An introduction to genetic analysis:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York
Freeman
1993
|
| Ausgabe: | 5. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 840 S. zahlr. Ill., graph. Darst. |
| ISBN: | 0716722852 |
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Datensatz im Suchindex
| _version_ | 1804122535971782656 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
PREFACE XII
GENETICS AND THE ORGANISM 1 GENETICS AND HUMAN AFFAIRS 2
GENETICS AND BIOLOGY 6
GENES AND ENVIRONMENT 8
TECHNIQUES OF GENETIC ANALYSIS 15 SUMMARY 17
CONCEPT MAPS 18
MENDELIAN ANALYSIS 19
MENDEL S EXPERIMENTS 20
SIMPLE MENDELIAN GENETICS IN HUMANS 30
SIMPLE MENDELIAN GENETICS IN AGRICULTURE 38
VARIANTS AND GENETIC DISSECTION 41 SUMMARY 42
CONCEPT MAP 42 * CHAPTER INTEGRATION PROBLEM 42 * SOLVED PROBLEMS 43 *
PROBLEMS 45
CHROMOSOME THEORY OF INHERITANCE 50
MITOSIS AND MEIOSIS 51
THE CHROMOSOME THEORY OF HEREDITY 58
SEX CHROMOSOMES AND SEX LINKAGE 66 THE PARALLEL BEHAVIOR OF AUTOSOMAL
GENES AND CHROMOSOMES 72
MENDELIAN GENETICS AND LIFE CYCLES 74 SUMMARY 79
CONCEPT MAP 80 * CHAPTER INTEGRATION PROBLEM 80 * SOLVED PROBLEMS 81 *
PROBLEMS 82
EXTENSIONS OF
MENDELIAN ANALYSIS 87
VARIATIONS ON DOMINANCE 88
MULTIPLE ALLELES 89
LETHAL ALLELES 91
SEVERAL GENES AFFECTING THE SAME CHARACTER 94
PENETRANCE AND EXPRESSIVITY 103 SUMMARY 104
CONCEPT MAP 105 * CHAPTER INTEGRATION PROBLEM 106 * SOLVED PROBLEMS 107
* PROBLEMS 109
LINKAGE I: BASIC EUKARYOTIC CHROMOSOME MAPPING 118
THE DISCOVERY OF LINKAGE 119
RECOMBINATION 121
LINKAGE SYMBOLISM 123
LINKAGE OF GENES ON THE X CHROMOSOME 124
LINKAGE MAPS 124
THREE-POINT TESTCROSS 128
IMAGE 2
VIII
CONTENTS
INTERFERENCE 130
T H E / 2 TEST 132
EARLY THOUGHTS ON THE NATURE OF CROSSING-OVER 135
LINKAGE MAPPING BY RECOMBIN- ATION IN HUMANS 137
SUMMARY 138
CONCEPT MAP 139 * CHAPTER INTEGRATION PROBLEM 139 * SOLVED PROBLEMS 140
* PROBLEMS 142
6 LINKAGE II. SPECIAL EUKARYOTIC CHROMOSOME MAPPING TECHNIQUES 149
ACCURATE CALCULATION OF LARGE MAP DISTANCES 150
ANALYSIS OF SINGLE MEIOSES 154 MITOTIC SEGREGATION AND RECOMBINATION 162
MAPPING HUMAN CHROMOSOMES 165 SUMMARY 168
CONCEPT MAP 169 * CHAPTER INTEGRATION PROBLEM 169 * SOLVED PROBLEMS 170
* PROBLEMS 172
7 GENE M U T A T I ON 178
SOMATIC VERSUS GERMINAL MUTATION 179 MUTANT TYPES 181
THE OCCURRENCE OF MUTATIONS 184 SELECTIVE SYSTEMS 188
MUTATION AND CANCER 195
MUTAGENS IN GENETIC DISSECTION 198 MUTATION BREEDING 199
SUMMARY 200
CONCEPT MAP 201 * CHAPTER INTEGRATION PROBLEM 201 * SOLVED PROBLEMS 201
* PROBLEMS 203
8 CHROMOSOME MUTATION I: CHANGES IN
CHROMOSOME STRUCTURE 205
THE TOPOGRAPHY OF CHROMOSOMES 206 TYPES OF CHANGES IN CHROMOSOME
DUPLICATIONS 215
SUMMARY 229
CONCEPT MAP 229 * CHAPTER INTEGRATION PROBLEM 229 * SOLVED PROBLEMS 230
* PROBLEMS 233
9 CHROMOSOME M U T A T I ON II:
CHANGES IN NUMBER 241
EUPLOIDY 242
ANEUPLOIDY 250
CHROMOSOME MECHANICS IN PLANT BREEDING 257
SUMMARY 259
CONCEPT MAP 259 * CHAPTER INTEGRATION PROBLEM 259 * SOLVED PROBLEMS 260
* PROBLEMS 261
10 RECOMBINATION IN BACTERIA AND THEIR VIRUSES 265
WORKING WITH MICROORGANISMS 266 BACTERIAL CONJUGATION 267
BACTERIAL RECOMBINATION AND MAPPING THE E. COLI CHROMOSOME 276 BACTERIAL
TRANSFORMATION 280 BACTERIOPHAGE GENETICS 282
TRANSDUCTION 289
MAPPING OF BACTERIAL CHROMOSOMES 293 BACTERIAL GENE TRANSFER IN REVIEW
294 SUMMARY 294
CONCEPT MAP 296 * CHAPTER INTEGRATION PROBLEM 296 * SOLVED PROBLEMS 296
* PROBLEMS 298
11 T HE STRUCTURE OF D NA 304
DNA: THE GENETIC MATERIAL 305 THE STRUCTURE OF DNA 307
REPLICATION OF DNA 313
MECHANISM OF DNA REPLICATION 320 DNA REPLICATION IN EUKARYOTES DNA AND
THE GENE
STRUCTURE 210
326 327
SUMMARY 329
CONCEPT MAP 330 * CHAPTER INTEGRATION PROBLEM 330 * SOLVED PROBLEMS 330
* PROBLEMS 330
IMAGE 3
CONTENTS
IX
12 T HE NATURE OF THE GENE 333
HOW GENES WORK 334
GENE - PROTEIN RELATIONSHIPS 337 GENETIC OBSERVATIONS EXPLAINED BY
ENZYME STRUCTURE 348
GENETIC FINE STRUCTURE 350
MUTATIONAL SITES 355
COMPLEMENTATION 361
SUMMARY 365
CONCEPT MAP 365 * CHAPTER INTEGRATION PROBLEM 365 * SOLVED PROBLEMS 366
* PROBLEMS 367
13 DNA FUNCTION 374
OVERVIEW 375
TRANSCRIPTION 375
TRANSLATION 382
THE GENETIC CODE 383
PROTEIN SYNTHESIS 391
UNIVERSALITY OF GENETIC INFORMATION TRANSFER 398
EUKARYOTIC RNA 400
MECHANISM OF GENE SPLICING 402 REVIEW 407
SUMMARY 407
CONCEPT MAP 410 * CHAPTER INTEGRATION PROBLEM 410 * SOLVED PROBLEMS 410
* PROBLEMS 411
14 RECOMBINANT DNA 415
RESTRICTION ENZYMES 416
THE FORMATION OF RECOMBINANT DNA 419
RECOMBINANT DNA METHODOLOGY 423 RECOMBINANT DNA AND SOCIAL
RESPONSIBILITY 433
SUMMARY 434
CONCEPT MAP 436 * CHAPTER INTEGRATION PROBLEM 436 * SOLVED PROBLEMS 436
* PROBLEMS 436
APPLICATIONS OF RECOMBINANT D NA 440
APPLICATIONS OF RECOMBINANT DNA TECHNOLOGY USING PROKARYOTES 441
RECOMBINANT DNA TECHNOLOGY IN EUKARYOTES: AN OVERVIEW 444
TRANSGENIC YEAST 445
TRANSGENIC PLANTS 450
TRANSGENIC ANIMALS 453
SCREENING FOR GENETIC DISEASES 453 IDENTIFYING DISEASE GENES 459
SUMMARY 461
CONCEPT MAP 461 * CHAPTER INTEGRATION PROBLEM 461 * SOLVED PROBLEMS 464
* PROBLEMS 465
16 T HE STRUCTURE AND F U N C T I ON OF EUKARYOTIC CHROMOSOMES 467
ONE DNA MOLECULE PER CHROMOSOME 468
THE ROLE OF HISTONE PROTEINS IN PACKAGING DNA 470
HIGHER ORDER COILING 471
HETEROCHROMATIN AND EUCHROMATIN 474 CHROMOSOME BANDS 475
CENTROMERIC DNA 477
SEQUENCE ORGANIZATION 478
REPLICATION AND TRANSCRIPTION OF CHROMATIN 487
SUMMARY 488
CONCEPT MAP 488 * CHAPTER INTEGRATION PROBLEM 488 * SOLVED PROBLEM 488 *
PROBLEMS 488
17 C O N T R OL OF GENE EXPRESSION 491
BASIC CONTROL CIRCUITS 492
DISCOVERY OF THE LAC SYSTEM: NEGATIVE CONTROL 493
CATABOLITE REPRESSION OF THE LAC OPERON: POSITIVE CONTROL 500
DUAL POSITIVE AND NEGATIVE CONTROL: THE ARABINOSE OPERON 503 METABOLIC
PATHWAYS 505
THE TRYPTOPHAN GENES: NEGATIVE CONTROL WITH SUPERIMPOSED ATTENTUATION
505
THE X PHAGE: A COMPLEX OF OPERONS 509
IMAGE 4
CONTENTS
MULTIOPERON REPRESSION 511
STRUCTURE OF REGULATORY PROTEINS 512 TRANSCRIPTION: GENE REGULATION IN
EUKARYOTES-AN OVERVIEW 512
CIS CONTROL OF TRANSCRIPTION 513 TRANS CONTROL OF TRANSCRIPTION 515
5-METHYLCYTOSINE REGULATION 521 POST-TRANSCRIPTIONAL CONTROL 521 CONTROL
OF UBIQUITOUS MOLECULES
IN EUKARYOTIC CELLS 521
SUMMARY 524
CONCEPT MAP 525 * CHAPTER INTEGRATION PROBLEM 525 * SOLVED PROBLEMS 525
* PROBLEMS 526
18 MECHANISMS OF GENETIC CHANGE I: GENE M U T A T I ON 529
THE MOLECULAR BASIS OF GENE MUTATIONS 531
SPONTANEOUS MUTATIONS 532
INDUCED MUTATIONS 539
REVERSION ANALYSIS 547
THE RELATIONSHIP BETWEEN MUTAGENS AND CARCINOGENS 547 BIOLOGICAL REPAIR
MECHANISMS 549 SUMMARY 558
CONCEPT MAP 558 * CHAPTER INTEGRATION PROBLEM 558 * SOLVED PROBLEMS 558
* PROBLEMS 559
19 MECHANISMS OF GENETIC CHANGE II: RECOMBINATION 561
GENERAL HOMOLOGOUS RECOMBINATION 562
THE HOLLIDAY MODEL 563
ENZYMATIC MECHANISM OF RECOMBINATION 571
SITE-SPECIFIC RECOMBINATION 572 RECOMBINATION AND CHROMOSOMAL
REARRANGEMENTS 575
DUPLICATION AND EVOLUTION 575
SUMMARY 575
CONCEPT MAP 575 * CHAPTER INTEGRATION PROBLEM 575 * SOLVED PROBLEMS 575
* PROBLEMS 576
20 MECHANISMS OF GENETIC CHANGE III: TRANSPOSABLE GENETIC ELEMENTS 579
INSERTION SEQUENCES 580
TRANSPOSONS 583
PHAGE MU 586
MECHANISM OF TRANSPOSITION 587 REARRANGEMENTS MEDIATED BY TRANSPOSABLE
ELEMENTS 592
REVIEW OF TRANSPOSABLE ELEMENTS IN PROKARYOTES 592
TY ELEMENTS IN YEAST 592
TRANSPOSABLE ELEMENTS IN DROSOPHILA 593 RETROVIRUSES 596
TRANSPOSITION VIA AN RNA INTERMEDIATE 597
CONTROLLING ELEMENTS IN MAIZE 598 REVIEW OF TRANSPOSABLE ELEMENTS IN
EUKARYOTES 602
SUMMARY 603
CONCEPT MAP 603 * CHAPTER INTEGRATION PROBLEM 603 * SOLVED PROBLEM 604 *
PROBLEMS 604
21 T HE EXTRANUCLEAR GENOME 605
VARIEGATION IN LEAVES OF HIGHER PLANTS 607
CYTOPLASMIC INHERITANCE IN FUNGI 609 SHELL COILING IN SNAILS: A RED
HERRING 611
EXTRANUCLEAR GENES IN CHLAMYDOMONAS 612
MITOCHRONDRIAL GENES IN YEAST 615 AN OVERVIEW OF THE MITOCHRONDRIAL
GENOME 620
AN OVERVIEW OF THE CHLOROPLAST GENOME 623
MITOCHONDRIAL DISEASES IN HUMANS 624 EXTRAGENOMIC PLASMIDS IN EUKARYOTES
625
HOW MANY COPIES? 626
SUMMARY 627
CONCEPT MAP 627 * CHAPTER INTEGRATION PROBLEM 628 * SOLVED PROBLEMS 629
* PROBLEMS 630
IMAGE 5
CONTENTS
XI
22 DEVELOPMENTAL GENETICS:
CELL FATE AND
PATTERN FORMATION 636
CELL FATE: WHEN DO THE CELLS AND NUCLEI OF HIGHER ORGANISMS LOSE THEIR
TOTIPOTENCY? 637
PATTERN FORMATION: THE ESTABLISH- MENT OF THE BASIC ANIMAL BODY PLAN 640
MUTATIONAL AND MOLECULAR ANALYSES OF THE BASIC BODY PLAN 645
COMMUNICATION BETWEEN CELLS AND THE ESTABLISHMENT OF CELL FATE 655
HOMEOTIC MUTATIONS AND THE ESTABLISHMENT OF SEGMENT IDENTITY 659
APPLYING THE FLY AND WORM
LESSONS TO OTHER ORGANISMS 661 SUMMARY 665
CONCEPT MAP 666 * CHAPTER INTEGRATION PROBLEM 666 * SOLVED PROBLEMS 667
* PROBLEMS 668
23 DEVELOPMENTAL GENETICS:
TOPICS IN GENE REGULATION
AND DIFFERENTIATION 671
PROTEINS AS DETERMINANTS OF CELLULAR CHARACTERISTICS 672
REGULATING THE SYNTHESIS OF PROTEINS 672 TRANSCRIPTIONAL REGULATION BY
TISSUE-SPECIFIC ENHANCERS 676 INTEGRATION OF TRANSCRIPTIONAL
CONTROL BETWEEN DIFFERENT TISSUES 680 TRANSCRIPT PROCESSING AND TISSUE-
SPECIFIC REGULATION 682
APPLICATIONS OF REGULATORY MECH- ANISMS TO CELL DIFFERENTIATION 682
CANCER AS A DEVELOPMENTAL GENETIC DISEASE 690
SUMMARY 699
CONCEPT MAP 699 * CHAPTER INTEGRATION PROBLEM 699 * SOLVED PROBLEMS 700
* PROBLEMS 701
24 QUANTITATIVE GENETICS 703
SOME BASIC STATISTICAL NOTIONS 704
GENOTYPES AND PHENOTYPIC DISTRIBUTION 713
NORM OF REACTION AND PHENOTYPIC DISTRIBUTION 715
THE HERITABILITY OF A TRAIT 716
DETERMINING NORMS OF REACTION 718 QUANTIFYING HERITABILITY 721
COUNTING AND LOCATING THE GENES 725 GENE ACTION 727
MORE ON ANALYZING VARIANCE 727 SUMMARY 732
CONCEPT MAP 733 * CHAPTER INTEGRATION PROBLEM 733 * SOLVED PROBLEMS 734
* PROBLEMS 734
25 POPULATION GENETICS 737
DARWIN S REVOLUTION 738
VARIATION AND ITS MODULATION 738 THE SOURCES OF VARIATION 747
THE EFFECT OF SEXUAL REPRODUCTION ON VARIATION 750
SELECTION 755
BALANCED POLYMORPHISM 760
MULTIPLE ADAPTIVE PEAKS 762
ARTIFICIAL SELECTION 763
RANDOM EVENTS 765
A SYNTHESIS OF FORCES 766
THE ORIGIN OF SPECIES 768
SUMMARY 769
CONCEPT MAP 770 * CHAPTER INTEGRATION PROBLEM 770 * SOLVED PROBLEMS 770
* PROBLEMS 772
FURTHER READING GLOSSARY ANSWERS TO SELECTED PROBLEMS INDEX
775 783 803
825
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| id | DE-604.BV008152402 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:15:26Z |
| institution | BVB |
| isbn | 0716722852 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-005379716 |
| oclc_num | 26934989 |
| open_access_boolean | |
| owner | DE-739 DE-91G DE-BY-TUM DE-19 DE-BY-UBM DE-20 DE-11 DE-188 DE-B768 |
| owner_facet | DE-739 DE-91G DE-BY-TUM DE-19 DE-BY-UBM DE-20 DE-11 DE-188 DE-B768 |
| physical | XI, 840 S. zahlr. Ill., graph. Darst. |
| publishDate | 1993 |
| publishDateSearch | 1993 |
| publishDateSort | 1993 |
| publisher | Freeman |
| record_format | marc |
| spelling | An introduction to genetic analysis Anthony J. F. Griffiths ... 5. ed. New York Freeman 1993 XI, 840 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Genetica gtt Génétique Génétique - Méthodologie Genetics Genetics Methodology CD-ROM (DE-588)4139307-7 gnd rswk-swf Methode (DE-588)4038971-6 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf 1\p (DE-588)4151278-9 Einführung gnd-content 2\p (DE-588)4123623-3 Lehrbuch gnd-content Genetik (DE-588)4071711-2 s Methode (DE-588)4038971-6 s DE-604 CD-ROM (DE-588)4139307-7 s 3\p DE-604 Griffiths, Anthony J. F. Sonstige oth SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005379716&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | An introduction to genetic analysis Genetica gtt Génétique Génétique - Méthodologie Genetics Genetics Methodology CD-ROM (DE-588)4139307-7 gnd Methode (DE-588)4038971-6 gnd Genetik (DE-588)4071711-2 gnd |
| subject_GND | (DE-588)4139307-7 (DE-588)4038971-6 (DE-588)4071711-2 (DE-588)4151278-9 (DE-588)4123623-3 |
| title | An introduction to genetic analysis |
| title_auth | An introduction to genetic analysis |
| title_exact_search | An introduction to genetic analysis |
| title_full | An introduction to genetic analysis Anthony J. F. Griffiths ... |
| title_fullStr | An introduction to genetic analysis Anthony J. F. Griffiths ... |
| title_full_unstemmed | An introduction to genetic analysis Anthony J. F. Griffiths ... |
| title_short | An introduction to genetic analysis |
| title_sort | an introduction to genetic analysis |
| topic | Genetica gtt Génétique Génétique - Méthodologie Genetics Genetics Methodology CD-ROM (DE-588)4139307-7 gnd Methode (DE-588)4038971-6 gnd Genetik (DE-588)4071711-2 gnd |
| topic_facet | Genetica Génétique Génétique - Méthodologie Genetics Genetics Methodology CD-ROM Methode Genetik Einführung Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005379716&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT griffithsanthonyjf anintroductiontogeneticanalysis |