Molecular genetics of sex determination:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego [u.a.]
Acad. Press
1994
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 518 S. Ill., graph. Darst. |
| ISBN: | 0127289607 |
Internformat
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| 245 | 1 | 0 | |a Molecular genetics of sex determination |c ed. by Stephen S. Wachtel |
| 264 | 1 | |a San Diego [u.a.] |b Acad. Press |c 1994 | |
| 300 | |a XVIII, 518 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Sex Determination |2 cabt | |
| 650 | 7 | |a Genetics |2 cabt | |
| 650 | 7 | |a Molecular Biology |2 cabt | |
| 650 | 7 | |a Chromosomes sexuels |2 ram | |
| 650 | 7 | |a Différenciation sexuelle |2 ram | |
| 650 | 7 | |a Détermination génétique du sexe |2 ram | |
| 650 | 7 | |a Geslachtsbepaling |2 gtt | |
| 650 | 7 | |a Geslachtschromosomen |2 gtt | |
| 650 | 4 | |a Chromosomes |x physiology | |
| 650 | 4 | |a Sex Determination (Genetics) | |
| 650 | 4 | |a Sex Reversal, Gonadal | |
| 650 | 4 | |a Sex chromosomes | |
| 650 | 4 | |a Sex determination, Genetic | |
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| 700 | 1 | |a Wachtel, Stephen S. |e Sonstige |4 oth | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-006188977 | ||
Datensatz im Suchindex
| _version_ | 1804123741839425536 |
|---|---|
| adam_text | Molecular Genetics
of Sex Determination
ill
Edited by
Stephen S Wachtel
Division of Reproductive Genetics
Depanment of Obstetria and Gynecology
University of Tennessee Memphis
Memphis Tennessee
UP)
Academic Press, Inc
A Division of Har court Brace amp;f Company
San Diego I New York • Boston
London • Sydney • Tokyo • Toronto
Contents
in
Contributors xiii
Preface xvii
1 The Search for the Male-Determining Gene 1
Stephen S Wachtel and Terrence R Tiersch
I Introduction 2
II H-Y Antigen 3
III Bkm Satellite DNA 5
IV The Zinc Finger Y Gene {ZFY) 8
V The Sex-Determining Region Y Gene (SRY) 14
VI SRY and the Search for TDF 16
VII TDF in Normal and Abnormal Sex Determination 18
VIII Summary 19
References 19
2 The Cloning of SRY 23
Andrew H Sinclair
I Mammalian Sex Determination 24
II The Human Y Chromosome 24
III Early Candidates for TDF 25
IV Searching for TDF on the Human y Chromosome 25
V Walking on the Y Chromosome: Identification of ZFY 26
VI Difficulties in Equating ZFY and TDF: The Role of
Marsupials 28
VII Reevaluation of the Y-Chromosome Deletion Map 28
VIII Mapping the Sex-Determining Region 29
IX SRY, A New Candidate for TDF 29
X Sequence Analysis of SR Y 32
XI Tissue Distribution and Expression of SRY 33
I v I
vl III Contents
XII Genetic Evidence Equating SRY and TDF:
Analysis of XY Females 35
XIII SRY Is the Testis-Determining Gene 38
References 39
3 The Mouse Y Chromosome 43
John Gubbay and Robin Lovell-Badge
I Introduction 44
II Sex Reversed (Sxr) 44
III The Role of Yq in Spermatogenesis 51
IV What Can We Learn from the Human
Y Chromosome? 52
V The Sry Gene 54
References 62
4 XX Sex Reversal in the Mouse 69
Anne McLaren
I Introduction 70
II Discovery of Sxr 70
III Male-Specific Antigen 71
IV Sex Reversal Sex-Reversed 72
V A Variant Sxr Fragment 73
VI DNA Fingerprinting of Sxr 74
VII Location of Tdy on the Mouse Y Chromosome 75
VIII Recombination with Sxr 76
IX Spermatogenesis Gene in Sxr 76
X Zinc Finger Genes in Sxr 78
References 79
5 XY Sex Reversal in the Mouse 83
Claude M Nagamine
I Introduction 84
II X¥ Sex Reversal 85
III XYd Sex Reversal 87
IV Conclusions 99
References 100
6 Conservation of the X-Linkage Group in Toto by All
Eutherian Mammals 107
Susumu Ohno
I Introduction 108
II Beginning of the Realization 108
, C on tentsIII Vfl
III Of Glucose-6-Phosphate Dehydrogenases and Mules,
Hinnies, and Hares 110
IV Of Tfm Loci, Androgen Receptors, and X-Linked
Genes for Primary Sex Determination 111
V Lazarus in Evolution: Resurrection of Trichrome
Vision in Higher Primates by Atavistic Mutations 114
VI Summary 119
References 120
7 X-Chromosome Inactivation 123
Mary F Lyon
I Early History of X-Chromosome Inactivation 124
II Early Ideas on Mechanisms 127
III Further Developments 129
IV Initiation and Maintenance of X-Inactivation 131
V Summary of Current Knowledge of X-Inactivation 132
VI Recent Developments 133
VII Conclusion 138
References 138
8 Sex Determination in Marsupials and Monotremes 143
Gregory K Hampikian, Desmond W Cooper, and
Jennifer A Marshall Graves
I Introduction 144
II Marsupial Development and the Experimental
Potential of Australian Mammals 144
III Mammalian Sex Differentiation: Conservation and
Divergence 147
IV Evolution of the Mammalian Sex Chromosomes 149
V Marsupials and the Quest for the Testis Determinant 154
VI Analysis of the Marsupial SRY Gene 159
VII Discussion • 160
References 166
9 The Feminine Mystique: The Initiation of
Sex Determination in Drosophila 171
CUdre Cronmiller and Helen K Salz
I Introduction 172
II Regulation of Somatic Sex Determination 173
III Regulation of Germline Sex Determination 195
IV Conclusion 198
References 198
Viil III Contents
10 The Human Y Chromosome 205
Ulrich Midler
I Introduction 206
II Deletion Mapping of the Testis-Determining
Locus (TDF) 207
III Testis-Determining Region of Yp 210
IV Preferential Breakage Site on Yp Involved in
the Origin of XX Males 212
V Sequences from Yq in an XX Male (No 102) 213
VI The Spermatogenesis Locus of Yq 216
VII X-Y Homologous Genes 218
VIIL Summary 219
References 220
11 DNA Sequence Homology between the
Human Sex Chromosomes 225
Nabeel A Affara and Malcolm A Ferguson-Smith
I
II
III
IV
V
XX Sex
Stephen
I
II
III
IV
V
VI
Introduction
The Pseudoautosomal Region
X-Y Homology in the Differential Region of
the Y Chromosome
Evolution of Sex Chromosome Homologies
Conclusion
References
Reversal in the Human
5 Wachtel
Introduction
XX Males
XX True Hermaphrodites
Familial Occurrence of XX Male Syndrome and
XX True Hermaphroditism: The Syndromes as
Alternative Faces of the Same Coin
Molecular Genetics of XX Sex Reversal
Conclusions
References
13 XY Sex Reversal in the Human 287
Stephen S Wachtel and Joe Leigh Simpson
I Introduction 288
II The Syndrome 289
Contents III fx
III
IV
V
VI
VII
VIII
Genetic Basis of XY Gonadal Dysgenesis
SRY and the Molecular Genetics of XY
Gonadal Dysgenesis
Interaction between SRY and Downstream Genes
Germ Cell Tumors in XY Gonadal Dysgenesis
Related Syndromes
Conclusions
References
14 Phenotypic Correlations of X-Chromosome Loss 311
E Kirk Neely and Ron G Rosenfeld
I Historical Introduction 312
II Major Features of Turner Syndrome 312
III Phenotype-Karyotype Correlations 325
IV Evidence from X-Chromosome Deletions and
Translocations 326
V X-Chromosome Loss and the Y Chromosome 329
VI Recent Molecular Approaches to the
Phenotype-Genotype Problem 331
VII Conclusion 333
References 334
15 Molecular Genetics of Androgen Insensitivity
Syndromes in Humans 341
Leonard Pinsky, Mark Trifiro, Lenore K Beitel, and
Morris Kaufman
I Introduction 342
II The Androgen-Response Apparatus 342
III Androgen Insensitivity 344
IV Structure-Function Organization of the Human
Androgen-Receptor Gene and Its Product 348
V Genotype-Phenotype Correlation of Androgen-
Receptor Gene Mutation in Humans 354
VI Conclusions 360
References 360
16 Male Pseudohermaphroditism 367
Milo Zachmann
I Introduction 368
II Defects of Testosterone Biosynthesis 369
XIII Contents
III Defect of Testosterone Metabolism
(5a-Reductase Deficiency) 376
IV Testicular Dysgenesis and Leydig Cell Aplasia
or Hypoplasia 378
V MPH in Various Syndromes 379
VI Recent Developments in Molecular Biology
Related to MPH 380
VII Importance for the Clinician and Conclusions 385
References 385
17 Molecular Genetics of Steroid
21 -Hydroxylase Deficiency 399
Maria I New and Christopher Crawford
I Cortisol Biosynthesis: Enzymes and Defects 400
II Clinical Forms of 21-Hydroxylase Deficiency 406
III Genes for Steroid 21-Hydroxylase
(Cytochrome P450c21) 411
IV Mutations and Rearrangements 415
V Summary 433
References 434
18 The Gene for Anti-Miillerian Hormone 439
Nathalie Josso, Sandrine Imbeaud, Jean-Yves Picard, and
Richard L Cate
I Introduction 440
II The AMH Gene Product 440
III Structure of the AMH Gene 442
IV Expression of the AMH Gene 444
V AMH Gene Mutations 448
References 451
19 Mullerian-lnhibiting Substance: Critical Roles in
Sexual Differentiation 457
Michael L Gustafson and Patricia K Donahoe
I Introduction 458
II Biochemistry of MIS 458
III Ontogeny of MIS 465
IV Regulation of MIS Expression 468
V Biological Roles for MIS 478
VI Antiproliferative Effects of MIS 486
Con tentsIII xl
VII Studies on Human MIS
VIII Summary 4 9 1
References 4 9 3
Index
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| spelling | Molecular genetics of sex determination ed. by Stephen S. Wachtel San Diego [u.a.] Acad. Press 1994 XVIII, 518 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Sex Determination cabt Genetics cabt Molecular Biology cabt Chromosomes sexuels ram Différenciation sexuelle ram Détermination génétique du sexe ram Geslachtsbepaling gtt Geslachtschromosomen gtt Chromosomes physiology Sex Determination (Genetics) Sex Reversal, Gonadal Sex chromosomes Sex determination, Genetic Geschlechtschromosom (DE-588)4157012-1 gnd rswk-swf Geschlechtsbestimmung (DE-588)4139674-1 gnd rswk-swf Molekulargenetik (DE-588)4039987-4 gnd rswk-swf Geschlechtschromosom (DE-588)4157012-1 s Geschlechtsbestimmung (DE-588)4139674-1 s DE-604 Molekulargenetik (DE-588)4039987-4 s Wachtel, Stephen S. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006188977&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular genetics of sex determination Sex Determination cabt Genetics cabt Molecular Biology cabt Chromosomes sexuels ram Différenciation sexuelle ram Détermination génétique du sexe ram Geslachtsbepaling gtt Geslachtschromosomen gtt Chromosomes physiology Sex Determination (Genetics) Sex Reversal, Gonadal Sex chromosomes Sex determination, Genetic Geschlechtschromosom (DE-588)4157012-1 gnd Geschlechtsbestimmung (DE-588)4139674-1 gnd Molekulargenetik (DE-588)4039987-4 gnd |
| subject_GND | (DE-588)4157012-1 (DE-588)4139674-1 (DE-588)4039987-4 |
| title | Molecular genetics of sex determination |
| title_auth | Molecular genetics of sex determination |
| title_exact_search | Molecular genetics of sex determination |
| title_full | Molecular genetics of sex determination ed. by Stephen S. Wachtel |
| title_fullStr | Molecular genetics of sex determination ed. by Stephen S. Wachtel |
| title_full_unstemmed | Molecular genetics of sex determination ed. by Stephen S. Wachtel |
| title_short | Molecular genetics of sex determination |
| title_sort | molecular genetics of sex determination |
| topic | Sex Determination cabt Genetics cabt Molecular Biology cabt Chromosomes sexuels ram Différenciation sexuelle ram Détermination génétique du sexe ram Geslachtsbepaling gtt Geslachtschromosomen gtt Chromosomes physiology Sex Determination (Genetics) Sex Reversal, Gonadal Sex chromosomes Sex determination, Genetic Geschlechtschromosom (DE-588)4157012-1 gnd Geschlechtsbestimmung (DE-588)4139674-1 gnd Molekulargenetik (DE-588)4039987-4 gnd |
| topic_facet | Sex Determination Genetics Molecular Biology Chromosomes sexuels Différenciation sexuelle Détermination génétique du sexe Geslachtsbepaling Geslachtschromosomen Chromosomes physiology Sex Determination (Genetics) Sex Reversal, Gonadal Sex chromosomes Sex determination, Genetic Geschlechtschromosom Geschlechtsbestimmung Molekulargenetik |
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