Immunopharmacology of mast cells and basophils:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Acad. Press
1993
|
| Schriftenreihe: | The handbook of immunopharmacology
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | X, 232 S. Ill., graph. Darst. |
| ISBN: | 0122622103 |
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Datensatz im Suchindex
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A S~- ^ 2 L -I IMMUNOPHAMACOLOJ$ MAST CELLS AND BASOPHILS EDITED BY JOHN
C. FOREMAN UNIVERSITY COLLEGE LONDON, LONDON, UK ACADEMIC PRESS HARCOURT
BRACE AND COMPANY, PUBLISHERS LONDON SAN DIEGO NEW YORK BOSTON SYDNEY
TOKYO TORONTO CONTENTS CONTRIBUTORS IX SERIES PREFACE XI PREFACE XII 1.
INTRODUCTION TO MAST CELLS AND BASOPHILS 1 JOHN C. FOREMAN 2.
DEVELOPMENT OF MAST CELLS AND BASOPHILS 5 YUKIHIKO KITAMURA, TSUTOMU
KASUGAI, SHINTARO NOMURA AND HIROSHI MATSUDA INTRODUCTION 5 DEVELOPMENT
OF MAST CELLS 6 2.1 USEFUL MUTANT ANIMALS 6 2.1.1 BEIGE MICE AND RATS 6
2.1.2 W MUTANT MICE AND WS MUTANT RATS 7 2.1.3 SI MUTANT MICE 9 2.1.4
MI/MI MICE 9 2.2 CULTURE OF MAST CELLS 9 2.2.1 SUSPENSION CULTURE 9
2.2.2 CLONAL CULTURE 10 2.3 DIFFERENTIATION PROCESS 11 2.4 REGULATION OF
DEVELOPMENT 11 2.4.1 T CELL-DEPENDENT DEVELOPMENT 11 2.4.1.1 IL-3 12
2.4.1.2 IL-4 12 2.4.1.3 IL-9 12 2.4.1.4 IL-10 12 4. 5. 6. 2.4.2
FIBROBLAST-DEPENDENT PROLIFERATION 12 2.4.2.1 COCULTUREOFMASTCELLSAND
FIBROBLASTS 13 2.4.2.2 MOLECULAR MECHANISMS 13 2.4.2.3 DEVELOPMENT OF
HUMAN MAST CELLS 15 2.5 EFFECT OF MICROENVIRONMENT ON PHENOTYPES 16
2.5.1 IN VIVO MICROENVIRONMENT 16 2.5.2 IN VITRO MICROENVIRONMENT 17 2.6
INHIBITION OF DEVELOPMENT 17 DEVELOPMENT OF BASOPHILS 18 3.1
DIFFERENTIATION PROCESS 18 3.2 REGULATION OF DEVELOPMENT 18 CONCLUDING
REMARKS 19 ACKNOWLEDGEMENTS 19 REFERENCES 19 3. MAST CELL HETEROGENEITY
29 KIM E. BARRETT AND FREDERICK L. PEARCE INTRODUCTION 29 1.1
DEFINITIONS AND NOMENCLATURE 29 MAST CELL GROWTH AND DIFFERENTIATION 30
2.1 MAST CELL PRECURSORS 30 2.2 MAST CELL GROWTH FACTORS 30 2.3 ROUTE TO
MAST CELL SUBPOPULATIONS 31 2.3.1 DEVELOPMENT OF MAST CELL SUBTYPES VIA
MATURATION 31 2.3.2 LINEAGE AS A ROUTE TO MAST CELL SUBTYPES 32 4. 5. 6.
EXPRESSION OF MAST CELL HETEROGENEITY 33 3.1 HISTOCHEMICAL
CHARACTERISTICS 33 3.2 MEDIATORS 33 3.3 FUNCTIONAL ASPECTS 36
IMPLICATIONS OF MAST CELL HETEROGENEITY 37 ACKNOWLEDGEMENTS 38
REFERENCES 38 VI CONTENTS 4. THE HIGH-AFFINITY IGE RECEPTOR GOTTFRIED
ALBER AND HENRY METZGER 43 1. INTRODUCTION 43 5. 2. THE GENES FOR THE
SUBUNITS 43 2.1 CHROMOSOMAL LOCALIZATION 43 2.2 GENOMIC ORGANIZATION 44
3. RECEPTOR EXPRESSION 44 3.1 DEVELOPMENTAL ASPECTS 44 3.2 BIOSYNTHESIS
44 3.3 EXPRESSION OF TRANSFECTED RECEPTORS 44 3.3.1 WILD-TYPE RECEPTORS
44 3.3.2 MUTANT RECEPTORS 44 4. STRUCTURE OF THE RECEPTOR 45 4.1
INDIVIDUAL SUBUNITS 45 4.1.1 THE A SUBUNIT 45 4.1.2 THE (3 SUBUNIT 45
4.1.3 THE 7 SUBUNIT 46 6. 4.2 COMPARISON WITH OTHER FC RECEPTORS 46 7.
STRUCTURE*FUNCTION RELATIONSHIPS 47 5.1 INTERACTION WITH IGE 47 5.1.1
GENERAL CHARACTERISTICS OF THE BINDING REACTION 47 5.1.2 SPECIFICITY 47
5.1.3 STOICHIOMETRY 47 5.1.4 SITES OF INTERACTION ON IGE; CONFORMATIONAL
CHANGES 47 5.1.5 SITES OF INTERACTION ON THE RECEPTOR 47 5.2 RECEPTOR
ACTIVATION 48 5.2.1 AGGREGATION AS THE INITIATING EVENT 48 5.2.2
SEQUELAE OF RECEPTOR ACTIVATION 48 CONCLUDING REMARKS 51 REFERENCES 51
5. NON-IMMUNOLVGICAL STIMULI OF MAST CELLS AND BASOPHIL LEUCOCYTES JOHN
C. FOREMAN 57 1. INTRODUCTION 57 2. PEPTIDES AND POLYBASIC COMPONENTS 57
2.1 COMPOUND 48/80 57 2.2 PEPTIDES FROM THE CH4 DOMAIN OF IGE 59 2.3
NEUROPEPTIDES 59 2.4 OTHER PEPTIDES 62 3. 4. 5. 6. 7. 8. ANAPHYLATOXINS
INTERLEUKINS 63 DEXTRAN 63 LECTINS 64 PROBES OF SIGNAL REFERENCES 65 62
TRANSDUCERS 65 6. SIGNAL-TRANSMISSION PATHWAYS IN MAST CELL EXOCYTOSIS
RONIT SAGI-EISENBERG 71 1. MAST CELLS AS A MODEL SYSTEM FOR THE STUDY OF
EXOCYTOSIS 71 2. MAST CELL SECRETAGOGUES 71 3. MAST CELL ACTIVATION 72
3.1 ROLE OF PHOSPHATIDYLINOSITOL (PI) HYDROLYSIS IN EXOCYTOSIS 72 3.2
ROLE OF CA 2+ IN THE CONTROL OF EXOCYTOSIS 73 3.3 ROLE OF IP3 IN
EXOCYTOSIS 74 3.4 ROLE OF PKC IN THE CONTROL OF EXOCYTOSIS 75 3.5
ADDITIONAL SIGNALS INVOLVED IN EXOCYTOSIS 77 3.6 ACTIVATION OF PLA2 AND
THE GENERATION OF AA AND ITS METABOLITES 77 3.7 ROLE OF PLD IN
EXOCYTOSIS 78 3.8 ROLE OF SERINE PROTEASES IN EXOCYTOSIS 78 3.9 ROLE OF
TYROSINE PHOSPHORYLATION IN EXOCYTOSIS 78 4. ROLE OF G-PROTEINS IN THE
CONTROL OF EXOCYTOSIS 79 4.1 ROLE OF G-PROTEINS IN ACTIVATING AND
REGULATING PIP2 BREAKDOWN 79 4.2 ROLE OF G-PROTEINS IN MAST CELL
DEGRANULATION 80 4.3 ACTIVATION OF GE BY BASIC SECRETAGOGUES OF MAST
CELLS 80 4.4 GE IS A PTX-SENSITIVE SUBSTRATE 82 4.5 ROLE OF PROTEIN
DEPHOSPHORYLATION IN EXOCYTOSIS: A POSSIBLE EFFECTOR SYSTEM FOR G E 82
5. SUMMARY 82 6. ACKNOWLEDGEMENT 83 7. REFERENCES 83 CONTENTS VII 7.
ULTRASTRUCTURAL ANALYSIS OF ANAPHYLACTIC AND PIECEMEAL DEGRANULATION OF
HUMAN MAST CELLS AND BASOPHILS 89 ANN M. DVORAK 1. INTRODUCTION 89 2.
HUMAN BASOPHILS 90 2.1 GENERAL ULTRASTRUCTURAL ANATOMY 2.2 PIECEMEAL
DEGRANULATION 90 2.3 ANAPHYLACTIC DEGRANULATION 97 3. HUMAN MAST CELLS
103 90 4. 5. 6. 3.1 GENERAL ULTRASTRUCTURAL ANATOMY 103 3.2 PIECEMEAL
DEGRANULATION 103 3.3 ANAPHYLACTIC DEGRANULATION 103 SUMMARY 109
ACKNOWLEDGEMENTS 110 REFERENCES 110 8. MAST CELL-DERIVED MEDIATORS 115
RAUNO J. HARVIMA AND LAWRENCE B. SCHWARTZ 1. INTRODUCTION 115 2.
MEDIATORS DERIVED FROM MAST CELLS AND BASOPHILS 115 2.1 PREFORMED
GRANULE-ASSOCIATED MEDIATORS 115 2.1.1 BIOGENIC AMINES 115 2.1.2 NEUTRAL
PROTEINASES 118 2.1.3 PROTEOGLYCANS 122 2.2 NEWLY GENERATED LIPID
MEDIATOR'S SYNTHESIZED FROM ARACHIDONIC ACID 4. 2.2.1 PROSTAGLANDIN D2
124 2.2.2 LEUKOTRIENES 125 2.2.3 PLATELET-ACTIVATING FACTOR 127 2.3
CYTOKINES 128 MEDIATORS AS CLINICAL INDICATORS OF MAST CELL AND BASOPHIL
INVOLVEMENT IN DISEASE 128 REFERENCES 129 123 9. DRUGS MODIFYING THE
RESPONSES OF MAST CELLS AND BASOPHILS YOSHIMICHI OKAYAMA AND MARTIN K.
CHURCH 139 1. INTRODUCTION 139 4. 2. DISPERSAL AND PURIFICATION OF MAST
CELLS AND 5. ASSESSMENT OF MEDIATOR RELEASE 139 6. 3. SODIUM
CROMOGLYCATE AND NEDOCROMIL 7. SODIUM 140 8. 3.1 POSSIBLE MECHANISMS OF
ACTION OF SCG AND NEDOCROMIL 142 /3-ADRENOCEPTOR AGONISTS 144
METHYLXANTHINES 144 ANTIHISTAMINES 144 CONCLUSIONS 148 REFERENCES 148
10. CUTANEOUS BASOPHIL HYPERSENSITIVITY * A TWENTY-YEAR PERSPECTIVE,
1970 TO 1990 153 ANN M. DVORAK AND HAROLD F. DVORAK 1. INTRODUCTORY
REMARKS 153 2. HISTORICAL PERSPECTIVE 154 3. DIFFERENCE BETWEEN
CUTANEOUS BASOPHIL HYPERSENSITIVITY AND DELAYED HYPERSENSITIVITY 154 4.
BASOPHIL TISSUE INFILTRATION IN MULTIPLE SPECIES, ORGANS, DISEASES AND
CIRCUMSTANCES 156 5. LACK OF SPECIFICITY OF THE MAJORITY OF BASOPHILS IN
CBH FOR SENSITIZING ANTIGEN 156 6. REGULAR PASSIVE TRANSFER OF CBH BY
APPROPRIATELY SENSITIZED LYMPH NODE CELLS 160 7. IMPORTANT INTERACTIONS
BETWEEN BASOPHILS AND LYMPHOCYTES IN CBH 160 7.1 INDUCTION OF CBH 160
7.2 CYTOKINES THAT AFFECT BASOPHIL FUNCTION 162 10. 11. 12. 7.2.1
BASOPHIL CHEMOTACTIC FACTOR 162 7.2.2 BASOPHIL MOTILE CONFIGURATION
FACTOR 162 7.2.3 HISTAMINE RELEASE FROM BASOPHILS EXPOSED TO LYMPHOCYTE
AND OTHER CELLULAR PRODUCTS 163 7.2.4 OTHER LYMPHOCYTE PRODUCTS 163
CRITERIA FOR MORPHOLOGICAL IDENTIFICATION OF BASOPHILS IN MULTIPLE
MAMMALIAN SPECIES 164 PMD IS A BASOPHIL RELEASE REACTION UNIQUELY
PRESENT IN CBH AND TISSUE BASOPHILS IN VIVO 168 SUMMARY 170
ACKNOWLEDGEMENTS 173 REFERENCES 173 VIII CONTENTS 11. MAST CELLS AND THE
LUNG C.P. PAGE AND E. MINSHALL 181 12. PLATELET ACTIVATING FACTOR 185
PROTEOGLYCANS 185 NEUTRAL PROTEASES 186 CYTOKINES 186 MAST CELL
INVOLVEMENT IN ASTHMA REFERENCES 188 MAST CELLS IN THE GASTROINTESTINAL
TRACT 197 H.R.P. MILLER 1. 2. 3. 4. 5. INTRODUCTION 181 EVIDENCE FOR
MAST CELL ACTIVATION IN ASTHMA 182 HISTAMINE 182 PROSTAGLANDIN D2 184
LIPOXYGENASE METABOLITES OF ARACHIDONIC ACID METABOLISM 184 6. 7. 8. 9.
10. 11. 186 197 INTRODUCTION AND HISTORICAL PERSPECTIVE MAST CELL
HETEROGENEITY 198 2.1 BIOCHEMISTRY AND HISTOCHEMISTRY OF GRANULE
GLYCOSAMINOGLYCANS 199 HETEROGENEITY OF GRANULE PROTEASE EXPRESSION 199
HETEROGENEITY AMONGST ISOLATED INTESTINAL MAST CELL SUBPOPULATIONS:
COMPARISON WITH BMMCS 202 SIGNALS THAT RECRUIT INTESTINAL MAST CELLS 203
3.1 IN VIVO ANALYSIS 203 2.2 2.3 6. 7. 3.2 IN VITRO CHARACTERIZATION OF
FACTORS CONTROLLING MAST CELL GROWTH 204 PHYSIOLOGICAL ROLE OF
GASTROINTESTINAL MAST CELLS 205 GASTROINTESTINAL MAST CELLS IN DISEASE
208 5.1 HELMINTHIASIS 208 5.2 ENTERIC AND SYSTEMIC ANAPHYLAXIS 208 5.3
CLINICAL DISEASES OF THE GI TRACT 209 CONCLUSIONS 210 REFERENCES 210
GLOSSARY 217 KEYS TO ILLUSTRATIONS 223 INDEX 229 |
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| spelling | Immunopharmacology of mast cells and basophils ed. by John C. Foreman London [u.a.] Acad. Press 1993 X, 232 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier The handbook of immunopharmacology Literaturangaben Basofiele granulocyten gtt Farmacologie gtt Immunologie gtt Mestcellen gtt Basophils Immunology Basophils physiology Mast Cells physiology Mast cells Immunology Mastzelle (DE-588)4194827-0 gnd rswk-swf Immunpharmakologie (DE-588)4026639-4 gnd rswk-swf Basophile Zelle (DE-588)4232590-0 gnd rswk-swf Basophile Zelle (DE-588)4232590-0 s Immunpharmakologie (DE-588)4026639-4 s DE-604 Mastzelle (DE-588)4194827-0 s Foreman, John C. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005876743&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Immunopharmacology of mast cells and basophils Basofiele granulocyten gtt Farmacologie gtt Immunologie gtt Mestcellen gtt Basophils Immunology Basophils physiology Mast Cells physiology Mast cells Immunology Mastzelle (DE-588)4194827-0 gnd Immunpharmakologie (DE-588)4026639-4 gnd Basophile Zelle (DE-588)4232590-0 gnd |
| subject_GND | (DE-588)4194827-0 (DE-588)4026639-4 (DE-588)4232590-0 |
| title | Immunopharmacology of mast cells and basophils |
| title_auth | Immunopharmacology of mast cells and basophils |
| title_exact_search | Immunopharmacology of mast cells and basophils |
| title_full | Immunopharmacology of mast cells and basophils ed. by John C. Foreman |
| title_fullStr | Immunopharmacology of mast cells and basophils ed. by John C. Foreman |
| title_full_unstemmed | Immunopharmacology of mast cells and basophils ed. by John C. Foreman |
| title_short | Immunopharmacology of mast cells and basophils |
| title_sort | immunopharmacology of mast cells and basophils |
| topic | Basofiele granulocyten gtt Farmacologie gtt Immunologie gtt Mestcellen gtt Basophils Immunology Basophils physiology Mast Cells physiology Mast cells Immunology Mastzelle (DE-588)4194827-0 gnd Immunpharmakologie (DE-588)4026639-4 gnd Basophile Zelle (DE-588)4232590-0 gnd |
| topic_facet | Basofiele granulocyten Farmacologie Immunologie Mestcellen Basophils Immunology Basophils physiology Mast Cells physiology Mast cells Immunology Mastzelle Immunpharmakologie Basophile Zelle |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005876743&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT foremanjohnc immunopharmacologyofmastcellsandbasophils |