Immunopharmacology of macrophages and other antigen presenting cells:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Acad. Press
1994
|
| Schriftenreihe: | The handbook of immunopharmacology
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XIV, 201 S. Ill., graph. Darst. |
| ISBN: | 0121378004 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804123957421408256 |
|---|---|
| adam_text | IMMUNOPHARMACOBGJ OF MOCROPHFLFLES AND OTHER ANTIGEN-PRESENTING CELLS
EDITED BY C.A.F.M. BRUIJNZEEL-KOOMEN UNIVERSITY HOSPITAL, UTRECHT, THE
NETHERLANDS AND E.C.M. HOEFSMIT VRIJE UNIVERSITEIT, AMSTERDAM, THE
NETHERLANDS ACADEMIC PRESS HARCOURT BRACE AND COMPANY, PUBLISHERS LONDON
SAN DIEGO NEW YORK BOSTON SYDNEY TOKYO TORONTO CONTENTS CONTRIBUTORS IX
SERIES PREFACE XI PREFACE XIII 1. MACROPHAGES: GENERAL ASPECTS 1 R.H.J.
BEELEN, M.G.H. BETJES AND E.W.A. KAMPERDIJK GENERAL INTRODUCTION 1
ORIGIN AND MORPHOLOGY OF MACROPHAGES 1 FUNCTIONAL MACROPHAGE
HETEROGENEITY 3 3.1 ENDOCYTOSIS 3 3.2 CYTOTOXICITY 3 3.3 REGULATION OF
THE INFLAMMATORY RESPONSE 3.4 REGULATION OF HAEMOPOIESIS 4 3.5
REGULATION OF THE IMMUNE RESPONSE 4 4. ANTIGEN PRESENTING CAPACITY OF
MACROPHAGES IN RELATION TO DC 4 5. REFERENCES 5 2. INTERACTION BETWEEN
CYTOKINES AND MONOCYTESLMACROPHAGES 7 A.A. TE VELDE 7 INTRODUCTION 7
MODULATION OF MONOCYTE/MACROPHAGE FUNCTIONAL ACTIVITIES BY CYTOKINES 8
2.1 REGULATION OF CYTOKINE SYNTHESIS BY MONOCYTES 8 2.2 CYTOKINES
REGULATE THE FUNCTION OF MONOCYTES/MACROPHAGES AS APC 9 2.3 CYTOKINES
REGULATE THE FUNCTION OF MONOCYTES/MACROPHAGES AS EFFECTOR CELLS 11
CYTOKINES AND THE TISSUE MACROPHAGE: THE KUPFFER CELL IN THE LIVER 13
3.1 THE ROLE OF ENDOTOXIN-ACTIVATED KUPFFER CELLS IN THE PATHOGENESIS OF
LIVER INJURY 13 3.2 KUPFFER CELLS AND PORTAL VENOUS TOLERANCE INDUCTION
17 CYTOKINES AND THE CLINICAL COURSE OF DISEASES 18 4.1 PRODUCTION OF
CYTOKINES BY CD4 + T HELPER CELLS 18 4.2 EFFECT OF THL-DERIVED CYTOKINES
ON HUMAN MONOCYTES 18 4.3 EFFECT OF TH2-DERIVED CYTOKINES ON HUMAN
MONOCYTES 18 4.3.1 EFFECT OF IL-4 ON HUMAN MONOCYTES 19 4.3.2 EFFECT OF
IL-4 ON MOUSE MACROPHAGES 19 4.3.3 EFFECT OF IL-10 ON HUMAN MONOCYTES
AND MURINE MACROPHAGES 20 4.4 IL-4 AND IFN7 HAVE OPPOSITE EFFECTS ON
MONOCYTE PHENOTYPE AND FUNCTION AND THE CLINICAL COURSE OF INFECTIONS 20
5. CONCLUDING REMARKS 23 5.1 MAB AGAINST CYTOKINES OR CYTOKINE RECEPTORS
23 5.2 ANTAGONISTIC CYTOKINES 23 5.3 NATURAL CYTOKINE RECEPTOR
ANTAGONISTS 23 5.4 NATURAL SOLUBLE CYTOKINE RECEPTORS 24 5.5
PHARMACOLOGICAL INTERVENTION 24 6. REFERENCES 24 VI CONTENTS 3. FUNCTION
OF ALVEOLAR MACROPHAGES 35 T. THEPEN AND C.E.G. HAVENITH 1. RESPIRATORY
SYSTEM 35 2. DEFENCE MECHANISMS IN THE RESPIRATORY TRACT 36 2.1
NON-SPECIFIC EXCLUSION MECHANISMS 36 2.2 IMMUNOLOGICAL DEFENCE
MECHANISMS 36 3. AM 36 3.1 INTRODUCTION 36 3.2 ORIGIN OF AM 36 3.3
HETEROGENEITY OF AM 37 3.4 AM AND IN VITRO ANTIGEN PRESENTATION 37 4. IN
VIVO REGULATION OF PULMONARY IMMUNE RESPONSES BY AM 38 4.1 IN SITU
DEPLETION OF AM 38 4.2 IN VIVO EFFECT OF AM DEPLETION ON THE PULMONARY
IMMUNE RESPONSE 38 4.3 4.4 REGULATION OF LUNG T CELL FUNCTION BY AM 38
ROLE OF AM IN CONTROLLING ANTIGEN PRESENTATION BY DC IN THE LUNG 39
4.4.1 ROLE OF AM AND DC IN T CELL PRIMING 39 4.4.2 IN VIVO REGULATION OF
ANTIGEN PRESENTING CAPACITY OF DC BY AM 39 ROLE OF AM IN THE INDUCTION
OF PROTECTIVE TOLERANCE AGAINST INHALED ALLERGENS 40 ROLE OF AM IN
CONTROLLING PULMONARY IMMUNE RESPONSES IN PRESENSITIZED ANIMALS 40 5.
CONCLUSIONS 40 6. REFERENCES 41 4.5 4.6 1. 2. 4. MORPHOLOGY OF DENDRITIC
CELLS 45 E.W.A. KAMPERDIJK, E. VAN VUGT, CD. RICHTERS AND R.H.J. BEELEN
INTRODUCTION 45 3. DC IN VITRO 52 1.1 CELL BIOLOGICAL ASPECTS OF DC 46
4. DC IN SITU. RELATION BETWEEN LC, VC AND IDC 48 2.1 LC IN SITU 48 2.2
VC IN SITU 49 2.3 IDC IN SITU 50 5. 6. FOLLICULARDC 55 4.1 FOLLICULAR DC
IN SITU 4.2 FOLLICULAR DC IN VITRO ACKNOWLEDGEMENTS 57 REFERENCES 58 55
57 5. HUMAN DENDRITIC CELLS: FUNCTION AND CYTOKINE PRODUCTION 63 D.N.J.
HART AND V.L. CALDER 1. INTRODUCTION 64 2. THE DC LINEAGE 64 2.1 A
DEFINITION OF DC 64 2.2 TYPES OF DC 66 2.2.1 BM DC 66 2.2.2 BLOOD DC 67
2.2.3 THYMICDC 67 2.2.4 INTERSTITIAL DC 67 2.2.5 AFFERENT LYMPHATIC DC
(VC) 67 2.2.6 LYMPHOID DC (IDC) 68 2.3 DC DIFFERENTIATION ANTIGENS 68 3.
DC FUNCTION 68 3.1 DC PRIMARY RESPONSES 68 3.2 DC ANTIGEN PROCESSING
PROPERTIES 69 3.3 DC CO-OPERATION WITH OTHER CELLS 70 3.4 DC
CO-STIMULATORY PROPERTIES 70 4. CO-STIMULATORY MOLECULES PRODUCED BY DC
72 4.1 B7/BB1 - A LIGAND FOR T LYMPHOCYTE CD28 72 4.2 THE PRODUCTION OF
CYTOKINES BY DC 73 4.2.1 IL-1 73 4.2.2 4.2.3 4.2.4 4.2.5 73 TNF 73
GM-CSF IL-6 75 OTHER CYTOKINES 75 5. DC CYTOKINE RECEPTOR EXPRESSION AND
CYTOKINE INHIBITOR PRODUCTION 75 5.1 IL-1 RECEPTORS 75 5.2 TNF RECEPTORS
75 5.3 GM-CSF RECEPTORS 75 5.4 IL-2 AND OTHER CYTOKINE RECEPTORS 76 5.5
CD40 76 5.6 CYTOKINE ANTAGONISTS 76 6. DC GROWTH AND DIFFERENTIATION 76
6.1 BM PRECURSORS 76 6.2 BLOOD PRECURSORS 77 6.3 RELATIONSHIP OF DC TO
THE MONOCYTE-MACROPHAGE LINEAGE 77 7. DC MIGRATION FROM NON-LYMPHOID TO
LYMPHOID TISSUES 78 7.1 INTERSTITIAL DC ANTIGEN UPTAKE AND MIGRATION 78
7.2 LYMPHATIC DC (VC) AND IDC 79 CONTENTS VII 7.3 DC MIGRATION IN
EFFERENT LYMPH 79 7.4 DC MIGRATION VIA BLOOD 79 9. 7.5 DC ANTIGEN ACCESS
AND THYMIC TOLERANCE 79 SIGNALS 3 AND 4 IN DC-T CELL ACTIVATION 80 8.1
SIGNAL 3: MHC MEDIATED INTRACELLULAR DC SIGNALLING 80 8.2 SIGNAL 4:
CYTOKINE REGULATION OF DC 10. CO-STIMULATORY PROPERTIES 80 8.2.1 IL-1 80
8.2.2 TNF 81 11. 8.2.3 GM-CSF 81 12. 8.2.4 IFN 7 81 13. 8.3 CONCLUSION
81 MANIPULATION OF IMMUNE RESPONSES 81 9.1 DC IMMUNIZATION 81 9.2 DC IN
TRANSPLANTATION 81 9.3 DC IN AUTOIMMUNE DISEASE 82 9.4 METHODS FOR
MANIPULATING DC FUNCTION 82 DC MALIGNANCIES 83 10.1 HISTIOCYTOSIS 83
10.2 HODGKIN S DISEASE 83 CONCLUDING REMARKS 83 ACKNOWLEDGEMENTS 83
REFERENCES 83 6. DENDRITIC CELLS IN ATOPIC DISEASE 93 G.C. MUDDE, W.
FOKKENS AND C.A.F.M. BRUIJNZEEL-KOOMEN INTRODUCTION 93 LC 94 2.1 LC
ADHESION MOLECULES 94 2.2 FC RECEPTORS ON LC 94 ANTIGEN UPTAKE
MECHANISMS 95 IGE BEARING LC IN AD 95 4.1 FUNCTION OF FCR-BOUND IGE ON
LC 95 4.1.1 IGE MEDIATED ANTIGEN CAPTURE 95 4.1.2 IGE MEDIATED ANTIGEN
CAPTURE BY LC 95 5. THE ROLE OF LC IN ATOPIC DISEASE 96 5.1 THE ROLE OF
LC IN AD 96 5.2 THE ROLE OF LC IN ALLERGIC RHINITIS 96 6. CONCLUSION 97
7. REFERENCES 97 7. THE BOLE OF DENDRITIC CELLS IN IMMUNE DEFENCE OF THE
AIRWAYS 99 P.G. HOLT REGULATION OF T CELL ACTIVATION IN RESPONSE TO
INHALED ANTIGENS: THEORETICAL CONSIDERATIONS 99 DISTRIBUTION AND SURFACE
PHENOTYPE OF DC POPULATIONS WITHIN THE RESPIRATORY TRACT 100 2.1
DISTRIBUTION 100 2.2 STRUCTURE AND SURFACE PHENOTYPE OF DC IN NORMAL
LUNG TISSUE 105 EFFECT OF INFLAMMATION ON THE POPULATION DYNAMICS AND
SURFACE PHENOTYPE OF RESPIRATORY TRACT DC 106 FUNCTIONAL STUDIES ON
ANTIGEN UPTAKE AND PRESENTATION BY LUNG AND AIRWAY DC 109 4.1 ANTIGEN
PRESENTATION IN VITRO 109 4.2 APC ACTIVITY IN VIVO 109 6. 7. 4.3
REGULATION OF THE APC FUNCTIONS OF LUNG DC IN SITU 109 REGULATION OF THE
IN SITU APC FUNCTION(S) OF RESPIRATORY TRACT DC BY ENDOGENOUS LUNG
MACROPHAGES 110 5.1 IN VIVO SUPPRESSION OF T CELL ACTIVATION BY LUNG
MACROPHAGES 110 5.1.1 DIRECT EFFECTS OF PAM ON THE IN VITRO FUNCTION(S)
OF LUNG DC 110 5.1.2 IN VIVO MODULATION OF IMMUNE FUNCTION(S) IN THE
LUNG BY PAM 111 LUNG AND AIRWAY DC IN THE NEONATE 111 CONCLUSIONS 112
REFERENCES 112 8. DENDRITIC CELLS IN AUTOIMMUNE DISEASE 117 W. ALLAERTS
AND H.A. DREXHAGE 3.1.2 LYMPHOCYTOTOXIC AND AUTOANTIBODY- INTRODUCTION
117 CLASSIFICATION OF AUTOIMMUNE DISEASES 118 ORGAN-SPECIFIC AUTOIMMUNE
DISEASES 119 3.1 AUTOIMMUNE SKIN DISEASES 119 3.1.1 APC IN AUTOIMMUNE
SKIN DISEASES 120 EPITHELIAL CELL INTERACTIONS IN AUTOIMMUNE SKIN
DISEASES 121 3.2 ENDOCRINE AUTOIMMUNE DISEASES 122 3.2.1
ENDOCRINE-SPECIFIC AUTOANTIBODIES 123 VIII CONTENTS 3.2.2
LYMPHOCYTOTOXIC RESPONSE AND DC IN ENDOCRINE AID 123 3.3 DC IN AID OF
THE LIVER, THE GUT, AND THE URINARY BLADDER 125 4. SYSTEMIC AUTOIMMUNE
DISEASES 127 5. 6. 4.1 DC IN RA 127 4.2 DC IN CONNECTIVE TISSUE DISEASES
OTHER THAN RA 128 SUMMARY 129 REFERENCES 129 9. THE BOLE OF DENDRITIC
CELLS IN TRANSPLANTATION 135 J.A. ROAKE AND J.M. AUSTYN 1. INTRODUCTION
136 2. AN OVERVIEW OF ALLOGRAFT REJECTION 136 2.1 T CELL MEDIATED IMMUNE
RESPONSES 136 2.2 REQUIREMENTS FOR THE ACTIVATION OF T CELLS 137 3. DC:
THE LINEAGE AND THEIR BIOLOGY 138 3.1 LYMPHOID DC 139 3.2 NON-LYMPHOID
DC 139 3.2.1 EPIDERMAL LC 139 3.2.2 DC OF OTHER NON-LYMPHOID TISSUES 140
3.3 THE ROLE OF CYTOKINES IN DC PHYSIOLOGY 142 3.4 CYTOKINES AS
MODULATORS OF DC PHENOTYPE AND FUNCTION 142 3.5 MIGRATORY PATHWAYS OF DC
146 3.6 MIGRATION VIA THE LYMPH 146 3.6.1 DC MIGRATION IN NORMAL LYMPH
146 3.6.2 DC MIGRATION FROM SITES OF INFLAMMATION 147 3.7 MIGRATION VIA
THE BLOOD 147 3.8 REGULATION OF DC MIGRATION 148 3.9 CYTOKINES AS
MEDIATORS OF THE MIGRATION OF NON-LYMPHOID DC 148 3.10 SUMMARY - THE
BIOLOGY OF DC 149 4. PASSENGER LEUCOCYTES AND THE INITIATION OF
ALLOGRAFT REJECTION 149 4.1 THE PASSENGER LEUCOCYTE CONCEPT 149 4.2
MANIPULATION OF PASSENGER LEUCOCYTES BEFORE TRANSPLANTATION: PRIMARILY
NON- VASCULARIZED GRAFTS 149 4.2.1 OVARY 149 4.2.2 THYROID 149 4.2.3
ISLETS OF LANGERHANS 150 4.2.4 THYMUS 150 4.2.5 SKIN 150 5. MANIPULATION
OF PASSENGER LEUCOCYTES BEFORE TRANSPLANTATION: FULLY VASCULARIZED
GRAFTS 151 5.1 DC AS THE SENSITIZING PASSENGER LEUCOCYTES 152 6. SITES
OF SENSITIZATION AFTER TRANSPLANTATION: PERIPHERAL VS. CENTRAL 153 6.1
SKIN GRAFTS 153 6.2 FULLY VASCULARIZED GRAFTS 154 6.3 DC MIGRATION AND
ITS REGULATION AFTER TRANSPLANTATION 154 7. ROUTES OF SENSITIZATION:
DIRECT VS. INDIRECT 156 7.1 THE BASIS OF ALLOREACTIVITY AND THE NATURE
OF TRANSPLANTATION ANTIGENS 156 7.2 THE INDIRECT ROUTE OF SENSITIZATION
156 7.3 RELATIVE CONTRIBUTIONS OF DIRECT AND INDIRECT ALLORECOGNITIORI
IN ALLOGRAFT REJECTION 157 8. THE INFLUENCE OF IMMUNOSUPPRESSION ON DC
FUNCTION IN TRANSPLANTATION 158 9. FUTURE PROSPECTS FOR MANIPULATION OF
DC IN CLINICAL TRANSPLANTATION 158 10. REFERENCES 159 10. CYCLOSPORIN
AND ANTIGEN PRESENTING CELL FUNCTION M.S. ROBERTS AND S.C. KNIGHT 171 3.
CYCLOSPORIN A 171 1.1 SOURCE AND STRUCTURE 171 1.2 IMMUNOSUPPRESSION BY
CSA 171 APC 172 2.1 ANTIGEN PROCESSING AND PRESENTATION 172 EFFECT OF
CSA ON THE FUNCTIONS OF APC 172 3.1 ACCESSORY FUNCTIONS OF APC 172 3.2
ANTIGEN PRESENTATION IN VITRO 173 3.3 DOSIMETRY OF CSA EFFECT ON APC 174
3.4 APC FUNCTION IN VIVO 175 3.5 POSSIBLE MECHANISMS OF ACTION OF CSA
175 4. REFERENCES 178 GLOSSARY 183 KEY TO ILLUSTRATIONS 191 INDEX 197
|
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| indexdate | 2024-07-09T17:38:01Z |
| institution | BVB |
| isbn | 0121378004 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006356286 |
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| physical | XIV, 201 S. Ill., graph. Darst. |
| publishDate | 1994 |
| publishDateSearch | 1994 |
| publishDateSort | 1994 |
| publisher | Acad. Press |
| record_format | marc |
| series2 | The handbook of immunopharmacology |
| spelling | Immunopharmacology of macrophages and other antigen presenting cells ed. by C. A. F. M. Bruijnzeel-Koomen ... London [u.a.] Acad. Press 1994 XIV, 201 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier The handbook of immunopharmacology Literaturangaben Makrophage (DE-588)4193041-1 gnd rswk-swf Immunpharmakologie (DE-588)4026639-4 gnd rswk-swf Makrophage (DE-588)4193041-1 s Immunpharmakologie (DE-588)4026639-4 s DE-604 Bruijnzeel-Koomen, Carla A. F. M. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006356286&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Immunopharmacology of macrophages and other antigen presenting cells Makrophage (DE-588)4193041-1 gnd Immunpharmakologie (DE-588)4026639-4 gnd |
| subject_GND | (DE-588)4193041-1 (DE-588)4026639-4 |
| title | Immunopharmacology of macrophages and other antigen presenting cells |
| title_auth | Immunopharmacology of macrophages and other antigen presenting cells |
| title_exact_search | Immunopharmacology of macrophages and other antigen presenting cells |
| title_full | Immunopharmacology of macrophages and other antigen presenting cells ed. by C. A. F. M. Bruijnzeel-Koomen ... |
| title_fullStr | Immunopharmacology of macrophages and other antigen presenting cells ed. by C. A. F. M. Bruijnzeel-Koomen ... |
| title_full_unstemmed | Immunopharmacology of macrophages and other antigen presenting cells ed. by C. A. F. M. Bruijnzeel-Koomen ... |
| title_short | Immunopharmacology of macrophages and other antigen presenting cells |
| title_sort | immunopharmacology of macrophages and other antigen presenting cells |
| topic | Makrophage (DE-588)4193041-1 gnd Immunpharmakologie (DE-588)4026639-4 gnd |
| topic_facet | Makrophage Immunpharmakologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006356286&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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