Molecular mechanisms in cellular growth and differentiation:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego u.a.
Academie Press
1991
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXII, 365 S. Ill., graph. Darst. |
| ISBN: | 0120853604 |
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| 245 | 1 | 0 | |a Molecular mechanisms in cellular growth and differentiation |c ed. by Anthony R. Bellvé ... |
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| 650 | 4 | |a Cell Differentiation |x physiology | |
| 650 | 4 | |a Cells |x Growth |v Regulations | |
| 650 | 4 | |a Gene Expression Regulation |x physiology | |
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Datensatz im Suchindex
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| adam_text | MOLECULAR MECHANISMS IN
CELLULAR GROWTH AND
DIFFERENTIATION
Edited by
Anthony R Bellve
Henry J Vogel
College of Physicians and Surgeons
Columbia University
New York, New York
ACADEMIC PRESS, INC
Harcourt Brace Jovanovich, Publishers
San Diego New York Boston
London Sydney Tokyo Toronto
Contents
Preface xv
PART I POLYPEPTIDE GROWTH FACTORS
AND OTHER SIGNALS: CELL MEMBRANE
RECEPTORS, TRANSDUCTION MECHANISMS,
AND PROLIFERATIVE RESPONSE
1 A Dual Binding Site Hypothesis of the Type I
Insulin-Like Growth Factor Receptor
JUDSON J VAN WYK AND SAMUEL J CASELLA
Introduction 3
Which Receptor Mediates the Actions of IGF-II? 4
References 8
2 Insulin Action on Membrane Protein Recycling
MICHAEL P CZECH, SILVIA CORVERA, MARK A
TEPPER, CAROL M BROCKLEBANK, AND
RICHARD G MACDONALD
Introduction 9
Membrane Protein Recycling 9
Conclusions 17
References 18
VI CONTENTS
3 Growth-Factor and Oncogene-Mediated S6
Phosphorylation during the Mitogenic Response:
A Novel S6 Kinase
PAUL JENO, L M BALLOU, AND GEORGE
THOMAS
Stimulation of S6 Phosphorylation 19
Activation of S6 Kinase 20
Phosphatases 21
Characteristics of the S6 Kinase 21
Pathways Involved in S6 Phosphorylation 22
References 23
4 Phosphorylation of pp60c-*rc
TONY HUNTER, CHRISTINE A CARTWRIGHT,
JAMES R WOODGETT, AND KATHLEEN L
GOULD
Introduction 25
Serine 12 27
Serine 17 29
Other Amino-Terminal Phosphorylations 30
Tyrosine 416 31
Tyrosine 527 32
Platelet-Derived Growth Factor Treatment 34
Neuronal ppar 1 35
ppGO^ 1 and Polyomavirus Middle T Antigen 3 7
Vanadate Treatment 3 9
Elevation of ppfSO115™1 Protein Kinase Activity
in Transformed Cells 39
Summary 40
References 41
G Proteins May Exist as Polymeric Proteins:
A Basis for the Disaggregation Theory
of Hormone Action
MARTIN RODBELL
Introduction 45
Depolymerization Theory 47
Current Thoughts on G Proteins 47
Some Structural Aspects of G Proteins 49
Pertussis Toxin Actions 51
Effects of Detergents on G Proteins 52
CONTENTS VII
Signal Transduction and Cytoskeletal Elements 55
Summary and Speculations 55
References 57
6 Pleiotropic Functions of the Insulin Receptor
ALAN R SALTIEL
Introduction 59
Purification and Biological Characterization of the Insulin-
Sensitive Enzyme Modulators 61
The Enzyme Modulators Are Inositol Phosphate Glycans 6 2 i
The Inositol Phosphate Glycan Enzyme Modulators Are
Produced by an Insulin-Sensitive Phosphatidylinositol
Glycan-Specific Phospholipase C Activity 65
Turnover of Glycosylphosphatidvlinositol in Insulin Action 66
References 67
7 Cooperative Regulation of Gene Expression in
Liver Cells by Hormones and Extracellular
Matrix
LOLA M REID, ISABEL ZVIBVEL,
TOHRU WATANABE, YASU FUJITA, MARIA
ACELLI, KATE MONTGOMERY, ANDREA KRAFT,
AND ANDREAS OCHS
Introduction 69
Cell Culture 71
Gene Expression in Normal Liver 80
Gene Expression Studies in Hepatoma Cells 90
Hypotheses on the Mechanisms of Matrix and Hormonal
Regulation of Gene Expression: Delivery of Protein
Hormones to the Nucleus by
Proteoglycan/Glycosaminoglycan Carriers 94
Summary 95
References 98
Receptor-Ligand Interactions: Role in Cancer
Invasion and Metastasis
MARK E SOBEL AND LANCE A LIOTTA
Introduction 107
Basement Membrane and the Three-Step
Hypothesis of Invasion 108
Components of Basement Membrane 108
Laminin Receptor 109
Vlll CONTENTS
Role of Laminin and Laminin Receptor in
Tumor Cell Metastasis 109
Monoclonal Antibodies to Human Laminin Receptor 110
Isolation of Human Laminin Receptor cDNA 110
Overlapping Domain of Laminin Receptor cDNA Inserts 111
Nucleotide and Deduced Amino Acid Sequence of the 2H5
Epitope of Human Laminin Receptor 113
Synthetic Peptides and the Putative Ligand Binding Domain
of Laminin Receptor 116
Expression of Laminin Receptor mRNA 116
Conclusions 118
References 119
Control of Cell Proliferation by Transforming
Growth Factors
H L MOSES, J BARNARD, C C BASCOM,
R D BEAUCHAMP, R J COFFEY,
R M LYONS, AND N J SIPES
Introduction 121
Transforming Growth Factor-a 121
Transforming Growth Factor-B 123
Autocrine Regulation of Epithelial Cells by Transforming
Growth Factors-a and -B 125
References 126
PART H POLYPEPTIDE GROWTH FACTORS
AND THEIR CELL MEMBRANE RECEPTORS:
RELATION TO ONCOGENES
10 The EGF Receptor Protooncogene: Structure,
Evolution of Properties of Receptor Mutants
JOSEPH SCHLESSINGER
Introduction 131
Structure of the EGF Receptor 132
Properties of EGF Receptor Mutants 133
References 134
CONTENTS ix
11 Biological Effects of the v-erbA Oncogene in
Transformation of Avian Erythroid Cells
BJORN VENNSTROM, HARTMUT BEUG, KLAUS
DAMM, DOUGLAS ENGEL, ULLRICH GEHRING,
THOMAS GRAF, ALBERTO MUNOZ, JAN SAP,
AND MARTIN ZENKE
Biological Effects of the v-erbA and v-erbB Oncogenes 138
Comparison of the v-erbA an d c-erbA 138
Effects of Mutant v-erbA Genes on Erythroblasts 140
How Does v-erbA Contribute to Transformation of
Erythroblasts? 141
Conclusions 145
References 147
12 ras Transformation of 3T3 Cells Induces Basic
Fibroblast Growth Factor Synthesis in Vitro and
in Vivo
MICHAEL KLAGSBRUN, PAUL FANNING, AND
SNEZNA ROGELJ
Introduction 149
Results 150
Discussion 151
References 154
13 Cellular Oncogenes Conferring Growth Factor
Independence on NIH 3T3 Cells
MITCHELL GOLDFARB
Introduction 157
Results 158
Discussion 171
References 172
14 Potential Function of the mos Protooncogene in Germ
Cell Differentiation and Early Development
GEOFFREY M COOPER
Introduction 175
Expression of mos in Male Germ Cells 177
CONTENTS
Expression of mos in Oocytes 178
Posttranscriptional Processing of mos in Eggs 179
References 181
PART HI POLYPEPTIDE GROWTH FACTORS
AND THEIR CELL MEMBRANE RECEPTORS:
ROLE IN DIFFERENTIATION AND
DEVELOPMENT
15 Pleiotypic Actions of the Seminiferous
Growth Factor
ANTHONY R BELLVE AND WENXIN ZHENG
Introduction 187
Expression of Mitogenic Activity 188
Biochemical Characterization 189
Two Testicular Cell Lines: TM3 Leydig and TM4 Sertoli Cells 191
Proliferation of TM3 Leydig and TM4 Sertoli Cells 192
Extracellular Accumulation of Sulfated Glycoprotein 194
Synthesis of Specific Peptides 196
Immunological Properties of Heparin-Binding Growth Factors 200
Discussion 201
References 203
16 Regulation of Blood Vessel Growth and
Differentiation
WERNER RISAU, HANNES DREXLER, HANS-
GUNTER ZERWES, HARALD SCHNURCH,
URSULA ALBRECHT, AND RUPERT HALLMANN
Introduction
Growth and Development
Embryonic Stem Cells as an Experimental Model System for
Early Vascular Development
Endothelial Cell Differentiation
Concluding Remarks
References
CONTENTS XI
17 Vascular Endothelium: Role in Albumin
Transport
G E PALADE AND A J MILICI
Multiplicity of Endothelial Functions 223
General Organization 224
Continuous Microvascular Endothelium 225
Physiological Data 226
Attempts at Structural-Functional Integration 227
Perspectives 245
References 246
18 A Growth Factor Homologous Gene Controlling
Pattern Formation in Drosophila
WILLIAM M GELBART
Introduction 249
Overview of the Organization of the decapentaplegic Gene 249
Contribution of the Hin Region to dpp Function 250
Nature of the dpp Polypeptide 254
References 257
PART IV SEQUENCE-SPECIFIC DNA-BINDING
PROTEINS: ROLE IN DIFFERENTIATION
AND DEVELOPMENT
19 The Role of Master Regulatory Genes in
Controlling Development
E B LEWIS
Text 261
References - 265
20 engrailed, A Gene for All Segments
THOMAS KORNBERG, CHIHIRO HAMA,
NICHOLAS J GAY, AND STEPHEN J POOLE
Introduction 267
The engrailed Gene Promoter 268
The engrailed Protein Is a Phosphoprotein 269
References 278
CONTENTS
Sequence-Specific DNA-Binding Activities of Even-Skipped
and Other Homeo Box Proteins in Drosophila
TIMOTHY HOEY, MANFRED FRASCH, AND
MICHAEL LEVINE
Introduction 279
Results 281
Discussion 296
Materials and Methods 301
References 303
Identification and Characterization of Two Mouse Genes,
EN-1 and EN-2, with Sequence Homology to the
engrailed and invected Genes of Drosophila
GAIL R MARTIN AND ALEXANDRA L JOYNER
Introduction 305
Results 308
Discussion 315
References 317
Structure and Developmental Expression of
Murine Homeo Box Genes
PETER GRUSS, CAROLA DONY, BERND
FOHRING, AND MICHAEL KESSEL
Introduction 319
Results and Discussion 320
References 325
PART V SMALL MOLECULES IN DIFFERENTIATION
AND DEVELOPMENT
Molecular Dissection of Pattern Formation in Vertebrate
Limbs: Concepts and Experimental Approaches
GREGOR EICHELE AND CHRISTINA THALLER
Background 329
Retinoic Acid Mimics ZPA Tissue and Induces Pattern
Duplications in a Highly Specific Way 331
CONTENTS xiii
Retinoic Acid Can Induce Digit Formation in the Absence of
ZPA Tissue 334
Limb Buds Contain Endogenous Retinoic Acid 336
Future Problems 339
References 340
25 Differentiation of a Multipotent Human
Intestinal Cell Line: Expression of Villin, a
Structural Component of Brush Borders
D LOUVARD, M ARPIN, E COUDRIER, B
DUDOUET, J FINIDORI, A GARCIA, O
GODERFROY, C HUET, E PRINGAULT, S
ROBINE, AND C SAHUQUILLO MERINO
The Intestinal Epithelium: A Model System for Study of Cell
Differentiation and the Development of a Polarized
Cytoskeleton 341
A Pluripotent Human Intestinal Cell Line That Can Be
Induced to Differentiate in Culture 343
Organization of Intestinal Brush Border Cytoskeleton 344
Villin, a Calcium-Regulated Actin-Binding Protein 347
Villin Is an Organ-Specific Marker in Adults and Embryos 348
Villin Expression during Intestinal Differentiation 350
Summary and Conclusions 351
References 351
Index 355
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| indexdate | 2024-07-09T17:07:41Z |
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| spelling | Molecular mechanisms in cellular growth and differentiation ed. by Anthony R. Bellvé ... San Diego u.a. Academie Press 1991 XXII, 365 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cellules - Croissance - Régulation Facteurs de croissance Mécanismes autocrines Mécanismes paracriniens Autocrine mechanisms Cell Differentiation physiology Cells Growth Regulations Gene Expression Regulation physiology Growth Substances physiology Growth factors Paracrine mechanisms Receptors, Cell Surface physiology Signal Transduction physiology Zellwachstum (DE-588)4190674-3 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Zelldifferenzierung (DE-588)4067536-1 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 s Zelldifferenzierung (DE-588)4067536-1 s DE-604 Zellwachstum (DE-588)4190674-3 s Bellvé, Anthony R. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005046314&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular mechanisms in cellular growth and differentiation Cellules - Croissance - Régulation Facteurs de croissance Mécanismes autocrines Mécanismes paracriniens Autocrine mechanisms Cell Differentiation physiology Cells Growth Regulations Gene Expression Regulation physiology Growth Substances physiology Growth factors Paracrine mechanisms Receptors, Cell Surface physiology Signal Transduction physiology Zellwachstum (DE-588)4190674-3 gnd Molekularbiologie (DE-588)4039983-7 gnd Zelldifferenzierung (DE-588)4067536-1 gnd |
| subject_GND | (DE-588)4190674-3 (DE-588)4039983-7 (DE-588)4067536-1 |
| title | Molecular mechanisms in cellular growth and differentiation |
| title_auth | Molecular mechanisms in cellular growth and differentiation |
| title_exact_search | Molecular mechanisms in cellular growth and differentiation |
| title_full | Molecular mechanisms in cellular growth and differentiation ed. by Anthony R. Bellvé ... |
| title_fullStr | Molecular mechanisms in cellular growth and differentiation ed. by Anthony R. Bellvé ... |
| title_full_unstemmed | Molecular mechanisms in cellular growth and differentiation ed. by Anthony R. Bellvé ... |
| title_short | Molecular mechanisms in cellular growth and differentiation |
| title_sort | molecular mechanisms in cellular growth and differentiation |
| topic | Cellules - Croissance - Régulation Facteurs de croissance Mécanismes autocrines Mécanismes paracriniens Autocrine mechanisms Cell Differentiation physiology Cells Growth Regulations Gene Expression Regulation physiology Growth Substances physiology Growth factors Paracrine mechanisms Receptors, Cell Surface physiology Signal Transduction physiology Zellwachstum (DE-588)4190674-3 gnd Molekularbiologie (DE-588)4039983-7 gnd Zelldifferenzierung (DE-588)4067536-1 gnd |
| topic_facet | Cellules - Croissance - Régulation Facteurs de croissance Mécanismes autocrines Mécanismes paracriniens Autocrine mechanisms Cell Differentiation physiology Cells Growth Regulations Gene Expression Regulation physiology Growth Substances physiology Growth factors Paracrine mechanisms Receptors, Cell Surface physiology Signal Transduction physiology Zellwachstum Molekularbiologie Zelldifferenzierung |
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