Immunopharmacology of the heart:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Acad. Press
1993
|
| Schriftenreihe: | The handbook of immunopharmacology
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | X, 146 S. Ill., graph. Darst. |
| ISBN: | 0122002458 |
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Datensatz im Suchindex
| _version_ | 1804123709570547712 |
|---|---|
| adam_text | 3-2.3 ^- IMMUNOPHARMACOFOFFY THE HEART EDITED BY MICHAEL J. CURTIS
KING S COLLEGE, LONDON, UK ACADEMIC PRESS HARCOURT BRACE AND COMPANY,
PUBLISHERS LONDON SAN DIEGO NEW YORK BOSTON SYDNEY TOKYO TORONTO
CONTENTS CONTRIBUTORS IX SERIES PREFACE XI PREFACE XN 1. DISEASES OF THE
HEART: OVERVIEW AND IDENTIFICATION OF POSSIBLE TARGETS FOR
IMMUNOPHARMACOLQGICAL INTERVENTION 1 R. FERRARI, C. CECONI, L. COMINI,
A. ALBERTINI AND O. VISIOLI 1. INTRODUCTION 1 2. ACUTE RHEUMATIC FEVER 1
3. MYOCARDITIS 2 4. PERICARDITIS 3 5. CARDIAC TRANSPLANT REJECTION 3 6.
VASCULITIS 3 7. ACQUIRED IMMUNODEFICIENCY SYNDROME 4 8. IMMUNE CYTOKINES
AND CARDIAC DISEASE IN GENERAL 4 9. REFERENCES 5 2. METHODS FOR
EVALUATING CARDIAC FUNCTION 7 MICHAEL K. PUGSLEY AND M.J.A. WALKER
INTRODUCTION 7 3.1 1.1 IMMUNOLOGY AND CARDIAC FUNCTION 7 1.2 EVALUATION
OF CARDIAC FUNCTION 8 1.2.1 MECHANICS 8 1.2.2 ELECTROPHYSIOLOGY 8 1.2.3
FLOW 9 1.2.4 BIOCHEMISTRY 9 1.2.5 ANATOMY 9 4. CHOICE OF CARDIAC TISSUE
FOR STUDY 9 2.1 IMMUNOLOGICALLY CHALLENGED CARDIAC TISSUE 9 2.2
TRANSPLANTED CARDIAC TISSUE 10 5. 2.3 NORMAL CARDIAC TISSUE 11 6.
METHODS USED TO DETERMINE CARDIAC FUNCTION IN 7. INTACT ANIMALS AND
INTACT HEARTS 11 CARDIAC OUTPUT, CARDIAC CHAMBER PRESSURES AND CORONARY
FLOW (INVASIVE AND NON-INVASIVE) 11 3.2 ELECTROPHYSIOLOGICAL METHODS 14
3.3 INDUCTION OF ARRHYTHMIAS 15 3.4 INDUCTION OF MYOCARDIAL ISCHAEMIA
AND INFARCTION 16 ISOLATED CARDIAC TISSUE PREPARATIONS 17 4.1 ISOLATED
AND CULTURED HEART CELLS 17 4.2 ISOLATED CARDIAC TISSUES IN VITRO 18 4.3
ISOLATED WHOLE HEARTS 19 SUMMARY 21 ACKNOWLEGEMENTS 22 REFERENCES 22 3.
IMMUNOPHARMACOHGY OF THE CORONARY VASCULAR ENDOTHELIUM 29 ALLAN M. LEFER
1. NORMAL FUNCTION AND PATHOPHYSIOLOGICAL ALTERATION OF THE CORONARY
ENDOTHELIUM 29 2. ENDOTHELIALLY DERIVED ADHESION AND ANTI-ADHESION
MOLECULES 30 2.1 ADHESION MOLECULES 30 2.2 ANTI-ADHESION MOLECULES 31
2.3 THE EDRF/NO SYSTEM 32 THE CORONARY ENDOTHELIUM IN DISEASE PROCESSES
AND ITS IMMUNOPHARMACOLOGY 32 3.1 MYOCARDIAL ISCHAEMIA - REPERFUSION AND
THE CORONARY ENDOTHELIUM 33 3.2 ANGIOPLASTY AND RESTENOSIS 37 VI
CONTENTS 3.3 HYPERCHOLESTEROLAEMIA AND ATHEROSCLEROSIS 37 4. SUMMARY AND
CONCLUSIONS 38 5. ACKNOWLEDGEMENT 39 6. REFERENCES 39 4. THE BOLE OF
MACROPHAGES AND THE MODIFICATION OFLDL IN THE PATHQGENESIS OF
ATHEROSCLEROSIS 43 VICTOR M. DARLEY-USMAR AND DAVID G. HASSALL 1 .
INTRODUCTION 43 2. NORMAL ARTERY, FATTY STREAKS AND FIBROUS PLAQUE 44 3.
MACROPHAGES IN THE VESSEL WALL 44 3.1 MONOCYTE ADHERENCE 45 3.2 FOAM
CELLS AND MODIFIED LDL 45 4. MECHANISMS OF LDL MODIFICATION 47 5. 4.1
LIPID PEROXIDATION IN THE LDL PARTICLE 47 6. 4.2 MECHANISMS OF
INITIATION AND PROPAGATION OF LIPID PEROXIDATION 49 4.3 THE BIOLOGICAL
PROPERTIES OF OXIDIZED LDL 50 4.4 THE IMMUNOLOGICAL PROPERTIES OF
OXIDIZED LDL 50 INHIBITION OF FOAM CELL FORMATION 50 REFERENCES 51 5.
THE BOLE OF LEUKOCYTES IN ISCHAEMIC HEART DISEASE 55 MARK L. ENTMAN,
GILBERT L. KUKIELKA, CHRISTIE M. BALLANTYNE AND C. WAYNE SMITH 1.
INTRODUCTION: REACTION TO INJURY IN ISCHAEMIA AND REPERFUSION 55 4. 2.
ISCHAEMIA: REPERFUSION INJURY AND ITS AETIOLOGY 56 2.1
PATHOPHYSIOLOGICAL PARADIGM 56 2.2 THE EFFECT OF ANTI-NEUTROPHIL THERAPY
ON ISCHAEMIA-REPERFUSION INJURY 57 3. FACTORS CONTRIBUTING TO NEUTROPHIL
LOCALIZATION IN ISCHAEMIC AND REPERFUSED HEARTS 58 3.1 TRAPPING OF
LEUKOCYTES IN THE MICRO VESSELS 58 3.2 INTERCELLULAR ADHESION AND
INFLAMMATORY INJURY - CD18 AND THE LEUKOCYTE B2 5. INTEGRINS 59 3.3 THE
ALPHA SUBUNIT OF LEUKOCYTE INTEGRINS AND THEIR SPECIFICITY FOR
CD18-DEPENDENT 6. FUNCTIONS 59 3.3.1 ALPHA SUBUNIT SPECIFICITY AND
INTERCELLULAR ADHESION 60 3.3.2 ALPHA SUBUNIT SPECIFICITY AND NEUTROPHIL
MIGRATION 61 3.3.3 LEUKOCYTE INTEGRINS AND ADHESION- DEPENDENT
CYTOTOXICITY-MAC-1 ADHESION TO PARENCHYMAL (MYOCYTE) 7. ICAM-1 61 3.4
THE SELECTIN FAMILY OF ADHESION LIGANDS - POTENTIAL ROLE IN ISCHAEMIA 62
3.4.1 P-SELECTIN 63 8. 3.4.2 E-SELECTIN 63 9. 3.4.3 L-SELECTIN 63
CHEMOTACTIC FACTORS - SIGNALS THAT INITIATE INFLAMMATION IN ISCHAEMIA -
REPERFUSION INJURY 63 4.1 COMPLEMENT ACTIVATION 63 4.2 LIPID-DERIVED
AUTACOIDS 64 4.3 REACTIVE OXYGEN SPECIES AS CHEMOTACTIC ACTIVATORS 65
4.3.1 EVIDENCE FOR P-SELECTIN UP REGULATION 65 4.3.2 PAF PRODUCTION AND
OXIDATIVE STRESS 66 POTENTIAL MECHANISMS OF NEUTROPHIL-INDUCED
PARENCHYMAL INJURY IN ISCHAEMIA-REPERFUSION INJURY 66 THE CELL BIOLOGY
OF INFLAMMATORY INJURY IN ISCHAEMIA-REPERFUSION: A WORKING HYPOTHESIS 67
6.1 CHEMOTAXIS 67 6.2 NEUTROPHIL ADHESION TO ENDOTHELIUM 68 6:3 CYTOKINE
STIMULATION OF ADHESION MOLECULE SYNTHESIS 68 6.4 CYTOTOXICITY OF
NEUTROPHILS 69 THERAPEUTIC INTERVENTION INTO THE REACTION TO INJURY: A
CELL BIOLOGICAL APPROACH 69 7.1 ANTI-COMPLEMENT APPROACHES 69 7.2
ANTI-ADHESION APPROACHES 70 SUMMARY 70 REFERENCES 70 CONTENTS VII 6.
COMPLEMENT ACTIVATION IN CARDIAC DISEASE 75 ROGER D. ROSSEN 4. EFFECTS
OF INTRACARDIAC COMPLEMENT ACTIVATION 78 1. INTRODUCTION 75 2. WHAT ARE
THE CHARACTERISTICS OF ISCHAEMIC HEART TISSUE THAT MAKE IT A
PARTICULARLY EFFICIENT NON- IMMUNE ACTIVATOR OF THE COMPLEMENT CASCADE?
75 3. MECHANISMS LIKELY TO PROMOTE RELEASE OF COMPLEMENT-FIXING CARDIAC
SUBCELLULAR ORGANELLES DURING ISCHAEMIC INJURY 78 6. 7. 8. INFLUENCES
WHICH MAY PROTECT CARDIAC TISSUES AGAINST THE POWERFUL EFFECTOR
MECHANISMS RELEASED BY COMPLEMENT ACTIVATION 81 SUMMARY 83
ACKNOWLEDGEMENTS 83 REFERENCES 83 7. PREVENTION OF SUDDEN CARDIAC DEATH
BY IMMUNOPHARMACOLOGICAL INTERVENTION 87 MICHAEL J. CURTIS 1. ABSTRACT
87 2. SUDDEN CARDIAC DEATH 87 3. MECHANISM OF ARRHYTHMOGENESIS IN
ISCHAEMIA, INFARCTION AND REPERFUSION 88 4. NATURAL HISTORY OF
ARRHYTHMOGENESIS IN ISCHAEMIC HEART DISEASE 89 5. PHASE-1, PHASE-2 AND
REPERFUSION ARRHYTHMIAS: ROLE OF THE IMMUNE SYSTEM 90 6. PROPOSED
CRITERIA FOR EVALUATING THE ROLE OF COMPONENTS OF THE IMMUNE SYSTEM IN
ARRHYTHMOGENESIS 91 7. PAF (AND PLATELETS) 92 8. PROSTAGLANDINS AND
THROMBOXANES 93 9. LEUKOTRIENES 94 10. 5-HT 94 11. HISTAMINE 95 12. FREE
RADICALS (*) 96 13. FUTURE CONSIDERATIONS 96 14. CONCLUSION 96 15.
ACKNOWLEDGEMENTS 96 16. REFERENCES 97 8. INFLAMMATORY MEDIATORS AND THE
STUNNED MYOCARDIUM 101 GARRETT J. GROSS 1. INTRODUCTION 101 1.1 STUNNED
MYOCARDIUM 101 2. ROLE OF NEUTROPHILS 101 3. ROLE OF ARACHIDONIC ACID
PATHWAY 3.1 CYCLO-OXYGENASE 102 3.2 THROMBOXANE (TXA2) 103 3.3
PROSTAGLANDINS 104 3.3.1 ILOPROST 104 102 3.3.2 PROSTAGLANDIN EI (PGEI)
106 3.4 LEUKOTRIENES 106 4. PAF 106 5. CORTICOSTEROIDS 107 5.1
METHYLPREDNISOLONE 107 6. CONCLUSIONS 107 7. REFERENCES 108 9.
IMMUNOTHERAPY AND BEPERFUSION INJURY IN THE HEART 109 TSUTOMU YAMAZAKI,
YOSHINORI SEKO, RYOZO NAGAI AND YOSHIO YAZAKI 1. INTRODUCTION 109 2.
MATERIALS AND METHODS 111 2.1 MONOCLONAL ANTIBODIES 111 2.2 SURGICAL
PROCEDURES 111 2.3 IMMUNOHISTOCHEMICAL STUDY 111 2.4 ANTIBODY TREATMENT
STUDY 111 2.5 STATISTICAL ANALYSES 111 3. RESULTS AND DISCUSSION 111 4.
5. 3.1 3.2 LEUKOCYTE INFILTRATION INTO THE REPERFUSED MYOCARDIUM 111
EXPRESSION OF ICAM-1 ON VASCULAR ENDOTHELIAL CELLS 112 3.3 ANTIBODY
TREATMENT STUDY 114 CONCLUSIONS 114 REFERENCES 115 VIII CONTENTS 10.
IMMUNOPHARMACOLQGY OF HEART TRANSPLANTATION 117 S. NYULASSY, J. SLEZAK
AND T. RAVINGEROVA 1. INTRODUCTION 117 2. IMMUNOLOGY OF REJECTION 2.1
ACUTE REJECTION 118 118 2.1.1 IMMUNOLOGY 118 2.1.2 PATHOLOGY 118 2.1.2.1
EFFECT OF REJECTION ON THE CONDUCTING SYSTEM 121 2.1.2.2 EFFECT OF
TREATMENT 121 2.2 HYPERACUTE REJECTION 121 2.3 CHRONIC REJECTION 121
2.3.1 IMMUNOLOGY 121 2.3.2 PATHOLOGY 121 2.4 IMMUNOGENETICS OF HEART
TRANSPLANTATION 122 2.4.1 MAJOR HISTOCOMPATIBILITY COMPLEX 122 2.5
DIAGNOSIS OF REJECTION 122 2.5.1 CLINICAL ASSESSMENT 122 2.5.2
MYOCARDIAL BIOPSY 122 THERAPY OF REJECTION 122 3.1 IMMUNOSUPPRESSIVE
CHEMOTHERAPY 123 3.1.1 CLASSIC IMMUNOSUPPRESSION 123 3.1.1.1
GLUCOCORTICOSTEROIDS 123 3.1.1.2 AZATHIOPRINE 123 3.1.2 CYDOSPORIN A 123
3.1.3 NEW DRUGS 123 3.2 POLYCLONAL AND MONOCLONAL ANTIBODIESL23 3.2.1
ANTI-LYMPHOCYTE ANTIBODIES 123 3.2.2 MONOCLONAL ANTIBODIES (MABS) 124
3.3 THERAPEUTIC STRATEGIES 124 3.3.1 OTHER AGENTS 124 FURTHER
IMMUNOLOGICALLY RELEVANT PROBLEMS 124 4.1 IMMUNOSUPPRESSION AND
INFECTION 124 4.2 GRAFT ATHEROSCLEROSIS 124 4.3 POST-TRANSPLANT
LYMPHOPROLIFERATIVE DISEASE 125 PERSPECTIVES 125 REFERENCES 126 GLOSSARY
129 KEY TO ILLUSTRATIONS 135 INDEX 141
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| id | DE-604.BV009261418 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:34:05Z |
| institution | BVB |
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| language | English |
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| physical | X, 146 S. Ill., graph. Darst. |
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| series2 | The handbook of immunopharmacology |
| spelling | Immunopharmacology of the heart ed. by Michael J. Curtis London [u.a.] Acad. Press 1993 X, 146 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier The handbook of immunopharmacology Literaturangaben Hart- en vaatziekten gtt Immunologie gtt Adjuvants, Immunologic therapeutic use Cardiovascular pharmacology Heart Diseases immunology Heart Diseases therapy Heart Diseases Immunotherapy Heart Effect of drugs on Immunity drug effects Immunopharmacology Transplantation Immunology Immunpharmakologie (DE-588)4026639-4 gnd rswk-swf Herz (DE-588)4024632-2 gnd rswk-swf Herz (DE-588)4024632-2 s Immunpharmakologie (DE-588)4026639-4 s DE-604 Curtis, Michael J. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006163098&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Immunopharmacology of the heart Hart- en vaatziekten gtt Immunologie gtt Adjuvants, Immunologic therapeutic use Cardiovascular pharmacology Heart Diseases immunology Heart Diseases therapy Heart Diseases Immunotherapy Heart Effect of drugs on Immunity drug effects Immunopharmacology Transplantation Immunology Immunpharmakologie (DE-588)4026639-4 gnd Herz (DE-588)4024632-2 gnd |
| subject_GND | (DE-588)4026639-4 (DE-588)4024632-2 |
| title | Immunopharmacology of the heart |
| title_auth | Immunopharmacology of the heart |
| title_exact_search | Immunopharmacology of the heart |
| title_full | Immunopharmacology of the heart ed. by Michael J. Curtis |
| title_fullStr | Immunopharmacology of the heart ed. by Michael J. Curtis |
| title_full_unstemmed | Immunopharmacology of the heart ed. by Michael J. Curtis |
| title_short | Immunopharmacology of the heart |
| title_sort | immunopharmacology of the heart |
| topic | Hart- en vaatziekten gtt Immunologie gtt Adjuvants, Immunologic therapeutic use Cardiovascular pharmacology Heart Diseases immunology Heart Diseases therapy Heart Diseases Immunotherapy Heart Effect of drugs on Immunity drug effects Immunopharmacology Transplantation Immunology Immunpharmakologie (DE-588)4026639-4 gnd Herz (DE-588)4024632-2 gnd |
| topic_facet | Hart- en vaatziekten Immunologie Adjuvants, Immunologic therapeutic use Cardiovascular pharmacology Heart Diseases immunology Heart Diseases therapy Heart Diseases Immunotherapy Heart Effect of drugs on Immunity drug effects Immunopharmacology Transplantation Immunology Immunpharmakologie Herz |
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