Use of hard gelatin capsules and sodium alginates in peroral prolonged-release formulations:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
1994
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Helsinki, Univ., Diss., 1994 |
| Beschreibung: | Getr. Zählung graph. Darst. |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | DIVISION OF BIOPHARMACEUTICS AND PHARMACOKINETICS DEPARTMENT OF PHARMACY
UNIVERSITY OF HELSINKI FINLAND INSTITUTE OF PHARMACY UNIVERSITY OF TARTU
ESTONIA USE OF HARD GELATIN CAPSULES AND SODIUM ALGINATES IN PERORAL
PROLONGED-RELEASE FORMULATIONS PEEP VESKI ACADEMIC DISSERTATION TO BE
PRESENTED, WITH THE PERMISSION OF THE FACULTY OF SCIENCE OF THE
UNIVERSITY OF HELSINKI, FOR PUBLIC CRITICISM IN AUDITORIUM XIII ON JUNE
10TH 1994 AT 12 O CLOCK NOON. HELSINKI 1994 CONTENTS PAGE ABSTRACT 5
LIST OF ORIGINAL PUBLICATIONS 6 1. INTRODUCTION 7 1.1. PROLONGED-RELEASE
DRUG PREPARATIONS 7 1.2. HARD GELATIN CAPSULES 9 1.3. PRESS-COATED
PROLONGED-RELEASE TABLETS 10 1.4. SODIUM ALGINATES 11 1.5. IBUPROFEN 11
1.6. PSEUDOEPHEDRINE HYDROCHLORIDE 12 2. AIMS OF STUDY 14 3. MATERIALS
AND METHODS 15 3.1. SODIUM ALGINATES 15 3.2. MODEL DRUGS 15 3.3.
ADDITIVES 15 3.4. PREPARATION OF CAPSULE FORMULATIONS 15 3.5. PLUG
FORMATION 16 3.6. PREPARATION OF PRESS-COATED TABLETS : 16 3.7.
DISSOLUTION TESTS N 3.7.1. DISSOLUTION OF IBUPROFEN 17 3.7.2.
DISSOLUTION OF PSEUDOEPHEDRINE HYDROCHLORIDE 17 3.8. PENETRATION OF
DISSOLUTION MEDIUM INTO CAPSULES , 18 3.9. BIOAVAILABILITY STUDIES 18
3.10. PLASMA ASSAYS 19 3.10.1. DETERMINATION OF IBUPROFEN 19 3.10.2.
DETERMINATION OF PSEUDOEPHEDRINE 19 3.11. PHARMACOKINETIC PARAMETERS 20
4. RESULTS AND DISCUSSION 21 4.1. EFFECTS OF DIFFERENT GRADES OF SODIUM
ALGINATE ON PHARMACEUTICAL PROPERTIES OF FORMULATIONS 21 4.1.1. SODIUM
ALGINATE AS A DILUENT IN HARD GELATIN CAPSULES (II) 21 4.1.2. SODIUM
ALGINATE IN COATS OF PRESS-COATED TABLETS (IV) 22 4.1.3. EFFECTS OF
DISSOLUTION PH ON PROPERTIES OF SODIUM ALGINATE CAPSULES (V) 23 4.2.
PENETRATION OF DISSOLUTION MEDIUM INTO CAPSULES 28 4.3. EFFECT OF PLUG
FORMATION ON IN VITRO PROPERTIES OF PSEUDOEPHEDRINE HYDROCHLORIDE
CAPSULES 29 4.4. BIOAVAILABILITY OF SODIUM-ALGINATE-BASED FORMULATIONS
32 4.4.1. BIOAVAILABILITY OF IBUPROFEN FROM HARD GELATIN CAPSULES (III)
32 4.4.2. BIOAVAILABILITY OF IBUPROFEN FROM PRESS-COATED TABLETS (TV) 33
4.4.3. BIOAVAILABILITY OF PSEUDOEPHEDRINE HYDROCHLORIDE FROM HARD
GELATIN CAPSULES (V) 34 4.5. COMPARISON OF IN VITRO AND IN VIVO RESULTS
34 5. CONCLUSIONS 36 PREFERENCES 37 ACKNOWLEDGEMENTS V 44
|
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| indexdate | 2024-07-09T17:42:12Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006530628 |
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| physical | Getr. Zählung graph. Darst. |
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| spelling | Veski, Peep Verfasser aut Use of hard gelatin capsules and sodium alginates in peroral prolonged-release formulations Peep Veski 1994 Getr. Zählung graph. Darst. txt rdacontent n rdamedia nc rdacarrier Helsinki, Univ., Diss., 1994 Hartgelatine (DE-588)4156306-2 gnd rswk-swf Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 gnd rswk-swf Alginate (DE-588)4313271-6 gnd rswk-swf Arzneikapsel (DE-588)4143174-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Hartgelatine (DE-588)4156306-2 s Arzneikapsel (DE-588)4143174-1 s Alginate (DE-588)4313271-6 s Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 s DE-604 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006530628&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Veski, Peep Use of hard gelatin capsules and sodium alginates in peroral prolonged-release formulations Hartgelatine (DE-588)4156306-2 gnd Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 gnd Alginate (DE-588)4313271-6 gnd Arzneikapsel (DE-588)4143174-1 gnd |
| subject_GND | (DE-588)4156306-2 (DE-588)4165181-9 (DE-588)4313271-6 (DE-588)4143174-1 (DE-588)4113937-9 |
| title | Use of hard gelatin capsules and sodium alginates in peroral prolonged-release formulations |
| title_auth | Use of hard gelatin capsules and sodium alginates in peroral prolonged-release formulations |
| title_exact_search | Use of hard gelatin capsules and sodium alginates in peroral prolonged-release formulations |
| title_full | Use of hard gelatin capsules and sodium alginates in peroral prolonged-release formulations Peep Veski |
| title_fullStr | Use of hard gelatin capsules and sodium alginates in peroral prolonged-release formulations Peep Veski |
| title_full_unstemmed | Use of hard gelatin capsules and sodium alginates in peroral prolonged-release formulations Peep Veski |
| title_short | Use of hard gelatin capsules and sodium alginates in peroral prolonged-release formulations |
| title_sort | use of hard gelatin capsules and sodium alginates in peroral prolonged release formulations |
| topic | Hartgelatine (DE-588)4156306-2 gnd Kontrollierte Wirkstofffreisetzung (DE-588)4165181-9 gnd Alginate (DE-588)4313271-6 gnd Arzneikapsel (DE-588)4143174-1 gnd |
| topic_facet | Hartgelatine Kontrollierte Wirkstofffreisetzung Alginate Arzneikapsel Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006530628&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT veskipeep useofhardgelatincapsulesandsodiumalginatesinperoralprolongedreleaseformulations |