Handbook of membrane channels: molecular and cellular physiology
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego u.a.
Acad. Press
1994
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIX, 591 S. Ill., graph. Darst. |
| ISBN: | 0125506406 |
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| 245 | 1 | 0 | |a Handbook of membrane channels |b molecular and cellular physiology |c ed. by Camillo Peracchia |
| 264 | 1 | |a San Diego u.a. |b Acad. Press |c 1994 | |
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| 650 | 4 | |a Gap Junctions |x physiology | |
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| 650 | 4 | |a Ion Channels |x physiology | |
| 650 | 4 | |a Ion channels |v Handbooks, manuals, etc | |
| 650 | 4 | |a Mitochondria |x physiology | |
| 650 | 4 | |a Mitochondrial menbranes |v Handbooks, manuals, etc | |
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Datensatz im Suchindex
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|---|---|
| adam_text | Handbook of
Membrane Channels
MOLECULAR AND CELLULAR PHYSIOLOGY
Edited by
Camillo Peracchia
Department of Physiology
University of Rochester
School of Medicine and Dentistry
Rochester, New York
Academic Press
San Diego New York Boston London Sydney Tokyo Toronto
Contents
Contributors xv
Preface xix
SECTION
I
CHANNELS OF
PLASMA MEMBRANES
PART
A
Potassium Channels
Conservation of K+ Channel Properties in
Gene Subfamilies
N Vivienne Shen and Paul / Pfaffinger
I What Is Homology? 5
II Primary Sequence Homology 7
III Structural Homology 9
IV Functional Homology 13
V Integrating Homology Analyses 14
VI Conclusions 15
References 15
Permeation Properties of Cloned
K+ Channels
Ted Begenisich
I Introduction 17
II Probing the Structure of K+ Channel Pores 19
III Mutagenic Alterations of Pore Selectivity 20
IV Mutagenic Alterations of the Current-Voltage
Relationship 20
V Multi-ion Nature of K+ Channels 22
VI Structural Model of the Pore 22
VII Mathematical Model for Ion Permeation 24
VIII Limitations 26
References 26
Gating Currents of Cloned Shaker
K+ Channels
Enrico Stefani, Ligia Toro, Eduardo Perozo,
and Francisco Bezanilla
I Introduction 29
II Methods 30
III Results and Discussion 31
IV Summary and Conclusions 38
References 39
Shaw-Related K+ Channels in Mammals
E Vega-Saenz de Miera, M Weiser, C Kentros, D Lau,
H Moreno, P Serodio, and B Rudy
I Introduction 41
II Molecular Diversity and Neuronal
Function 41
III Families of K+Channel Genes 42
IV Toward an Understanding of the Functional
Role of Mammalian SJiazu-Related Proteins 44
V Summary and Perspectives 72
References 73
vii
CONTENTS
Molecular Workings of Large Conductance
(Maxi) Ca2+-Activated K+ Channels
Ramon Latorre
I Introduction 79
II Channel Gating 80
III Selectivity, Ion Conduction, and Blockade 87
IV Toxins That Block Maxi K+(Ca2+) Channels 95
References 97
PART
B
Sodium Channels
Ionic Channels of Myelinated Axons
Peter Shrager and Jin V Wu
I Ionic Channels at Nodes and Paranodes 105
II Patch Voltage Clamp Recording of Macroscopic
Currents from the Internodes of Axons 106
III Internodal Channel Function Analyzed by
Optical Recording of Propagating Action
Potentials in Demyelinated Fibers 109
IV Single-Channel Recording from Demyelinated
Paranodes and Internodes 109
V Summary 112
References 112
Cardiac Sodium Channel Expression in
Xenopus Oocytes
Douglas S Krafte
I Introduction 115
II Sodium Channel Function in the Heart 115
III Method to Express Cardiac Sodium Channels
from Tissue RNA 116
IV Electrophysiological Properties of Expressed
Cardiac Sodium Channels 117
V Channel Blockade by Tetrodotoxin 117
VI Blockade of Expressed Cardiac Sodium
Channels by Class I Antiarrhythmic
Drugs 118
VII Pharmacological Slowing of Channel
Inactivation 118
VIII Summary 119
References 119
Molecular Analysis of Sodium
Channel Inactivation
Alan L Goldin
I Introduction 121
II Effects of Low Molecular Weight Proteins on
Sodium Channel Inactivation 123
III Role of the Subunit in Sodium Channel
Inactivation 125
IV Ball and Chain Model of Sodium Channel
Inactivation 126
V Role of the Cytoplasmic Linker between
Domains III and IV in Inactivation 126
VI Effects of Deletions and Charge
Neutralization in the III—IV Linker on
Inactivation 127
VII Cluster of Hydrophobic Residues in the III—IV
Linker Is Critical for Inactivation 129
VIII Functional Analogy of the Inactivation
Regions of Sodium and Potassium
Channels 130
IX Clinical Relevance of Disorders of Sodium
Channel Inactivation 131
X Future Directions 132
References 132
Unitary Properties of the Batrachotoxin
Trapped State of Voltage-Sensitive
Sodium Channels
Edward Moczydlowski and Laurent Schild
I Introduction 137
II Gating Behavior 139
III Ion Permeation 147
IV Pharmacology of Block 150
V Summary 156
References 156
Contents ix
PARTc
Calcium Channels
Molecular Biology of Voltage-Dependent
Calcium Channels
Yasuo Mori
I Introduction 163
II Structural Diversity and Differential Expression
of Calcium Channels 164
III Heterologous Expression of Calcium
Channels 171
IV Conclusions 173
References 173
Structure and Function of Skeletal Muscle
and Cardiac Dihydropyridine Receptors
Tsutomu Tanabe
I Introduction 177
II Subunit Composition of Calcium
Channels 177
III Molecular Structure of the Skeletal Muscle and
Cardiac DHP Receptor 178
IV Functional Expression of the DHP
Receptor 179
V Functional Region-of the DHP Receptor 181
VI Conclusion 183
References 184
Molecular Pharmacology of Cardiac
L-Type Calcium Channels
Robert S Kass
I Introduction 187
II Calcium Channel Antagonists: Defining the
Basic Categories 188
III Identifying the Phenylalkylamine Binding
Site 190
IV Dihydropyridine Modulation of L-Type
Channels 191
V Calcium Channels as Dihydropyridine
Receptors 192
VI A Unique Role for Calcium in the Mechanism
of Action of Calcium Channel
Antagonists? 192
VII Probing the Dihydropyridine Binding Site
Location 194
VIII Summary 196
References 196
Pharmacology of Different Types of
Calcium Channels in Rat Neurons
Bruce P Bean and Isabelle M Mintz
I Introduction 199
II Overview 199
III T-Type Channels 200
IV L-Type Channels 200
V N-Type Channels: cu-Conotoxin 204
VI P-Type Channels: w-Aga-IVA 205
VII Coexistence of Channel Types and Undefined
Channel Types 208
VIII Future Directions 208
References 209
PART
D
Chloride Channels
Voltage-Dependent Kinetics of the Fast
Chloride Channel
David S Weiss
I Introduction 213
II Voltage Dependence of Single Fast Chloride
Channels 213
III Kinetic Stability 216
IV Voltage-Dependent Gating Mechanisms 217
V Testing Other Models 219
VI Other Kinetic Features of the Fast Chloride
Channel 222
VII Summary 224
References 227
xii CONTENTS
IV Connexins in the Lens 405
V Functional Studies of Cloned and Native Gap
Junctions 405
References 409
PART
H
Channels of the MIP Family
The MIP Transmembrane Channel
Gene Family
Ana B Chepelinsky
I Introduction 413
II MIP Family in Vertebrates 417
III MIP Family in Drosophila 424
IV MIP Family in Plants 424
V MIP Family in Bacteria 426
VI MIP Family in Yeast 426
VII Summary 426
References 427
PART
I
Calmodulin-Regulated Channels
Calmodulin-Sensitive Channels
Yoshiro Saimi, Kit-Yin Ling, and Ching Kung
I Calmodulin and Calmodulin-Binding
Targets 435
II Calmodulin-Gated Ion Channels in
Paramecium 436
III trp and trpl Gene Products: Photosensory
Channels in Drosophila 438
IV Calcium-Dependent K+ Channels in Kidney
and Colon 438
V Others 440
VI Conclusions 440
References 441
PART
J
Channels of Unicellular Organisms
Microbial Channels
Boris Martinac, Xin-Liang Zhou, Andrzej Kubalski,
Sergei Sukharev, and Ching Kung
I Patch-Clamp Investigation of Microbes 447
II Paramecium 447
III Dictyostelium 450
IV Yeasts and Other Fungi 450
V Escherichia coli 452
VI Conclusion 455
References 456
SECTION
II
CHANNELS OF
INTRACELLULAR MEMBRANES
PART
A
Channels of Calcium Stores
Ryanodine Receptor/Ca2+-Release
Channel of Excitable Tissues
Gerhard Meissner
I Introduction 465
II Microsomal Membrane Fractions Enriched in
Ca2+-Release and [3H]Ryanodine-Binding
Activities 466
III Isolation of 30 S RyR/Ca2+-Release
Channel 466
IV RyR/Caz+-Release Channel Conducts Mono-
and Divalent Cations 468
Contents xiii
V RyR/Ca2+-Release Channel Is a Ligand-Gated
Channel 470
VI Conclusion 472
References 472
PART
B
Mitochondrial Channels
Pharmacology of Ryanodine-Sensitive
Ca2+-Release Channels
Ildiko Zimanyi and Isaac N Pessah
I Introduction 475
II Pharmacology of the SR/Ca2+-Release
Channel 476
III Mechanism of Ryanodine Action 481
IV Concluding Remarks 489
References 491
Mitochondrial Membrane Channels
Henry Tedeschi and Kathleen IV Kinnally
I Historical Perspective 529
II Channels of the Outer Membrane 530
III Channels of the Inner Membrane 533
IV Interaction between Inner and Outer
Membranes 541
V Channel Behavior of Translocators in
Reconstituted Systems 542
VI Possible Physiological Roles 543
References 544
InsP3 Receptor and Intracellular
Calcium Release
Trevor J Shuttleworth
I Historical Perspective 495
II Identification and Characterization of the InsP3
Receptor 496
III Structural Studies of the Receptor 497
IV Receptor Function 500
V Conclusions 506
References 506
ATP-Sensitive K+ Channels in the Inner
Membrane of Rat Liver Mitochondria
I Inoue and T Higuti
I Introduction 549
II Patch Clamp to Giant Mitoplast 549
III Effect of 4-Aminopyridine 550
IV ATP Sensitivity of the Channel 551
V Effect of Glibenclamide 551
VI Possible Role of the KATP Channel 553
References 554
InsP3 Receptor: Functional Properties
and Regulation
Ilya Bezprozvanny and Barbara E Ehrlich
I Introduction 511
II Identification and Purificaton of InsP3R 512
III Molecular Cloning of InsP3R 513
IV Functional Studies of InsP3R/Ca2+
Channel 514
V Regulation of InsP3R Function 516
VI Summary 523
References 523
PARTc
Channels of Exocytotic Fusion
Structure and Regulation of the Exocytotic
Fusion Pore
Jonathan R Monck, Andres F Oberhauser,
Peter E R Tatham, and Julio M Fernandez
I Fusion Pores and Cell Function 557
II Rapid-Freeze Electron Microscopy of the Fusion
Pore 558
xiv CONTENTS
III Measurements of Exocytosis and the Fusion
Pore 559
IV Fusion Pore Develops in Distinct Stages 563
V Kinetic Analysis of Fusion Pore Activity 567
VI Molecular Mechanisms of Fusion Pore
Formation 570
VII Exocytotic Fusion Pore as a Lipidic Structure
Supported by a Protein Scaffold 572
VIII Conclusions 576
References 576
Index 581
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| indexdate | 2024-07-09T17:42:47Z |
| institution | BVB |
| isbn | 0125506406 |
| language | English |
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| spelling | Handbook of membrane channels molecular and cellular physiology ed. by Camillo Peracchia San Diego u.a. Acad. Press 1994 XIX, 591 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Ion Channels cabt Cell Membranes cabt Ionenkanalen gtt Membranen gtt Cell Membrane physiology Cell membranes Handbooks, manuals, etc Gap Junctions physiology Gap junctions (Cell biology) Handbooks, manuals, etc Ion Channels physiology Ion channels Handbooks, manuals, etc Mitochondria physiology Mitochondrial menbranes Handbooks, manuals, etc Ionenkanal (DE-588)4138699-1 gnd rswk-swf Ionenkanal (DE-588)4138699-1 s DE-604 Peracchia, Camillo Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006554126&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Handbook of membrane channels molecular and cellular physiology Ion Channels cabt Cell Membranes cabt Ionenkanalen gtt Membranen gtt Cell Membrane physiology Cell membranes Handbooks, manuals, etc Gap Junctions physiology Gap junctions (Cell biology) Handbooks, manuals, etc Ion Channels physiology Ion channels Handbooks, manuals, etc Mitochondria physiology Mitochondrial menbranes Handbooks, manuals, etc Ionenkanal (DE-588)4138699-1 gnd |
| subject_GND | (DE-588)4138699-1 |
| title | Handbook of membrane channels molecular and cellular physiology |
| title_auth | Handbook of membrane channels molecular and cellular physiology |
| title_exact_search | Handbook of membrane channels molecular and cellular physiology |
| title_full | Handbook of membrane channels molecular and cellular physiology ed. by Camillo Peracchia |
| title_fullStr | Handbook of membrane channels molecular and cellular physiology ed. by Camillo Peracchia |
| title_full_unstemmed | Handbook of membrane channels molecular and cellular physiology ed. by Camillo Peracchia |
| title_short | Handbook of membrane channels |
| title_sort | handbook of membrane channels molecular and cellular physiology |
| title_sub | molecular and cellular physiology |
| topic | Ion Channels cabt Cell Membranes cabt Ionenkanalen gtt Membranen gtt Cell Membrane physiology Cell membranes Handbooks, manuals, etc Gap Junctions physiology Gap junctions (Cell biology) Handbooks, manuals, etc Ion Channels physiology Ion channels Handbooks, manuals, etc Mitochondria physiology Mitochondrial menbranes Handbooks, manuals, etc Ionenkanal (DE-588)4138699-1 gnd |
| topic_facet | Ion Channels Cell Membranes Ionenkanalen Membranen Cell Membrane physiology Cell membranes Handbooks, manuals, etc Gap Junctions physiology Gap junctions (Cell biology) Handbooks, manuals, etc Ion Channels physiology Ion channels Handbooks, manuals, etc Mitochondria physiology Mitochondrial menbranes Handbooks, manuals, etc Ionenkanal |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006554126&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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