Immunology:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York
Freeman
1994
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 660 S. Ill., zahlr. graph. Darst. |
| ISBN: | 0716724006 0716726432 |
Internformat
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| 100 | 1 | |a Kuby, Janis |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Immunology |c Janis Kuby |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a New York |b Freeman |c 1994 | |
| 300 | |a XX, 660 S. |b Ill., zahlr. graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Immunology |2 cabt | |
| 650 | 4 | |a Immunologie | |
| 650 | 7 | |a Immunologie |2 gtt | |
| 650 | 4 | |a Immune System | |
| 650 | 4 | |a Immunity | |
| 650 | 4 | |a Immunology | |
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Datensatz im Suchindex
| _version_ | 1804124158778408960 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
PREFACE XVII / OVERVIEW OF THE IMMUNE SYSTEM 1
HISTORICAL PERSPECTIVE 2 DISCOVERY OF HUMORAL AND CELLULAR IMMUNITY 3
EARLY THEORIES OF IMMUNITY 4 INNATE (NONSPECIFIC) IMMUNITY 4 ANATOMIC
BARRIERS 4
PHYSIOLOGIC BARRIERS 5 ENDOCYTIC AND PHAGOCYTIC BARRIERS 6 BARRIERS
CREATED BY THE INFLAMMATORY RESPONSE 7
ACQUIRED (SPECIFIC) IMMUNITY 10 THE CELLS OF THE IMMUNE SYSTEM 10 B
LYMPHOCYTES 10 T LYMPHOCYTES 11
ANTIGEN-PRESENTING CELLS 12 FUNCTIONS OF HUMORAL AND CELL-MEDIATED
IMMUNE RESPONSES 12 RECOGNITION OF ANTIGEN BY B AND T
LYMPHOCYTES 14 GENERATION OF LYMPHOCYTE SPECIFICITY AND DIVERSITY 14
ROLE OF THE MAJOR HISTOCOMPATIBILITY
COMPLEX 15 PROCESSING AND PRESENTATION OF ANTIGENS 15 CLONAL SELECTION
OF LYMPHOCYTES 16 CELLULAR INTERACTIONS REQUIRED FOR GENERATION
OF IMMUNE RESPONSES 18 ACTIVATION AND PROLIFERATION OF T HELPER CELLS 18
GENERATION OF THE HUMORAL RESPONSE 19
GENERATION OF THE CELL-MEDIATED RESPONSE 20
REFERENCES 20 STUDY QUESTIONS 20
2 EXPERIMENTAL SYSTEMS 23
EXPERIMENTAL ANIMAL MODELS 24 INBRED STRAINS 24 ADOPTIVE-TRANSFER
SYSTEMS 26 SCID MICE AND SCID- HUMAN MICE 26
CELL-CULTURE SYSTEMS 27 PRIMARY LYMPHOID CULTURES 27 CLONED LYMPHOID
CELL LINES 27 HYBRID LYMPHOID CELL LINES 28 RECOMBINANT DNA TECHNOLOGY
29 RESTRICTION-ENDONUCLEASE CLEAVAGE OF DNA 30 RESTRICTION MAPPING OF
DNA 32 CLONING OF DNA SEQUENCES 32
CLONING VECTORS 32 CLONING OF COMPLEMENTARY DNA 33 CLONING OF GENOMIC
DNA 33 SELECTION OF DNA CLONES 36
SOUTHERN BLOTTING 36 NORTHERN BLOTTING 37 POLYMERASE CHAIN REACTION 37
ANALYSIS OF DNA REGULATORY
SEQUENCES 38 DNA FOOTPRINTING 39 GEL-SHIFT ANALYSIS 40 CAT ASSAY 40 GENE
TRANSFER INTO MAMMALIAN CELLS 41 TRANSFER OF CLONED GENES INTO CULTURED
CELLS 41 TRANSFER OF CLONED GENES INTO MOUSE EMBRYOS 41 TRANSGENIC MICE
41
GENE-TARGETED KNOCK-OUT MICE 42
IMAGE 2
VIII CONTENTS
SUMMARY 44
REFERENCES 44
STUDY QUESTIONS 45
J CELLS AND ORGANS OF THE
IMMUNE SYSTEM 47 CELLS OF THE IMMUNE SYSTEM 48 HEMATOPOIESIS 48 SPLEEN
COLONY-FORMING ASSAY 48
HEMATOPOIETIC GROWTH FACTORS 50 REGULATION OF HEMATOPOIESIS 51
ENRICHMENT OF HEMATOPOIETIC STEM CELLS 55 CLINICAL USES OF PLURIPOTENT
STEM CELLS 56 LYMPHOID CELLS 57
B LYMPHOCYTES 58 T LYMPHOCYTES 60 NULL CELLS X? MONONUCLEAR CELLS 62
PHAGOCYTOSIS 63 ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES 64 ANTIGEN
PROCESSING AND PRESENTATION 65 SECRETION OF FACTORS 65 GRANULOCYTIC
CELLS 66
NEUTROPHILS 66 EOSINOPHILS 67 BASOPHILS 67 MAST CELLS 67
DENDRITIC CELLS 67 ORGANS OF THE IMMUNE SYSTEM 68 PRIMARY LYMPHOID
ORGANS 68 THYMUS 68
BONE MARROW 72 SECONDARY LYMPHOID ORGANS 72 LYMPH NODES 73 SPLEEN 75
MUCOSAL-ASSOCIATED LYMPHOID TISSUE 76 LEUKOCYTE RECIRCULATION 77
CELL-ADHESION MOLECULES 78 NEUTROPHIL EXTRAVASATION 79
LYMPHOCYTE EXTRAVASATION 80 HIGH-ENDOTHELIAL VENULES 80 HOMING OF
LYMPHOCYTES 81 ADHESION-MOLECULE INTERACTIONS 82 CLINICAL REDUCTION OF
EXTRAVASATION 82 SUMMARY 83 REFERENCES 83
STUDY QUESTIONS 84
4 ANTIGENS 85
IMMUNOLOGIC PROPERTIES OF ANTIGENS 85 FACTORS THAT INFLUENCE
IMMUNOGENICITY 86
CONTRIBUTION OF THE IMMUNOGEN TO IMMUNOGENICITY 86 FOREIGNNESS 87
MOLECULAR SIZE 87
CHEMICAL COMPOSITION AND HETEROGENEITY 87 DEGRADABILITY 87 CONTRIBUTION
OF THE BIOLOGICAL SYSTEM TO
IMMUNOGENICITY 87 GENOTYPE OF THE RECIPIENT ANIMAL 87 IMMUNOGEN DOSAGE
AND ROUTE OF ADMINISTRATION 89 ADJUVANTS 89 EPITOPES 91
PROPERTIES OF B-CELL EPITOPES 92 PROPERTIES OF T-CELL EPITOPES 96
HAPTENS AND THE STUDY OF ANTIGENICITY 100
VIRAL AND BACTERIAL ANTIGENS 103 VIRAL ANTIGENS 104 BACTERIAL ANTIGENS
105
MITOGENS 106 SUMMARY 107
REFERENCES 107
STUDY QUESTIONS 108
5 IMMUNOGLOBULINS: STRUCTURE
AND FUNCTION 109 BASIC STRUCTURE OF IMMUNOGLOBULINS 109
IMMUNOGLOBULIN SEQUENCING STUDIES 111 ROLE OF MULTIPLE MYELOMA 112
LIGHT-CHAIN SEQUENCING 112 HEAVY-CHAIN SEQUENCING 112
IMMUNOGLOBULIN FINE STRUCTURE 113 IMMUNOGLOBULIN DOMAINS 114
VARIABLE-REGION DOMAINS: STRUCTURE AND FUNCTION 117
CONSTANT-REGION DOMAINS: STRUCTURE AND FUNCTION 118 C H L AND C L
DOMAINS 118 HINGE REGION 119
OTHER CONSTANT-REGION DOMAINS 120 IMMUNOGLOBULIN RECEPTOR COMPLEX 122
MEMBRANE IMMUNOGLOBULIN 122 B-CELL RECEPTOR COMPLEX 122 ANTIGENIC
DETERMINANTS ON IMMUNOGLOBULINS 123
ISOTYPIC DETERMINANTS 123 ALLOTYPIC DETERMINANTS 123 IDIOTYPIC
DETERMINANTS 124
IMAGE 3
CONTENTS IX
IMMUNOGLOBULIN ISOTYPES 124 IMMUNOGLOBULIN G (IGG) 124 IMMUNOGLOBULIN M
(IGM) 124 IMMUNOGLOBULIN A (IGA) 127 IMMUNOGLOBULIN E (IGE) 129
IMMUNOGLOBULIN D (IGD) 129
THE IMMUNOGLOBULIN SUPERFAMILY 129 SUMMARY 131
REFERENCES 132
STUDY QUESTIONS 132
ANTIGEN-ANTIBODY
INTERACTIONS 135 STRENGTH OF ANTIGEN-ANTIBODY INTERACTIONS 135 ANTIBODY
AFFINITY 136 ANTIBODY AVIDITY 138 CROSS-REACTIVITY 139 PRECIPITIN
REACTIONS 139 PRECIPITIN REACTIONS IN FLUIDS 140 PRECIPITIN REACTIONS IN
GELS 141
RADIAL IMMUNODIFFUSION (MANCINI METHOD) 141 DOUBLE IMMUNODIFFUSION
(OUCHTERLONY METHOD) 142 IMMUNOELECTROPHORESIS 143
AGGLUTINATION REACTIONS 146 HEMAGGLUTINATION 146 BACTERIAL AGGLUTINATION
146 PASSIVE AGGLUTINATION 146 AGGLUTINATION INHIBITION 147
RADIOIMMUNOASSAY 147 ENZYME-LINKED IMMUNOSORBENT ASSAY 148
WESTERN BLOTTING 150
IMMUNOFLUORESCENCE 151
IMMUNOELECTRON MICROSCOPY 153
SUMMARY 153
REFERENCES 154
STUDY QUESTIONS 154
HYBRIDOMAS AND MONOCLONAL
ANTIBODY 157 FORMATION AND SELECTION OF HYBRID CELLS 158
PRODUCTION OF MONOCLONAL ANTIBODIES 160 GENERATING B-CELL HYBRIDOMAS 160
SCREENING FOR MONOCLONAL ANTIBODY SPECIFICITY L60 PROPAGATING HYBRIDOMAS
SECRETING SPECIFIC MONOCLONAL ANTIBODIES 163 PRODUCING HUMAN MONOCLONAL
ANTIBODY 163 USES FOR MONOCLONAL ANTIBODIES 164 PURIFICATION OF PROTEINS
164 IDENTIFICATION AND ISOLATION OF LYMPHOCYTE
SUBPOPULATIONS AND CLONES 165 TUMOR DETECTION AND IMAGING 165 TUMOR
KILLING 166 DIAGNOSTIC REAGENTS 167 ENGINEERED MONOCLONAL ANTIBODIES 168
CHIMERIC MONOCLONAL ANTIBODIES 168 MONOCLONAL ANTIBODY HETEROCONJUGATES
170 MONOCLONAL ANTIBODIES CONSTRUCTED FROM IMMUNOGLOBULIN-GENE LIBRARIES
170 CATALYTIC MONOCLONAL ANTIBODIES
(ABZYMES) 171 T-CELL HYBRIDOMAS 172 SUMMARY 172
REFERENCES 172
STUDY QUESTIONS 173
8 ORGANIZATION AND EXPRESSION
OF IMMUNOGLOBULIN GENES 175 GENETIC MODEL COMPATIBLE WITH IMMUNOGLOBULIN
STRUCTURE 176 GERM-LINE AND SOMATIC-VARIATION MODELS 176 DRYER AND
BENNETT TWO-GENE MODEL 177 EARLY VERIFICATION OF THE DRYER AND BENNETT
HYPOTHESIS 177
MULTIGENE ORGANIZATION OF IMMUNOGLOBULIN GENES 179 A-CHAIN MULTIGENE
FAMILY 179 K-CHAIN MULTIGENE FAMILY 179
HEAVY-CHAIN MULTIGENE FAMILY 180
VARIABLE-REGION GENE REARRANGEMENTS 181 V-J REARRANGEMENTS IN
LIGHT-CHAIN DNA 181 V-D-J REARRANGEMENTS IN HEAVY-CHAIN
DNA 182 MECHANISM OF VARIABLE-REGION DNA REARRANGEMENTS 183
RECOMBINATION SIGNAL SEQUENCES 183
JOINING OF GENE SEGMENTS 183 RECOMBINATION-ACTIVATING GENES 184
PRODUCTIVE AND NONPRODUCTIVE REARRANGEMENTS 187 ALLELIC EXCLUSION 187
IMAGE 4
CONTENTS
REGULATION OF IMMUNOGLOBULIN-GENE TRANSCRIPTION 189 EFFECT OF DNA
REARRANGEMENTS ON TRANSCRIPTION 189
ROLE OF DNA-BINDING PROTEINS 190 GENERATION OF ANTIBODY DIVERSITY 191
MULTIPLE GERM-LINE V, D, AND J GENE SEGMENTS 192
COMBINATORIAL V-J AND V-D-J JOINING 192 JUNCTIONAL FLEXIBILITY 193
N-REGION NUCLEOTIDE ADDITION 193
SOMATIC MUTATION 194 ASSOCIATION OF HEAVY AND LIGHT CHAINS 195 CLASS
SWITCHING AMONG CONSTANT- REGION GENES 196
EXPRESSION OF IMMUNOGLOBULIN GENES 197 DIFFERENTIAL RNA PROCESSING OF
PRIMARY TRANSCRIPTS 197
EXPRESSION OF MEMBRANE-BOUND OR SECRETED IMMUNOGLOBULIN 197 SIMULTANEOUS
EXPRESSION OFLGM AND IGD 199 SYNTHESIS, ASSEMBLY, AND SECRETION OF
IMMUNOGLOBULINS 200 B-CELL DEVELOPMENTAL STAGES 201 ANTIGEN-INDEPENDENT
PHASE 202 ANTIGEN-DEPENDENT PHASE 203
SUMMARY 204 REFERENCES 205
STUDY QUESTIONS 205
9 MAJOR HISTOCOMPATIBILITY
COMPLEX 209 GENERAL ORGANIZATION AND INHERITANCE OF THE MHC 210
LOCATION AND FUNCTION OF MHC REGIONS 210 MHC HAPLOTYPES 210 CONGENEIC
MOUSE STRAINS 212 CLASS I MHC MOLECULES AND GENES 213 STRUCTURE OF CLASS
I MOLECULES 214 STRUCTURE OF CLASS I GENES 215 PEPTIDE BINDING BY CLASS
I MOLECULES 216 CLASS II MHC MOLECULES AND GENES 218
STRUCTURE OF CLASS II MOLECULES 218 STRUCTURE OF CLASS II GENES 220
PEPTIDE BINDING BY CLASS II MOLECULES 220 POLYMORPHISM OF CLASS I AND
CLASS II MHC MOLECULES 220
CLASS III MHC MOLECULES 222
MAPPING OF THE MHC 222 MAPPING TECHNIQUES 223 SEROLOGIC MAPPING 223
FUNCTIONAL MAPPING 223
RESTRICTION-ENZYME MAPPING 225 DETAILED GENOMIC MAP OF MHC GENES 227 MAP
OF CLASS I MHC 228 MAP OF CLASS II MHC 228
MAP OF CLASS III MHC 228 EXPRESSION OF MHC MOLECULES 229 CELLULAR
EXPRESSION 229 REGULATION OF MHC EXPRESSION 230
PROBING MHC STRUCTURE AND FUNCTION 230 EXON SHUFFLING AND SITE-DIRECTED
MUTAGENESIS 231 TRANSFECTION OF MHC GENES 232 MHC AND IMMUNE
RESPONSIVENESS 232
DETERMINANT-SELECTION MODEL 232 HOLES-IN-THE-REPERTOIRE MODEL 233 MHC
AND SUSCEPTIBILITY TO INFECTIOUS DISEASES 234
SUMMARY 234
REFERENCES 235
STUDY QUESTIONS 236
W ANTIGEN PROCESSING AND
PRESENTATION 239 S E L F - M HC RESTRICTION OF T CELLS 240 ROLE OF
ANTIGEN-PRESENTING CELLS 241 EARLY EVIDENCE FOR ANTIGEN PROCESSING AND
PRESENTATION 241 CELLS THAT FUNCTION IN ANTIGEN PRESENTATION 242 ANTIGEN
PROCESSING 243
ENDOCYTIC PROCESSING PATHWAY 243 CYTOSOLIC PROCESSING PATHWAY 244
ANTIGEN PRESENTATION 245 ASSEMBLY AND STABILIZATION OF MHC
MOLECULES 245 SEGREGATION OF MHC MOLECULES 246 CLASS I ENDOGENOUS
PATHWAY 247 CLASS II EXOGENOUS PATHWAY 248 CLINICAL APPLICATIONS 249
SUMMARY 249
REFERENCES 249
STUDY QUESTIONS 250
IMAGE 5
CONTENTS XI
// T-CELL RECEPTOR 251
T-CELL RECEPTORS 252 FUNCTIONAL ASSAYS FOR THE T-CELL RECEPTOR 252 EARLY
STUDIES OF THE T-CELL RECEPTOR 252 ISOLATION OF T-CELL RECEPTORS WITH
MONOCLONAL
ANTIBODIES 253 STRUCTURE OF T-CELL RECEPTORS 255
ORGANIZATION AND REARRANGEMENT OF TCR GENES 255
IDENTIFYING AND CLONING THE TCR GENES 255 TCR MULTIGENE FAMILIES 256
VARIABLE-REGION GENE REARRANGEMENTS 257 ALLELIC EXCLUSION OF TCR A AND *
GENES 258
STRUCTURE OF REARRANGED TCR GENES 258 GENERATION OF TCR DIVERSITY 259
T-CELL RECEPTOR COMPLEX: TCR- CD3 261
T-CELL ACCESSORY MEMBRANE MOLECULES 263 CD4 AND CD8 CORECEPTORS 263
OTHER ACCESSORY MOLECULES 264
T C R - A N T I G E N - M HC INTERACTION 264 AFFINITY OF TCR FOR
ANTIGEN-MHC COMPLEXES 264 TCR-PEPTIDE INTERACTION 265
TCR-MHC INTERACTION 267 MODEL OF TCR-PEPTIDE-MHC INTERACTION 268
ALLOREACTIVITY OF T CELLS 268
SUMMARY 270
REFERENCES 270
STUDY QUESTIONS 271
12 T-CELL ACTIVATION, MATURATION,
AND DIFFERENTIATION 273 T-CELL MATURATION 274 T-CELL DEVELOPMENTAL
PATHWAYS 274 THYMIC SELECTION OF THE T-CELL REPERTOIRE 275
POSITIVE AND NEGATIVE THYMIC SELECTION 276 EXPERIMENTAL EVIDENCE FOR
POSITIVE SELECTION 277 EXPERIMENTAL EVIDENCE FOR NEGATIVE
SELECTION 279 UNSOLVED QUESTIONS REGARDING THYMIC SELECTION 282
T H - C E LL ACTIVATION 284 284 TCR-COUPLED SIGNALING PATHWAYS THE
CO-STIMULATORY SIGNAL 287 GENE ACTIVATION BY DNA-BINDING PROTEINS 289
CLONAL EXPANSION VERSUS CLONAL ANERGY 289
MATURE PERIPHERAL T-CELL POPULATIONS 291 AY? T CELLS 291
NAIVE T CELLS 291 EFFECTOR T CELLS 292 MEMORY T CELLS 292 Y 5 T CELLS
293
SUMMARY 294
REFERENCES 295
STUDY QUESTIONS 295
/J CYTOKINES 297
GENERAL PROPERTIES OF CYTOKINES 297 DISCOVERY AND PURIFICATION OF
CYTOKINES 300 FUNCTIONAL IDENTIFICATION 300 BIOCHEMICAL PURIFICATION 300
CLONING OF CYTOKINE GENES 301
STRUCTURE OF CYTOKINES 302
FUNCTION OF CYTOKINES 302
CYTOKINE RECEPTORS 306
GENERAL STRUCTURE OF CYTOKINE RECEPTORS 307 SIGNAL TRANSDUCTION BY
CYTOKINE RECEPTORS 308 IL-2 RECEPTOR 309 CYTOKINE ANTOGONISTS 310
CYTOKINE SECRETION AND BIOLOGICAL
ACTIVITY OF T H1 AND T H2 SUBSETS 311
ROLE OF CYTOKINES IN THE INFLAMMATORY
RESPONSE 313 ACUTE INFLAMMATORY RESPONSE 313 CHRONIC INFLAMMATORY
RESPONSE 316
CYTOKINES AND DISEASE 318 BACTERIAL SEPTIC SHOCK 318 BACTERIAL TOXIC
SHOCK AND RELATED DISEASES 318
LYMPHOID AND MYELOID CANCERS 319 CHAGAS DISEASE 319 CYTOKINE-RELATED
THERAPIES 319
SUMMARY 321
REFERENCES 321
STUDY QUESTIONS 322
14 GENERATION OF THE HUMORAL
IMMUNE RESPONSE 323 KINETICS OF THE HUMORAL RESPONSE 324 PRIMARY
RESPONSE 325 SECONDARY RESPONSE 325
IMAGE 6
XII CONTENTS
EXPERIMENTAL SYSTEMS 326 IN VITRO GENERATION OF THE HUMORAL RESPONSE 326
HEMOLYTIC PLAQUE ASSAY 326 IDENTIFICATION OF CELLS REQUIRED FOR
INDUCTION OF HUMORAL IMMUNITY 328
RESPONSE TO THYMUS-DEPENDENT ANTIGENS 328 RESPONSE TO THYMUS-INDEPENDENT
ANTIGENS 329 USE OF HAPTEN-CARRIER CONJUGATES TO STUDY CELLULAR
INTERACTIONS 330 RECOGNITION OF CARRIER EPITOPES BY T H
CELLS 330
MHC RESTRICTION IN THE INTERACTION BETWEEN T H AND B CELLS 332
ASSOCIATIVE RECOGNITION 333 STEPS IN B-CELL ACTIVATION,
PROLIFERATION, AND DIFFERENTIATION 333 ANTIGEN PRESENTATION BY B CELLS
334 FORMATION OF T H -CELL/B-CELL CONJUGATE 335 CONTACT-DEPENDENT HELP
MEDIATED BY
CD40-CD40L INTERACTION 336 DIRECTIONAL RELEASE OF CYTOKINES FROM T H
CELLS 336
SIGNAL GENERATION BY MEMBRANE EVENTS AND CYTOKINES 336 MEMBRANE SIGNALS
337 CYTOKINE SIGNALS 339 INDUCTION OF THE HUMORAL RESPONSE IN VIVO 339
AFFINITY MATURATION 342 CLASS SWITCHING 343 GENERATION OF MEMORY B CELLS
343
SUMMARY 344 REFERENCES 345
STUDY QUESTIONS 345
CELL-MEDIATED IMMUNITY 347
DIRECT CYTOTOXIC RESPONSE 348 CTL-MEDIATED CYTOTOXICITY 348 PHASE I:
ACTIVATION AND DIFFERENTIATION OF CTL PRECURSORS 348
PHASE II: CTL-MEDIATED DESTRUCTION OF TARGET CELLS 351 NK-CELL-MEDIATED
CYTOTOXICITY 356 NK-CELL LINEAGE 356
MECHANISM OF NK-CELL KILLING 357 REGULATION OF NK-CELL CYTOTOXICITY 357
ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY 358
EXPERIMENTAL ASSESSMENT OF CELL-MEDIATED CYTOTOXICITY 359
MIXED-LYMPHOCYTE REACTION (MLR) 359 CELL-MEDIATED LYMPHOLYSIS (CML) 360
GRAFT-VERSUS-HOST REACTION 361 DELAYED-TYPE HYPERSENSITIVITY
RESPONSE 362 PHASES OF THE DTH RESPONSE 362 CYTOKINES INVOLVED IN DTH
REACTION 363 PROTECTIVE ROLE OF THE DTH RESPONSE 364 DETECTION OF THE
DTH REACTION 365
PATHOLOGIC DTH RESPONSES 366 SUMMARY 366 REFERENCES 367
STUDY QUESTIONS 367
F 6 IMMUNE REGULATION AND
TOLERANCE 369 REGULATION OF IMMUNE RESPONSIVENESS 370 EFFECT OF PRIOR
ANTIGEN EXPOSURE 370 ANTIGEN-MEDIATED REGULATION 370
ANTIBODY-MEDIATED SUPPRESSION 371 IMMUNE COMPLEXES AS REGULATORS 371
CYTOKINE-MEDIATED REGULATION 371 IDIOTYPE REGULATION: THE NETWORK THEORY
372 T-CELL-MEDIATED SUPPRESSION 374
LACK OF EVIDENCE FOR DISTINCT T S -CELL SUBPOPULATION 375 POSSIBLE
EXPLANATIONS FOR T-CELL-MEDIATED SUPPRESSION 376 NEUROENDOCRINE
REGULATION
(NEUROIMMUNOMODULATION) 377 TOLERANCE 379 PROPERTIES OF TOLERANCE
INDUCTION 380 FACTORS AFFECTING EXPERIMENTALLY INDUCED
TOLERANCE 381 ANTIGEN STRUCTURE, DOSAGE, AND ROUTE OF ADMINISTRATION 381
SUSCEPTIBILITY OFTANDB CELLS 382 MECHANISMS OF TOLERANCE INDUCTION 382
EXPERIMENTAL INDUCTION OFB-CELL TOLERANCE 383 EXPERIMENTAL INDUCTION OF
T-CELL TOLERANCE 386 SUMMARY 389 REFERENCES 389
STUDY QUESTIONS 390
J THE COMPLEMENT SYSTEM 393
THE COMPLEMENT COMPONENTS 394 INITIAL STEPS IN COMPLEMENT ACTIVATION 395
IMAGE 7
CONTENTS XIII
CLASSICAL PATHWAY 395 ALTERNATIVE PATHWAY 400 FORMATION OF
MEMBRANE-ATTACK COMPLEX 401
REGULATION OF THE COMPLEMENT SYSTEM 402
COMPLEMENT-BINDING RECEPTORS 404 TYPE 1 COMPLEMENT RECEPTOR (CR1) 404
TYPE 2 COMPLEMENT RECEPTOR (CR2) 406 TYPE 3 AND TYPE 4 COMPLEMENT
RECEPTOR
(CR3 AND CR4) 406 RECEPTORS FOR C3A, C4A, AND C5A 406 BIOLOGICAL
CONSEQUENCES OF COMPLEMENT ACTIVATION 406
CELL LYSIS 407 INFLAMMATORY RESPONSE 409 OPSONIZATION OF ANTIGEN 409
VIRAL NEUTRALIZATION 410 SOLUBILIZATION OF IMMUNE COMPLEXES 411
COMPLEMENT DEFICIENCIES 411 SUMMARY 413
REFERENCES 413
STUDY QUESTIONS 414
L8 HYPERSENSITIVE REACTIONS 417
GELL AND COOMBS CLASSIFICATION 418 IGE-MEDIATED (TYPE I)
HYPERSENSITIVITY 419 CONSEQUENCES OF TYPE I REACTIONS 419
SYSTEMIC ANAPHYLAXIS 419 LOCALIZED ANAPHYLAXIS 420 COMPONENTS OF TYPE I
REACTIONS 421 ALLERGENS 421
REAGINIC ANTIBODY (IGE) 422 MAST CELLS AND BASOPHILS 422 IGE-BINDING FC
RECEPTORS 423 MECHANISM OF IGE-MEDIATED
DEGRANULATION 424 RECEPTOR CROSS-LINKAGE 425 ACTIVATION OF PROTEIN
TYROSINE KINASES 425 METHYLATION OF MEMBRANE
PHOSPHOLIPIDS 425 INFLUX OFCA 2+ 426 CHANGES IN CAMP LEVELS 426 FUSION
OF GRANULES WITH PLASMA
MEMBRANE 427 MEDIATORS OF TYPE I REACTIONS 427 HISTAMINE 428
LEUKOTRIENES 428
CYTOKINES 429 REGULATION OF THE TYPE I RESPONSE 429
CYTOKINE-MEDIATED REGULATION OF TYPE I RESPONSE 429 REGULATION OF IGE
PRODUCTION BY IGE- BINDING FACTORS 430 DETECTION OF TYPE I
HYPERSENSITIVITY 432 THERAPY FOR TYPE I HYPERSENSITIVITIES 432
ANTIBODY-MEDIATED CYTOTOXIC (TYPE II) HYPERSENSITIVITY 434 TRANSFUSION
REACTIONS 434
HEMOLYTIC DISEASE OF THE NEWBORN 436 DRUG-INDUCED HEMOLYTIC ANEMIA 437
AUTOIMMUNE TYPE II REACTIONS 438 IMMUNE COMPLEX - MEDIATED (TYPE III)
HYPERSENSITIVITY 438 LOCALIZED TYPE III REACTIONS 438 GENERALIZED TYPE
III REACTIONS 438 T DTH-MEDIATED (TYPE IV)
HYPERSENSITIVITY 440
SUMMARY 441
STUDY QUESTIONS 442
REFERENCES 442
79 AUTOIMMUNITY 445
AUTOIMMUNE DISEASE IN HUMANS 446 ORGAN-SPECIFIC AUTOIMMUNE DISEASES 447
DISEASES MEDIATED BY DIRECT CELLULAR DAMAGE 447
DISEASES MEDIATED BY STIMULATING AUTOANTIBODIES 448 DISEASE MEDIATED BY
BLOCKING AUTOANTIBODIES 450 SYSTEMIC AUTOIMMUNE DISEASES 450 ANIMAL
MODELS FOR AUTOIMMUNE
DISEASE 451 SPONTANEOUS AUTOIMMUNITY IN ANIMALS 451 EXPERIMENTALLY
INDUCED AUTOIMMUNITY IN ANIMALS 452 ROLE OF THE CD4+ T CELL, MHC, AND
T-CELL RECEPTOR IN AUTOIMMUNITY 453 EVIDENCE FOR CD4+ T-CELL ROLE 453
EVIDENCE FOR ASSOCIATION WITH THE MHC 453 EVIDENCE FOR ASSOCIATION WITH
THE T-CELL
RECEPTOR 455
PROPOSED MECHANISMS FOR INDUCTION OF AUTOIMMUNITY 455 RELEASE OF
SEQUESTERED ANTIGENS 455
MOLECULAR MIMICRY 456 INAPPROPRIATE EXPRESSION OF CLASS II MHC MOLECULES
458 CYTOKINE IMBALANCE 459
IMAGE 8
XIV CONTENTS
DYSFUNCTION OF THE IDIOTYPE NETWORK REGULATORY PATHWAYS 460 DYSFUNCTION
OF T-CELL- MEDIATED IMMUNE REGULATION 461 POLYCLONAL B-CELL ACTIVATION
462 TREATMENT OF AUTOIMMUNE DISEASES 462
CURRENT THERAPIES 462 EXPERIMENTAL THERAPEUTIC APPROACHES 463 T-CELL
VACCINATION 463 PEPTIDE BLOCKADE OF MHC MOLECULES 463
MONOCLONAL-ANTIBODY TREATMENT 464 TOLERANCE INDUCTION BY ORAL ANTIGEN
465 SUMMARY 465 REFERENCES 465
STUDY QUESTIONS 466
20 VACCINES 469
ACTIVE AND PASSIVE IMMUNIZATION 470 PASSIVE IMMUNIZATION 470 ACTIVE
IMMUNIZATION 471 DESIGNING VACCINES FOR ACTIVE IMMUNIZATION 473
WHOLE-ORGANISM VACCINES 474 ATTENTUATED VIRAL OR BACTERIAL VACCINES 474
INACTIVATED VIRAL OR BACTERIAL VACCINES 476 PURIFIED MACROMOLECULES AS
VACCINES 476
RECOMBINANT ANTIGEN VACCINES 477
RECOMBINANT VECTOR VACCINES 477
SYNTHETIC PEPTIDE VACCINES 478
MULTIVALENT SUBUNIT VACCINES 480
ANTI-IDIOTYPE VACCINES 480
SUMMARY 481
REFERENCES 482
STUDY QUESTIONS 482
2/ IMMUNE RESPONSE TO INFECTIOUS
DISEASES 483 VIRAL INFECTIONS 484 VIRAL NEUTRALIZATION BY HUMORAL
ANTIBODY 485 CELL-MEDIATED ANTIVIRAL MECHANISMS 485
VIRAL EVASION OF HOST-DEFENSE MECHANISMS 485 INFLUENZA 486 PROPERTIES OF
THE INFLUENZA VIRUS 486
HOST RESPONSE TO INFLUENZA INFECTION 489 BACTERIAL INFECTIONS 490 IMMUNE
RESPONSE TO EXTRACELLULAR AND INTRACELLULAR BACTERIA 490
BACTERIAL EVASION OF HOST-DEFENSE MECHANISMS 490 CONTRIBUTION OF THE
IMMUNE RESPONSE TO BACTERIAL PATHOGENESIS 493 DIPHTHERIA
(CORYNEBACTERIUM
DIPHTHERIAE) 493 TUBERCULOSIS (MYCOBACTERIUM TUBERCULOSIS) 494 LYME
DISEASE (BORRELIA BURGDORFERI) 496 PROTOZOAN DISEASES 497
MALARIA {PLASMODIUM SPECIES) 497 PLASMODIUM LIFE CYCLE AND PATHOGENESIS
OF MALARIA 497 HOST RESPONSE TO PLASMODIUM INFECTION 498 DESIGN OF
MALARIA VACCINES 498 AFRICAN SLEEPING SICKNESS ( TRYPANOSOMA
SPECIES) 501 DISEASES CAUSED BY PARASITIC WORMS (HELMINTHS) 503
SCHISTOSOMIASIS {SCHISTOSOMA SPECIES) 503
SUMMARY 505 REFERENCES 506
STUDY QUESTIONS 506
22 IMMUNODEFICIENCY DISEASES 509
CLASSIFICATION OF IMMUNODEFICIENCIES 509 PHAGOCYTIC DEFICIENCIES 510
REDUCTION IN NEUTROPHIL COUNT (NEUTROPENIA) 511
DEFECTIVE PHAGOCYTIC FUNCTION 513 ADHERENCE DEFECT 513 CHEMOTACTIC
DEFECT 513 KILLING DEFECT 513 HUMORAL DEFICIENCIES 515
X-LINKED AGAMMAGLOBULINEMIA 515 X-LINKED HYPER-IGM SYNDROME 516 COMMON
VARIABLE HYPOGAMMAGLOBULINEMIA 516
SELECTIVE IMMUNOGLOBULIN DEFICIENCIES 516 CELL-MEDIATED DEFICIENCIES 517
DIGEORGE SYNDROME (CONGENITAL THYMIC APLASIA) 517
NUDE MICE 518 COMBINED HUMORAL AND CELL-MEDIATED DEFICIENCIES 519
RETICULAR DYSGENESIS 519
BARE-LYMPHOCYTE SYNDROME 519 SEVERE COMBINED IMMUNODEFICIENCY SYNDROME
519 ADA DEFICIENCY AND PNP DEFICIENCY 520
SCID MICE AND SC/RF-HUMAN MICE 521 WISKOTT-ALDRICH SYNDROME 521
IMAGE 9
CONTENTS XV
COMPLEMENT DEFICIENCIES 521 SUMMARY 521
REFERENCES 521
STUDY QUESTIONS 522
23 THE IMMUNE SYSTEM IN AIDS 523
DISCOVERY OF AIDS AND ITS CAUSATIVE AGENT 523 INCIDENCE OF AIDS 524
IDENTIFICATION OF HUMAN IMMUNODEFICIENCY
VIRUS (HIV) 524 EVOLUTIONARY RELATIONSHIPS OF HIV 524 ORIGIN OF HIV AND
INITIAL APPEARANCE OF AIDS 526 HIV: STRUCTURE AND INFECTIOUS PROCESS 526
HIV INFECTION OF TARGET CELLS 526 ENTRY OF HIV INTO CELLS 527
INTEGRATION OF HIV INTO HOST GENOME 528 ACTIVATION OF HIV PROVIRUS 529
ROLE OF INFECTED CELLS IN HIV
TRANSMISSION 529 HIV GENOME 531 MECHANISM OF HIV ACTIVATION: LATENCY TO
LYTIC CYCLE 532 GENETIC VARIATION IN HIV 533
ROLE OF IMMUNE SYSTEM IN SELECTING HIV VARIANTS 534 VARIATION IN THE
ENVELOPE GLYCOPROTEINS 534 CLINICAL DIAGNOSIS OF AIDS 535 HIV
DESTRUCTION OF CD4+ T CELLS 538
DEPLETION OF HIV-INFECTED CD4+ T CELLS 538 DEPLETION OF UNINFECTED CD4+
T CELLS 539 SYNCYTIA FORMATION 539 DESTRUCTION MEDIATED BY SOLUBLE GPL20
540
INTERFERENCE WITH T-CELL MATURATION 541 INAPPROPRIATE PROGRAMMED CELL
DEATH 541
IMMUNOLOGIC ABNORMALITIES IN AIDS 542 PATHOLOGIC CHANGES IN LYMPH NODES
543 REDUCED ANTIGEN-SPECIFIC RESPONSES BY T H CELLS 543 INEFFECTIVE
ANTIBODY RESPONSE 544 CYTOKINE IMBALANCE 544 DECREASED DTH RESPONSE 545
IMPAIRED CTL ACTIVITY 546 DISTURBANCES IN IMMUNE REGULATION 547
SEROLOGIC PROFILE OF HIV INFECTION 547 SCREENING TESTS FOR HIV INFECTION
548
DEVELOPMENT OF AN AIDS VACCINE 548
OBSTACLES TO DEVELOPMENT OF AN AIDS VACCINE 549 EXPERIMENTAL AIDS
VACCINES 550 INACTIVATED WHOLE VIRUSES 550
CLONED ENVELOPE GLYCOPROTEINS 552 ATTENUATED VIRUSES 553 RECOMBINANT
VIRUSES CARRYING HIV GENES 553
SYNTHETIC CROWN-SEQUENCE PEPTIDES 554 CLONED CD4 554 ANTI-IDIOTYPE
ANTIBODIES 555 SUMMARY 556 REFERENCES 556
STUDY QUESTIONS 557
24 TRANSPLANTATION
IMMUNOLOGY 559 THE IMMUNOLOGIC BASIS OF GRAFT REJECTION 560 SPECIFICITY
AND MEMORY OF REJECTION
RESPONSE 560 ROLE OF CELL-MEDIATED RESPONSES 560 TRANSPLANTATION
ANTIGENS 562 MECHANISMS INVOLVED IN GRAFT REJECTION 563
SENSITIZATION STAGE 563 EFFECTOR STAGE 563 CLINICAL MANIFESTATIONS OF
GRAFT REJECTION 564 HYPERACUTE REJECTION 565 ACUTE REJECTION 566
CHRONIC REJECTION 566
TISSUE TYPING 566
567 GENERAL IMMUNOSUPPRESSIVE THERAPY MITOTIC INHIBITORS 568
CORTICOSTEROIDS 568 CYCLOSPORIN A, FK506, AND RAPAMYCIN 569 TOTAL
LYMPHOID IRRADIATION 570 ANTILYMPHOCYTE SERUM 570 SPECIFIC
IMMUNOSUPPRESSIVE THERAPY 571
MONOCLONAL ANTIBODIES TO T-CELL COMPONENTS OR CYTOKINES 571 AGENTS THAT
BLOCK CO-STIMULATORY SIGNAL 572 DONOR-CELL MICROCHIMERISM 572
CLINICAL TRANSPLANTATION 573 BONE MARROW TRANSPLANTS 573 ORGAN
TRANSPLANTS 574 TRANSPLANTS TO IMMUNOLOGICALLY PRIVILEGED
SITES 575 SUMMARY 575 REFERENCES 576
STUDY QUESTIONS 576
IMAGE 10
XVI CONTENTS
25 CANCER AND THE IMMUNE SYSTEM 579 CANCER: ORIGIN AND TERMINOLOGY 579
MALIGNANT TRANSFORMATION OF CELLS 581 TRANSFORMATION INDUCED BY CHEMICAL
OR
PHYSICAL CARCINOGENS 581 VIRUS-INDUCED TRANSFORMATION 582 ONCOGENES AND
CANCER INDUCTION 582 FUNCTION OF ONCOGENES 583
INDUCTION OF CELLULAR PROLIFERATION 583 INHIBITION OF CELLULAR
PROLIFERATION 584 REGULATION OF PROGRAMMED CELL DEATH 584 CONVERSION OF
PROTO-ONCOGENES TO ONCOGENES 584 INDUCTION OF CANCER: A MULTISTEP
PROCESS 586 TUMORS OF THE IMMUNE SYSTEM 586 TUMOR ANTIGENS 588
TUMOR-SPECIFIC ANTIGENS 588
CHEMICALLY OR PHYSICALLY INDUCED TUMOR ANTIGENS 588 VIRALLY INDUCED
TUMOR ANTIGENS 590 TUMOR-ASSOCIATED ANTIGENS 590
ONCOFETAL TUMOR ANTIGENS 591 ONCOGENE PROTEINS AS TUMOR ANTIGENS 592
IMMUNE RESPONSE TO TUMORS 592
ROLE OF CTLS 592 ROLE OF NATURAL KILLER CELLS 593
ROLE OF MACROPHAGES 594 ROLE OF HUMORAL ANTIBODY 594 IMMUNE SURVEILLANCE
THEORY 594 TUMOR EVASION OF THE IMMUNE SYSTEM IMMUNOLOGIC ENHANCEMENT OF
TUMOR
GROWTH 595 MODULATION OF TUMOR ANTIGENS 595 REDUCTION IN CLASS I MHC
MOLECULES ON TUMOR CELLS 595
CANCER IMMUNOTHERAPY 596 IMMUNE ADJUVANTS 597 CYTOKINE THERAPY 598
INTERFERONS 598
TUMOR NECROSIS FACTORS 598 IN VITRO -ACTIVATED LAK AND TIL CELLS GENE
THERAPY 600 MONOCLONAL ANTIBODIES 601 TUMOR-CELL VACCINES 602
SUMMARY 602 REFERENCES 603
STUDY QUESTIONS 604
GLOSSARY 605
ANSWERS 615
CREDITS 634
INDEX 640
595
599
|
| any_adam_object | 1 |
| author | Kuby, Janis |
| author_facet | Kuby, Janis |
| author_role | aut |
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| bvnumber | BV009807382 |
| callnumber-first | Q - Science |
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| callnumber-subject | QR - Microbiology |
| classification_rvk | XD 2700 |
| classification_tum | MED 450f BIO 200f CHE 880f |
| ctrlnum | (OCoLC)29668353 (DE-599)BVBBV009807382 |
| dewey-full | 616.07/9 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.07/9 |
| dewey-search | 616.07/9 |
| dewey-sort | 3616.07 19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Chemie Medizin |
| edition | 2. ed. |
| format | Book |
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| id | DE-604.BV009807382 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:41:13Z |
| institution | BVB |
| isbn | 0716724006 0716726432 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006490474 |
| oclc_num | 29668353 |
| open_access_boolean | |
| owner | DE-91G DE-BY-TUM DE-355 DE-BY-UBR DE-188 |
| owner_facet | DE-91G DE-BY-TUM DE-355 DE-BY-UBR DE-188 |
| physical | XX, 660 S. Ill., zahlr. graph. Darst. |
| publishDate | 1994 |
| publishDateSearch | 1994 |
| publishDateSort | 1994 |
| publisher | Freeman |
| record_format | marc |
| spelling | Kuby, Janis Verfasser aut Immunology Janis Kuby 2. ed. New York Freeman 1994 XX, 660 S. Ill., zahlr. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Immunology cabt Immunologie Immunologie gtt Immune System Immunity Immunology Immunologie (DE-588)4026637-0 gnd rswk-swf Immunsystem (DE-588)4026643-6 gnd rswk-swf Immunologie (DE-588)4026637-0 s DE-604 Immunsystem (DE-588)4026643-6 s 1\p DE-604 SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006490474&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Kuby, Janis Immunology Immunology cabt Immunologie Immunologie gtt Immune System Immunity Immunology Immunologie (DE-588)4026637-0 gnd Immunsystem (DE-588)4026643-6 gnd |
| subject_GND | (DE-588)4026637-0 (DE-588)4026643-6 |
| title | Immunology |
| title_auth | Immunology |
| title_exact_search | Immunology |
| title_full | Immunology Janis Kuby |
| title_fullStr | Immunology Janis Kuby |
| title_full_unstemmed | Immunology Janis Kuby |
| title_short | Immunology |
| title_sort | immunology |
| topic | Immunology cabt Immunologie Immunologie gtt Immune System Immunity Immunology Immunologie (DE-588)4026637-0 gnd Immunsystem (DE-588)4026643-6 gnd |
| topic_facet | Immunology Immunologie Immune System Immunity Immunsystem |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006490474&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT kubyjanis immunology |