Antimalarial drugs: 1 Biological background, experimental methods, and drug resistance
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1984
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| Schriftenreihe: | Handbook of experimental pharmacology
68,1 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 484 S. Ill., graph. Darst. |
| ISBN: | 3540126163 |
Internformat
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Datensatz im Suchindex
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I ANTIMALARIAL DRUGS I BIOLOGICAL BACKGROUND, EXPERIMENTAL METHODS, AND
DRUG RESISTANCE CONTRIBUTORS A. L. AGER, JR. -V. BOONPUCKNAVIG * S.-C.
CHOU * K. A. CONKLIN D.W.DAVIDSON,JR. * R. E. DESJARDINS * M.FERNEX*
PC.C.GARNHAM H. M. GILLES * M. H. HEIFFER * D.W. KORTE, JR. * M. R. LEVY
G. H. MITCHELL * W. PETERS * S. PUNYAGUPTA * W. H. G. RICHARDS K. H.
RIECKMANN * R. N. ROSSAN * I. W. SHERMAN * T. SRICHAIKUL G. A.T. TARGETT
* D. C. WARHURST EDITORS W. PETERS AND W.H.G. RICHARDS UNIVERSITATS-
BIBLIOTHEK SPRINGER-VERLAG BERLIN HEIDELBERG NEW YORK TOKYO 1984
CONTENTS THE MALARIA PARASITES CHAPTER 1 LIFE CYCLES. P. C. C. GARNHAM.
WITH 4 FIGURES A. INTRODUCTION 3 B. GENERAL CHARACTERS OF PLASMODIUM S.L
4 C. LIFE CYCLE OF PLASMODIUM SPECIES 7 I. LIFE CYCLE IN MAMMALIAN
MALARIA 7 II. LIFE CYCLE IN AVIAN MALARIA 15 III. LIFE CYCLE IN
REPTILIAN MALARIA 18 D. SPECIFIC EXAMPLES 19 I. HUMAN SPECIES OF
PLASMODIUM 20 II. RODENT MALARIA PARASITES 24 III. HEPATOCYSTIS KOCHI
(SYN . PLASMODIUM KOCHI) 25 E. ABNORMAL MODES OF TRANSMISSION 25 I.
INFECTION FROM A BLOOD SOURCE 25 II. TRANSMISSION FROM AN ANIMAL
RESERVOIR 26 III. LIFE CYCLE IN ABNORMAL HOSTS 26 REFERENCES 27 CHAPTER
2 METABOLISM. I. W. SHERMAN. WITH 6 FIGURES A. INTRODUCTION 31 B.
BIOCHEMICAL DETERMINANTS OF PARASITE SPECIFICITY FOR THE HOST CELL . .
31 C. MEMBRANE PROTEINS OF THE INFECTED ERYTHROCYTE 33 D. PLASMODIAL
MEMBRANE PROTEINS 35 E. LIPIDS OF MALARIA-INFECTED ERYTHROCYTES 35 F.
PLASMODIAL MEMBRANE LIPIDS 37 G. METABOLIC PATHWAYS 38 I. CARBOHYDRATE
TRANSPORT AND METABOLISM 38 II. PROTEIN SYNTHESIS 47 III. NUCLEIC ACIDS
51 IV. LIPID BIOSYNTHESIS 59 V. VITAMINS AND COFACTORS 60 X CONTENTS H.
BIOCHEMICAL CHARACTERISTICS OF THE ERYTHROCYTE AND HOST-PARASITE
RELATIONSHIPS 65 I. SICKLE CELL HAEMOGLOBIN 65 II. OTHER HAEMOGLOBINS
AND THALASSAEMIA 66 III. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY
AND REDUCED GLUTATHIONE CONTENT 67 IV. ADENOSINE TRIPHOSPHATE DEFICIENCY
68 J. CATION ALTERATIONS 69 K. CONCLUSION 69 REFERENCES 70 CHAPTER 3 IN
VITRO CULTURE TECHNIQUES. W. H. G. RICHARDS. WITH 1 FIGURE A.
INTRODUCTION 83 B. ASEXUAL INTRAERYTHROCYTIC STAGES 83 I. BASIC PROBLEMS
OF IN VITRO CULTURE 83 II. TECHNIQUES OF CULTIVATION 86 III. DRUG
TESTING 88 IV. NEW DEVELOPMENTS 89 V. CONCLUSION 90 C. TISSUE STAGES 90
I. INTRODUCTION 90 . II. AVIAN STUDIES 90 III. RODENT MODELS 91 D.
GAMETOCYTOGENESIS IN VITRO 92 E. SPOROGONIC STAGES 94 F. CONCLUSIONS 95
REFERENCES 95 HOST RESPONSES TO MALARIA CHAPTER 4 IMMUNITY. G. H.
MITCHELL A. INTRODUCTION 101 B. THE CLINICAL EXPRESSION OF IMMUNITY TO
MALARIA IN MAN 103 C. MALARIA ANTIGENS, THE INDUCTION OF IMMUNITY AND
PROTECTIVE MECHANISMS IN INFECTION AND VACCINATION 104 I. SPECIFICITY OF
ANTIMALARIAL IMMUNE RESPONSES 104 II. IMMUNE RESPONSE TO SPOROZOITES 105
III. IMMUNE RESPONSE TO THE EXOERYTHROCYTIC PHASE 106 IV. IMMUNE
RESPONSE TO THE SEXUAL STAGES 106 V. IMMUNE RESPONSE TO ASEXUAL
ERYTHROCYTIC PARASITES 107 VI. EVASION OF THE IMMUNE RESPONSE ILL VII.
THE ANATOMICAL AND CELLULAR BASES OF IMMUNITY TO MALARIA . . .113
CONTENTS XI D. IMMUNOSTIMULANTS AND IMMUNOLOGICAL ADJUVANTS IN THE
INDUCTION OF IMMUNE RESPONSES TO MALARIA 114 I. DIFFERENTIATION BETWEEN
NON-SPECIFIC IMMUNOSTIMULANT AND ADJUVANT EFFECTS 115 II. MYCOBACTERIA
AND SYNTHETIC ANALOGUES OF THEIR CELL WALL COMPONENTS AS MALARIA VACCINE
ADJUVANTS 116 III. NON-BACTERIAL ADJUVANTS IN MALARIA VACCINES 117
REFERENCES 118 CHAPTER 5 CLINICAL PATHOLOGY. V. BOONPUCKNAVIG, T.
SRICHAIKUL, AND S. PUNYAGUPTA WITH 34 FIGURES A. INTRODUCTION 127 B.
PATHOGENESIS 127 I. THE PARASITES 128 II. HOST-PARASITE INTERACTION 128
C. CLINICOPATHOLOGICAL CORRELATION 131 I. UNCOMPLICATED MALARIA 131 II.
COMPLICATED MALARIA 132 REFERENCES 168 EXPERIMENTAL MODELS CHAPTER 6 IN
VITRO TECHNIQUES FOR ANTIMALARIAL DEVELOPMENT AND EVALUATION R. E.
DESJARDINS. WITH 4 FIGURES A. INTRODUCTION . 179 B. THE ROLE OF IN VITRO
METHODS IN ANTIMICROBIAL DRUG RESEARCH. . . .179 I. ADVANTAGES 180 II.
LIMITATIONS 181 III. SPECIFIC APPLICATIONS TO MALARIA 182 C. SHORT-TERM
IN VITRO CULTURES 183 I. PLASMODIUM KNOWLESI 184 II. PLASMODIUM BERGHEI
186 III. PLASMODIUM FALCIPARUM 189 D. CONTINUOUS CULTURE TECHNOLOGY FOR
PLASMODIUM FALCIPARUM 191 I. IMPROVED EVALUATION AND MONITORING OF DRUG
RESPONSES . . . .191 II. STUDIES ON MODE OF ACTION AND KINETICS 193 III.
A SEMIAUTOMATED TECHNIQUE OF ANTIMALARIAL EVALUATION . . . .195 IV.
OTHER APPLICATIONS 198 E. THE FUTURE ROLE OF IN VITRO TECHNIQUES 199
REFERENCES 201 XII CONTENTS CHAPTER 7 USE OF AVIAN MALARIAS (IN VIVO).
W. H. G. RICHARDS. WITH 1 FIGURE A. INTRODUCTION 207 B. EXPERIMENTAL
HOSTS AND METHODS 208 I. TRANSMISSION BY BLOOD INOCULATION 208 II. DRUG
TESTING 209 C. CHEMOTHERAPY ' 209 I. QUININE 209 II. 4-AMINOQUINOLINES
210 III. 8-AMINOQUINOLINES 211 IV. SULPHONAMIDES AND SULPHONES 213 V.
ANTIFOLATES 215 VI. AMIDINOUREAS 218 VII. QUINOLINEMETHANOLS 220 D.
CONCLUSION 220 REFERENCES 220 CHAPTER 8 RODENT MALARIA MODELS. A. L.
AGER, JR. A. INTRODUCTION 225 B. BLOOD SCHIZONTOCIDES . 226 I.
SINGLE-DOSE REGIMENS 226 II. MULTIPLE-DOSE REGIMENS 228 C. TISSUE
SCHIZONTOCIDES 232 I. MOST'STEST 232 II. BERBERIAN'S TEST 240 III.
VINCKE'S TEST 240 IV. GREGORY AND PETERS' TEST 240 V. HILL'S TEST 246
VI. FINK'S TEST. . . 248 VII. KING'S TEST 250 VIII. RANE AND KINNAMON'S
TEST 250 D. RESIDUAL BLOOD SCHIZONTOCIDES 251 I. SCHNEIDER'S TEST 251
II. THOMPSON'S TEST 252 III. SUSTAINED RELEASE IMPLANT TEST 255 E.
RESIDUAL TISSUE SCHIZONTOCIDES 256 REFERENCES 260 CHAPTER 9 MALARIA
MODELS IN SIMIAN HOSTS. R. N . ROSSAN. WITH 1 FIGURE A. INTRODUCTION 265
B. USE IN BLOOD SCHIZONTOCIDE STUDIES 266 I. SIMIAN PLASMODIA 266 II.
HUMAN PLASMODIA 268 CONTENTS XIII C. USE IN TISSUE SCHIZONTOCIDE STUDIES
273 I. SIMIAN PLASMODIA 273 II. HUMAN PLASMODIA 275 D. CONCLUSION 277
REFERENCES 277 CHAPTER 10 SURROGATE MODELS FOR ANTIMALARIALS. S.-C.
CHOU, K. A. CONKLIN, M. R. LEVY, AND D. C. WARHURST. WITH 13 FIGURES A.
ISOLATED ENZYME SYSTEMS. M. R. LEVY AND S.-C. CHOU 281 I. INTRODUCTION
281 II. EFFECTS OF CHLOROQUINE ON RECEPTOR-MEDIATED ENDOCYTOSIS . . . .
282 III. EFFECTS OF CHLOROQUINE ON UPTAKE AND TRANSPORT OF LYSOSOMAL
ENZYMES 286 IV. PROTEASE INHIBITORS: EFFECTS ON PARASITE PROTEASE AND ON
PARASITE BIOSYNTHETIC PROCESSES AND GROWTH 289 V. SUMMARY 292 B.
PROTOZOA OTHER THAN PLASMODIUM. K. A. CONKLIN AND S.-C. CHOU . . . 292
I. INTRODUCTION 292 II. EXPERIMENTAL MODELS 292 III. CONCLUSION 302 C.
DRUG-INDUCED CLUMPING TEST. D. C. WARHURST 303 I. INTRODUCTION 303 II.
EXPERIMENTAL APPROACH 304 III. ANALYSIS OF AUTOPHAGIC VACUOLE FORMATION
311 IV. INSIGHTS INTO ANTIMALARIAL MODE OF ACTION 318 V. DRUG-SCREENING
APPLICATIONS 321 VI. CONCLUSIONS 322 REFERENCES 322 CHAPTER 11
INTERACTIONS BETWEEN CHEMOTHERAPY AND IMMUNITY. G. A. T. TARGETT WITH 7
FIGURES A. INTRODUCTION 331 B. IMMUNE RESPONSES IN MALARIA 331 I. INNATE
RESISTANCE 331 II. ACQUIRED IMMUNITY 332 C. IMMUNODEPRESSION BY MALARIA
INFECTIONS 333 D. IMMUNE DEPENDENCE OF ANTIMALARIAL CHEMOTHERAPY 334 E.
IMMUNODEPRESSIVE EFFECTS OF ANTIMALARIAL DRUGS 339 F. CHEMOTHERAPY AND
INDUCTION OF IMMUNITY 340 G. IMMUNOPATHOLOGICAL CHANGES IN MALARIA 342
I. TROPICAL SPLENOMEGALY SYNDROME 342 II. RENAL LESIONS 343 III.
CEREBRAL MALARIA 343 XIV CONTENTS H. IMMUNOPOTENTIATION AND CHEMOTHERAPY
343 J. CONCLUSIONS 344 REFERENCES . 345 PRECLINICAL AND CLINICAL TRIAL
TECHNIQUES CHAPTER 12 PRECLINICAL TESTING. M. H. HEIFFER, D. E.
DAVIDSON, JR., AND D. W. KORTE, JR. WITH 1 FIGURE A. INTRODUCTION 351 B.
EFFICACY INVESTIGATIONS 354 I. EMPIRICAL VERSUS RATIONAL DRUG SYNTHESIS
354 II. DRUG-SCREENING MODELS 355 C. BLOOD SCHIZONTOCIDAL TESTING 356 I.
PRIMARY TESTING 356 II. SECONDARY TESTING 357 D. TISSUE SCHIZONTOCIDAL
TESTING 358 E. MISCELLANEOUS MODELS 359 F. TOXICOLOGICAL INVESTIGATIONS
359 I. GENERAL 359 II. ACUTE TOXICITY 361 III. SUBACUTE TOXICITY 361 IV.
CHRONIC TOXICITY 364 G. PHARMACODYNAMIC INVESTIGATIONS 366 H. CONCLUDING
REMARKS 369 REFERENCES 370 CHAPTER 13 CLINICAL TRIALS - PHASES I AND II.
M. FERNEX. WITH 2 FIGURES A. INTRODUCTION 375 I. OBJECTIVES OF TRIALS IN
INDIVIDUAL SUBJECTS 375 II. PREREQUISITES FOR ADMINISTERING A NEW DRUG
IN MAN 376 III. DEFINITION OF PHASES FOR CLINICAL TRIALS 376 IV.
CLASSIFICATION OF ANTIMALARIALS 377 V. RESISTANCE TO SCHIZONTOCIDAL
DRUGS 379 VI. ETHICAL CONSIDERATIONS 379 B. PHASE I 380 I. INITIAL
TRIALS IN VOLUNTEERS 380 II. TOLERANCE AND PHARMACOKINETICS IN THE
TARGET POPULATION . . . . 385 C. PHASE II 386 I. GENERAL CONSIDERATIONS
386 II. TRIALS IN EXPERIMENTALLY INFECTED PATIENTS OR VOLUNTEERS 386
III. TRIALS IN NATURALLY INFECTED SUBJECTS 388 REFERENCES 394 CONTENTS
XV CHAPTER 14 CLINICAL TRIALS - PHASES III AND IV AND FIELD TRIALS M.
FERNEX. WITH 1 FIGURE A. PHASE III 399 I. OBJECTIVE AND DESIGN OF THE
STUDIES 399 II. SELECTION OF PATIENTS AND RISK FACTORS 400 III. SPECIAL
TESTS REQUIRED 401 B. PHASE IV 402 I. SAFETY STUDIES 402 II.
PHARMACOKINETICS 402 III. EFFICACY STUDIES 402 IV. SYMPTOMATIC TREATMENT
OF MALARIA 403 V. CONCLUSION 404 C. FIELD TRIALS 404 I. INTRODUCTION AND
OBJECTIVES 404 II. DESIGN AND SELECTION OF PARTICIPANTS 405 III.
EXTENDED FIELD TRIALS 405 IV. CONCLUSION 407 REFERENCES 408 CHAPTER 15
PHARMACOGENETIC FACTORS IN ANTIMALARIAL DRUG TESTING. H. M. GILLES WITH
4 FIGURES A. RED-CELL GENETIC FACTORS 411 I. THE HAEMOGLOBINOPATHIES 411
II. THALASSAEMIAS 414 III. ENZYME DEFICIENCIES 416 B. ACETYLATOR
PHENOTYPE 418 C. BLOOD GROUPS 419 D. CONCLUSION .419 REFERENCES '. . 419
ANTIMALARIAL DRUG RESISTANCE CHAPTER 16 HISTORY AND CURRENT STATUS OF
DRUG RESISTANCE. W. PETERS WITH 5 FIGURES A. INTRODUCTION 423 B. HISTORY
OF EXPERIMENTAL RESEARCH ON ANTIMALARIAL DRUG RESISTANCE . . 423 I.
DIHYDROFOLATE REDUCTASE INHIBITORS 428 II. NAPHTHOQUINONES AND RELATED
COMPOUNDS 429 III. PRIMAQUINE 429 IV. AMINOALCOHOLS RELATED TO QUININE
429 XVI CONTENTS C. HISTORY OF DRUG RESISTANCE IN MAN 430 I. QUININE AND
4-AMINOALCOHOLS 430 II. MEPACRINE AND 4-AMINOQUINOLINES 431 III.
DIHYDROFOLATE REDUCTASE INHIBITORS 435 IV. PRIMAQUINE AND OTHER
8-AMINOQUINOLINES 437 D. FUTURE PROBLEMS AND PROSPECTS 438 I. BIOLOGICAL
FACTORS IN THE DISSEMINATION OF CHLOROQUINE RESISTANCE 438 II. THE
GEOGRAPHICAL EXTENSION OF CHLOROQUINE RESISTANCE IN P. FALCIPARUM 439 E.
CONCLUSION 439 REFERENCES 440 CHAPTER 17 EVALUATION OF DRUG RESISTANCE
IN MAN. K. H. RIECKMANN WITH 2 FIGURES A. INTRODUCTION 447 B. EVALUATION
OF DRUG RESISTANCE IN VIVO 447 I. RESISTANCE TO CHLOROQUINE 447 II.
RESISTANCE TO OTHER ANTIMALARIALS 449 III. DISADVANTAGES OF IN VIVO
EVALUATION OF DRUG RESISTANCE . . . . 449 C. EVALUATION OF DRUG
RESISTANCE IN VITRO 451 I. MACROTECHNIQUE USING VENOUS BLOOD SPECIMENS
451 II. MICROTECHNIQUE USING CAPILLARY BLOOD SPECIMENS 454 D. MONITORING
OF DRUG RESISTANCE 458 REFERENCES 459 CHAPTER 18 EXPERIMENTAL PRODUCTION
OF DRUG RESISTANCE. W. PETERS WITH 7 FIGURES A. INTRODUCTION 461 B.
MODES OF DRUG RESISTANCE DEVELOPMENT 462 C. TECHNIQUES 463 I. IN VITRO
PROCEDURE 463 II. SEMI IN VITRO TECHNIQUES 464 III. TISSUE CULTURE 464
IV. IN VIVO TECHNIQUES 465 V. INDIRECT METHODS 471 D. CONCLUSION 471
REFERENCES 472 SUBJECT INDEX 475 |
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| spelling | Antimalarial drugs 1 Biological background, experimental methods, and drug resistance ed.: W. Peters ... Berlin [u.a.] Springer 1984 XVIII, 484 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 68,1 Handbook of experimental pharmacology 68 Antimalarials cabt Antiprotozoal Agents cabt Peters, Wallace Sonstige oth Ager, A. L. Sonstige oth Baurain, R. Sonstige oth (DE-604)BV009392884 1 Handbook of experimental pharmacology 68,1 (DE-604)BV002390716 68,1 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006231385&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Antimalarial drugs Handbook of experimental pharmacology Antimalarials cabt Antiprotozoal Agents cabt |
| title | Antimalarial drugs |
| title_auth | Antimalarial drugs |
| title_exact_search | Antimalarial drugs |
| title_full | Antimalarial drugs 1 Biological background, experimental methods, and drug resistance ed.: W. Peters ... |
| title_fullStr | Antimalarial drugs 1 Biological background, experimental methods, and drug resistance ed.: W. Peters ... |
| title_full_unstemmed | Antimalarial drugs 1 Biological background, experimental methods, and drug resistance ed.: W. Peters ... |
| title_short | Antimalarial drugs |
| title_sort | antimalarial drugs biological background experimental methods and drug resistance |
| topic | Antimalarials cabt Antiprotozoal Agents cabt |
| topic_facet | Antimalarials Antiprotozoal Agents |
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