Angiotensin receptors:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Plenum Press
1994
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXI, 413 S. Ill., graph. Darst. |
| ISBN: | 030644691X |
Internformat
MARC
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| 245 | 1 | 0 | |a Angiotensin receptors |c ed. by Juan M. Saavedra ... |
| 264 | 1 | |a New York [u.a.] |b Plenum Press |c 1994 | |
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| 650 | 4 | |a Angiotensins |x Receptors | |
| 650 | 4 | |a Angiotensins |x metabolism | |
| 650 | 4 | |a Cloning, Molecular | |
| 650 | 4 | |a Receptors, Angiotensin |x chemistry | |
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Datensatz im Suchindex
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| adam_text | ANGIOTENSIN RECEPTORS EDITED BY JUAN M. SAAVEDRA NATIONAL INSTITUTE OF
MENTAL HEALTH NATIONAL INSTITUTES OF HEALTH BETHESDA, MARYLAND AND
PIETER B. M. W. M. TIMMERMANS THE DUPONT MERCK PHARMACEUTICAL COMPANY
WILMINGTON, DELAWARE PLENUM PRESS * NEW YORK AND LONDON CONTENTS CHAPTER
1 ANGIOTENSIN II RECEPTOR: MOLECULAR CLONING, FUNCTIONS, AND REGULATION
1 TADASHI INAGAMI, MASATO MIZUKOSHI, AND DENG-FU GUO 1. INTRODUCTION 1
2. CLONING OF ANGIOTENSIN II RECEPTOR CDNA 2 3. STRUCTURE OF ATI
RECEPTOR 3 4. FUNCTIONAL PROPERTIES OF CLONED AND EXPRESSED ATI
RECEPTORS 5 5. FUNCTIONAL DOMAINS OF ATIA RECEPTOR 7 6. REGULATION OF
ATI RECEPTOR AND ITS GENE EXPRESSION 9 6.1. DOWNREGULATION OF RECEPTOR
MOLECULE 9 6.2. REGULATION OF GENE EXPRESSION 10 7. FUTURE DIRECTIONS 12
REFERENCES 13 CHAPTER 2 MOLECULAR BIOLOGY OF ANGIOTENSIN II RECEPTORS 17
BERNARD LASSEGUE, KATHY K. GRIENDLING, AND R. WAYNE ALEXANDER 1.
INTRODUCTION 17 2. EARLY EVIDENCE OF ANG II RECEPTOR DIVERSITY 18 3.
DISCRIMINATION OF ATI AND AT2 SITES WITH SPECIFIC LIGANDS 19 4.
PHYSIOLOGICAL EFFECTS MEDIATED BY ATI AND AT2 RECEPTORS 21 5. CLONING OF
THE ATI RECEPTOR 23 6. STRUCTURE-ACTIVITY RELATIONSHIP OF THE ATI
RECEPTOR 25 7. ORGANIZATION OF THE ATI RECEPTOR GENE 25 8. CLONING OF
ATI SUBTYPES: AT )A AND ATIB 26 9. TISSUE DISTRIBUTION OF THE ATIA AND
ATIB SUBTYPES IN THE RAT 27 10. OTHER ATI RECEPTOR SUBTYPES 27 11.
NON-ATI AND NON-AT2 ANG II BINDING SITES 28 XI XII CONTENTS 12.
REGULATION OF EXPRESSION OF THE ATI MRNA 29 13. SIGNALING THROUGH THE
ATI RECEPTOR 31 13.1. COUPLING TO PHOSPHOLIPASE C 31 13.2. COUPLING TO
PHOSPHOLIPASE D 33 13.3. COUPLING TO PHOSPHOLIPASE A2 33 13.4. COUPLING
TO ADENYLATE CYCLASE 33 13.5. COUPLING TO CALCIUM CHANNELS 34 13.6.
COUPLING TO OTHER ION CHANNELS 34 13.7. TEMPORAL SEQUENCE OF SIGNALING
EVENTS: EXAMPLE OF SMOOTH MUSCLE 34 13.8. DESENSITIZATION OF THE ATI
RECEPTOR 36 14. SUBTYPES OF AT2 BINDING SITES 36 15. TISSUE DISTRIBUTION
AND ONTOGENY OF AT2 BINDING SITES 37 16. REGULATION OF AT2 BINDING SITES
38 17. FUNCTION OF AT2 BINDING SITES: SIGNALING 38 18. CONCLUSION 39
REFERENCES 40 CHAPTER 3 DEFINING ANGIOTENSIN RECEPTOR SUBTYPES 49 ANDREW
T. CHIU, RONALD D. SMITH, AND PIETER B.M.W.M. TIMMERMANS 1. HISTORICAL
PERSPECTIVE 49 2. DEFINING AT RECEPTOR SUBTYPES BY SELECTIVE ANTAGONISTS
OR LIGANDS 50 3. DEFINING AT RECEPTOR SUBTYPES BY BIOCHEMICAL
CHARACTERISTICS .... 53 4. DEFINING RECEPTOR SUBTYPES BY GENETIC CODINGS
57 5. CONCLUDING REMARKS 60 REFERENCES .....: . 7 60 CHAPTER 4 MEDICINAL
CHEMISTRY OF ANGIOTENSIN II ANTAGONISTS 67 WILLIAM J. GREENLEE AND RUTH
R. WEXLER 1. INTRODUCTION 67 2. ANGIOTENSIN II RECEPTOR SUBTYPES 68 3.
PEPTIDIC ANTAGONISTS OF ANG II 68 3.1. CARBOXY-TERMINAL MODIFICATIONS 69
3.2. AMINO-TERMINAL MODIFICATIONS 70 3.3. CONFORMATIONALLY RESTRICTED
ANALOGUES OF ANG II 71 CONTENTS XIII 4. DISCOVERY AND STRUCTURE-ACTIVITY
RELATIONSHIPS OF ATI -SELECTIVE NONPEPTIDIC ANTAGONISTS 72 4.1.
DEVELOPMENT OF LOSARTAN AND SK&F 108,566 72 4.2. DEVELOPMENT OF NEW
NONPEPTIDIC ANG II ANTAGONISTS 74 4.3. IMIDAZOLE BIPHENYLTETRAZOLE
ANTAGONISTS RELATED TO LOSARTAN .. 75 4.4. FUSED IMIDAZOLE ANTAGONISTS
77 4.5. OTHER FIVE-MEMBERED RING ANTAGONISTS 78 4.6. ANTAGONISTS
INCORPORATING SIX-MEMBERED HETEROCYCLIC RINGS 78 4.7. NONHETEROCYCLIC
ANTAGONIST DESIGNS 80 4.8. NON-BIPHENYLTETRAZOLE ANTAGONIST DESIGNS 80
4.9. BALANCED (ATI/AT 2 ) ANTAGONISTS 81 5. IN VIVO PHARMACOLOGY OF
ANG II ANTAGONISTS 82 6. PROPERTIES OF ATI-SELECTIVE ANTAGONISTS 83 7.
CONCLUSIONS 85 REFERENCES 85 CHAPTER 5 THE ANGIOTENSIN II AT 2 RECEPTOR
SUBTYPE 95 MARC DE GASPARO, NIGEL R. LEVENS, BRUNO KAMBER, PASCAL FURET,
STEVEN WHITEBREAD, VERONIQUE BRECHLER, AND SERGE P. BOTTARI 1.
STRUCTURE-ACTIVITY STUDIES WITH ANG II 96 2. CGP 42112: A SELECTIVE
LIGAND FOR THE AT2 RECEPTOR 98 3. THE AT2 RECEPTOR: DISTRIBUTION AND
BINDING CHARACTERISTICS 100 4. SIGNAL TRANSDUCTION MECHANISM OF THE AT2
RECEPTOR 103 4.1. ROLE OF G-PROTEINS 103 4.2. INHIBITION OF T-TYPE CA 2+
CURRENTS 105 5. HETEROGENEITY OF THE AT2 RECEPTOR? 106 6. HOW SELECTIVE
ARE PD 123177 OR PD 123319 AND CGP 42112 FOR THE AT2 RECEPTOR SUBTYPE?
107 7. DOES THE AT2 RECEPTOR PLAY A PHYSIOLOGICAL ROLE? 108 7.1. THE AT2
RECEPTOR AND RENAL FUNCTION 109 7.2. THE AT2 RECEPTOR AND CEREBRAL BLOOD
FLOW 110 7.3. THE AT2 RECEPTOR AND COGNITIVE FUNCTION 110 7.4. THE AT2
RECEPTOR AND BALLOON INJURY ILL 7.5. THE AT2 RECEPTOR AND REPRODUCTION
ILL 7.6. THE AT2 RECEPTOR AND WATER INTAKE ILL 8. CONCLUSIONS ( 112
REFERENCES 113 XIV CONTENTS CHAPTER 6 MEDICINAL CHEMISTRY OF AT2
RECEPTORS 119 JEREMY J. EDMUNDS AND JOHN C. HODGES 1. INTRODUCTION 119
2. AT 2 SELECTIVE PEPTIDES 120 3. AT2 SELECTIVE NONPEPTIDES 121 4. TOOLS
FOR THE STUDY OF THE ANGIOTENSIN AT2 RECEPTOR 124 5. DUAL ACTION ANG II
ANTAGONISTS 127 6. SUMMARY 127 REFERENCES 129 CHAPTER 7 PHARMACOLOGY OF
AT2 RECEPTORS 135 JOAN A. KEISER AND ROBERT L. PANEK 1. INTRODUCTION 135
2. AT2 RECEPTOR EXPRESSION IN VITRO 136 2.1. BIOCHEMICAL
CHARACTERIZATION 136 2.2. SPECIES AND TISSUE DISTRIBUTION OF AT2
RECEPTORS 138 3. ROLE OF AT2 RECEPTORS IN THE CENTRAL NERVOUS SYSTEM 138
4. AT2 RECEPTORS IN REPRODUCTION 140 5. EXPRESSION AND FUNCTION OF AT2
RECEPTORS IN HEART AND KIDNEY .... 142 6. SUMMARY 143 REFERENCES 144
CHAPTER 8 BRAIN ANGIOTENSIN II RECEPTOR SUBTYPES 151 JUAN M. SAAVEDRA 1.
BRAIN ANGIOTENSIN II RECEPTORS 151 2. BRAIN ANG II RECEPTOR SUBTYPES 153
2.1. DISCOVERY AND NOMENCLATURE 153 2.2. LOCALIZATION AND DEVELOPMENT
153 2.3. FURTHER HETEROGENEITY OF BRAIN ANG II RECEPTORS 159 2.4.
SELECTIVE EFFECTS OF ANGIOTENSIN RECEPTOR SUBTYPES 167 3. CONCLUSIONS
171 REFERENCES F . 172 CONTENTS XV CHAPTER 9 SECOND MESSENGERS FOR BRAIN
ANGIOTENSIN RECEPTOR SUBTYPES 177 FRANK M. J. HEEMSKERK AND JUAN M.
SAAVEDRA 1. INTRODUCTION 177 1.1. ANGIOTENSIN II IN THE BRAIN 177 1.2.
SECOND MESSENGER SYSTEMS 179 1.3. AIM OF THIS CHAPTER 180 2. CALCIUM AND
INOSITOL PHOSPHATE TURNOVER 180 2.1. BRAIN 180 2.2. NEURAL CELLS IN
CULTURE 181 3. CAMP AND ADENYLATE CYCLASE 182 3.1. BRAIN 182 3.2. NEURAL
CELLS IN CULTURE 183 4. CGMP, GUANYLATE CYCLASE, AND NITRIC OXIDE 183
4.1. BRAIN 183 4.2. NEURAL CELLS IN CULTURE 183 5. OTHER SIGNAL
TRANSDUCTION MECHANISMS 184 5.1. ARACHIDONIC ACID AND RELATED SUBSTANCES
184 5.2. (DE)-PHOSPHORYLATION 185 6. CONCLUSIONS 185 REFERENCES 187
CHAPTER 10 ANGIOTENSIN RECEPTOR SUBTYPES AND CEREBRAL BLOOD FLOW 193
CHRISTER STRBMBERG, LIISA NDVERI, AND JUAN M. SAAVEDRA 1. INTRODUCTION
193 2. ANG II RECEPTORS AND-ANGIOTENSIN-CONVERTING ENZYME IN CEREBRAL
BLOOD VESSELS 194 2.1. MICROVESSELS 194 2.2. RESISTANCE ARTERIES 194 3.
ACTIONS OF ANG II ON CEREBRAL ARTERIES 194 3.1. IN VITRO PREPARATIONS
194 3.2. IN VIVO MODELS 196 4. ANG II EFFECTS OF CBF 196 5. EFFECTS OF
ANG II ON CBF IN DISEASE MODELS 198 5.1. HYPERTENSION 198 5.2. CHRONIC
HEART FAILURE 198 5.3. STROKE K 198 XVI CONTENTS 5.4. SUBARACHNOID
HEMORRHAGE 199 6. CONCLUSION AND CLINICAL IMPLICATIONS 199 REFERENCES
200 CHAPTER 11 ANGIOTENSIN II RECEPTOR SUBTYPES AND GROWTH 205 MOHAN
VISWANATHAN AND JUAN M. SAAVEDRA 1. ANGIOTENSIN II AND GROWTH 205 2. ANG
II RECEPTOR SUBTYPE EXPRESSION DURING DEVELOPMENT 206 2.1. FETUS 206
2.2. AORTA 206 2.3. KIDNEY 206 2.4. HEART 206 2.5. FIBROBLASTS 209 2.6.
BRAIN 209 3. ANG II RECEPTOR SUBTYPES AND RESPONSE TO INJURY 209 3.1.
WOUND HEALING 211 3.2. VASCULAR INJURY 211 3.3. TUMOR 215 4. ANG II AND
ANGIOGENESIS 217 5. CONCLUSIONS 217 REFERENCES 217 CHAPTER 12 INHIBITING
THE EFFECTS OF ANGIOTENSIN II ON CARDIOVASCULAR HYPERTROPHY IN
EXPERIMENTAL HYPERTENSION 221 JAMES J. MORTON 1. INTRODUCTION 221 2. THE
DEVELOPMENT AND FUNCTION OF THE VASCULATURE 221 3. VASCULAR HYPERTROPHY
222 4. THE VASCULAR AMPLIFIER 223 5. LOAD-INDEPENDENT VASCULAR
HYPERTROPHY 224 6. ANG II AND VASCULAR GROWTH 224 7. EFFECT OF ANG II
INHIBITION ON HYPERTENSION AND VASCULAR HYPERTROPHY 225 8. DOES VASCULAR
STRUCTURE DETERMINE BLOOD PRESSURE? 228 9. PULSE PRESSURE AND VASCULAR
HYPERTROPHY 229 10. CONCLUSION F . 230 REFERENCES 230 CONTENTS XVII
CHAPTER 13 INHIBITING THE EFFECTS OF ANGIOTENSIN ON CARDIOVASCULAR
HYPERTROPHY 235 KAJ P. METSDRINNE, MONIKA STOLL, MECHTHILD FALKENHAHN,
PETER GOHLKE, AND THOMAS UNGER 1. DEFINITION OF CARDIOVASCULAR
HYPERTROPHY 236 1.1. EFFECTS OF ANG II ON GROWTH OF VASCULAR SMOOTH
MUSCLE CELLS 236 1.2. EFFECTS OF ANG II ON GROWTH OF CARDIOMYOCYTES 237
1.3. EFFECTS OF ANG II ON DEVELOPMENT OF CARDIAC FIBROSIS 238 2.
INHIBITING THE EFFECTS OF THE RAS ON VASCULAR HYPERTROPHY 238 2.1. ACE
INHIBITORS 238 2.2. ANGIOTENSIN RECEPTOR ANTAGONISTS 241 3. INHIBITING
THE EFFECTS OF THE RAS ON CARDIAC HYPERTROPHY 242 3.1. ACE INHIBITORS
243 3.2. ANGIOTENSIN RECEPTOR ANTAGONISTS 246 4. CONCLUSIONS 247
REFERENCES 248 CHAPTER 14 ANGIOTENSIN ANTAGONISTS IN MODELS OF HEART
FAILURE 255 JOSEPH M. CAPASSO 1. INTRODUCTION 255 2. METHODS AND
MATERIALS .257 2.1. ANIMAL MODEL OF MYOCARDIAL INFARCTION 257 2.2.
GLOBAL CARDIAC GEOMETRY: VENTRICULAR REMODELING AFTER INFARCTION 257
2.3. HEMODYNAMIC EVALUATION 258 2.4. DNA SYNTHESIS IN VIABLE MYOCYTES
261 3. DATA ANALYSIS 262 4. RESULTS 262 4.1. REGIONAL VARIATION IN
VENTRICULAR ANATOMY 266 4.2. LEFT VENTRICULAR WALL STRESS 269 4.3.
MYOCYTE CONTRACTILITY 270 4.4. DNA SYNTHESIS 274 5. DISCUSSION 275 5.1.
ACE INHIBITION VERSUS ATI BLOCKADE 275 5.2. CHAMBER REMODELING AND
MYOCARDIAL INFARCTION 277 5.3. HEMODYNAMIC PERFORMANCE OF CAPTOPRIL AND
LOSARTAN 278 XVIII CONTENTS 5.4. CELLULAR MORPHOMETRY AND MYOCYTE
CONTRACTILITY 278 5.5. CAPTOPRIL AND MYOCYTE PROPERTIES AFTER INFARCTION
279 5.6. VENTRICULAR FAILURE AND DNA SYNTHESIS IN MYOCYTES 280 5.7.
CAPTOPRIL TREATMENT, MYOCARDIAL INFARCTION, AND DNA SYNTHESIS IN MYOCYTE
NUCLEI 281 5.8. MYOCARDIAL INFARCTION, VENTRICULAR FUNCTION, AND CARDIAC
HYPERTROPHY 282 REFERENCES 283 CHAPTER 15 ANGIOTENSIN II RECEPTOR
ANTAGONISM IN AN OVINE MODEL OF HEART FAILURE: COMPARISON WITH ACE AND
RENIN INHIBITION 287 MICHAEL ANDREW FITZPATRICK, MIRIAM RADEMAKER, AND
ERIC A. ESPINER 1. INTRODUCTION 287 2. PATHOPHYSIOLOGY OF HEART
FAILURE*AN OVERVIEW WITH OBSERVATIONS FROM THE RAPID VENTRICULAR PACING
MODEL 288 3. PHARMACOLOGICAL BLOCKADE OF THE RAS 289 4. ACUTE EFFECTS OF
ANG II RECEPTOR ANTAGONISM IN OVINE HEART FAILURE 290 4.1. EXPERIMENTAL
DESIGN 290 4.2. BASELINE MEASUREMENTS 291 4.3. ACUTE HORMONAL EFFECTS OF
LOSARTAN 291 4.4. ACUTE HEMODYNAMIC EFFECTS OF LOSARTAN 294 4.5. RENAL
EFFECTS OF LOSARTAN 296 4.6. DOSE RESPONSE 297 5. COMPARISON OF THE
ACUTE EFFECTS OF ATI RECEPTOR ANTAGONISM AND ACE INHIBITION 297 5.1.
ACUTE EFFECTS OF CAPTOPRIL IN OVINE HEART FAILURE 297 5.2. COMPARISON OF
CAPTOPRIL AND LOSARTAN 298 6. COMPARISON OF THE ACUTE EFFECTS OF RENIN
AND ACE INHIBITION 299 7. FUTURE RESEARCH DIRECTIONS 303 7.1.
DISTRIBUTION AND REGULATION OF AT RECEPTORS IN HEART FAILURE 303 7.2.
EFFECTS OF ATI RECEPTOR ANTAGONISTS ON LOCAL RAS IN HEART FAILURE 304
7.3. LONG-TERM EFFECTS OF ATI RECEPTOR ANTAGONISM AND CLINICAL STUDIES
IN HEART FAILURE 305 8. CONCLUSION 305 REFERENCES 305 CONTENTS XIX
CHAPTER 16 ANGIOTENSIN ANTAGONISTS IN MODELS OF HEART FAILURE 309 THOMAS
E. RAYA, EUGENE MORKIN, AND STEVEN GOLDMAN 1. INTRODUCTION 309 2.
ANGIOTENSIN RECEPTOR BLOCKADE IN ISCHEMIC CARDIOMYOPATHY 310 3.
ANGIOTENSIN RECEPTOR BLOCKADE IN OTHER MODELS OF HEART FAILURE .. 313
3.1. RAPID PACING MODEL 313 3.2. ARTERIAL-VENOUS SHUNT MODEL 314 3.3.
AORTIC REGURGITATION MODEL 315 4. TISSUE RENIN-ANGIOTENSIN SYSTEM IN THE
HEART 315 5. IMPLICATIONS AND FUTURE DIRECTIONS .....315 REFERENCES 317
CHAPTER 17 ANGIOTENSIN ANTAGONISTS IN MODELS OF HYPERTENSION 319 PANCRAS
C. WONG 1. INTRODUCTION 319 2. ANIMAL MODELS OF HYPERTENSION 321 2.1.
RENAL HYPERTENSIVE ANIMALS 321 2.2. GENETIC HYPERTENSIVE ANIMALS 325
2.3. DEOXYCORTICOSTERONE ACETATE-SALT HYPERTENSIVE ANIMALS 330 2.4.
MISCELLANEOUS HYPERTENSIVE MODELS 330 3. SUMMARY 331 REFERENCES 332
CHAPTER 18 ANGIOTENSIN II ANTAGONISM AND RENAL FUNCTION 337 KESHWAR
BABOOLAL AND TIMOTHY W. MEYER 1. ANGIOTENSIN II RECEPTOR ANTAGONISM IN
THE NORMAL KIDNEY 337 1.1. ANGIOTENSIN II RECEPTORS IN THE KIDNEY 337
1.2. EFFECTS OF EXOGENOUS ANG II 337 1.3. EFFECTS OF ENDOGENOUS ANG II
REVEALED BY RECEPTOR ANTAGONISM 338 2. RECEPTOR ANTAGONISM IN
EXPERIMENTAL RENAL DISEASE 340 2.1. RENAL ABLATION 340 2.2. DIABETES
MELLITUS 346 2.3. NEPHROSIS .. / 347 XX CONTENTS 2.4. OTHER CONDITIONS
349 3. ANG II RECEPTOR ANTAGONISM IN CLINICAL RENAL DISEASE 349
REFERENCES 349 CHAPTER 19 ANGIOTENSIN RECEPTORS AND RENAL FUNCTION 353
DAVID P. CHAN AND JOHN C. BURNETT, JR. 1. INTRODUCTION 353 2. RECEPTOR
TYPES 353 3. LOCALIZATION OF RECEPTORS 355 4. FUNCTION OF ATI RECEPTORS
356 4.1. GLOMERULUS 356 4.2. RENAL VASCULATURE 357 4.3. JUXTAGLOMERULAR
APPARATUS AND ADRENAL GLAND 358 4.4. RENAL TUBULES 358 5. FUNCTION OF
AT2 RECEPTORS 358 6. SUMMARY 360 REFERENCES 360 CHAPTER 20 CLINICAL
APPLICATION OF TREATMENT WITH ANGIOTENSIN RECEPTOR ANTAGONISTS 363
MICHEL BURNIER, BERNARD WAEBER, AND HANS R. BRUNNER 1. INTRODUCTION 363
2. ANGIOTENSIN II RECEPTOR BLOCKADE IN NORMOTENSIVE VOLUNTEERS 364 2.1.
PHARMACODYNAMIC-PHARMACOKINETIC AND DOSE-FINDING STUDIES 364 2.2.
EFFECTS ON THE RENIN-ANGIOTENSIN SYSTEM 367 2.3. EFFECT ON BLOOD
PRESSURE 367 2.4. RENAL EFFECTS OF LOSARTAN 368 3. ANG II RECEPTOR
BLOCKADE IN HYPERTENSION 368 4. ANG II RECEPTOR BLOCKADE IN PATIENTS
WITH CHRONIC RENAL FAILURE OR CONGESTIVE HEART FAILURE 371 5. SIDE
EFFECTS 373 6. CONCLUSIONS 374 REFERENCES 375 CONTENTS XXI CHAPTER 21
ANGIOTENSIN RECEPTOR STIMULATION OF TRANSFORMING GROWTH FACTOR-P* IN RAT
SKIN AND WOUND HEALING 377 M. IAN PHILLIPS, BIRGITTA KIMURA, AND ROBERT
GYURKO 1. INTRODUCTION 377 2. TISSUE RAS IN SKIN 378 3. ANGIOTENSIN
RECEPTORS DURING WOUND HEALING 383 4. ANGIOTENSIN DURING WOUND HEALING
384 5. ANGIOTENSIN RECEPTOR REGULATION OF PHOSPHATIDYLINOSITOL
HYDROLYSIS 386 6. ANG II INDUCED CALCIUM SIGNALING IN SKIN FIBROBLASTS
388 7. ANG II STIMULATION OF TGF-(3 IN SKIN FIBROBLASTS 391 8.
CONCLUSIONS 393 REFERENCES 395 INDEX 397
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| discipline | Biologie Medizin |
| format | Book |
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| id | DE-604.BV009861770 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:42:10Z |
| institution | BVB |
| isbn | 030644691X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006529548 |
| oclc_num | 29911324 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| physical | XXI, 413 S. Ill., graph. Darst. |
| publishDate | 1994 |
| publishDateSearch | 1994 |
| publishDateSort | 1994 |
| publisher | Plenum Press |
| record_format | marc |
| spelling | Angiotensin receptors ed. by Juan M. Saavedra ... New York [u.a.] Plenum Press 1994 XXI, 413 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Angiotensins Receptors Angiotensins metabolism Cloning, Molecular Receptors, Angiotensin chemistry Rezeptor (DE-588)4049722-7 gnd rswk-swf Angiotensine (DE-588)4142455-4 gnd rswk-swf Angiotensine (DE-588)4142455-4 s Rezeptor (DE-588)4049722-7 s DE-604 Saavedra, Juan M. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006529548&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Angiotensin receptors Angiotensins Receptors Angiotensins metabolism Cloning, Molecular Receptors, Angiotensin chemistry Rezeptor (DE-588)4049722-7 gnd Angiotensine (DE-588)4142455-4 gnd |
| subject_GND | (DE-588)4049722-7 (DE-588)4142455-4 |
| title | Angiotensin receptors |
| title_auth | Angiotensin receptors |
| title_exact_search | Angiotensin receptors |
| title_full | Angiotensin receptors ed. by Juan M. Saavedra ... |
| title_fullStr | Angiotensin receptors ed. by Juan M. Saavedra ... |
| title_full_unstemmed | Angiotensin receptors ed. by Juan M. Saavedra ... |
| title_short | Angiotensin receptors |
| title_sort | angiotensin receptors |
| topic | Angiotensins Receptors Angiotensins metabolism Cloning, Molecular Receptors, Angiotensin chemistry Rezeptor (DE-588)4049722-7 gnd Angiotensine (DE-588)4142455-4 gnd |
| topic_facet | Angiotensins Receptors Angiotensins metabolism Cloning, Molecular Receptors, Angiotensin chemistry Rezeptor Angiotensine |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006529548&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT saavedrajuanm angiotensinreceptors |