Conjugation dependent carcinogenicity and toxicity of foreign compounds:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego u.a.
Acad. Press
1994
|
| Schriftenreihe: | Advances in pharmacology
27 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben. - Einzelaufnahme eines Zs.-Bandes |
| Beschreibung: | XVI, 519 S. Ill., graph. Darst. |
| ISBN: | 0120329271 |
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| adam_text | 5 O % , ? ADVANCES IN PHARMACOLOGY VB/UME 27 CONJUGATION-DEPENDENT
CARCINOGENICITY AND TOXICITY OF FOREIGN COMPOUNDS EDITED BY M. W. ANDERS
DEPARTMENT OF PHARMACOLOGY UNIVERSITY OF ROCHESTER ROCHESTER, NEW YORK
WOLFGANG DEKANT INSTITUT FUR TOXIKOLOGIE UNIVERSITDT WTIRZBURG WURZBURG,
GERMANY ACADEMIC PRESS A DIVISION OF HARCOURT BRACE & COMPANY SAN DIEGO
NEW YORK BOSTON LONDON SYDNEY TOKYO TORONTO CONTENTS CONTRIBUTORS XV
HISTORICAL PERSPECTIVES ON CONJUGATION-DEPENDENT BIOACTIVATION OF
FOREIGN COMPOUNDS JAMES A. MILLER AND YOUNG-JOON SURH I. METABOLIC
RESEARCH LEADING TO CONJUGATION-DEPENDENT BIOACTIVATION OF
4-DIMETHYLAMINOAZOBENZENE AND 2-ACETYLAMINOFLUORENE 1 A. INTRODUCTION 1
B. COVALENT BINDING OF CARCINOGENS TO TISSUE MACROMOLECULES 2 C. HEPATIC
MICROSOMAL METABOLISM OF CARCINOGENS AND ITS INDUCTION BY UNRELATED
CHEMICALS 3 D. CONJUGATION-DEPENDENT BIOACTIVATION OF DAB AND AAF 4 E.
CONCLUSION 8 II. IMPORTANT OBSERVATIONS LEADING TO BIOACTIVATION OF
FOREIGN COMPOUNDS VIA GLUTATHIONE CONJUGATION, METHYLATION, AND EPOXIDE
FORMATION AND HYDROLYSIS 8 A. INTRODUCTION 8 B. GLUTATHIONE CONJUGATION
8 C. METHYLATION 10 D. EPOXIDE FORMATION AND HYDROLYSIS 11 REFERENCES 12
PARTI GLUTATHIONE-DEPENDENT TOXICITY ENZYMOLOGY OF MICROSOMAL
GLUTATHIONE S-TRANSFERASE CLAES ANDERSSON, ERIFILI MOSIALOU, ROLF
WEINANDER, AND RALF MORGENSTERN I. INTRODUCTION 19 A. MOLECULAR
PROPERTIES 20 B. SUBCELLULAR, EXTRAHEPATIC, AND PHYLOGENETIC
DISTRIBUTION 20 II. CATALYSIS 22 III. ACTIVATION 26 IV. THE ACTIVATED
ENZYME 30 CONTENTS V. THIOL SUBSTRATES 30 VI. CONCLUDING REMARKS 31
REFERENCES 32 ENZYMOLOGY OF CYTOSOLIC GLUTATHIONE S-TRANSFERASES BRIAN
KETTERER AND LUCIA G. CHRISTODOULIDES I. INTRODUCTION 37 II. THE GST
SUPERGENE FAMILY 42 III. STRUCTURE OF GSTS INCLUDING THEIR ACTIVE SITES
43 IV. ENZYME KINETICS 46 V. GENE STRUCTURE AND GENE REGULATION 49 VI.
SPECIFIC EXAMPLES ILLUSTRATING THE PROPERTIES OF GSTS 54 A. AFLATOXIN B
R INDUCED LIVER CANCER IN EXPERIMENTAL ANIMALS AND HUMANS 54 B. GSTS AND
HUMAN LUNG CANCER: EFFECT OF GSTM1 POLYMORPHISM AND ITS POSSIBLE
MECHANISM 55 C. INDUSTRIAL CHEMICALS: TOXICATION AND DETOXICATION 57 D.
POLYMORPHISM IN THE HUMAN THETA CLASS FAMILY 59 E. GSTS AND THE
DETOXICATION OF XENOBIOTIC ORGANIC HYDROPEROXIDES AND ENDOGENOUS LIPID
AND DNA HYDROPEROXIDES 59 VII. CONCLUSIONS 60 REFERENCES 62 ENZYMOLOGY
OF CYSTEINE S-CONJUGATE /3-LYASES ARTHUR J. L. COOPER I. INTRODUCTION 71
II. ENZYMES THAT CLEAVE THE THIOETHER BOND OF S-SUBSTITUTED CYSTEINES 76
III. BACTERIAL CYSTEINE 5-CONJUGATE /3-LYASES 78 IV. MAMMALIAN CYSTEINE
S-CONJUGATE /3-LYASES 83 A. HUMAN LIVER CYSTEINE 5-CONJUGATE /3-LYASE 83
B. RAT LIVER CYSTEINE 5-CONJUGATE /3-LYASE/KYNURENINASE 83 C.
KYNURENINASE-TYPE CYSTEINE 5-CONJUGATE /3-LYASE IN THE BRAIN 85 D. RAT
KIDNEY CYSTEINE 5-CONJUGATE /3-LYASE/GLUTAMINE TRANSAMINASE K 86 E.
PROPERTIES OF CYTOSOLIC RAT GLUTAMINE TRANSAMINASE K/CYSTEINE
5-CONJUGATE /3-LYASE 89 F. TISSUE DISTRIBUTION OF GLUTAMINE TRANSAMINASE
K/CYSTEINE 5-CONJUGATE /3-LYASES IN MAMMALS 91 G. METABOLIC FUNCTIONS OF
GLUTAMINE TRANSAMINASE K 92 CONTENTS VI H. MITOCHONDRIAL GLUTAMINE
TRANSAMINASE K/CYSTEINE 5-CONJUGATE /3-LYASE 93 I. OTHER CYSTEINE
5-CONJUGATE /3-LYASES IN THE RAT KIDNEY 94 J. COMMENTS ON THE
DISTRIBUTION OF GLUTAMINE TRANSAMINASE K/ CYSTEINE 5-CONJUGATE /3-LYASE
IN RAT KIDNEY AND BRAIN 95 V. DESIGN OF PRODRUGS DIRECTED TOWARD
GLUTAMINE K/CYSTEINE 5-CONJUGATE /3-LYASE IN THE KIDNEY 98 VI.
CONCLUSIONS 103 NOTE ADDED IN PROOF 104 REFERENCES 104 FORMATION AND
FATE OF NEPHROTOXIC AND CYTOTOXIC GLUTATHIONE 5-CONJUGATES: CYSTEINE
CONJUGATE /3-LYASE PATHWAY WOLFGANG DEKANT, SPYRIDON VAMVAKAS, AND M. W.
ANDERS I. INTRODUCTION 115 II. BIOSYNTHESIS OF TOXIC GLUTATHIONE
5-CONJUGATES 116 III. FATE OF 5-CONJUGATES 120 A. ENZYMATIC PROCESSING
OF TOXIC GLUTATHIONE 5-CONJUGATES 120 B. PHYSIOLOGICAL DISPOSITION OF
TOXIC GLUTATHIONE 5-CONJUGATES 123 IV. BIOACTIVATION OF CYTOTOXIC AND
NEPHROTOXIC CYSTEINE 5-CONJUGATES 131 A. UNSTABLE THIOLS AS PRODUCTS OF
/3-LYASE-CATALYZED METABOLISM 133 B. CHEMICALLY STABLE THIOLS AS
PRODUCTS OF /3-LYASE-CATALYZED METABOLISM 136 V. CELLULAR EFFECTS OF
CYTOTOXIC AND NEPHROTOXIC CYSTEINE 5-CONJUGATES 137 A. NEPHROTOXICITY IN
VIVO 137 B. CYTOTOXICITY IN VITRO 138 C. BIOCHEMICAL MECHANISMS OF
5-CONJUGATE CYTOTOXICITY 140 D. MUTAGENICITY OF CYSTEINE AND GLUTATHIONE
5-CONJUGATES IN BACTERIA 142 E. STRUCTURE-MUTAGENICITY AND
STRUCTURE-CYTOTOXICITY 143 F. GENOTOXICITY IN CULTURED KIDNEY CELLS 144
G. GENOTOXICITY IN VIVO 144 H. INDUCTION OF PROTOONCOGENE EXPRESSION 145
I. POSSIBLE MECHANISMS IN THE NEPHROCARCINOGENICITY OF HALOALKENES 146
REFERENCES 147 CONTENTS REVERSIBILITY IN GLUTATHIONE-CONJUGATE FORMATION
THOMAS A. BAILLIE AND KELEM KASSAHUN I. INTRODUCTION 163 II. CLASSES OF
COMPOUNDS THAT UNDERGO REVERSIBLE CONJUGATION WITH GLUTATHIONE 164 A.
ISOTHIOCYANATES 164 B. ISOCYANATES 169 C. A,/3-UNSATURATED CARBONYL
COMPOUNDS 174 D. MISCELLANEOUS 177 III. CONCLUSIONS 177 REFERENCES 178
GLUTATHIONE CONJUGATION AS A MECHANISM FOR THE TRANSPORT OF REACTIVE
METABOLITES TERRENCE J. MONKS AND SERRINE S. LAU I. INTRODUCTION 183 II.
GLUTATHIONE CONJUGATION AS A MECHANISM FOR THE TRANSPORT OF REDOX ACTIVE
COMPOUNDS 184 A. TARGETING OF QUINONES TO THE KIDNEY BY CONJUGATION WITH
GLUTATHIONE 184 III. TRANSPORT OF GLUTATHIONE-CONJUGATED REDOX COMPOUNDS
TO THE KIDNEY AS A COMMON FACTOR IN CHEMICAL-INDUCED
NEPHROCARCINOGENICITY 190 A. HYDROQUINONE 190 B.
3-TERR-BUTYL-4-HYDROXYANISOLE 191 C. CATECHOL ESTROGENS 192 IV.
-Y-GLUTAMYLTRANSPEPTIDASE AND THE TOXICITY OF GLUTATHIONE-CONJUGATED
REDOX COMPOUNDS 196 V. TARGETING OF GLUTATHIONE CONJUGATES TO NEOPLASTIC
TISSUES EXPRESSING -Y-GLUTAMYLTRANSPEPTIDASE 196 VI. DEVELOPMENTAL
TOXICITY OF GLUTATHIONE-CONJUGATED REDOX COMPOUNDS 197 VII. TRANSPORT OF
REVERSIBLE GLUTATHIONE CONJUGATES 198 A. GLUTATHIONE AND THE TRANSPORT
OF HEAVY METALS 198 B. ISOTHIOCYANATES 199 C. ACROLEIN AND OTHER
A,/3-UNSATURATED ALDEHYDES 199 VIII. GLUTATHIONE, NITRIC OXIDE, AND
ENDOTHELIAL-DERIVED RELAXING FACTOR 201 IX. SUMMARY 202 REFERENCES 202
CONTENTS METABOLISM AND GENOTOXICITY OF DIHALOALKANES F. PETER
GUENGERICH I. INTRODUCTION 211 II. ADDUCTS DERIVED FROM
1,2-DIHALOETHANES 213 A. CHARACTERIZATION OF DNA ADDUCTS DERIVED FROM
WC-DIHALOETHANES 213 B. MECHANISM OF ENZYMATIC FORMATION OF DNA ADDUCTS
217 C. MODULATION OF DNA ADDUCT LEVELS 219 D. FATES OF DNA ADDUCTS 220
E. PROTEIN AND GLUTATHIONE ADDUCTS AND TOXICITY 221 III. OTHER
DIHALOALKANES 223 A. 1,2-DIBROMO-3-CHLOROPROPANE 223 B. 1,4-DIIODOBUTANE
224 C. METHYLENE DIHALIDES 225 IV. BASIS OF MUTAGENICITY OF ETHYLENE
DIBROMIDE 226 V. CONCLUSIONS 230 REFERENCES 230 BIOACTIVATION OF THIOLS
BY ONE-ELECTRON OXIDATION REX MUNDAY I. INTRODUCTION 237 II. REACTIONS
OF THE THIYL RADICAL 238 A. FORMATION OF DISULFIDE VIA THE DISULFIDE
RADICAL ANION 238 B. REACTION WITH OXYGEN 239 C. OXIDATION REACTIONS 240
D. DIMERIZATION 242 E. ADDITION TO UNSATURATED COMPOUNDS 242 F.
REARRANGEMENT 242 III. PATHWAYS FOR ONE-ELECTRON OXIDATION OF THIOLS 242
A. METAL-CATALYZED OXIDATION OF THIOLS 242 B. OXIDATION OF THIOLS BY
HEMOGLOBIN 244 C. OXIDATION OF THIOLS BY FREE RADICALS 244 D. OXIDATION
OF THIOLS BY QUINONES AND BY ALLOXAN 245 IV. STRUCTURAL EFFECTS ON
ONE-ELECTRON OXIDATION OF THIOLS 249 V. BENEFICIAL AND HARMFUL EFFECTS
OF THIYL RADICAL FORMATION 252 A. GLUTATHIONE AS A RADICAL SCAVENGER 252
B. RADIATION PROTECTION BY THIOLS AND THE OXYGEN EFFECT 252 C.
CYTOTOXICITY OF AMINOTHIOLS 253 D. MUTAGENICITY OF THIOLS 254 E. LIPID
PEROXIDATION 256 F. REACTIONS OF GLUTATHIONE INVOLVING PEROXIDASES 257
G. ANTI-CANCER ACTIVITY OF METAL COMPLEXES 257 CONTENTS H. HEMOLYTIC
ACTIVITY OF THIOLS AND DISULFIDES 257 I. TOXICITY OF
EPIDITHIODIOXOPIPERAZINE DERIVATIVES 258 J. FORMATION OF CYTOTOXIC
SPECIES THROUGH ONE-ELECTRON OXIDATION OF GLUTATHIONE BY XENOBIOTICS 259
VI. CONCLUSION 260 REFERENCES 261 GLUTATHIONE MERCAPTIDES AS TRANSPORT
FORMS OF METALS N. BALLATORI I. INTRODUCTION 271 II. FORMATION OF
GLUTATHIONE MERCAPTIDES 272 III. ROLES OF GLUTATHIONE IN THE DISPOSITION
AND TOXICITY OF METALS 274 A. MOBILIZATION AND DELIVERY OF METALS
BETWEEN LIGANDS 274 B. TRANSPORT OF METALS ACROSS CELL MEMBRANES AS
GLUTATHIONE COMPLEXES 277 C. CELLULAR UPTAKE OF GLUTATHIONE AND
GLUTATHIONE ADDUCTS: INTER- AND INTRAORGAN METABOLISM OF
GLUTATHIONE-METAL COMPLEXES 282 D. GLUTATHIONE AS REDUCTANT OR COFACTOR
FOR REDOX REACTIONS OF METAL COMPOUNDS 288 IV. SUMMARY 290 REFERENCES
290 PART II SULFATE CONJUGATE-DEPENDENT TOXICITY BIOCHEMISTRY OF
CYTOSOLIC SULFOTRANSFERASES INVOLVED IN BIOACTIVATION CHARLES N. FALANY
AND TERESA W. WILBORN I. INTRODUCTION 301 A. IMPORTANCE OF SULFATION 303
B. BIOACTIVATION BY SULFATION 304 C. CLASSIFICATION OF SULFOTRANSFERASES
305 II. CLASSES OF CYTOSOLIC SULFOTRANSFERASE INVOLVED IN THE
BIOACTIVATION OF XENOBIOTICS 306 A. CYTOSOLIC HYDROXYSTEROID
SULFOTRANSFERASES 307 B. CYTOSOLIC PHENOL/HYDROXYARYLAMINE
SULFOTRANSFERASES 313 III. SUMMARY 324 REFERENCES 325 CONTENTS
CARCINOGEN ACTIVATION BY SULFATE CONJUGATE FORMATION CHRISTOPHER J.
MICHEJDA AND MARILYN B. KROEGER KOEPKE I. INTRODUCTION 331 II. AROMATIC
HYDROXYLAMINES AND AMIDES 335 A. AMINOFLUORENES 335 B. PHENACETIN AND
ITS METABOLITES 339 C. AMINOAZO DYES AND BENZIDINES 342 D.
HETEROAROMATIC AMINES 345 III. HYDROXYMETHYL AROMATICS AND ALCOHOLS 346
A. HYDROXYMETHYL AROMATICS 346 B. TERPENES 349 C. /8-AMINOETHYL ALCOHOLS
AND DERIVATIVES 352 D. OTHER COMPOUNDS 355 IV. SUMMARY 356 REFERENCES
357 PART III GLUCURONIDE CONJUGATE-DEPENDENT TOXICITY
UDP-GLUCURONOSYLTRANSFERASES AND THEIR ROLE IN METABOLISM AND
DISPOSITION OF CARCINOGENS KARL WALTER BOCK I. INTRODUCTION 367 II.
FACTORS AFFECTING GLUCURONIDE FORMATION IN CELLS 368 A. AVAILABILITY OF
UDP-GLUCURONIC ACID 368 ; B. MEMBRANE FACTORS AFFECTING UGT ACTIVITY 368
C. UGT ISOZYMES 370 III. REGULATION OF UGT ISOZYMES 373 A. GENERAL
FEATURES 373 B. REGULATION OF PHENOL UGTS BY THE AH RECEPTOR 374 C.
PERSISTENT ALTERATIONS OF PHENOL UGT IN PRENEOPLASTIC LIVER 374 IV.
ROLES OF UGTS IN METABOLISM AND DISPOSITION OF CARCINOGENS 375 A. ROLES
OF UGTS IN DETOXICATION OF CARCINOGENS 375 B. GLUCURONIDES AS TRANSPORT
FORMS OF CARCINOGENS 376 V. CONCLUSIONS AND FUTURE PROSPECTS 376 NOTE
ADDED IN PROOF 378 REFERENCES 378 CONTENTS BIOACTIVATION BY
GLUCURONIDE-CONJUGATE FORMATION PARNIAN ZIA-AMIRHOSSEINI, HILDEGARD
SPAHN-LANGGUTH, AND LESLIE Z. BENET I. INTRODUCTION 385 A. TYPES OF
GLUCURONIDES 385 B. PHARMACOLOGIC ACTIVITY 386 II. REACTIVITY OF ACYL
GLUCURONIDES 387 A. ACYL MIGRATION AND HYDROLYSIS 388 B. REACTION WITH
SMALL MOLECULES 388 C. REACTION WITH MACROMOLECULES 389 III. POSSIBLE
ROLE OF ACYL GLUCURONIDES IN THE TOXICITY OF DRUGS 393 REFERENCES 394
PART IV BIOACTIVATION AND BIOCONVERSION N-ACETYLTRANSFERASES,
O-ACETYLTRANSFERASES, AND N,O- ACETYLTRANSFERASES: ENZYMOLOGY AND
BIOACTIVATION PATRICK E. HANNA I. INTRODUCTION 401 II.
N-ACETYLTRANSFERASE 402 A. MULTIPLE AT-ACETYLTRANSFERASES 403 III.
O-ACETYLTRANSFERASE 405 A. MAMMALIAN O-ACETYLTRANSFERASES 405 B.
BACTERIAL O-ACETYLTRANSFERASE 410 IV. JV-ARYLHYDROXAMIC
N,O-ACYLTRANSFERASE 412 A. CYTOSOLIC AF,O-ACYLTRANSFERASE 412 B.
MICROSOMAL N,O-ACYLTRANSFERASE 415 * V. N-ACYLOXYARYLAMINES 417 A.
SYNTHESIS 417 B. CHEMICAL REACTIVITY 418 REFERENCES 421 AMINOACYLASES M.
W. ANDERS AND WOLFGANG DEKANT I. INTRODUCTION 431 II. ENZYMOLOGY OF THE
AMINOACYLASES 432 A. ACYLASE I 433 B. ASPARTOACYLASE 436 CONTENTS XIII
C. ACYLLYSINE DEACYLASE 437 D. ACYLASE HI 437 E. LIVER AMINOACYLASES 438
III. XENOBIOTIC BIOACTIVATION BY AMINOACYLASES 439 A. TOXICITY OF
HALOALKENE-DERIVED MERCAPTURATES 439 B. THE ROLE OF AMINOACYLASES IN THE
MUTAGENICITY OF HALOALKENE-DERIVED MERCAPTURATES 440 C. THE ROLE OF
AMINOACYLASES IN HALOALKENE-DERIVED MERCAPTURATE TOXICITY 441 D.
CONTRIBUTION OF AMINOACYLASES TO TOXICITY OF HYDROQUINONE-DERIVED
MERCAPTURATES 443 E. AMINOACYLASE-DEPENDENT ACTIVATION OF THE HERBICIDE
AF-ACETYLGLUFOSINATE 444 REFERENCES 444 BIOACTIVATION BY
S-ADENOSYLATION, S-METHYLATION, OR N-METHYLATION JERALD L. HOFFMAN I.
INTRODUCTION: SYNTHESIS AND UTILIZATION OF ADOMET 449 II. BIOACTIVATION
OF XENOBIOTIC METHIONINE ANALOGS BY S-ADENOSYLATION CATALYZED BY ADOMET
SYNTHETASE 454 A. ETHIONINE INDUCTION OF FATTY LIVER 454 B. ETHIONINE
CARCINOGENESIS 455 C. MUTAGENICITY AND CARCINOGENICITY OF VINTHIONINE
458 D. LIVER SPECIFICITY OF METHIONINE ANALOGS 460 III. XENOBIOTIC
BIOACTIVATION BY N-METHYLATION OF AZAHETEROCYCLIC COMPOUNDS 461 A.
BIOSYNTHESIS OF PARAQUAT 461 B. N-METHYLATION OF ENVIRONMENTAL OR
ENDOGENOUS TOXINS IN PARKINSON S DISEASE 462 IV. XENOBIOTIC
BIOACTIVATION BY S-METHYLATION 469 REFERENCES 473 BYCONVERSION OF
PRODRUGS BY CONJUGATE-PROCESSING ENZYMES SPYRIDON VAMVAKAS AND M. W.
ANDERS I. INTRODUCTION 479 II. BIOCONVERSION OF PRODRUGS BY
CONJUGATE-PROCESSING ENZYMES 480 A. AMINOACYLASES 480 B. CYSTEINE
CONJUGATE /3-LYASE 481 C. -Y-GLUTAMYLTRANSFERASE AND DIPEPTIDASES 483 D.
AMINO- AND CARBOXYPEPTIDASES 488 CONTENTS E. OXOPROLINASE 489 F.
/3-GLUCURONIDASE 491 G. ESTERASES 492 HI. FUTURE POSSIBILITIES FOR
DEVELOPMENT OF CONJUGATE-BASED PRODRUGS 495 REFERENCES 496
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| id | DE-604.BV009743886 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:40:07Z |
| institution | BVB |
| isbn | 0120329271 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006444293 |
| oclc_num | 30523118 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-12 DE-355 DE-BY-UBR DE-20 DE-188 DE-578 |
| owner_facet | DE-19 DE-BY-UBM DE-12 DE-355 DE-BY-UBR DE-20 DE-188 DE-578 |
| physical | XVI, 519 S. Ill., graph. Darst. |
| publishDate | 1994 |
| publishDateSearch | 1994 |
| publishDateSort | 1994 |
| publisher | Acad. Press |
| record_format | marc |
| series2 | Advances in pharmacology |
| spelling | Conjugation dependent carcinogenicity and toxicity of foreign compounds ed. by M. W. Anders ... Conjugation-dependent carcinogenicity and toxicity of foreign compounds San Diego u.a. Acad. Press 1994 XVI, 519 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in pharmacology 27 Literaturangaben. - Einzelaufnahme eines Zs.-Bandes Carcinogeniteit gtt Geconjugeerde systemen gtt Pharmacologie Préparations pharmaceutiques - Métabolisme Toxiciteit gtt Drugs Metabolism Pharmaceutical Preparations metabolism Fremdstoff (DE-588)4155390-1 gnd rswk-swf Carcinogenität (DE-588)4206051-5 gnd rswk-swf Toxizität (DE-588)4078372-8 gnd rswk-swf Biotransformation (DE-588)4006908-4 gnd rswk-swf Toxikologie (DE-588)4060538-3 gnd rswk-swf Xenobiotikum (DE-588)4193155-5 gnd rswk-swf Fremdstoff (DE-588)4155390-1 s Carcinogenität (DE-588)4206051-5 s Toxikologie (DE-588)4060538-3 s DE-604 Xenobiotikum (DE-588)4193155-5 s Biotransformation (DE-588)4006908-4 s Toxizität (DE-588)4078372-8 s Anders, M. W. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006444293&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Conjugation dependent carcinogenicity and toxicity of foreign compounds Carcinogeniteit gtt Geconjugeerde systemen gtt Pharmacologie Préparations pharmaceutiques - Métabolisme Toxiciteit gtt Drugs Metabolism Pharmaceutical Preparations metabolism Fremdstoff (DE-588)4155390-1 gnd Carcinogenität (DE-588)4206051-5 gnd Toxizität (DE-588)4078372-8 gnd Biotransformation (DE-588)4006908-4 gnd Toxikologie (DE-588)4060538-3 gnd Xenobiotikum (DE-588)4193155-5 gnd |
| subject_GND | (DE-588)4155390-1 (DE-588)4206051-5 (DE-588)4078372-8 (DE-588)4006908-4 (DE-588)4060538-3 (DE-588)4193155-5 |
| title | Conjugation dependent carcinogenicity and toxicity of foreign compounds |
| title_alt | Conjugation-dependent carcinogenicity and toxicity of foreign compounds |
| title_auth | Conjugation dependent carcinogenicity and toxicity of foreign compounds |
| title_exact_search | Conjugation dependent carcinogenicity and toxicity of foreign compounds |
| title_full | Conjugation dependent carcinogenicity and toxicity of foreign compounds ed. by M. W. Anders ... |
| title_fullStr | Conjugation dependent carcinogenicity and toxicity of foreign compounds ed. by M. W. Anders ... |
| title_full_unstemmed | Conjugation dependent carcinogenicity and toxicity of foreign compounds ed. by M. W. Anders ... |
| title_short | Conjugation dependent carcinogenicity and toxicity of foreign compounds |
| title_sort | conjugation dependent carcinogenicity and toxicity of foreign compounds |
| topic | Carcinogeniteit gtt Geconjugeerde systemen gtt Pharmacologie Préparations pharmaceutiques - Métabolisme Toxiciteit gtt Drugs Metabolism Pharmaceutical Preparations metabolism Fremdstoff (DE-588)4155390-1 gnd Carcinogenität (DE-588)4206051-5 gnd Toxizität (DE-588)4078372-8 gnd Biotransformation (DE-588)4006908-4 gnd Toxikologie (DE-588)4060538-3 gnd Xenobiotikum (DE-588)4193155-5 gnd |
| topic_facet | Carcinogeniteit Geconjugeerde systemen Pharmacologie Préparations pharmaceutiques - Métabolisme Toxiciteit Drugs Metabolism Pharmaceutical Preparations metabolism Fremdstoff Carcinogenität Toxizität Biotransformation Toxikologie Xenobiotikum |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006444293&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT andersmw conjugationdependentcarcinogenicityandtoxicityofforeigncompounds |