Cell surface and extracellular glycoconjugates: structure and function
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego u.a.
Acad. Press
1993
|
| Schriftenreihe: | Biology of extracellular matrix series
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 314 S. Ill., graph. Darst. |
| ISBN: | 0125896301 |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | CELL SURFACE AND
EXTRACELLULAR
GLYCOCONJUGATES
Structure and Function
Edited by DAVID D ROBERTS
Laboratory of Pathology
National Cancer Institute
National Institutes of Health
Bethesda, Maryland
ROBERT P MECHAM
Department of Cell Biology and Physiology
Washington University School of Medicine
St Louis, Missouri
ACADEMIC PRESS, INC
A Division of Harcourt Brace amp; Company
San Diego New York Boston
London Sydney Tokyo Toronto
Contents
CONTRIBUTORS ix
PREFACE xi
Use of Structural Analyses to Examine the Functions of N- and
O-Linked Sugar Chains of Glycoproteins
KIYOSHIFURUKAWA and AKIRA KOBATA
I Introduction 1
II Analysis of Sugar Composition 2
III Release of Oligosaccharides from Polypeptide Backbone 4
IV Fractionation of Oligosaccharides 12
V Structural Analysis of Oligosaccharides 12
VI Methylation Analysis 19
VII Fractionation and Structural Estimation of Oligosaccharides
by Lectin Column Chromatography 20
References 26
Structure and Biology of Pericellular Proteoglycans
JOHN R COUCHMAN and ANNE WOODS
I Introduction 33
II Cell Surface Proteoglycans 35
III Basement Membranes 50
IV Biglycan 64
V Concluding Remarks 66
References 68
Glycosyl Phosphatidylinositol-Linked Membrane Proteins:
Structure, Biosynthesis, and Function
TAMARA L DOERING
I Background 83
II Experimental Approaches 87
III Functions of Glycosyl Phosphatidylinositol Anchors 96
V
vi CONTENTS
IV Glycosyl Phospatidylinositol Anchors in Disease 104
V Current Research Priorities 106
References 108
The Use of Glycosylation Inhib i tors to S tudy
Glycoconjugate Func t ion
ALAN D ELBEIN
I Introduction 119
II Structure and Biosynthesis of N-Linked Oligosaccharides 123
III Structure and Biosynthesis of Glycosyl Phosphatidylinositol
Anchors 132
IV Inhibitors of Lipid-Linked Saccharide Synthesis 133
V Inhibitors of N-Linked Glycoprotein Processing 145
VI Effects of Inhibitors of Protein Synthesis, or Compounds That
Modify Protein Structure, on N-Linked Glycosylation 157
VII Effects of Inhibitors of Polyprenol Synthesis on N-Linked
Glycosylation 159
VIII Inhibitors of Golgi Trafficking Affect N-Linked Glycosylation 161
K Inhibitors oftheGlycan Portion of Membrane Anchors 162
X Summary and Future Directions 164
References 166
Use of Mammalian Cell Mutants to Study the Functions of
N- and O-Linked Glycosylation
PAMELA STANLEY
I Introduction 181
II Carbohydrates of Glycoproteins 183
III Glycosylation Mutants of Mammalian Cells 190
IV Use of Mutants to Analyze Carbohydrate Function 201
V Use of Glycosylation Mutants to Optimize Carbohydrate
Function: Glycosylation Engineering 210
VI Conclusions 212
References 212
The Structure and Function of Glycosphingolipid Receptors
in Inflammation and Cancer
BRUCE A MACHER and CHERYL L M STULTS
I Introduction 223
II Glycosphingolipids and E-Selection 224
III Function of Glycosphingolipids in Mediating Cell-Substratum
Interactions 229
References 239
CONTENTS vii
Biochemical and Molecular Biological Approaches to Modify
Oligosaccharides: Analysis of Glycosylation Funct ion in
Human Choriogonadotropin
0 P BAHL, N R THOTAKURA, and W Y CHEN
I Introduction 245
II Structures of Glycoprotein Hormones 246
III Modification of Oligosaccharides and Its Effects on Function 247
IV Conclusions 266
References 267
The Role of Glycosylation in Adhesive Protein Function
MARVIN L TANZER, MARTIN S GINIGER, JOHN W DEAN III, and
S CHANDRASEKARAN
I Introduction 271
II Protein Glycosylation 272
III N-Glycosylation Inhibitors 275
IV Principles of Cell Adhesion 276
V Adhesive Proteins 277
VI Adhesion Receptors 288
VII Epilogue 297
References 298
INDEX 309
|
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| isbn | 0125896301 |
| language | English |
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| publishDate | 1993 |
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| spelling | Cell surface and extracellular glycoconjugates structure and function ed. by David D. Roberts ... San Diego u.a. Acad. Press 1993 XII, 314 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biology of extracellular matrix series Glycoconjugaten gtt Membranen gtt Glycoconjugates Membrane Lipids Membrane Proteins Membrane lipids Membrane proteins Grundsubstanz (DE-588)4224942-9 gnd rswk-swf Glykokonjugate (DE-588)4131221-1 gnd rswk-swf Plasmamembran (DE-588)4067550-6 gnd rswk-swf Glykolipide (DE-588)4157740-1 gnd rswk-swf Glykoproteine (DE-588)4071905-4 gnd rswk-swf Zelle (DE-588)4067537-3 gnd rswk-swf Plasmamembran (DE-588)4067550-6 s Glykoproteine (DE-588)4071905-4 s DE-604 Glykokonjugate (DE-588)4131221-1 s Grundsubstanz (DE-588)4224942-9 s Zelle (DE-588)4067537-3 s Glykolipide (DE-588)4157740-1 s Roberts, David D. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005503803&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cell surface and extracellular glycoconjugates structure and function Glycoconjugaten gtt Membranen gtt Glycoconjugates Membrane Lipids Membrane Proteins Membrane lipids Membrane proteins Grundsubstanz (DE-588)4224942-9 gnd Glykokonjugate (DE-588)4131221-1 gnd Plasmamembran (DE-588)4067550-6 gnd Glykolipide (DE-588)4157740-1 gnd Glykoproteine (DE-588)4071905-4 gnd Zelle (DE-588)4067537-3 gnd |
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| title | Cell surface and extracellular glycoconjugates structure and function |
| title_auth | Cell surface and extracellular glycoconjugates structure and function |
| title_exact_search | Cell surface and extracellular glycoconjugates structure and function |
| title_full | Cell surface and extracellular glycoconjugates structure and function ed. by David D. Roberts ... |
| title_fullStr | Cell surface and extracellular glycoconjugates structure and function ed. by David D. Roberts ... |
| title_full_unstemmed | Cell surface and extracellular glycoconjugates structure and function ed. by David D. Roberts ... |
| title_short | Cell surface and extracellular glycoconjugates |
| title_sort | cell surface and extracellular glycoconjugates structure and function |
| title_sub | structure and function |
| topic | Glycoconjugaten gtt Membranen gtt Glycoconjugates Membrane Lipids Membrane Proteins Membrane lipids Membrane proteins Grundsubstanz (DE-588)4224942-9 gnd Glykokonjugate (DE-588)4131221-1 gnd Plasmamembran (DE-588)4067550-6 gnd Glykolipide (DE-588)4157740-1 gnd Glykoproteine (DE-588)4071905-4 gnd Zelle (DE-588)4067537-3 gnd |
| topic_facet | Glycoconjugaten Membranen Glycoconjugates Membrane Lipids Membrane Proteins Membrane lipids Membrane proteins Grundsubstanz Glykokonjugate Plasmamembran Glykolipide Glykoproteine Zelle |
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