Release and bioavailability of ibuprofen from hard gelatin capsules containing different diluents:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
1993
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Helsinki, Univ., Diss., 1993 |
| Beschreibung: | Getr. Zählung Ill., graph. Darst. |
| ISBN: | 9529046073 |
Internformat
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Datensatz im Suchindex
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| adam_text | - 00 3 PHARMACEUTICAL TECHNOLOGY DIVISION DEPARTMENT OF PHARMACY,
UNIVERSITY OF HELSINKI HELSINKI, FINLAND RELEASE AND BIOAVAILABILITY OF
IBUPROFEN FROM HARD GELATIN CAPSULES CONTAINING DIFFERENT DILUENTS SAIJA
OJANTAKANEN ACADEMIC DISSERTATION TO BE PRESENTED, WITH THE PERMISSION
OF THE FACULTY OF SCIENCE OF THE UNIVERSITY OF HELSINKI, FOR PUBLIC
CRITICISM IN AUDITORIUM XII ON MAY 28TH, 1993, AT 12 NOON. HELSINKI 1993
CONTENTS PAGE ACKNOWLEDGEMENTS 7 ABSTRACT 8 LIST OF ORIGINAL
PUBLICATIONS 9 ABBREVIATIONS 10 1. INTRODUCTION 11 2. AIMS OF THE STUDY
13 3. MATERIALS AND METHODS 14 3.1. MODEL DRUG (II-VI) 14 3.2. DILUENTS
(I-VI) 14 3.3. CAPSULE FORMULATIONS (I-VI) 17 3.3.1. FORMULATIONS FOR
TESTS OF IN VITRO DISSOLUTION AND IN VIVO BIOAVAILABILITY (II-VI) 17
3.3.2. FORMULATIONS FOR STUDIES OF IN VIVO DISINTEGRATION (I) 17 3.4.
DISSOLUTION TESTS IN VITRO (II, III, IV, VI) 18 3.5. IN VIVO
DISINTEGRATION OF CAPSULES IN THE DOG (I) 18 3.6. BIOAVAILABILITY
STUDIES IN MAN (II, III, V, VI) 19 3.6.1. EXPERIMENTAL PROCEDURE 19
3.6.2. PLASMA ASSAY 20 3.6.3. PHARMACOKINETIC PARAMETERS 21 4. RESULTS
AND DISCUSSION 22 4.1. EFFECT OF DILUENTS ON THE RELEASE OF IBUPROFEN IN
VITRO (II, III, IV,VI) 22 4.2. EFFECT OF DILUENTS ON IN VIVO
DISINTEGRATION OF HARD GELATIN CAPSULES IN THE DOG (I) 24 4.3. EFFECT OF
DILUENTS ON THE BIOAVAILABILITY OF IBUPROFEN FROM HARD GELATIN CAPSULES
IN MAN (II, III, V, VI) 25 4.4. IN VITRO/ IN VIVO CORRELATION 31 5.
CONCLUSIONS 34 6. REFERENCES 36
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T17:19:14Z |
| institution | BVB |
| isbn | 9529046073 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-005538623 |
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| spelling | Ojantakanen, Saija Verfasser aut Release and bioavailability of ibuprofen from hard gelatin capsules containing different diluents Saija Ojantakanen 1993 Getr. Zählung Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Helsinki, Univ., Diss., 1993 Hartgelatine (DE-588)4156306-2 gnd rswk-swf Arzneikapsel (DE-588)4143174-1 gnd rswk-swf Ibuprofen (DE-588)4123405-4 gnd rswk-swf Bioverfügbarkeit (DE-588)4145660-9 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Ibuprofen (DE-588)4123405-4 s Hartgelatine (DE-588)4156306-2 s Arzneikapsel (DE-588)4143174-1 s Bioverfügbarkeit (DE-588)4145660-9 s DE-604 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005538623&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ojantakanen, Saija Release and bioavailability of ibuprofen from hard gelatin capsules containing different diluents Hartgelatine (DE-588)4156306-2 gnd Arzneikapsel (DE-588)4143174-1 gnd Ibuprofen (DE-588)4123405-4 gnd Bioverfügbarkeit (DE-588)4145660-9 gnd |
| subject_GND | (DE-588)4156306-2 (DE-588)4143174-1 (DE-588)4123405-4 (DE-588)4145660-9 (DE-588)4113937-9 |
| title | Release and bioavailability of ibuprofen from hard gelatin capsules containing different diluents |
| title_auth | Release and bioavailability of ibuprofen from hard gelatin capsules containing different diluents |
| title_exact_search | Release and bioavailability of ibuprofen from hard gelatin capsules containing different diluents |
| title_full | Release and bioavailability of ibuprofen from hard gelatin capsules containing different diluents Saija Ojantakanen |
| title_fullStr | Release and bioavailability of ibuprofen from hard gelatin capsules containing different diluents Saija Ojantakanen |
| title_full_unstemmed | Release and bioavailability of ibuprofen from hard gelatin capsules containing different diluents Saija Ojantakanen |
| title_short | Release and bioavailability of ibuprofen from hard gelatin capsules containing different diluents |
| title_sort | release and bioavailability of ibuprofen from hard gelatin capsules containing different diluents |
| topic | Hartgelatine (DE-588)4156306-2 gnd Arzneikapsel (DE-588)4143174-1 gnd Ibuprofen (DE-588)4123405-4 gnd Bioverfügbarkeit (DE-588)4145660-9 gnd |
| topic_facet | Hartgelatine Arzneikapsel Ibuprofen Bioverfügbarkeit Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005538623&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT ojantakanensaija releaseandbioavailabilityofibuprofenfromhardgelatincapsulescontainingdifferentdiluents |