Trace and ultratrace analysis by HPLC:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York u.a.
Wiley
1992
|
| Schriftenreihe: | Chemical analysis
115 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 419 S. graph. Darst. |
| ISBN: | 0471514195 |
Internformat
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| 300 | |a XI, 419 S. |b graph. Darst. | ||
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| 650 | 4 | |a Chromatography, High Pressure Liquid |x methods | |
| 650 | 4 | |a High performance liquid chromatography | |
| 650 | 4 | |a Trace Elements |x analysis | |
| 650 | 4 | |a Trace analysis | |
| 650 | 4 | |a Ultratrace analysis | |
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Datensatz im Suchindex
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|---|---|
| adam_text | TRACE AND ULTRATRACE ANALYSIS BY HPLC SATINDER AHUJA DEVELOPMENT
DEPARTMENT PHARMACEUTICALS DIVISION CIBA-GEIGY CORPORATION SUFFERN, NEW
YORK A WILEY-INTERSCIENCE PUBLICATION JOHN WILEY & SONS, INC. NEW YORK /
CHICHESTER / BRISBANE / TORONTO / SINGAPORE CONTENTS CHAPTER 1 THE SCOPE
OF TRACE AND ULTRATRACE ANALYSIS BY HPLC 1 1.1. SAMPLING AND SAMPLE
PREPARATION 2 1.2. METHOD VALIDATION AND INTERLABORATORY VARIATIONS 3
1.3. METHODOLOGY 3 1.4. SELECT APPLICATIONS 5 1.4.1. BIOTECHNOLOGY 5
1.4.2. DIAGNOSTIC STUDIES 7 1.4.3. DISCOVERY OF NEW COMPOUNDS 8 1.4.4.
BEVERAGES/FOOD 8 1.4.5. FUEL 9 1.4.6. PHARMACOKINETIC STUDIES/METABOLIC
ACTIVITY 9 1.4.7. IN VIVO STUDIES 12 REFERENCES 13 CHAPTER 2 THEORETICAL
CONSIDERATIONS 15 2.1. PEAK WIDTH 16 2.2. THEORETICAL PLATE EQUATIONS 19
2.3. PEAK BROADENING 23 2.4. CONSIDERATIONS FOR HPLC EQUIPMENT 25 2.5.
DETECTION LIMITS 29 2.6. HIGH-RESOLUTION LIQUID CHROMATOGRAPHY 31 2.7.
VARIOUS ROUTES TO HIGH RESOLUTION 32 2.8. OPTIMUM COLUMN SELECTION:
CONVENTIONAL VERSUS SMALL-PRACTICE VERSUS MICROBORE COLUMNS 32
REFERENCES 34 VN VLLL CONTENTS CHAPTER 3 CHAPTER 4 CHAPTER 5 EQUIPMENT
CONSIDERATIONS 3.1. 3.2. 3.3. 3.4. REFE SOLVENT DELIVERY SYSTEMS 3.1.1.
SOLVENT DELAY AND TRANSITION 3.1.2. PULSE COMPENSATION 3.1.3. CORROSIVE
SOLUTIONS EQUIPMENT-RELATED PROBLEMS 3.2.1. DISPERSION IN COLUMNS 3.2.2.
DISPERSION IN TUBES 3.2.3. ARTIFACT PEAKS SEPARATION CONDITIONS 3.3.1.
RESOLUTION 3.3.2. GRADIENT ELUTION MICROCOLUMN HPLC 3.4.1. SAMPLE
INTRODUCTION 3.4.2. DETECTOR 3.4.3. TUBULAER CONNECTIONS 3.4.4. SELECT
APPLICATIONS RENCES SENSITIVE DETECTORS IN HPLC 4.1. 4.2. 4.3. 4.4. 4.5.
4.6. UV DETECTORS FLUORESCENCE DETECTORS 4.2.1. MISCELLANEOUS
LUMINESCENCE DETECTORS ELECTROCHEMICAL DETECTORS REFRACTIVE INDEX
DETECTORS MASS SPECTROMETRIC DETECTORS MISCELLANEOUS DETECTORS
REFERENCES SAMPLE PREPARATION 5.1. 5.2. 5.3. PRECIPITATION OF
UNDESIRABLE COMPONENTS LIQUID-SOLID EXTRACTION LIQUID-LIQUID EXTRACTION
5.3.1. CHOICE OF SOLVENT 5.3.2. MIXING 37 38 47 49 49 50 52 53 53 55 56
58 59 64 66 67 69 72 75 77 82 88 91 102 105 111 115 121 121 122 122 124
125 CONTENTS IX 5.3.3. SALTING-OUT 126 5.3.4. PARTITION COEFFICIENTS 126
5.4. ULTRAFILTRATION 129 5.5. ION-PAIR EXTRACTION 130 5.6.
DERIVATIZATION 131 5.7. COMPLEX FORMATION 131 5.8. FREEZE-DRYING 132
5.9. SOLID-PHASE EXTRACTION 132 5.9.1. SOLID-PHASE EXTRACTION COLUMNS
135 5.10. ION EXCHANGERS 138 5.11. SPECIALIZED COLUMNS 140 5.12.
PRECONCENTRATION 143 5.13. PRECOLUMN SWITCHING 145 5.14. CLEANUP
PROCEDURES FOR FEEDS 147 5.15. MISCELLANEOUS 155 REFERENCES 156 CHAPTER
6 METHOD DEVELOPMENT FOR TRACE AND ULTRATRACE ANALYSIS 161 6.1. GENERAL
CONSIDERATIONS 162 6.1.1. SAMPLE PROPERTIES 163 6.1.2. SEPARATION
CONDITIONS 164 6.1.3. RESOLUTION 166 6.2. COLUMN SELECTION 166 6.2.1.
COLUMN EVALUATIONS 169 6.3. MOBILE-PHASE SELECTION IN HPLC 170 6.3.1.
SOLVENT CLASSIFICATION 171 6.3.2. MOBILE-PHASE ADDITIVES 175 6.4. MODES
OF CHROMATOGRAPHY 175 6.4.1. ADSORPTION CHROMATOGRAPHY 175 6.4.2. NORMAL
BONDED PHASES 178 6.4.3. REVERSED-PHASE CHROMATOGRAPHY 180 6.4.4.
ION-EXCHANGE CHROMATOGRAPHY 185 6.5. SPECIAL CONSIDERATIONS 193 6.5.1.
EFFECT OF TEMPERATURE 193 6.5.2. GRADIENT ELUTION 195 X CONTENTS 6.5.3.
MULTIMODAL LIQUID CHROMATOGRAPHY 198 REFERENCES 204 CHAPTER 7
SELECTIVITY OPTIMIZATION FOR TRACE AND ULTRATRACE ANALYSIS 209 7.1.
ADSORPTION/NORMAL-PHASE CHROMATOGRAPHY 209 7.1.1. SOLVENT STRENGTH 210
7.1.2. MODULATORS 213 7.1.3. MOBILE-PHASE OPTIMIZATION STRATEGIES 214
7.1.4. EFFECT OF SAMPLE STRUCTURE ON RETENTION 215 7.1.5. MOBILE-PHASE
EFFECTS IN NORMAL-PHASE CHROMATOGRAPHY 218 7.1.6. SOLVENT STRENGTH
ADJUSTMENT 219 7.1.7. SELECTIVITY EFFECTS 220 7.2. REVERSED-PHASE
CHROMATOGRAPHY 220 7.2.1. SELECTIVITY OF REVERSED-PHASE 222 7.2.2.
COLUMN EFFICIENCY 223 7.2.3. PROBLEMS WITH HPLC COLUMNS 224 7.2.4.
COLUMN EVALUATIONS 225 7.2.5. RETENTION MECHANISM 229 7.2.6. ELUOTROPIC
SOLVENT SCALE 231 7.2.7. MOBILE-PHASE SELECTION AND OPTIMIZATION 235
7.2.8. EFFECT ON SELECTIVITY 239 7.2.9. TEMPERATURE SELECTIVITY 241 7.3.
ION-PAIR CHROMATOGRAPHY 242 7.3.1. THEORETICAL CONSIDERATIONS 244 7.3.2.
COLUMNS 247 7.3.3. MOBILE-PHASE SELECTION AND OPTIMIZATION 250 7.3.4.
OTHER SEPARATION VARIABLES 259 7.3.5. RETENTION MECHANISM 260 7.4.
COMPUTER-BASED OPTIMIZATIONS 268 REFERENCES 272 CONTENTS XI CHAPTER 8
OPTIMIZING DETECTABILITY 279 8.1. DETECTION LIMITS AND NOISE 280 8.2.
COLUMN EVALUATIONS FOR DETECTABILITY OPTIMIZATION 281 287 291 294 300
303 303 303 304 335 335 340 346 350 356 366 377 382 382 386 398
REFERENCES 400 8.3. 8.4. 8.5. DETECTOR EVALUATION AND OPTIMIZATION
DERIVATIZATION MISCELLANEOUS APPROACHES REFERENCES CHAPTER 9
APPLICATIONS 9.1. 9.2. 9.3. 9.4. PHARMACEUTICAL/BIOMEDICAL 9.1.1.
PHARMACEUTICAL PURITY 9.1.2. METHOD DEVELOPMENT STRATEGIES FOOD 9.2.1.
RELIABILITY OF DATA 9.2.2. MEDICATED FEEDS 9.2.3. DAIRY PRODUCTS 9.2.4.
SEAFOOD 9.2.5. MEAT PRODUCTS 9.2.6. FRUITS AND VEGETABLES 9.2.7.
BEVERAGES ENVIRONMENT 9.3.1. SAMPLE PREPARATION 9.3.2. APPLICATIONS
COSMETICS INDEX 413
|
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| author | Ahuja, Satinder 1933- |
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| dewey-sort | 3543 3894 |
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| discipline | Chemie / Pharmazie |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T17:17:24Z |
| institution | BVB |
| isbn | 0471514195 |
| language | English |
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| owner | DE-703 DE-634 DE-83 DE-188 |
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| physical | XI, 419 S. graph. Darst. |
| publishDate | 1992 |
| publishDateSearch | 1992 |
| publishDateSort | 1992 |
| publisher | Wiley |
| record_format | marc |
| series | Chemical analysis |
| series2 | Chemical analysis A Wiley-Interscience publication |
| spelling | Ahuja, Satinder 1933- Verfasser (DE-588)135610028 aut Trace and ultratrace analysis by HPLC Satinder Ahuja New York u.a. Wiley 1992 XI, 419 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Chemical analysis 115 A Wiley-Interscience publication HPLC gtt Sporenanalyse gtt Chromatography, High Pressure Liquid methods High performance liquid chromatography Trace Elements analysis Trace analysis Ultratrace analysis HPLC (DE-588)4072641-1 gnd rswk-swf HPLC (DE-588)4072641-1 s DE-604 Chemical analysis 115 (DE-604)BV000008780 115 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005459530&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ahuja, Satinder 1933- Trace and ultratrace analysis by HPLC Chemical analysis HPLC gtt Sporenanalyse gtt Chromatography, High Pressure Liquid methods High performance liquid chromatography Trace Elements analysis Trace analysis Ultratrace analysis HPLC (DE-588)4072641-1 gnd |
| subject_GND | (DE-588)4072641-1 |
| title | Trace and ultratrace analysis by HPLC |
| title_auth | Trace and ultratrace analysis by HPLC |
| title_exact_search | Trace and ultratrace analysis by HPLC |
| title_full | Trace and ultratrace analysis by HPLC Satinder Ahuja |
| title_fullStr | Trace and ultratrace analysis by HPLC Satinder Ahuja |
| title_full_unstemmed | Trace and ultratrace analysis by HPLC Satinder Ahuja |
| title_short | Trace and ultratrace analysis by HPLC |
| title_sort | trace and ultratrace analysis by hplc |
| topic | HPLC gtt Sporenanalyse gtt Chromatography, High Pressure Liquid methods High performance liquid chromatography Trace Elements analysis Trace analysis Ultratrace analysis HPLC (DE-588)4072641-1 gnd |
| topic_facet | HPLC Sporenanalyse Chromatography, High Pressure Liquid methods High performance liquid chromatography Trace Elements analysis Trace analysis Ultratrace analysis |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005459530&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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