The beginnings of cancer in the cell: an interdisciplinary approach
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1994
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | VII, 194 S. Ill., graph. Darst. |
| ISBN: | 3540579621 0387579621 |
Internformat
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| 100 | 1 | |a Ladik, János |d 1929- |e Verfasser |0 (DE-588)10808356X |4 aut | |
| 245 | 1 | 0 | |a The beginnings of cancer in the cell |b an interdisciplinary approach |c J. Ladik ; W. Förner |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1994 | |
| 300 | |a VII, 194 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literaturangaben | ||
| 650 | 7 | |a Neoplasms |2 cabt | |
| 650 | 7 | |a Cell Biology |2 cabt | |
| 650 | 7 | |a Cancer - Étiologie |2 ram | |
| 650 | 7 | |a Cancérogenèse |2 ram | |
| 650 | 2 | |a Cancérogènes | |
| 650 | 7 | |a Cancérogènes |2 ram | |
| 650 | 7 | |a Cellules - Activation |2 ram | |
| 650 | 2 | |a Effets des rayonnements | |
| 650 | 2 | |a Exposition environnementale | |
| 650 | 2 | |a Oncogènes | |
| 650 | 7 | |a Oncogènes |2 ram | |
| 650 | 2 | |a Transformation cellulaire néoplasique | |
| 650 | 2 | |a Tumeurs - étiologie | |
| 650 | 4 | |a Cancer cells | |
| 650 | 4 | |a Carcinogenesis | |
| 650 | 4 | |a Carcinogens | |
| 650 | 4 | |a Cell Transformation, Neoplastic | |
| 650 | 4 | |a Cell transformation | |
| 650 | 4 | |a Environmental Exposure | |
| 650 | 4 | |a Neoplasms |x etiology | |
| 650 | 4 | |a Oncogenes | |
| 650 | 4 | |a Radiation Effects | |
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| 689 | 1 | 1 | |a Carcinogenese |0 (DE-588)4069853-1 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Förner, Wolfgang |e Verfasser |4 aut | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-006455602 | ||
Datensatz im Suchindex
| _version_ | 1804124106245799936 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
PREFACE 1
INTRODUCTION (THE HISTORY OF CANCER) 5
REFERENCES 10
1 DO WE CARRY THE CAUSE OF CANCER IN OUR GENES? 13
1.1 VIRAL CANCER CAUSING GENES 14
1.2 ONCOGENES IN PLANTS AND ANIMALS 16
1.3 HUMAN CANCER CAUSING .GENES 20
REFERENCES 24
2 ACTIVATION OF CANCER-CAUSING GENES (BIOCHEMICAL DISCUSSION) . . .. 29
2.1 ACTIVATION OF ONCOGENES THROUGH MUTATIONS 29
2.2 OVERACTIVATION OF SOME NORMAL GENES 35
2.2.1 OVERACTIVATION BY DNA SEGMENTS OF VIRAL ORIGIN . . 35 2.2.2
TRANSLOCATION OF GENES 38
2.3 OTHER BIOCHEMICAL POSSIBILITIES OF ONCOGENE ACTIVATION . .. 40 2.3.1
AMPLIFICATION 40
2.3.2 ANTIONCOGENE DEACTIVATION 42
2.3.3 DNA TRANSPOSITION 43
REFERENCES 43
3 THE ROLE OF EXTERNAL FACTORS IN THE START OF THE CANCEROUS CHANGE IN A
CELL 47
3.1 DIFFERENT CANCER INITIATING CHEMICAL COMPOUNDS
(CARCINOGENS) AND THEIR MOST IMPORTANT REACTIONS IN THE CELL 47
3.2 THE ROLE OF ELECTROMAGNETIC AND PARTICLE RADIATION 60
3.3 OTHER FACTORS INVOLVED IN CANCER INITIATION, E.G. ROLE OF TRACE
ELEMENTS IN THE CELL, HEAT OR CONTINOUS LOCAL PRESSURE 67
3.4 THE ROLE OF A SECOND GROUP OF CHEMICALS: CANCER
PROMOTERS 68
REFERENCES 74
IMAGE 2
4 A BRIEF SUMMARY OF THE STRUCTURE OF DNA AND PROTEINS AND THEIR
BIOLOGICAL ROLE 83
4.1 THE CHEMICAL AND GEOMETRICAL STRUCTURE OF DNA AND PROTEINS 83
4.2 THE BIOLOGICAL ROLE OF DNA AND PROTEINS 97
REFERENCES 100
5 MECHANISM OF ONCOGENE ACTIVATION OR ANTIONCOGENE INACTIVATION BY
EXTERNAL FACTORS 103
5.1 CARCINOGENS AND RADIATION AFFECT DNA NOT ONLY LOCALLY . 103 5.2
LOCAL EFFECTS OF CARCINOGENS AND THEIR EFFECT ON ONCOGENE ACTIVATION
(POINT MUTATIONS) 108
5.3 DIFFERENT LONG RANGE PHYSICAL EFFECTS OF CARCINOGENS . .. 112 5.3.1
ENERGY BANDS IN DNA AND PROTEINS AND THEIR CHANGE THROUGH CARCINOGEN
BINDING 112
5.3.2 DIFFERENT LONG-RANGE EFFECTS OF CARCINOGENS BOUND TO DNA OR
PROTEINS 123
5.3.3 CONNECTIONS BETWEEN THE DIFFERENT LONG RANGE PHYSICAL EFFECTS OF
CARCINOGENS AND THE ACTIVATION OF ONCOGENES 130
5.4 THE EFFECTS OF RADIATION ON DNA 131
5.4.1 DIRECT HIT UV RADIATION 132
5.4.2 PARTICLE RADIATION 135
5.4.3 QUALITATIVE THEORY OF DOUBLE STRAND BREAKS AND INACTIVATION OF
ANTIONCOGENES 136
REFERENCES 138
6 THE DISTURBANCE OF CELL-SELF-REGULATION DUE TO ONCOGENE ACTIVATION AND
ANTIONCOGENE INACTIVATION 141
6.1 CHANGES IN PROTEIN STRUCTURES AND CONCENTRATIONS DUE TO ONCOGENE
ACTIVATION AND ANTIONCOGENE INACTIVATION 141 6.2 QUALITATIVE DESCRIPTION
OF A MATHEMATICAL MODEL FOR THE CHEMICAL REACTIONS CHARACTERIZING LIVING
CELLS AND THEIR
ENSEMBLES 143
6.2.1 GENERAL CONSIDERATIONS 143
6.2.2 DESCRIPTION OF A SINGLE CELL 144
6.3 MODEL FOR A CELL WITH A CHANGED STATIONARY STATE (INITIATION OF THE
CANCEROUS STATE) 148
REFERENCES 149
VI
IMAGE 3
7 THE ROLE OF THE CENTRAL NERVOUS SYSTEM IN THE MALIGNANT
TRANSFORMATION OF CELLS IN HIGHER ORGANISMS 151
REFERENCES . 155
WHAT SHOULD BE DONE 157
8.1 INTRODUCTION 157
8.2 SOME CANCER-CELL-SPECIFIC CURATIVE METHODS 158
8.3 DEVELOPMENTS IN EARLY TUMOR DETECTION 159
8.4 POSSIBILITIES OF PREVENTION OF CANCER 159
REFERENCES 164
APPENDIX: OUTLINES OF A MORE GENERAL THEORY OF CANCER INITIATION IN THE
CELL 167
A.I INTRODUCTORY REMARKS 167
A.2 PROTEINS AS GOOD DISORDERED AMORPHOUS SEMICONDUCTORS . 168 A.3 THE
NORMAL AND CANCEROUS STATE OF LIVING MATTER 173 REFERENCES 174
INDEX 177
VII
|
| any_adam_object | 1 |
| author | Ladik, János 1929- Förner, Wolfgang |
| author_GND | (DE-588)10808356X |
| author_facet | Ladik, János 1929- Förner, Wolfgang |
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| author_sort | Ladik, János 1929- |
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| callnumber-first | R - Medicine |
| callnumber-label | RC268 |
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| callnumber-subject | RC - Internal Medicine |
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| ctrlnum | (OCoLC)30625066 (DE-599)BVBBV009759016 |
| dewey-full | 616.99/4071 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.99/4071 |
| dewey-search | 616.99/4071 |
| dewey-sort | 3616.99 44071 |
| dewey-tens | 610 - Medicine and health |
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| isbn | 3540579621 0387579621 |
| language | English |
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| physical | VII, 194 S. Ill., graph. Darst. |
| publishDate | 1994 |
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| spelling | Ladik, János 1929- Verfasser (DE-588)10808356X aut The beginnings of cancer in the cell an interdisciplinary approach J. Ladik ; W. Förner Berlin [u.a.] Springer 1994 VII, 194 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Neoplasms cabt Cell Biology cabt Cancer - Étiologie ram Cancérogenèse ram Cancérogènes Cancérogènes ram Cellules - Activation ram Effets des rayonnements Exposition environnementale Oncogènes Oncogènes ram Transformation cellulaire néoplasique Tumeurs - étiologie Cancer cells Carcinogenesis Carcinogens Cell Transformation, Neoplastic Cell transformation Environmental Exposure Neoplasms etiology Oncogenes Radiation Effects Zelle (DE-588)4067537-3 gnd rswk-swf Carcinogenese (DE-588)4069853-1 gnd rswk-swf Carcinogenese (DE-588)4069853-1 s DE-604 Zelle (DE-588)4067537-3 s Förner, Wolfgang Verfasser aut SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006455602&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ladik, János 1929- Förner, Wolfgang The beginnings of cancer in the cell an interdisciplinary approach Neoplasms cabt Cell Biology cabt Cancer - Étiologie ram Cancérogenèse ram Cancérogènes Cancérogènes ram Cellules - Activation ram Effets des rayonnements Exposition environnementale Oncogènes Oncogènes ram Transformation cellulaire néoplasique Tumeurs - étiologie Cancer cells Carcinogenesis Carcinogens Cell Transformation, Neoplastic Cell transformation Environmental Exposure Neoplasms etiology Oncogenes Radiation Effects Zelle (DE-588)4067537-3 gnd Carcinogenese (DE-588)4069853-1 gnd |
| subject_GND | (DE-588)4067537-3 (DE-588)4069853-1 |
| title | The beginnings of cancer in the cell an interdisciplinary approach |
| title_auth | The beginnings of cancer in the cell an interdisciplinary approach |
| title_exact_search | The beginnings of cancer in the cell an interdisciplinary approach |
| title_full | The beginnings of cancer in the cell an interdisciplinary approach J. Ladik ; W. Förner |
| title_fullStr | The beginnings of cancer in the cell an interdisciplinary approach J. Ladik ; W. Förner |
| title_full_unstemmed | The beginnings of cancer in the cell an interdisciplinary approach J. Ladik ; W. Förner |
| title_short | The beginnings of cancer in the cell |
| title_sort | the beginnings of cancer in the cell an interdisciplinary approach |
| title_sub | an interdisciplinary approach |
| topic | Neoplasms cabt Cell Biology cabt Cancer - Étiologie ram Cancérogenèse ram Cancérogènes Cancérogènes ram Cellules - Activation ram Effets des rayonnements Exposition environnementale Oncogènes Oncogènes ram Transformation cellulaire néoplasique Tumeurs - étiologie Cancer cells Carcinogenesis Carcinogens Cell Transformation, Neoplastic Cell transformation Environmental Exposure Neoplasms etiology Oncogenes Radiation Effects Zelle (DE-588)4067537-3 gnd Carcinogenese (DE-588)4069853-1 gnd |
| topic_facet | Neoplasms Cell Biology Cancer - Étiologie Cancérogenèse Cancérogènes Cellules - Activation Effets des rayonnements Exposition environnementale Oncogènes Transformation cellulaire néoplasique Tumeurs - étiologie Cancer cells Carcinogenesis Carcinogens Cell Transformation, Neoplastic Cell transformation Environmental Exposure Neoplasms etiology Oncogenes Radiation Effects Zelle Carcinogenese |
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