The biology of life span: a quantitative approach
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English Russian |
| Veröffentlicht: |
Chur u.a.
Harwood
1991
|
| Ausgabe: | Rev. and updated Engl. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Aus dem Russ. übers. - EST: Biologija prodobzitel'nosti zizni <engl.> |
| Beschreibung: | VII, 385 S. graph. Darst. |
| ISBN: | 3718649837 |
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Datensatz im Suchindex
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| adam_text | THE BIOLOGY OF LIFE SPAN
A Quantitative Approach
Leonid A ^lavrilov
A N Belozerskii Laboratory of Molecular Biology and Bioorganic Chemistry,
Moscow State University, USSR
and
Natalia S Gavrilova
All-Union Institute for Medical Information, Moscow, USSR
Revised and Updated
English Edition
Edited by
Academician V P Skulachev
Translated from the Russian by
John and Liliya Payne
harwood academic publishers
chur • london • paris • new york • melbourne
CONTENTS
Preface 1
Acknowledgements 3
Chapter 1 Introduction 5
1 1 Why is it necessary to study life span? 5
1 2 Short history of the subject 10
1 3 The present state of the discipline IS
Chapter 2 Individual Differences in Lifetime 21
2 1 Where should the study of life span begin? 21
2 2 Individual differences - the key issue in the
biology of life span 22
2 3 The nature of variability in lifetimes 31
2 4 In search of the life span distribution law 39
2 5 The Gompertz-Makeham law 50
2 6 Unresolved issues and problems 61
Chapter 3 The Human Life Span 64
3 1 Specific questions connected with research into the
human life span 64
3 2 Regularities of human mortality 67
3 3 The biological characteristics of the human life span 72
3 4 The epidemiological approach to studying the
biology of the human life span 86
3 5 Prospects for human life span extension 106
v
vi CONTENTS
Chapter 4 Species-specific Life Span 117
4 1 Review of ideas about species-specific life span 117
4 2 Is there a species-specific life span limit? 125
4 3 The concept of species-specific life span
invariants 132
4 4 The Strehler-Mildvan correlation 141
4 5 The compensation effect of mortality 148
Chapter 5 The Search for the Mechanisms Which
Determine Life Span 157
51A self-destruction program or wear and tear? 157
5 2 Analysis of inter-species differences in the
duration of life 165
5 3 Analysis of intra-species differences in the
duration of life 175
5 4 Analysis of sex differences in lifetimes 182
5 5 Experiments in life extension 205
5 6 The limit of cell division: the key to the
mechanism which determines life span? 210
5 7 Reliability theory: the methodological foundation
for research into the mechanisms which determine
life span 225
Chapter 6 Mathematical Models of Life Span 232
61- Introduction 232
6 2 The need for a critical attitude to mathematical
models of life span 235
6 3 Limiting distributions of the life spans of
biological systems 240
6 4 The model of the avalanche-like destruction of
an organism in natural aging 246
6 5 The model of a multiply redundant system
saturated with defects 252
6 6 The model of a redundant system with an arbitrary
number of defects 258
6 7 The heterogeneous population model 264
CONTENTS vii
6 8 The model of accumulation of defects with
constant intensity of the flow of damage 272
6 9 The problem of the diversity of causes of death
and their interaction 276
6 10 Concluding remarks 285
Conclusion 290
Appendix 1 List of published animal life tables 293
Appendix 2
Table A Features which show a positive correlation
with the life span of organisms 310
Table B Features which show a negative correlation
with the life span of organisms 317
Table C Features which show a weak correlation with
the life span of organisms 322
References 326
Subject Index 367
|
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| language | English Russian |
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| spelling | Gavrilov, Leonid A. Verfasser aut The biology of life span a quantitative approach Leonid A. Gavrilov and Natalia S. Gavrilova Rev. and updated Engl. ed. Chur u.a. Harwood 1991 VII, 385 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Aus dem Russ. übers. - EST: Biologija prodobzitel'nosti zizni <engl.> Longévité - Aspect physiologique Longévité - Aspect physiologique ram Longevity Physiological aspects Longevity physiology Lebenserwartung (DE-588)4167016-4 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf Lebenserwartung (DE-588)4167016-4 s Physiologie (DE-588)4045981-0 s DE-604 Gavrilova, Natalia S. Verfasser aut HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005939347&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gavrilov, Leonid A. Gavrilova, Natalia S. The biology of life span a quantitative approach Longévité - Aspect physiologique Longévité - Aspect physiologique ram Longevity Physiological aspects Longevity physiology Lebenserwartung (DE-588)4167016-4 gnd Physiologie (DE-588)4045981-0 gnd |
| subject_GND | (DE-588)4167016-4 (DE-588)4045981-0 |
| title | The biology of life span a quantitative approach |
| title_auth | The biology of life span a quantitative approach |
| title_exact_search | The biology of life span a quantitative approach |
| title_full | The biology of life span a quantitative approach Leonid A. Gavrilov and Natalia S. Gavrilova |
| title_fullStr | The biology of life span a quantitative approach Leonid A. Gavrilov and Natalia S. Gavrilova |
| title_full_unstemmed | The biology of life span a quantitative approach Leonid A. Gavrilov and Natalia S. Gavrilova |
| title_short | The biology of life span |
| title_sort | the biology of life span a quantitative approach |
| title_sub | a quantitative approach |
| topic | Longévité - Aspect physiologique Longévité - Aspect physiologique ram Longevity Physiological aspects Longevity physiology Lebenserwartung (DE-588)4167016-4 gnd Physiologie (DE-588)4045981-0 gnd |
| topic_facet | Longévité - Aspect physiologique Longevity Physiological aspects Longevity physiology Lebenserwartung Physiologie |
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