anton, Raymond F. Sonstige oth Handbook of experimental pharmacology 114 (DE-604)BV002390716 114 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006589880&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The pharmacology of alcohol abuse Handbook of experimental pharmacology Ethanol cabt Metabolism cabt Alcoholism cabt Drug Therapy cabt Alcohol gtt Alcoholisme gtt Stofwisseling gtt Alcohol Physiological effect Alcoholism drug therapy Alcoholism metabolism Disease Models, Animal Ethanol pharmacology Physiologie (DE-588)4045981-0 gnd Ethanol (DE-588)4125880-0 gnd Alkoholmissbrauch (DE-588)4068547-0 gnd Alkoholismus (DE-588)4001220-7 gnd Alkohol (DE-588)4001210-4 gnd Pharmakologie (DE-588)4045687-0 gnd Sekundärkrankheit (DE-588)4131705-1 gnd |
| subject_GND | (DE-588)4045981-0 (DE-588)4125880-0 (DE-588)4068547-0 (DE-588)4001220-7 (DE-588)4001210-4 (DE-588)4045687-0 (DE-588)4131705-1 |
| title | The pharmacology of alcohol abuse |
| title_auth | The pharmacology of alcohol abuse |
| title_exact_search | The pharmacology of alcohol abuse |
| title_full | The pharmacology of alcohol abuse contributors R. F. Anton ... Ed. Henry R. Kranzler |
| title_fullStr | The pharmacology of alcohol abuse contributors R. F. Anton ... Ed. Henry R. Kranzler |
| title_full_unstemmed | The pharmacology of alcohol abuse contributors R. F. Anton ... Ed. Henry R. Kranzler |
| title_short | The pharmacology of alcohol abuse |
| title_sort | the pharmacology of alcohol abuse |
| topic | Ethanol cabt Metabolism cabt Alcoholism cabt Drug Therapy cabt Alcohol gtt Alcoholisme gtt Stofwisseling gtt Alcohol Physiological effect Alcoholism drug therapy Alcoholism metabolism Disease Models, Animal Ethanol pharmacology Physiologie (DE-588)4045981-0 gnd Ethanol (DE-588)4125880-0 gnd Alkoholmissbrauch (DE-588)4068547-0 gnd Alkoholismus (DE-588)4001220-7 gnd Alkohol (DE-588)4001210-4 gnd Pharmakologie (DE-588)4045687-0 gnd Sekundärkrankheit (DE-588)4131705-1 gnd |
| topic_facet | Ethanol Metabolism Alcoholism Drug Therapy Alcohol Alcoholisme Stofwisseling Alcohol Physiological effect Alcoholism drug therapy Alcoholism metabolism Disease Models, Animal Ethanol pharmacology Physiologie Alkoholmissbrauch Alkoholismus Alkohol Pharmakologie Sekundärkrankheit |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006589880&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002390716 |
| work_keys_str_mv | AT kranzlerhenryr thepharmacologyofalcoholabuse AT antonraymondf thepharmacologyofalcoholabuse |