Replication and transcription of chromatin:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English Russian |
| Veröffentlicht: |
Boca Raton u.a.
CRC Press
1993
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Aus d. Russ. übers. |
| Beschreibung: | 269 S. Ill., graph. Darst. |
| ISBN: | 0849368030 |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | Replication
and
Transcription of
Chromatin
Roumen Tsanev, MD, Ph D,D Sci
Institute of Molecular Biology
George Russev, Ph D,D Sci
Institute of Molecular Biology
Iliya Pashev, MD, Ph D,D Sci
Institute of Molecular Biology
Jordanka Zlatanova, Ph D,D Sci
Institute of Genetics
Bulgarian Academy of Sciences
Sofia, Bulgaria
CRC Press
Boca Raton Ann Arbor London Tokyo
TABLE OF CONTENTS
Chapter 1
Main Features of the Molecular Organization of Chromatin
I General Outlines
II First Level of DNA Folding — the Nucleosome
A TheHistones
1 Main Characteristics of Histone Species
2 Occurrence of Histones 3
3 Tissue Specificity of Histones 5
4 Origin and Evolution of Histones 6
B The Nucleosome 8
1 Main Structural Characteristics of Nucleosomes 8
2 Heterogeneity of Nucleosomes 11
3 Nucleosome Positioning 12
4 Conformational Changes of Nucleosomes 14
III Second Level of DNA Folding — Higher Order Structures 14
A The 30 nm Chromatin Fiber 14
B The Role of Histone HI in Chromatin Condensation 21
C Higher Levels of Chromatin Organization 24
IV Chromatin Loops 24
A Scaffold/Matrix Attached Regions (SARs/MARs) 28
B Protein Composition of the Nuclear Matrices 29
1 Lamins 30
2 Topoisomerase II 31
3 Repressor-Activator Binding Protein-1 (RAP-1) 32
4 RNA Polymerases 32
5 Tissue-Specific Matrix Proteins 32
References 33
Chapter 2
Replication of Chromatin 49
I Problems of Chromatin Replication 49
II Basic Features of DNA Replication 50
A Initiation of DNA Replication 50
1 Replication Origins Replicons 50
2 Double Replication Gene Amplification 52
3 Mapping of Origins 54
4 Origins and Chromatin Structure 62
5 The Strand Separation Model 63
B Mechanisms of Initiation and Elongation of DNA Chains
Replication Fork 67
C Termination of DNA Replication Telomeres 74
D Fidelity of DNA Replication Proofreading 76
III Characteristics and Nucleosomal Organization of Replicating
Chromatin 77
IV Histones and Nucleosomes during Replication 79
A Synthesis and Metabolic Stability of Histones 80
1 Histone Synthesis 80
2 Histone Genes and mRNA 80
3 Transcriptional Regulation 81
4 Regulation of Histone mRNA 3 -Processing 82
5 Regulation of mRNA Stability 83
6 Histone Metabolism 84
B Possible Conformational Changes of Nucleosomes
during DNA Replication 84
C Sites of Deposition of the New Histones 85
D Nucleosome Assembly During DNA Replication 87
E Interaction of Histones with the Two Complementary
DNA Strands 93
F Segregation of Parental and New Nucleosomes Between
the Two Daughter DNA Molecules 96
V Chromatin Replication and Nucleosome-Free Sites 103
A Reproduction of Nucleosome-Free Sites 104
B Changes in the Nucleosome-Free Pattern 105
VI DNA Imprinting 106
A Imprinting by DNA Methylation 106
B Possible Imprinting Role of DNA-Bound Proteins 107
C Possible Imprinting Role of Constitutive
Chromatin Loops 108
VII Relationships Between Replication and Transcription 109
VIII Control of Chromatin Replication 112
A Controlling Factors 112
B The Role of the Nuclear Matrix in Chromatin Replication 114
C The Role of Supercoiling and Higher Order Structures 115
References 116
Chapter 3
Transcription of Chromatin 137
I The Problem of Gene Expression 137
II Structural and Informational Aspects of Transcription 137
A General Characteristics of Active Chromatin 138
B Informational Aspects of Transcription Genetic and
Epigenetic Information 138
III Cis-Trans Interactions 139
A C/j-Acting Regulatory DNA Elements 139
B Trans-Acting Protein Factors 141
1 DNA-Binding Domains 144
2 Transcription-Activating Domains 147
3 Families of Transcription Factors with Related
DNA-Binding Specificities 148
4 Regulation of the Activity of Transcription Factors 149
5 Evolutionary Conservatism of Cis-Trans Interactions 150
IV The Process of Transcription 157
A Eukaryotic DNA-Dependent RNA Polymerases
Types of Transcription 157
B The Preinitiation Complex 158
1 Polymerase I Transcription Complex 158
2 Polymerase II Transcription Complex 160
3 Polymerase III Transcription Complex 162
C Initiation of RNA Synthesis, Elongation, and Pausing 163
D Termination of Transcription 164
V Transcription and Chromatin Structure 165
A Histones, Nucleosomes, and Transcription 165
1 The Effect of Nucleosomes on Initiation and
Cis-Trans Interactions 166
2 Nucleosomes in the Process of Elongation 172
3 Transcription-Associated Conformational Changes
of Nucleosomes 179
4 Possible Mechanisms of Transcription Through
Nucleosomes 184
5 The Role of Nonallelic Histone Variants 188
B Transcription and Higher-Order Structures 190
1 Active Genes and Higher-Order Structures 190
2 The Role of Histone HI 192
C The Role of Chromatin Loops and the Nuclear Matrix 198
1 Chromatin Loop Pattern and Transcription 198
2 The Effect of Protein Composition of the
Matrix-Loop Complexes 199
3 The Role of DNA Supercoiling 200
4 Localization of SARs/MARs with Respect to
Promoters and Transcription Regulatory Sequences 203
5 The Role of SARs/MARs in Defining Borders
(Boundaries) of Active and Inactive Chromatin
Domains 203
6 Coordinate Regulation of Genes in a Loop? 206
VI The Role of Posttranslational Modifications of Histones 207
A Acetylation 207
1 Reversible Postsynthetic Acetylation of Histones 207
2 The Effect of Histone Acetylation on Chromatin
Structure 207
3 Histone Acetylation and Transcription 209
B Poly(ADP-ribosyl)ation 210
C Ubiquitination 212
1 Histone Ubiquitination and Gene Transcription 212
2 Histone Ubiquitination and Chromatin Structure 213
VII The Role of DNA Methylation 214
A Methylation of Eukaryotic DNA 214
B DNA Methylation and Gene Expression 215
C The Effect of DNA Methylation on DNA and Chromatin
Structure 216
D DNA Methylation: a Cause or a Consequence of Gene
Inactivation? 217
VIII Cellular Reprogramming and Chromatin Structure 219
IX Genetic Networks 222
References 224
Index 261
|
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| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Book |
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| id | DE-604.BV007566340 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:04:50Z |
| institution | BVB |
| isbn | 0849368030 |
| language | English Russian |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-004936729 |
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| owner_facet | DE-12 DE-355 DE-BY-UBR DE-188 |
| physical | 269 S. Ill., graph. Darst. |
| publishDate | 1993 |
| publishDateSearch | 1993 |
| publishDateSort | 1993 |
| publisher | CRC Press |
| record_format | marc |
| spelling | Replication and transcription of chromatin Roumen Tsanev ... Boca Raton u.a. CRC Press 1993 269 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Aus d. Russ. übers. Chromosom (DE-588)4010162-9 gnd rswk-swf Replikation (DE-588)4153174-7 gnd rswk-swf Chromatin (DE-588)4010152-6 gnd rswk-swf Transkription Genetik (DE-588)4185906-6 gnd rswk-swf Chromatin (DE-588)4010152-6 s Replikation (DE-588)4153174-7 s DE-604 Transkription Genetik (DE-588)4185906-6 s Chromosom (DE-588)4010162-9 s Canev, Rumen G. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004936729&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Replication and transcription of chromatin Chromosom (DE-588)4010162-9 gnd Replikation (DE-588)4153174-7 gnd Chromatin (DE-588)4010152-6 gnd Transkription Genetik (DE-588)4185906-6 gnd |
| subject_GND | (DE-588)4010162-9 (DE-588)4153174-7 (DE-588)4010152-6 (DE-588)4185906-6 |
| title | Replication and transcription of chromatin |
| title_auth | Replication and transcription of chromatin |
| title_exact_search | Replication and transcription of chromatin |
| title_full | Replication and transcription of chromatin Roumen Tsanev ... |
| title_fullStr | Replication and transcription of chromatin Roumen Tsanev ... |
| title_full_unstemmed | Replication and transcription of chromatin Roumen Tsanev ... |
| title_short | Replication and transcription of chromatin |
| title_sort | replication and transcription of chromatin |
| topic | Chromosom (DE-588)4010162-9 gnd Replikation (DE-588)4153174-7 gnd Chromatin (DE-588)4010152-6 gnd Transkription Genetik (DE-588)4185906-6 gnd |
| topic_facet | Chromosom Replikation Chromatin Transkription Genetik |
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