Pharmacological investigations on muscarinic and purinergic receptors in rabbit isolated vas deferens: modulation of the neurogenic biphasic contractions and characterization of the prejunctional muscarinic heteroreceptors mediating inhibition of evoked release of endogenous noradrenaline
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
1994
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VI, 143 S. Ill., graph. Darst. |
Internformat
MARC
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| 001 | BV009934523 | ||
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| 008 | 941206s1994 ad|| m||| 00||| engod | ||
| 016 | 7 | |a 942860519 |2 DE-101 | |
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| 035 | |a (DE-599)BVBBV009934523 | ||
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| 049 | |a DE-91 |a DE-29T |a DE-355 |a DE-11 |a DE-188 | ||
| 100 | 1 | |a Grimm, Ulrike M. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Pharmacological investigations on muscarinic and purinergic receptors in rabbit isolated vas deferens |b modulation of the neurogenic biphasic contractions and characterization of the prejunctional muscarinic heteroreceptors mediating inhibition of evoked release of endogenous noradrenaline |c by Ulrike M. Grimm |
| 264 | 1 | |c 1994 | |
| 300 | |a VI, 143 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Frankfurt (Main), Univ., Diss., 1994 | ||
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-006581890 | |
Datensatz im Suchindex
| _version_ | 1807774124402016256 |
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| adam_text |
TABLE
OF
CONTENTS
PAGE
1.
INTRODUCTION
AND
AIM
OF
THE
THESIS
1
1.1.
INTRODUCTION
1
1.1.1.
MUSCARINIC
RECEPTOR
SUBCLASSIFICATION
1
1.1.2.
MOLECULAR
DIVERSITY
OF
MUSCARINIC
RECEPTORS
7
1.1.3.
MUSCARINIC
RECEPTOR
NOMENCLATURE
8
1.1.4.
LOCALISATION
AND
FUNCTION
OF
MUSCARINIC
RECEPTORS
9
1.1.4.1.
MUSCARINIC
RECEPTORS
IN
THE
BRAIN
9
1.1.4.2.
PERIPHERAL
POSTSYNAPTIC
MUSCARINIC
RECEPTORS
10
1.1.4.3.
PRESYNAPTIC
MUSCARINIC
RECEPTORS
11
1.1.4.3.1.
MUSCARINIC
HETERORECEPTORS
IN
PERIPHERAL
TISSUES
12
1.1.4.3.2.
MUSCARINIC
HETERORECEPTORS
IN
THE
CNS
18
1.1.4.3.3.
MUSCARINIC
AUTORECEPTORS
IN
PERIPHERAL
TISSUES
20
1.
1.4.3.4.
MUSCARINIC
AUTORECEPTORS
IN
THE
CNS
25
1.1.5.
SIGNAL
TRANSDUCTION
PATHWAYS
OF
MUSCARINIC
RECEPTORS
27
1.1.6.
THE
STRUCTURE
OF
MUSCARINIC
RECEPTORS
31
1.1.7.
THERAPEUTIC
POTENTIAL
OF
SELECTIVE
MUSCARINIC
AGONISTS
AND
ANTAGONISTS
32
1.1.8.
THE
RABBIT
VAS
DEFERENS
34
1.2.
AIM
OF
THE
THESIS
38
2.
MATERIALS
AND
METHODS
41
2.1.
DRUGS
41
2.1.1.
COMMERCIALLY
AVAILABLE
COMPOUNDS
41
2.1.2.
GIFTS
42
2.1.3.
SYNTHESES
42
2.1.4.
PREPARATION
OF
BUFFERS
AND
SOLUTIONS
42
2.2.
ANIMALS
43
23.
METHODS
43
2.3.1.
CONTRACTION
EXPERIMENTS
ON
THE
FIELD-STIMULATED
RABBIT
ISOLATED
VAS
DEFERENS
43
2.3.1.1.
TISSUE
PREPARATION
43
2.3.1.2.
STIMULATION
PARAMETERS
44
2.3.1.3.
TESTING
OF
DRUGS
44
2.3.1.4.
ANALYSIS
OF
DATA
45
2.3.2.
NORADRENALINE
OVERFLOW
FROM
THE
RABBIT
VAS
DEFERENS
46
2.3.2.1.
TISSUE
PREPARATION
46
2.3.2.2.
STIMULATION
OF
NORADRENALINE
RELEASE
46
2.3.2.3.
DETERMINATION
OF
NORADRENALINE
47
2.3.2.4.
TESTING
OF
DRUGS
48
2.3.2.5.
ANALYSIS
OF
DATA
49
2.4.
STATISTICS
50
3.
RESULTS
51
3.1.
CONTRACTION
EXPERIMENTS
ON
THE
RABBIT
VAS
DEFERENS
51
3.1.1.
CHARACTERIZATION
OF
THE
BIPHASIC
RESPONSES
ELICITED
BY
TRAINS
OF
PULSES
51
3.1.1.1.
THE
INFLUENCE
OF
YOHIMBINE
AND
(-)-COCAINE
52
3.1.1.2.
EFFECT
OF
TETRODOTOXIN
53
3.1.1.3.
EFFECTS
OF
PRAZOSIN,
SURAMIN
AND
A,P-METHYLENE
ATP
53
3.1.2.
MODULATION
OF
THE
BIPHASIC
RESPONSE
55
3.1.2.1.
EFFECT
OF
HEXAMETHONIUM
55
3.1.2.2.
EFFECT
OF
PHYSOSTIGMINE
56
3.1.2.3.
EFFECTS
OF
THE
MUSCARINIC
ANTAGONISTS:
ATROPINE,
PIRENZEPINE,
AF-DX
384
AND
P-F-HHSID
57
3.1.2.3.1.
ATROPINE
IN
COMBINATION
WITH
HEMICHOLINIUM-3
58
3.1.2.4.
EFFECTS
OF
MUSCARINIC
RECEPTOR
AND
X2-ADRENOCEPTOR
AGONISTS
58
3.1.2.4.1.
ARECAIDINE
PROPARGYL
ESTER
3.I.2.4.2.
4-CL-MCN-A-343
3.I.2.4.3.
CLONIDINE
58
59
61
3.2.
NORADRENALINE
OVERFLOW
FROM
THE
RABBIT
VAS
DEFERENS
62
3.2.1.
BASAL
NORADRENALINE
OVERFLOW
62
3.2.2.
STIMULATION-EVOKED
OVERFLOW
OF
NORADRENALINE
AT
4
HZ
62
3.2.2.I.
EFFECT
OF
TETRODOTOXIN
AND
OMISSION
OF
CALCIUM
63
3.2.2.2.
EFFECT
OF
ATROPINE
AND
DPCPX
64
3.2.2.3.
EFFECT
OF
MUSCARINIC
AGONISTS
65
3.2.3.
STIMULATION-EVOKED
OVERFLOW
OF
NORADRENALINE
AT
1
HZ
67
3.2.3.1.
THE
INFLUENCE
OF
VARIOUS
PREJUNCTIONAL
MECHANISMS
67
3.2.3.2.
EFFECTS
OF
EXOGENOUS
MUSCARINIC
AGONISTS
AND
ATROPINE
USING
A
KREBS
SOLUTION
SUPPLEMENTED
WITH
CORTICOSTERONE,
(-)-COCAINE,
RAUWOLSCINE
AND
DPCPX
69
3.2.3.3.
EFFECT
OFPPADS
71
3.2.3.4.
EFFECTS
OF
EXOGENOUS
MUSCARINIC
AGONISTS
AND
ANTAGONISTS
USING
A
KREBS
SOLUTION
SUPPLEMENTED
WITH
CORTICOSTERONE,
(-)-COCAINE,
RAUWOLSCINE,
DPCPX,
PPADS
AND
INDOMETHACIN
72
4.
DISCUSSION
79
4.1.
CONTRACTION
EXPERIMENTS
ON
THE
RABBIT
VAS
DEFERENS
79
4.1.1.
CHARACTERIZATION
OF
THE
BIPHASIC
RESPONSES
ELICITED
BY
TRAINS
OF
PULSES
79
4.1.1.1.
EFFECT
OF
TETRODOTOXIN
79
4.1.1.2.
EFFECTS
OF
PRAZOSIN,
SURAMIN
AND
A,(5-METHYLENE
ATP
80
4.1.1.3.
THE
INFLUENCE
OF
YOHIMBINE
AND
COCAINE
80
4.1.2.
MODULATION
OF
THE
BIPHASIC
RESPONSE
81
4.1.2.1.
EFFECT
OF
HEXAMETHONIUM
81
4.1.2.2.
EFFECT
OF
PHYSOSTIGMINE
82
4.1.2.3.
EFFECTS
OF
MUSCARINIC
ANTAGONISTS:
ATROPINE,
PIRENZEPINE,
AF-DX
384
AND
P-F-HHSID
82
4.I.2.3.I.
ATROPINE
IN
COMBINATION
WITH
HEMICHOLINHIM-3
84
4.1.2.4.
EFFECTS
OF
MUSCARINIC
RECEPTOR
AND
A2*ADRENOCEPTOR
AGONISTS
85
4.1.2.4.1.
ARECAIDINE
PROPARGYL
ESTER
85
4.1.2.4.2.
4-CL-MCN-A-343
86
4.1.2.4.3.
CLONIDINE
87
4.1.2.4.4.
DIFFICULTIES
IN
INHIBITION
OF
THE
TONIC
CONTRACTION
88
4.2.
NORADRENALINE
OVERFLOW
FROM
THE
RABBIT
VAS
DEFERENS
89
4.2.1.
BASAL
NORADRENALINE
OVERFLOW
89
4.2.2.
THE
EFFECTS
OF
COCAINE
AND
CORTICOSTERONE
89
4.2.3.
THE
EFFECT
OFRAUWOLSCINE
90
4.2.4.
THE
INFLUENCE
OF
VARIOUS
PREJUNCTIONAL
MECHANISMS
90
4.2.4.1.
OMISSION
OF
CALCIUM
AND
EFFECTS
OF
TETRODOTOXIN
90
4.2.4.2.
EFFECTS
OFDPCPX
AND
CP-66.713-27
91
4.2.4.3.
EFFECTS
OF
PPADS
AND
INDOMETHACIN
91
4.2.5.
EFFECTS
OF
EXOGENOUS
MUSCARINIC
AGONISTS
AND
ANTAGONISTS
92
4.2.5.1.
MUSCARINIC
AGONISTS
92
4.2.5.2.
AFFINITY
VALUES
OF
MUSCARINIC
ANTAGONISTS
95
4.2.6.
NOVEL
SUBTYPES
OF
MUSCARINIC
RECEPTORS
?
99
4.2.7.
CONCLUSION
99
5.
SUMMARY
101
5.1.
CONTRACTION
EXPERIMENTS
ON
THE
RABBIT
VAS
DEFERENS
102
5.2.
NORADRENALINE
OVERFLOW
FROM
THE
RABBIT
VAS
DEFERENS
103
6.
ZUSAMMENFASSUNG
105
6.1.
KONTRAKTIONS-EXPERIMENTE
AM
VAS
DEFERENS
DES
KANINCHENS
106
6.2.
NORADRENALIN-OVERFLOW-MESSUNG
AM
VAS
DEFERENS
DES
KANINCHENS
108
7.
GLOSSARY
OF
ABBREVIATIONS
111
8.
REFERENCES
115
9.
LIST
OF
ACTIVE
PARTICIPATIONS
IN
CONGRESSES
AND
139
SYMPOSIA
10.
LIST
OF
PUBLICATIONS
141
11.
CURRICULUM
VITAE
143 |
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| genre_facet | Hochschulschrift |
| id | DE-604.BV009934523 |
| illustrated | Illustrated |
| indexdate | 2024-08-19T00:35:51Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006581890 |
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| owner_facet | DE-91 DE-BY-TUM DE-29T DE-355 DE-BY-UBR DE-11 DE-188 |
| physical | VI, 143 S. Ill., graph. Darst. |
| publishDate | 1994 |
| publishDateSearch | 1994 |
| publishDateSort | 1994 |
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| spelling | Grimm, Ulrike M. Verfasser aut Pharmacological investigations on muscarinic and purinergic receptors in rabbit isolated vas deferens modulation of the neurogenic biphasic contractions and characterization of the prejunctional muscarinic heteroreceptors mediating inhibition of evoked release of endogenous noradrenaline by Ulrike M. Grimm 1994 VI, 143 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Frankfurt (Main), Univ., Diss., 1994 Ratte (DE-588)4177011-0 gnd rswk-swf Samenleiter (DE-588)4179026-1 gnd rswk-swf Purinozeptor (DE-588)4176398-1 gnd rswk-swf Muscarinrezeptor (DE-588)4170773-4 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Muscarinrezeptor (DE-588)4170773-4 s Purinozeptor (DE-588)4176398-1 s Samenleiter (DE-588)4179026-1 s Ratte (DE-588)4177011-0 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006581890&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Grimm, Ulrike M. Pharmacological investigations on muscarinic and purinergic receptors in rabbit isolated vas deferens modulation of the neurogenic biphasic contractions and characterization of the prejunctional muscarinic heteroreceptors mediating inhibition of evoked release of endogenous noradrenaline Ratte (DE-588)4177011-0 gnd Samenleiter (DE-588)4179026-1 gnd Purinozeptor (DE-588)4176398-1 gnd Muscarinrezeptor (DE-588)4170773-4 gnd |
| subject_GND | (DE-588)4177011-0 (DE-588)4179026-1 (DE-588)4176398-1 (DE-588)4170773-4 (DE-588)4113937-9 |
| title | Pharmacological investigations on muscarinic and purinergic receptors in rabbit isolated vas deferens modulation of the neurogenic biphasic contractions and characterization of the prejunctional muscarinic heteroreceptors mediating inhibition of evoked release of endogenous noradrenaline |
| title_auth | Pharmacological investigations on muscarinic and purinergic receptors in rabbit isolated vas deferens modulation of the neurogenic biphasic contractions and characterization of the prejunctional muscarinic heteroreceptors mediating inhibition of evoked release of endogenous noradrenaline |
| title_exact_search | Pharmacological investigations on muscarinic and purinergic receptors in rabbit isolated vas deferens modulation of the neurogenic biphasic contractions and characterization of the prejunctional muscarinic heteroreceptors mediating inhibition of evoked release of endogenous noradrenaline |
| title_full | Pharmacological investigations on muscarinic and purinergic receptors in rabbit isolated vas deferens modulation of the neurogenic biphasic contractions and characterization of the prejunctional muscarinic heteroreceptors mediating inhibition of evoked release of endogenous noradrenaline by Ulrike M. Grimm |
| title_fullStr | Pharmacological investigations on muscarinic and purinergic receptors in rabbit isolated vas deferens modulation of the neurogenic biphasic contractions and characterization of the prejunctional muscarinic heteroreceptors mediating inhibition of evoked release of endogenous noradrenaline by Ulrike M. Grimm |
| title_full_unstemmed | Pharmacological investigations on muscarinic and purinergic receptors in rabbit isolated vas deferens modulation of the neurogenic biphasic contractions and characterization of the prejunctional muscarinic heteroreceptors mediating inhibition of evoked release of endogenous noradrenaline by Ulrike M. Grimm |
| title_short | Pharmacological investigations on muscarinic and purinergic receptors in rabbit isolated vas deferens |
| title_sort | pharmacological investigations on muscarinic and purinergic receptors in rabbit isolated vas deferens modulation of the neurogenic biphasic contractions and characterization of the prejunctional muscarinic heteroreceptors mediating inhibition of evoked release of endogenous noradrenaline |
| title_sub | modulation of the neurogenic biphasic contractions and characterization of the prejunctional muscarinic heteroreceptors mediating inhibition of evoked release of endogenous noradrenaline |
| topic | Ratte (DE-588)4177011-0 gnd Samenleiter (DE-588)4179026-1 gnd Purinozeptor (DE-588)4176398-1 gnd Muscarinrezeptor (DE-588)4170773-4 gnd |
| topic_facet | Ratte Samenleiter Purinozeptor Muscarinrezeptor Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006581890&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT grimmulrikem pharmacologicalinvestigationsonmuscarinicandpurinergicreceptorsinrabbitisolatedvasdeferensmodulationoftheneurogenicbiphasiccontractionsandcharacterizationoftheprejunctionalmuscarinicheteroreceptorsmediatinginhibitionofevokedreleaseofendogenousnoradrenalin |