Tunicamycin:
Examines effects of tunicamycin in biosynthesis, microbiology and virology, as well as its actions on vertebrate cells.
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Tokyo
Japan Scientific Societies Pr.
1982
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | Examines effects of tunicamycin in biosynthesis, microbiology and virology, as well as its actions on vertebrate cells. |
| Beschreibung: | XII, 220 S. zahlr. Ill., graph. Darst. |
| ISBN: | 476225309X |
Internformat
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| 300 | |a XII, 220 S. |b zahlr. Ill., graph. Darst. | ||
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| 520 | 3 | |a Examines effects of tunicamycin in biosynthesis, microbiology and virology, as well as its actions on vertebrate cells. | |
| 650 | 4 | |a Glycoproteins |x Synthesis | |
| 650 | 4 | |a Tunicamycin |x Physiological effect | |
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Datensatz im Suchindex
| _version_ | 1804121904399777792 |
|---|---|
| adam_text | TUNICAMYCIN
edited by
GAKUZO TAMURA
Department of Agricultural Chemistry
University of Tokyo, Tokyo
JAPAN SCIENTIFIC SOCIETIES PRESS
Tokyo
CONTENTS
Preface vii
DISCOVERY AND CHEMISTRY OF TUNICAMYCIN
G Tamura and T Ito 3
I Discovery of Tunicamycin 3
II Chemistry of Tunicamycin 10
1 Isolation and properties of tunicamycin 10
1) Isolation of tunicamycins by high-performance liquid
chromatography 10
2) Physical properties of tunicamycins 11
3) Tunicamycin-like antibiotics 15
2 Degradative studies of tunicamycin 16
1) Fatty acids 17
2) Tunicaminyl uracil 19
3 Chemical structure of tunicamycin 29
INHIBITION OF GLYCOCONJUGATE BIOSYNTHESIS BY
TUNICAMYCIN A Takatsuki and G Tamura 35
I Discovery of Specific Inhibitory Action of Tunicamycin on
Glycoconjugate Biosynthesis 37
ix
X
II Effect of Tunicamycin on Glycoprotein Biosynthesis :
1 Lipid pathway in glycoprotein biosynthesis ;
2 Effect of tunicamycin on formation of lipid-linked intermediates
in glycoprotein biosynthesis
3 Relationship between structure and activity of tunicamycin
III Other Antibiotics and Agents Which Inhibits the Lipid Pathway
in Glycoprotein Biosynthesis
1 Bacitracin
2 Amphomycin :
3 Showdomycin ;
4 Diumycin :
5 Tsushimycin ;
6 2-Deoxy-D-glucose
7 Other sugar analogues
8 Aryl phosphates
9 Oxygenated sterols and ML-236B (compactin)
IV Effect of Tunicamycin on Biosynthesis of Glycoconjugates Other
Than Glycoproteins
1 Bacterial cell wall glycoconjugate biosynthesis
2 Chitin biosynthesis
3 Glycosaminoglycan biosynthesis
4 Glycolipid biosynthesis
Concluding Remarks
TUNICAMYCIN IN MICROBIOLOGY
M Yamasaki, A Takatsuki, and G Tamura
I Effect of Tunicamycin on Bacteria
1 Antimicrobial spectrum of tunicamycin
2 Morphology
3 Transport of glutamic acid
4 Secretion of extracellular enzymes
5 Competent cell formation
6 Macromolecular synthesis
7 Synthesis of cell surface glycoconjugates
a) Peptidoglycan
CONTENT
b) Teichoic acid
c) Teichuronic acid
8 Tunicamycin resistamt mutants •
a) Tunicamycin resistant mutants of Bacillus subtilis •
b) Breeding of a-amylase super producing strains of
Bacillus subtilis
c) Mapping of tmr genes
d) Cloning of tmr gene
e) Mechanism of resistance to tunicamycin
II Effect of Tunicamycin on Yeasts
1 Growth
2 Secretory and vacuole enzyme synthesis
III Effect of Tunicamycin on Fungi
IV Effect on Slime Molds, Algae, Tetrahymena, and Parasites
Conclusions •
TUNICAMYCIN IN VIROLOGY
R T Schwarz and MFG Schmidt
I Biosynthesis of Viral Glycoproteins
II Effect of Oligosaccharidic Chains on Conformation of Viral
Glycoproteins
III Role of Carbohydrate in Processing of Viral Glycoproteins
IV Relation between Glycosylation and Acylation of Viral
Glycoproteins
V Effect of Inhibition of Glycosylation on the Formation of Virions
VI Effects of Inhibition of Glycosylation on Hemagglutination,
Neuraminidase Activity, and Virus-induced Membrane Fusion :
VII Some Applications of Tunicamycin as a Tool in Molecular
Virology • ]
1 Discrimination of the type of oligosaccharidic chains of
proteins ]
2 Characterization of viral glycoproteins • 1
3 Cell biological aspects of virus formation 1
Conclusions - • - - • • 1
Xll
ACTIONS OF TUNICAMYCIN ON VERTEBRATE CELLS
K M Yamada and K Olden
I General Approaches
1 Uses of tunicamycin in vertebrate cells
2 Specificity of action
3 Anomalous results
II Studies of Glycoprotein Secretion
1 Mechanisms of secretion
2 Metabolism and function of fibronectin
3 Secretion of procoUagen and proteoglycans
4 Secretion of hormones •
5 Packaging of lysosomal enzymes
III Membrane Glycoproteins
1 Transmembrane proteins
2 Hormone receptors
3 Membrane transport components
IV Cell Morphology and Growth
1 Normal cells
2 Transformed cells
V Embryonic Development
1 Morphogenesis
2 Differentiation
VI Effects on Glycoprotein Function
General Conclusions
TUNICAMYCIN IN BIOLOGICAL RESEARCH IN JAPAN
K Onodera
I Virology
II Biochemistry
III Cell Biology
IV Developmental Biology
V Neurobiology
BIBLIOGRAPHY
SUBJECT INDEX
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| id | DE-604.BV007593544 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:05:23Z |
| institution | BVB |
| isbn | 476225309X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-004961655 |
| oclc_num | 8833620 |
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| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XII, 220 S. zahlr. Ill., graph. Darst. |
| publishDate | 1982 |
| publishDateSearch | 1982 |
| publishDateSort | 1982 |
| publisher | Japan Scientific Societies Pr. |
| record_format | marc |
| spelling | Tunicamycin ed. by Gakuzo Tamura Tokyo Japan Scientific Societies Pr. 1982 XII, 220 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Examines effects of tunicamycin in biosynthesis, microbiology and virology, as well as its actions on vertebrate cells. Glycoproteins Synthesis Tunicamycin Physiological effect Tunicamycin (DE-588)4671195-8 gnd rswk-swf Tunicamycin (DE-588)4671195-8 s DE-604 Tamura, Gakuzo Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004961655&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Tunicamycin Glycoproteins Synthesis Tunicamycin Physiological effect Tunicamycin (DE-588)4671195-8 gnd |
| subject_GND | (DE-588)4671195-8 |
| title | Tunicamycin |
| title_auth | Tunicamycin |
| title_exact_search | Tunicamycin |
| title_full | Tunicamycin ed. by Gakuzo Tamura |
| title_fullStr | Tunicamycin ed. by Gakuzo Tamura |
| title_full_unstemmed | Tunicamycin ed. by Gakuzo Tamura |
| title_short | Tunicamycin |
| title_sort | tunicamycin |
| topic | Glycoproteins Synthesis Tunicamycin Physiological effect Tunicamycin (DE-588)4671195-8 gnd |
| topic_facet | Glycoproteins Synthesis Tunicamycin Physiological effect Tunicamycin |
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