Pharmacology of the skin: 1 Pharmacology of skin systems, autocoids in normal and inflamed skin
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1989
|
| Schriftenreihe: | Handbook of experimental pharmacology
87,1 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIX, 510 S. Ill., graph. Darst. |
| ISBN: | 3540194037 0387194037 |
Internformat
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| 245 | 1 | 0 | |a Pharmacology of the skin |n 1 |p Pharmacology of skin systems, autocoids in normal and inflamed skin |c eds. Malcolm W. Greaves ... |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1989 | |
| 300 | |a XXIX, 510 S. |b Ill., graph. Darst. | ||
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| 490 | 1 | |a Handbook of experimental pharmacology |v 87,1 | |
| 490 | 0 | |a Handbook of experimental pharmacology |v ... | |
| 650 | 7 | |a Skin Diseases |2 cabt | |
| 650 | 7 | |a Drug Therapy |2 cabt | |
| 650 | 7 | |a Dermatological Agents |2 cabt | |
| 650 | 4 | |a Farmacología dermatológica | |
| 650 | 4 | |a Piel - Enfermedades | |
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| 700 | 1 | |a Abramson, David I. |d 1905-2002 |e Sonstige |0 (DE-588)131421859 |4 oth | |
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Datensatz im Suchindex
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| adam_text | PHARMACOLOGY OF THE SKIN I PHARMACOLOGY OF SKIN SYSTEMS AUTOCOIDS IN
NORMAL AND INFLAMED SKIN CONTRIBUTORS D. I. ABRAMSON, J. C. ALLEN, H. P.
BADEN, R. C. BENYON, A. G. BIRD, S. D. BRAIN, K. A. BROWN, E.
CHRISTOPHERS, M. K. CHURCH, L. S. CLEGG, K. J. COLLINS, W I. CRANSTON,
R. P. R. DAWBER, D. C. DUMONDE, C. J. DUNN, J. A. EDWARDSON, V EISEN, B.
A. ELLIS, J. C. FOREMAN, M. J. FORREST, M. GOOS, M. W GREAVES, S. T.
HOLGATE, V K. HOPSU-HAVU, A. B. KAY, C. M. LAPIERE, F. LAWLOR, B. LYNN,
P. MAUVAIS-JARVIS, J. MORLEY, B.Y NUSGENS, E.M. SAIHAN, C. SCHUBERT, S.
SHUSTER, A. J. THODY, G. VOLDEN, A. J. WARDLAW, S. I. WASSERMAN, T. J.
WILLIAMS, D. A. WILLOUGHBY, F. WRIGHT, M. A. ZAR, V A. ZIBOH EDITORS
MALCOLM W. GREAVES AND SAM SHUSTER SPRINGER-VERLAG BERLIN HEIDELBERG NEW
YORK LONDON PARIS TOKYO CONTENTS SECTION A: PHARMACOLOGY OF SKIN SYSTEMS
CHAPTER 1 THE EPIDERMIS E. CHRISTOPHERS, C. SCHUBERT, AND M. GOOS. WITH
9 FIGURES 3 A. THE STRUCTURE OF EPIDERMIS 3 I. THE EXTERNAL SURFACE OF
SKIN 3 II. HISTOLOGY OF EPIDERMIS 5 1. INTRODUCTION 5 2. THE BASEMENT
MEMBRANE 6 3. FINE STRUCTURE OF EPIDERMAL CELLS 8 4. LAMELLAR GRANULES
10 5. INTERCELLULAR JUNCTIONS 11 6. REGIONAL DIFFERENCES IN EPIDERMAL
STRUCTURE 13 B. EPIDERMAL REPLACEMENT 14 I. EPIDERMAL RENEWAL RATES 14
II. EFFECTS OF EXTERNAL INFLUENCES 15 III. MIGRATION OUT OF THE BASAL
LAYER 16 IV. THE FORMATION OF EPIDERMAL CELL COLUMNS . . 17 V. THE
ZIPPER MECHANISM LEADING TO COLUMN FORMATION ; . . 19 C. THE
LANGERHANS CELL . 21 I. MORPHOLOGICAL FEATURES 21 II. ORIGIN 24 III.
FUNCTIONAL PROPERTIES 24 IV. ROLE IN DISEASE 24 D. CONCLUSION 25
REFERENCES 25 CHAPTER 2 KERATIN H. P. BADEN. WITH 7 FIGURES 31 A.
INTRODUCTION 31 B. FIBROUS PROTEINS 32 C. KERATOHYALIN 36 XII CONTENTS
D. CORNIFIED ENVELOPE 38 E. DESMOSOMES 40 F. MEMBRANE COATING GRANULES
41 REFERENCES 41 CHAPTER 3 REGULATION OF EPIDERMAL GROWTH E. M. SAIHAN
45 A. CYCLIC NUCLEOTIDES 45 I. EFFECTS OF CYCLIC AMP ON DIFFERENT
EPIDERMAL CELLS 45 II. CYCLIC GMP 47 III. RECEPTORS 47 B. PROSTAGLANDINS
48 C. EPIDERMAL GROWTH FACTOR 49 I. CHEMICAL COMPOSITION AND PROPERTIES
49 II. HUMAN EGF 50 III. LEVEL OF EGF 50 IV. EGF RECEPTOR 50 V. EGF IN
CELL PROLIFERATION AND DIFFERENTIATION 51 D. CHALONES OF THE SKIN 51 E.
CALCIUM AND CALMODULIN 52 F. HISTAMINE 53 G. CONCLUSION 53 REFERENCES 54
CHAPTER 4 EPIDERMAL LIPOGENESIS (ESSENTIAL FATTY ACIDS AND LIPID
INHIBITORS) V. A. ZIBOH. WITH 3 FIGURES I . . 59 A. INTRODUCTION AND
HISTORICAL CONSIDERATIONS 59 B. ESSENTIAL FATTY ACIDS 60 I. BIOSYNTHESIS
AND METABOLISM 60 II. PHYSIOLOGICAL FUNCTIONS IN THE SKIN 60 III. ROLE
AS PRECURSORS OF PROSTAGLANDINS AND RELATED LIPIDS . . . . . 61 C.
ESSENTIAL FATTY ACID DEFICIENCY 61 I. MACROSCOPIC AND MICROSCOPIC
APPEARANCE OF THE SKIN DURING DEFICIENCY 61 II. ALTERED PATTERNS OF
POLYUNSATURATED FATTY ACIDS 62 III. INCREASED METABOLIC ACTIVITY DURING
DEFICIENCY : . 63 IV. DEFICIENCY IN HUMAN SKIN 63 D. EPIDERMAL
LIPOGENESIS AND ITS REGULATION 64 I. INTERRELATIONSHIPS OF METABOLIC
PATHWAYS 64 II. REGULATION OF EPIDERMAL LIPOGENESIS 65 REFERENCES 66
CONTENTS XIII CHAPTER 5 FIBROBLASTS, COLLAGEN, ELASTIN, PROTEOGLYCANS
AND GLYCOPROTEINS C. M. LAPIERE AND B. V. NUSGENS 69 A. INTRODUCTION 69
B. FIBROBLASTS ARE DIFFERENTIATED CELLS 69 C. COLLAGEN 70 I. MOLECULAR
STRUCTURE AND DISTRIBUTION 70 II. BIOSYNTHESIS 73 III. POLYMERISATION 74
IV. DEGRADATION 75 D. ELASTIN 75 I. THE ELASTIC FIBRE 75 II.
BIOSYNTHESIS, POLYMERISATION AND DEGRADATION 76 E. PROTEOGLYCANS AND
GLYCOSAMINOGLYCANS 76 I. MOLECULAR STRUCTURE 76 II. BIOSYNTHESIS,
ORGANISATION AND DEGRADATION 77 F. STRUCTURAL GLYCOPROTEINS 78 I.
FIBRONECTIN, LAMININ, ENTACTIN AND OTHERS 78 II. BIOSYNTHESIS 79 G.
REGULATION AND DISEASES 79 I. FIBROBLASTS 79 II. COLLAGEN 80 III.
ELASTIN 81 IV. PROTEOGLYCANS 82 V. STRUCTURAL GLYCOPROTEINS 82 H.
INTERACTION BETWEEN THE MACROMOLECULES OF THE CONNECTIVE TISSUE . . 83
J. CONCLUSIONS 83 REFERENCES 83 CHAPTER 6 DERMAL BLOOD VESSELS AND
LYMPHATICS D. I. ABRAMSON. WITH 9 FIGURES 89 A. DERMAL BLOOD CIRCULATION
89 I. FUNCTIONS OF DERMAL VASCULAR BED 89 II. ANATOMY OF DERMAL BLOOD
VESSELS 89 1. DISTRIBUTING ARTERIES 90 2. ARTERIOLES AND METARTERIOLES
90 3. CAPILLARY BED 90 4. ARTERIOVENOUS ANASTOMOSES (SHUNTS) 93 5.
VENULES 93 III. PHYSIOLOGY OF DERMAL BLOOD FLOW 96 1. ROLE OF CUTANEOUS
CIRCULATION IN BODY TEMPERATURE REGULATION 96 IV. NEURAL REGULATION OF
DERMAL BLOOD FLOW 96 1. SYMPATHETIC TRUNKS AND POSTGANGLIONIC PATHWAYS
96 XIV CONTENTS 2. ADRENERGIC SYMPATHETIC CONTROL OF DERMAL VESSELS 96
3. ADRENERGIC NEUROEFFECTOR END ORGANS 98 4. CUTANEOUS VASODILATOR
SYMPATHETIC NERVES 99 V. OTHER MECHANISMS FOR REGULATION OF DERMAL BLOOD
FLOW . . .101 1. HORMONAL CONTROL 101 2. LOCAL CONTROL 102 VI.
THERAPEUTIC MODULATION OF DERMAL BLOOD FLOW BY DRUGS . . . 103 1.
VASODILATOR AGENTS 103 2. VASOCONSTRICTOR AGENTS 105 B. DERMAL LYMPHATIC
CIRCULATION 106 I. ANATOMICAL CONSIDERATIONS 107 1. DERMAL LYMPH
CAPILLARIES (INITIAL LYMPHATICS) 107 2. DERMAL COLLECTING LYMPH CHANNELS
AND TRUNKS 108 3. DERMAL LYMPHATIC SYSTEM IN THE LIMBS 109 II.
PHYSIOLOGICAL CONSIDERATIONS 109 1. METHODS FOR STUDY OF LYMPH FLOW 109
2. MECHANISMS INVOLVED IN PASSAGE OF FLUIDS AND PANICULATE MATTER INTO
LYMPHATIC CAPILLARIES 109 3. FACTORS INVOLVED IN TRANSPORT OF LYMPH 110
4. ALTERATIONS IN CONCENTRATION OF LYMPH IN ITS PASSAGE THROUGH THE
LYMPHATICS ILL 5. RESPONSE OF LYMPHATICS TO INFLAMMATION ILL III.
PHARMACOLOGICAL CONSIDERATIONS ILL REFERENCES 112 CHAPTER 7 BLOOD FLOW -
INCLUDING MICROCIRCULATION M. J. FORREST AND T. J. WILLIAMS 117 A.
VISUAL ASSESSMENT 117 B. THERMAL MEASUREMENTS 118 I. THERMOMETRY AND
THERMOGRAPHY 118 II. THERMAL CLEARANCE (CONDUCTANCE) 118 C.
RADIOISOTOPIC TECHNIQUES 119 I. ISOTOPE EXTRACTION . 119 II. CLEARANCE
OF LOCALLY INJECTED RADIOLABELS . 121 D. RED BLOOD CELL VELOCITY
MEASUREMENTS 121 E. DOPPLER SHIFT TECHNIQUES 122 I. ULTRASOUND DOPPLER
122 II. LASER DOPPLER 123 F. PLETHYSMOGRAPHY 123 G. ELECTROMAGNETIC
FLOWMETERS 124 H. CONCLUSION 124 REFERENCES 124 CONTENTS XV CHAPTER 8
IMMUNOPHARMACOLOGY OF MAST CELLS M. K. CHURCH, R. C. BENYON, L. S.
CLEGG, AND S. T. HOLGATE. WITH 10 FIGURES 129 A. MAST CELL CONTENT OF
HUMAN SKIN 130 B. MAST CELL STRUCTURE 130 C. THE ONTOGENY OF MAST CELLS
132 D. PREFORMED GRANULE-ASSOCIATED MEDIATORS 135 I. BIOGENIC AMINES 136
1. HISTAMINE 136 2. 5-HYDROXYTRYPTAMINE 137 II. NEUTRAL PROTEASES 137
III. ACID HYDROLASES 138 IV. OTHER MAST CELL ENZYMES 139 V. CHEMOTACTIC
FACTORS 140 VI. PROTEOGLYCANS 140 E. NEWLY GENERATED INFLAMMATORY
MEDIATORS 142 I. CYCLO-OXYGENASE PRODUCTS OF ARACHIDONIC ACID 142 II.
THE LIPOXYGENASE PATHWAY 145 III. PLATELET ACTIVATING FACTOR 147 F.
MECHANISMS OF MAST CELL ACTIVATION 147 I. MECHANISMS OF IGE-DEPENDENT
MEDIATOR SECRETION FROM MAST CELLS 147 II. HUMAN MAST CELL ACTIVATION BY
IGE-DEPENDENT AND IGE-INDEPENDENT STIMULI 153 G. PHARMACOLOGICAL
MODULATION OF MEDIATOR SECRETION FROM SKIN MAST CELLS 156 H. CONCLUSIONS
158 REFERENCES 158 CHAPTER 9 LYMPHOCYTES J. MORLEY. WITH 3 FIGURES 167
A. INTRODUCTION 167 B. LYMPHOKINES 168 C. LYMPHOKINES AS MEDIATORS OF
CELLULAR IMMUNITY 168 D. REGULATION OF LYMPHOCYTE ACTIVATION 170 I. ROLE
OF ARACHIDONIC ACID 170 II. ROLE OF INTERLEUKINS 172 E. CONCLUSION 173
REFERENCES 173 XVI CONTENTS CHAPTER 10 STRUCTURE, FUNCTION AND CONTROL:
AFFERENT NERVE ENDINGS IN THE SKIN B. LYNN. WITH 1 FIGURE 175 A.
INTRODUCTION 175 B. FIBRE COMPOSITION OF CUTANEOUS NERVES 175 C.
MECHANORECEPTORS 175 I. INTRODUCTION 175 II. RAPIDLY ADAPTING
MECHANORECEPTORS 176 1. PACINIAN CORPUSCLES 176 2. RA AND FIELD
RECEPTORS 176 3. HAIR FOLLICLE RECEPTORS 176 III. SLOWLY ADAPTING
MECHANORECEPTORS 177 1. TYPE SAI 177 2. TYPE SAII 177 3. SLOWLY ADAPTING
HAIR FOLLICLE UNITS 178 4. C-MECHANORECEPTORS 178 IV. SUMMARY 178 D.
THERMORECEPTORS 179 I. COLD UNITS 179 II. WARM UNITS 179 E. NOCICEPTORS
179 I. HIGH THRESHOLD MECHANORECEPTOR UNITS 179 II. POLYMODAL NOCICEPTOR
UNITS 180 F. OVERVIEW: TYPES OF CUTANEOUS MECHANORECEPTOR,
THERMORECEPTOR AND NOCICEPTOR 181 G. MODULATION OF SENSITIVITY OF
CUTANEOUS RECEPTORS BY DRUGS . . . .182 I. INTRODUCTION 182 II.
CATECHOLAMINES 182 1. MECHANORECEPTORS 182 2. THERMORECEPTORS 182 3.
NOCICEPTORS 183 4. NERVE ENDINGS IN NEUROMAS 183 HI. INFLAMMATORY
MEDIATORS .183 1. HISTAMINE 183 2. SEROTONIN 184 3. BRADYKININ 184 4.
PROSTAGLANDINS . 184 5. MEDIATORS AND SENSITISATION 184 IV. OTHER AGENTS
THAT EXCITE CUTANEOUS RECEPTORS 185 1. CAPSAICIN 185 2. SUBSTANCE P 185
3. ACETYLCHOLINE 185 4. OTHER IRRITANTS 186 V. OTHER AGENTS THAT
MODULATE THE RESPONSES OF CUTANEOUS NERVE ENDINGS 187 VI. OVERVIEW:
DRUGS AND CUTANEOUS RECEPTORS 187 REFERENCES 188 CONTENTS XVII CHAPTER
11 SWEAT GLANDS: ECCRINE AND APOCRINE K. J. COLLINS. WITH 4 FIGURES 193
A. ANATOMICAL FEATURES 194 B. FINE STRUCTURE 195 I. ECCRINE GLANDS 195
II. APOCRINE GLANDS 198 C. INNERVATION 200 I. ECCRINE GLANDS 200 II.
APOCRINE GLANDS 201 D. SECRETORY FUNCTION OF ECCRINE GLANDS 202 I. THE
SECRETORY PROCESS AND SWEAT FORMATION 203 E. APOCRINE GLAND FUNCTION 205
F. PHARMACOLOGY OF SWEATING 206 I. ECCRINE GLANDS 206 II. NEUROHUMORAL
ASPECTS 207 1. DENERVATION 207 2. AXON REFLEX SWEATING 207 3.
HYPERHIDROSIS 208 III. APOCRINE GLANDS 208 REFERENCES 209 CHAPTER 12
THERMOREGULATION AND THE SKIN W.I.CRANSTON 213 A. SKIN BLOOD FLOW 213 I.
VASCULAR EFFECTS ON HEAT EXCHANGE 213 II. NERVOUS CONTROL OF CUTANEOUS
BLOOD FLOW 213 III. REFLEX CONTROL OF SKIN BLOOD FLOW . . 215 IV.
CENTRAL CONTROL OF SKIN BLOOD FLOW : . . 215 V. INTERACTIONS BETWEEN
THERMAL RECEPTORS .216 VI. EFFECTS OF LOCAL TEMPERATURE 216 B. SWEATING
217 I. NEURAL, HUMORAL AND LOCAL CONTROL 217 II. ACCLIMATION AND FATIGUE
OF SWEAT GLANDS .218 REFERENCES 218 CHAPTER 13 HAIR AND NAIL R. P. R.
DAWBER. WITH 4 FIGURES 223 A. HAIR FOLLICLE AND HAIR SHAFT 223 I.
FOLLICLE STRUCTURE 223 II. HAIR SHAFT STRUCTURE 226 XVIII CONTENTS III.
HAIR CYCLE 227 IV. ENDOCRINE CONTROL FACTORS 228 B. NAIL APPARATUS 228
REFERENCES 231 CHAPTER 14 THE SEBACEOUS GLANDS A. J. THODY AND S.
SHUSTER 233 A. INTRODUCTION 233 B. DEVELOPMENT 233 C. SEBUM 234 I.
FORMATION 234 II. COMPOSITION 235 III. FUNCTION 235 IV. FACTORS
AFFECTING THE RATE OF SEBUM PRODUCTION 235 D. CONTROL 236 I.
NON-ENDOCRINE CONTROL 236 II. ENDOCRINE CONTROL 237 1. ANDROGENS 237 2.
OESTROGENS 238 3. PROGESTERONE 238 4. GLUCOCORTICOIDS 239 5. THYROID
HORMONES 239 6. INSULIN 239 7. THE PITUITARY 239 8. THE EARLY ENDOCRINE
ENVIRONMENT 242 REFERENCES 242 CHAPTER 15 METABOLISM OF SEX STEROIDS F.
WRIGHT AND P. MAUVAIS-JARVIS. WITH 4 FIGURES 247 A. INTRODUCTION 247 B.
HYDROXYSTEROID DEHYDROGENASE ACTIVITIES 247 I. ANDROGENS 247 1.
DEHYDROEPIANDROSTERONE 247 2. J 4 -ANDROSTENE-3,17-DIONE 247 II.
OESTROGENS 248 III. PROGESTERONE 248 C. 5A-REDUCTION OF TESTOSTERONE AND
PROGESTERONE 248 I. TESTOSTERONE 248 II. PROGESTERONE 249 D. 3A- AND
3/?-HYDROXYSTEROID DEHYDROGENASES 250 I. ANDROGENS 250 II. PROGESTERONE
250 CONTENTS XIX E. NORMAL CONTROL OF ANDROGEN METABOLISM IN HUMAN SKIN
251 F. ABNORMAL CONTROL OF ANDROGEN METABOLISM IN HUMAN SKIN . . . . 251
G. CONCLUSION 253 REFERENCES 253 CHAPTER 16 MELANOPHORES, MELANOCYTES
AND MELANIN: ENDOCRINOLOGY AND PHARMACOLOGY A. J. THODY AND S. SHUSTER.
WITH 2 FIGURES 257 A. PIGMENT CELLS 257 B. DERMAL MELANOPHORES 257 C.
EPIDERMAL MELANOPHORES 258 D. MELANOSOME DISPERSION 258 E. MELANOGENESIS
258 F. MELANOCYTE STIMULATING HORMONE 260 I. PHYSIOLOGICAL SIGNIFICANCE
OF MSH PEPTIDES AS A PIGMENTARY HORMONE IN MAN 263 G. CATECHOLAMINES 264
H. MELATONIN 264 J. STEROIDS 265 K. PROSTAGLANDINS 266 REFERENCES 266
CHAPTER 17 CYTOKINES IN RELATION TO INFLAMMATORY SKIN DISEASE K. A.
BROWN, B. A. ELLIS, AND D. C. DUMONDE 271 A. INTRODUCTION 271 B.
INTERLEUKINS: STRUCTURE AND PHYSICOCHEMICAL PROPERTIES 271 C. BIOLOGICAL
ACTIVITIES OF INTERLEUKINS 273 D. INTERLEUKINS AND NORMAL SKIN **.***
274 E. DERMATOLOGICAL DISORDERS AND IL-1 * * * 275 F. DERMATOLOGICAL
DISORDERS AND IL-2 277 G. DERMATOLOGICAL DISORDERS, INTERLEUKINS, AND
LEUKOCYTE-ENDOTHELIAL INTERACTIONS 278 H. COMMENT 279 REFERENCES 280
SECTION B: AUTOCOIDS IN NORMAL AND INFLAMED SKIN CHAPTER 18 HISTAMINE,
HISTAMINE ANTAGONISTS AND CROMONES J. C. FOREMAN 289 A. INTRODUCTION 289
B. HISTAMINE CONTENT OF SKIN 290 XX CONTENTS C. HISTAMINE-FORMING
CAPACITY IN SKIN 293 D. HISTAMINE CATABOLISM IN SKIN 295 E. THE RELEASE
OF HISTAMINE FROM SKIN 296 F. APPLICATION OF HISTAMINE TO THE SKIN AND
THE PHARMACOLOGICAL MODIFICATION OF ITS EFFECTS 297 I. VASCULAR EFFECTS
297 II. SENSORY EFFECTS 299 III. OTHER EFFECTS 299 IV. ANTI-ALLERGIC
DRUGS 300 G. CLINICAL CONDITIONS ASSOCIATED WITH HISTAMINE IN SKIN 300
H. CONCLUDING REMARKS 301 REFERENCES 301 CHAPTER 19 KALLIKREINS AND
KININS V. EISEN. WITH 4 FIGURES 309 A. INTRODUCTION 309 B. CHEMISTRY AND
BIOLOGICAL ACTIVITIES OF KININS 310 I. PRINCIPAL TYPES OF KININS 310 II.
MECHANISMS OF BIOLOGICAL ACTIONS 311 III. ACTIONS ON BLOOD VESSELS 313
IV. PAIN-PRODUCING EFFECTS 314 V. OTHER ACTIONS OF KININS 315 C. KININ
FORMATION IN MAMMALS 315 I. SPECIFIC AND NON-SPECIFIC KININ-FORMING
ENZYMES 315 II. KININ FORMATION BY PLASMA KALLIKREINS AND OTHER PLASMA
ENZYMES 316 III. KININ FORMATION BY BLOOD CELLS 317 IV. GLANDULAR
KALLIKREINS 318 V. KININ FORMATION IN HUMAN SKIN 318 D. INHIBITORS OF
KININ FORMATION ** * 320 E. FATE IN THE BODY OF FORMED PLASMA KININS 321
F. KININS IN EXPERIMENTAL AND CLINICAL DAMAGE OF HUMAN SKIN . . . . 323
I. ASSESSMENT OF THE ROLE OF KININS 323 II. INFLAMMATION AND RELATED
CONDITIONS 324 G. CONCLUDING REMARKS 325 REFERENCES .327 CHAPTER 20
ACETYLCHOLINE, ATROPINE AND RELATED CHOLINERGICS AND ANTICHOLINERGICS M.
A. ZAR. WITH 3 FIGURES 331 A. CHOLINERGIC AGENTS 331 I. ACETYLCHOLINE
331 1. DISTRIBUTION 331 2. BIOSYNTHESIS AND STORAGE 332 CONTENTS XXI 3.
PHYSIOLOGICAL INACTIVATION 332 4. ACETYLCHOLINE IN SKIN 332 5.
PHARMACOLOGICAL ACTIONS 333 6. FUNCTIONAL SIGNIFICANCE IN SKIN 335 II.
ANTICHOLINESTERASE AGENTS 336 1. PHARMACOLOGICAL ACTIONS 337 III. OTHER
CHOLINOMIMETIC AGENTS 337 1. STABLE ESTERS OF CHOLINE 337 2. PILOCARPINE
338 B. ANTICHOLINERGIC DRUGS 339 I. CHEMISTRY 339 1. BELLADONNA
ALKALOIDS AND THEIR DERIVATIVES 339 2. SYNTHETIC ANTICHOLINERGIC AGENTS
340 II. MECHANISM OF ACTION 340 III. PHARMACOLOGICAL ACTIONS 341 1.
CARDIOVASCULAR SYSTEM 341 2. GASTROINTESTINAL TRACT 341 3. RESPIRATORY
TRACT 341 4. EYE 341 5. URINARY TRACT 341 6. SECRETORY GLANDS 341 7.
CENTRAL NERVOUS SYSTEM 341 8. SKIN 342 IV. ADVERSE EFFECTS 343 V. OTHER
CLASSES OF DRUG POSSESSING PRONOUNCED ANTICHOLINERGIC ACTIVITY 343 1.
HISTAMINE H 1 -RECEPTOR ANTAGONISTS 343 2. TRICYCLIC ANTIDEPRESSANTS 343
3. HALOALKYLAMINE A-ADRENOCEPTOR BLOCKING AGENTS 343 REFERENCES 343
CHAPTER 21 PROSTAGLANDINS, LEUKOTRIENES, RELATED COMPOUNDS AND THEIR
INHIBITORS S. D. BRAIN AND T. J. WILLIAMS. WITH 2 FIGURES 347 A.
DISCOVERY OF THE PROSTAGLANDINS : 347 B. BIOSYNTHESIS OF PROSTAGLANDINS
347 C. ACTION OF PROSTAGLANDINS IN SKIN 349 I. VASODILATATION 349 II.
OEDEMA FORMATION 349 III. LEUKOCYTE ACCUMULATION 351 IV. PAIN 351 D.
GENERATION OF PROSTAGLANDINS IN SKIN 352 E. DISCOVERY OF THE
LIPOXYGENASE PATHWAY 353 F. THE LEUKOTRIENES 354 XXII CONTENTS G. ACTION
OF LIPOXYGENASE PRODUCTS IN SKIN 355 I. VASOACTIVE EFFECTS 355 II.
LEUKOCYTE ACCUMULATION 355 III. OEDEMA FORMATION 356 H. GENERATION OF
LIPOXYGENASE PRODUCTS IN SKIN 357 J. INHIBITORS OF ARACHIDONATE
METABOLISM 358 K. CONCLUSION 360 REFERENCES 361 CHAPTER 22 SLOW REACTING
SUBSTANCE OF ANAPHYLAXIS S. I. WASSERMAN. WITH 1 FIGURE 367 A.
INTRODUCTION 367 B. PHYSICO-CHEMICAL CHARACTERISATION 368 C. FUNCTIONAL
CHARACTERISATION 370 D. INACTIVATION OF SRS-A 371 E. SUMMARY 372
REFERENCES 373 CHAPTER 23 COMPLEMENT A. G. BIRD. WITH 3 FIGURES 377 A.
INTRODUCTION 377 B. THE CLASSICAL PATHWAY 378 C. THE ALTERNATIVE PATHWAY
380 D. TERMINAL EVENTS IN THE COMPLEMENT CASCADE 382 E. BIOLOGICAL
ACTIVITIES RESULTING FROM COMPLEMENT ACTIVATION . . . . 382 I.
DIFFUSIBLE PRODUCTS . 383 II. RETAINED COMPLEMENT PRODUCTS 384 III.
MEMBRANE LYSIS 385 IV. SOLUBILISATION OF IMMUNE COMPLEXES 385 F.
REGULATION OF COMPLEMENT ACTIVATION 386 I. CT INHIBITOR 386 II. C4
BINDING PROTEIN 387 III. FACTORS H AND I 388 G. INHERITED DEFICIENCIES
OF COMPLEMENT COMPONENTS 388 I. BACTERIAL INFECTIONS 389 II.
^AUTO-IMMUNE OR IMMUNE COMPLEX DISEASES 389 H. COMPLEMENT IN SKIN
DISEASE 390 I. IMMUNE COMPLEX DISEASE 390 II. BULLOUS SKIN DISEASES 391
REFERENCES 393 CONTENTS XXIII CHAPTER 24 NEUTROPHIL AND EOSINOPHIL
CHEMOTAXIS AND CUTANEOUS INFLAMMATORY REACTIONS A. J. WARDLAW AND A. B.
KAY 395 A. INTRODUCTION 395 B. METHODS OF MEASURING CHEMOTAXIS AND CELL
ACCUMULATION 396 C. CHEMOTACTIC FACTORS FOR NEUTROPHILS AND EOSINOPHILS
397 I. COMPLEMENT-DERIVED FACTORS 399 II. CELL-DERIVED FACTORS 399 III.
LYMPHOKINES 400 IV. COAGULATION PRODUCTS 401 V. MICRO-ORGANISMS 401 D.
OTHER PROPERTIES OF CHEMOTACTIC FACTORS 401 E. CONTROL OF NEUTROPHIL AND
EOSINOPHIL LOCOMOTION 402 F. DEFECTS IN CHEMOTAXIS 403 I. IMPAIRED
GENERATION OF CHEMOATTRACTANTS 403 II. INHIBITION OF CHEMOTAXIS 403 III.
INTRINSIC DISORDERS OF GRANULOCYTE LOCOMOTION 403 G. SKIN DISEASES
ASSOCIATED WITH NEUTROPHIL INFILTRATION 404 H. SKIN DISEASE ASSOCIATED
WITH EOSINOPHIL INFILTRATION 404 J. CONCLUSIONS 405 REFERENCES 405
CHAPTER 25 NEUROPEPTIDES AND THE SKIN S. D. BRAIN AND J. A. EDWARDSON.
WITH 2 FIGURES 409 A. INTRODUCTION 409 B. BIOCHEMISTRY OF
PEPTIDE-MEDIATED SIGNALLING 410 C. DISTRIBUTION AND FUNCTIONS OF
PEPTIDES IN MAMMALIAN SKIN . . ... .412 I. TACHYKININS AND CGRP ,. . 412
II. VASOACTIVE INTESTINAL PEPTIDE 417 III. OTHER NEUROPEPTIDES 418 IV.
NEUROPEPTIDES AS GROWTH FACTORS? 418 D. CONCLUSIONS AND CLINICAL
IMPLICATIONS 419 REFERENCES 419 CHAPTER 26 POLYAMINES J. C. ALLEN. WITH
1 FIGURE 423 A. OCCURRENCE AND METABOLISM OF POLYAMINES 423 I.
INTRODUCTION 423 II. STRUCTURE AND OCCURRENCE 423 III. POLYAMINE
METABOLISM. 424 XXIV CONTENTS IV. REGULATION OF POLYAMINE BIOSYNTHESIS
425 V. INHIBITORS OF POLYAMINE BIOSYNTHESIS 426 B. POLYAMINES AND GROWTH
426 I. POLYAMINES AND CELL GROWTH 426 II. POLYAMINES AND TISSUE GROWTH
427 III. THE BIOCHEMICAL ROLE OF POLYAMINES 427 C. POLYAMINES AND
HYPERPROLIFERATIVE DISEASES 428 D. POLYAMINES IN SKIN 428 I. INDUCTION
OF POLYAMINE BIOSYNTHESIS IN SKIN 428 1. WOUND HEALING 428 2. EPIDERMAL
GROWTH FACTOR 429 3. ULTRAVIOLET IRRADIATION 429 4. TUMOUR PROMOTERS 430
II. POLYAMINES AND HYPERPROLIFERATIVE DISEASES OF THE SKIN . . . .431 1.
PSORIASIS 431 2. SKIN CANCERS 432 REFERENCES 433 CHAPTER 27 PROTEOLYTIC
ENZYMES IN RELATION TO SKIN INFLAMMATION G. VOLDEN AND V. K. HOPSU-HAVU.
WITH 1 FIGURE 441 A. INTRODUCTION 441 B. PROTEASES OF THE SKIN 441 I.
CLASSIFICATION 441 1. PROTEINASES 441 2. EXOPEPTIDASES 442 II. CELLULAR
LOCALISATION AND FUNCTIONS 443 1. LOCALISATION 443 2. FUNCTIONS . 443
C. PROTEASES IN INFLAMMATORY CELLS 444 I. GRANULOCYTES 444 II.
MACROPHAGES 445 III. OTHER INFLAMMATORY CELLS 446 D. PLASMA-DERIVED
PROTEASES 446 E. PROTEASE INHIBITORS AND ENHANCERS 446 I. PLASMA-DERIVED
INHIBITORS 446 II. INHIBITORS IN SKIN 447 III. PROTEASE ENHANCERS 448 F.
PROTEASES IN DIFFERENT PHASES OF INFLAMMATION 448 I. VASODILATATION AND
EXUDATION 448 II. CHEMOTAXIS 448 III. FIBRIN DEPOSITION AND FIBRINOLYSIS
449 IV. REPAIR AND CHRONIC INFLAMMATION 449 1. REPAIR 449 2. CHRONIC
INFLAMMATION 450 CONTENTS XXV G. INFLAMMATORY SKIN CONDITIONS 450 I.
IMMUNE REACTIONS 450 II. PSORIASIS 451 III. INFECTIONS 452 IV. IONISING
IRRADIATION AND ULTRAVIOLET LIGHT 454 1. IONISING IRRADIATION 454 2.
ULTRAVIOLET LIGHT 454 3. PORPHYRIA 455 H. DEFICIENCIES OF PROTEASES AND
THEIR INHIBITORS 455 I. PROTEASE DEFICIENCIES 455 II. INHIBITOR
DEFICIENCIES 455 J. PROTEASES AND PHARMACEUTICAL AGENTS 456 K.
CONCLUSION 457 REFERENCES 458 CHAPTER 28 THE INFLAMMATORY RESPONSE - A
REVIEW C. J. DUNN AND D. A. WILLOUGHBY 465 A. INTRODUCTION 465 B.
MEDIATORS OF VASCULAR CHANGES 465 C. MEDIATORS OF CELLULAR RESPONSES 466
I. ADHESION 466 II. CHEMOTAXIS AND LEUCOCYTE MIGRATION INHIBITION 468
III. PHAGOCYTOSIS AND RELEASE OF INFLAMMATORY MEDIATORS 470 REFERENCES
471 CHAPTER 29 SPECIFIC ACUTE INFLAMMATORY RESPONSES M. W. GREAVES AND
F. LAWLOR. WITH 5 FIGURES 479 A. INTRODUCTION 479 B. IMMEDIATE WEAL AND
FLARE RESPONSES 479 I. RESPONSES TO INTRADERMAL ANTIGEN INJECTION 480
II. THE URTICARIAS .480 1. PHYSICAL URTICARIAS 480 2. CHRONIC IDIOPATHIC
URTICARIA AND ANGIO-OEDEMA 481 C. DELAYED ACUTE INFLAMMATION 481 I.
ULTRAVIOLET INFLAMMATION 481 1. ULTRAVIOLET B RADIATION 482 2. UV-C
IRRADIATION 483 3. UV-A IRRADIATION 485 II. PHOTOCHEMOTHERAPY (PUVA)
ERYTHEMA 485 III. HEAT-INDUCED INFLAMMATION 486 XXVI CONTENTS IV.
TRAFURIL (TETRAHYDROFURFURYLNICOTINATE) 486 V. CONTACT ALLERGIC
DERMATITIS 488 VI. PRIMARY IRRITANT DERMATITIS 489 VII. ATOPIC
DERMATITIS 489 VIII. PSORIASIS 490 REFERENCES 491 SUBJECT INDEX 495
|
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| author_GND | (DE-588)131421859 |
| building | Verbundindex |
| bvnumber | BV009507904 |
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| id | DE-604.BV009507904 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:36:19Z |
| institution | BVB |
| isbn | 3540194037 0387194037 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006280896 |
| oclc_num | 644464454 |
| open_access_boolean | |
| owner | DE-12 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-20 DE-11 DE-188 DE-578 |
| owner_facet | DE-12 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-20 DE-11 DE-188 DE-578 |
| physical | XXIX, 510 S. Ill., graph. Darst. |
| publishDate | 1989 |
| publishDateSearch | 1989 |
| publishDateSort | 1989 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | Pharmacology of the skin 1 Pharmacology of skin systems, autocoids in normal and inflamed skin eds. Malcolm W. Greaves ... Berlin [u.a.] Springer 1989 XXIX, 510 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 87,1 Handbook of experimental pharmacology ... Skin Diseases cabt Drug Therapy cabt Dermatological Agents cabt Farmacología dermatológica Piel - Enfermedades Greaves, Malcolm W. Sonstige oth Abramson, David I. 1905-2002 Sonstige (DE-588)131421859 oth Atherton, David J. Sonstige oth (DE-604)BV009507903 1 Handbook of experimental pharmacology 87,1 (DE-604)BV002390716 87,1 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006280896&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pharmacology of the skin Handbook of experimental pharmacology Skin Diseases cabt Drug Therapy cabt Dermatological Agents cabt Farmacología dermatológica Piel - Enfermedades |
| title | Pharmacology of the skin |
| title_auth | Pharmacology of the skin |
| title_exact_search | Pharmacology of the skin |
| title_full | Pharmacology of the skin 1 Pharmacology of skin systems, autocoids in normal and inflamed skin eds. Malcolm W. Greaves ... |
| title_fullStr | Pharmacology of the skin 1 Pharmacology of skin systems, autocoids in normal and inflamed skin eds. Malcolm W. Greaves ... |
| title_full_unstemmed | Pharmacology of the skin 1 Pharmacology of skin systems, autocoids in normal and inflamed skin eds. Malcolm W. Greaves ... |
| title_short | Pharmacology of the skin |
| title_sort | pharmacology of the skin pharmacology of skin systems autocoids in normal and inflamed skin |
| topic | Skin Diseases cabt Drug Therapy cabt Dermatological Agents cabt Farmacología dermatológica Piel - Enfermedades |
| topic_facet | Skin Diseases Drug Therapy Dermatological Agents Farmacología dermatológica Piel - Enfermedades |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006280896&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV009507903 (DE-604)BV002390716 |
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