Glycopeptide antibiotics:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York u.a.
Dekker
1994
|
| Schriftenreihe: | Drugs and the pharmaceutical sciences
63 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 423 S. Ill., graph. Darst. |
| ISBN: | 0824791932 |
Internformat
MARC
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| 245 | 1 | 0 | |a Glycopeptide antibiotics |c ed. by Ramakrishnan Nagarajan |
| 264 | 1 | |a New York u.a. |b Dekker |c 1994 | |
| 300 | |a XIV, 423 S. |b Ill., graph. Darst. | ||
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| 650 | 7 | |a Antibiotica |2 gtt | |
| 650 | 4 | |a Antibiotiques glycopeptidiques | |
| 650 | 4 | |a Anti-Bacterial Agents | |
| 650 | 4 | |a Glycopeptide antibiotics | |
| 650 | 4 | |a Glycopeptides | |
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Datensatz im Suchindex
| _version_ | 1804124221224255488 |
|---|---|
| adam_text | ANNOOCS EDITED BY RAMAKIISHNAN NAGARAJAN LILLY RESEARCH LABORATORIES ELI
LILLY AND COMPANY INDIANAPOLIS, INDIANA MARCEL DEKKER, INC. NEW
YORK*BASEL*HONG KONG CONTENTS PREFACE V CONTRIBUTORS XIII 1.
GLYCOPEPTIDES: CLASSIFICATION, OCCURRENCE, AND DISCOVERY 1 RAYMOND C.
YAO AND LOUISE W. CRANDALL I. INTRODUCTION 1 II. CLASSIFICATION 2 III.
OCCURRENCE 6 IV. DISCOVERY AND SCREENING 7 V. CONCLUSION 20 VI. ADDENDUM
21 REFERENCES 21 2. SEPARATION METHODOLOGY 29 ROBERT D. SITRIN AND GAIL
FOLENA-WASSERMAN I. INTRODUCTION 29 II. CLASSIC METHODS FOR EXTRACTION
AND PURIFICATION 31 III. AFFINITY CHROMATOGRAPHY 33 IV. PREPARATIVE
REVERSED-PHASE HPLC 45 V. GENERAL GLYCOPEPTIDE ANTIBIOTIC ISOLATION
SCHEME 50 VI. ANALYTICAL SEPARATION TECHNIQUES 52 VII. CONCLUSIONS 56
REFERENCES 56 3. APPROACHES TO THE SYNTHESIS OF THE VANCOMYCIN AGLYCONES
63 DAVID E. EVANS AND KEITH M. DEVRIES I. INTRODUCTION 63 IX X CONTENTS
II. DEGRADATION STUDIES: FORMATION OF VANCOMYCIN AGLYCONE AND FURTHER
DEGRADATION TO AMINO ACID CONSTITUENTS 69 III. SYNTHESIS CHALLENGE 69
IV. MODEL STUDIES: APPROACHES TO THE SYNTHESIS OF THE VANCOMYCIN BINDING
POCKET 76 V. SYNTHESIS OF THE AMINO ACID SUBSTITUENTS 78 VI. SYNTHESIS
OF VANCOMYCIN AND RISTOCETIN SUBUNITS 85 VII. OXIDATIVE PHENOLIC
COUPLING STUDIES 90 VIII. FUTURE PROSPECTS 97 IX. CONCLUSION 101 X.
EPILOGUE 101 REFERENCES 101 4. CHEMISTRY OF CARBOHYDRATE COMPONENTS 105
FERENC SZTARICSKAI AND ISTVDN PELYVDS-FERENCZIK I. INTRODUCTION 105 II.
COMPOSITION AND STRUCTURAL ELUCIDATION OF THE CARBOHYDRATE UNITS BY
CHEMICAL METHODS 111 III. CHEMICAL SYNTHESIS OF THE AMINODEOXY SUGARS
131 IV. SYNTHESIS OF THE OLIGOSACCHARIDE SIDE CHAINS 168 ABBREVIATIONS
180 REFERENCES 181 5. STRUCTURE-ACTIVITY RELATIONSHIPS OF VANCOMYCIN
ANTIBIOTICS 195 RAMAKRISHNAN NAGARAJAN I. INTRODUCTION 195 II. SAR OF
THE CORE HEPTAPEPTIDE AMINO ACIDS 199 III. SAR OF SEMISYNTHETIC
GLYCOPEPTIDE ANTIBIOTICS 207 IV. SAR AND MODES OF ACTION 211 V.
CONCLUSIONS 212 REFERENCES 215 6. RESISTANCE AND MODE OF ACTION 219
THALIA I. NICAS AND NORRIS E. ALLEN I. MECHANISM OF ACTION OF VANCOMYCIN
AND OTHER GLYCOPEPTIDES 219 II. GLYCOPEPTIDE RESISTANCE 225 REFERENCES
233 CONTENTS XI 7. ANALYTICAL QUANTITATION AND CHARACTERIZATION 243
EUGENE L. INMAN AND C. L. WINELY I. VANCOMYCIN BIOANALYTICAL
METHODOLOGIES 244 II. VANCOMYCIN CHARACTERIZATION METHODOLOGIES 254 III.
CHARACTERIZATION OF OTHER GLYCOPEPTIDES 267 REFERENCES 269 8.
TEICOPLANIN 273 BETH P. GOLDSTEIN, RITA ROSINA, AND FRANCESCO PARENTI
273 274 274 276 282 284 293 294 9. VANCOMYCIN: A CLINICAL OVERVIEW 309
MICHAEL L. ZECKEL AND JAMES R. WOODWORTH I. PHARMACOKINETICS 309 II.
CLINICAL EFFICACY 323 III. VANCOMYCIN SAFETY 346 IV. THE FUTURE 364
REFERENCES 364 EPILOGUE 411 RAMAKRISHNAN NAGARAJAN INDEX 413 I. II. III.
IV. V. VI. VII. DISCOVERY CHEMISTRY FERMENTATION ANTIMICROBIAL ACTIVITY
TOXICOLOGY PHARMACOKINETICS PLACE OF TEICOPLANIN IN THERAPY REFERENCES
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T17:42:13Z |
| institution | BVB |
| isbn | 0824791932 |
| language | English |
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| physical | XIV, 423 S. Ill., graph. Darst. |
| publishDate | 1994 |
| publishDateSearch | 1994 |
| publishDateSort | 1994 |
| publisher | Dekker |
| record_format | marc |
| series | Drugs and the pharmaceutical sciences |
| series2 | Drugs and the pharmaceutical sciences |
| spelling | Glycopeptide antibiotics ed. by Ramakrishnan Nagarajan New York u.a. Dekker 1994 XIV, 423 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Drugs and the pharmaceutical sciences 63 Antibiotica gtt Antibiotiques glycopeptidiques Anti-Bacterial Agents Glycopeptide antibiotics Glycopeptides Vancomycin Glykopeptide (DE-588)4157743-7 gnd rswk-swf Vancomycin (DE-588)4293005-4 gnd rswk-swf Antibiotikum (DE-588)4002257-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Glykopeptide (DE-588)4157743-7 s Antibiotikum (DE-588)4002257-2 s DE-188 Vancomycin (DE-588)4293005-4 s Nagarajan, Ramakrishnan Sonstige oth Drugs and the pharmaceutical sciences 63 (DE-604)BV000002008 63 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006531540&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Glycopeptide antibiotics Drugs and the pharmaceutical sciences Antibiotica gtt Antibiotiques glycopeptidiques Anti-Bacterial Agents Glycopeptide antibiotics Glycopeptides Vancomycin Glykopeptide (DE-588)4157743-7 gnd Vancomycin (DE-588)4293005-4 gnd Antibiotikum (DE-588)4002257-2 gnd |
| subject_GND | (DE-588)4157743-7 (DE-588)4293005-4 (DE-588)4002257-2 (DE-588)4143413-4 |
| title | Glycopeptide antibiotics |
| title_auth | Glycopeptide antibiotics |
| title_exact_search | Glycopeptide antibiotics |
| title_full | Glycopeptide antibiotics ed. by Ramakrishnan Nagarajan |
| title_fullStr | Glycopeptide antibiotics ed. by Ramakrishnan Nagarajan |
| title_full_unstemmed | Glycopeptide antibiotics ed. by Ramakrishnan Nagarajan |
| title_short | Glycopeptide antibiotics |
| title_sort | glycopeptide antibiotics |
| topic | Antibiotica gtt Antibiotiques glycopeptidiques Anti-Bacterial Agents Glycopeptide antibiotics Glycopeptides Vancomycin Glykopeptide (DE-588)4157743-7 gnd Vancomycin (DE-588)4293005-4 gnd Antibiotikum (DE-588)4002257-2 gnd |
| topic_facet | Antibiotica Antibiotiques glycopeptidiques Anti-Bacterial Agents Glycopeptide antibiotics Glycopeptides Vancomycin Glykopeptide Antibiotikum Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006531540&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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