Gene amplification in mammalian cells: a comprehensive guide
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York u.a.
Dekker
1993
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXVII, 543 S. Ill., graph. Darst. |
| ISBN: | 0824787560 |
Internformat
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| 245 | 1 | 0 | |a Gene amplification in mammalian cells |b a comprehensive guide |c ed. by Rodney E. Kellems |
| 264 | 1 | |a New York u.a. |b Dekker |c 1993 | |
| 300 | |a XXVII, 543 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 650 | 4 | |a Gene amplification | |
| 650 | 4 | |a Gene amplification |x Research |x Methodology | |
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Datensatz im Suchindex
| _version_ | 1804121841921425408 |
|---|---|
| adam_text | A Comprehensive Guide
edited by
Rodney E Kellems
Baylor College of Medicine
Houston Texas
Marcel Dekker, Inc New York • Basel • Hong Kong
Contents
Foreword! Robert T Schimke Hi
Preface xiii
Contributors xxi
Introduction to Gene Amplification: Historical Background and Biological
Perspective 1
Rodney E Kellems
Part I: Organization and Structure of Amplified Genes
1 Cytogenetic Consequences of Gene Amplification: HSRs and DMs in
Antifolate-Resistant and Multidrug-Resistant Chinese Hamster and Mouse
Cells and in Human Neuroblastoma Cells with Amplified H-myc Proto-
Oncogenes 29
June L Biedler and Barbara A Spengler
2 Organization and Structure of Dihydrofolate Reductase Amplicons 43
Joyce L Hamlin
3 Analysis of Gene Amplification by In-Gel DNA Renaturation 55
Igor B Roninson
xv
xvi Contents
4 Molecular Cytogenetic Characterization of the Sequential Development of
Multidrug Resistance in Two Panels of Colchicine-Resistant Cell
Lines 71
Jeffrey M Trent, Marilyn L Slovak, Floyd Thompson, Eckart U Meese,
Paul S Meltzer, and Victor Ling
5 Effects of Methotrexate on Recombinant Sequences in Mammalian
Cells 85
Florian M Wurm and Maria G Pallavicini
Part II: Gene Amplification and Drug Resistance
6 Threonyl-tRNA Synthetase Gene Amplification in Borrelidin-Resistant
Mammalian Cells 97
Stuart M Arfin, Steven C Gerken, Kris J Kontis, and Matt E Cruzen
7 Amplification of Na,K-ATPase in Ouabain-Resistant HeLa Variants 107
John F Ash and Peter G Pauw
8 Asparagine Synthetase Gene Amplification in Albizziin-Resistant Hamster
and Human Cell Lines 119
Michael T Barrett and Irene L Andrulis,
9 Overproduction of Damage Recognition Proteins in Human Cells
Resistant to Cisplatin and Ultraviolet Radiation 131
Chuck C -K Chao
10 Ornithine Decarboxylase Gene Amplification 141
Philip Cqffino
11 Amplification of the IMP Dehydrogenase Gene in Mammalian Cells 149
Frank R Collart and Eliezer Huberman
12 Amplification and Analysis of the Mouse Dihydrofolate Reductase
Gene 159
Gray F Crouse
13 Amplification of the Adenylate-Deaminase 2 and Linked Genes
in Chinese Hamster Lung Fibroblasts 173
Michelle Debatisse, Franck Toledo, Bruno Robert De Saint Vincent,
and Gerard Buttin
14 Organization and Amplification of Metallothionein Genes in Eukaryotic
Cells 185
C Edgar Hildebrand, Deborah L Grady, and Raymond L Stallings
Contents xvii
15 Thymidylate Synthetase Gene Amplification in Drug-Resistant
Mammalian Cells 195
Lee F Johnson
16 Adenosine Deaminase: A Dominant Amplifiable Genetic Marker 207
Rodney E Kellems, Rueyling Lin, and A Craig Chinault
17 Amplification of the HPRT Gene 223
David W Melton
18 Amplification of the Gene for /V-Acetylglucosaminyl Phosphate
Transferase, an Enzyme Catalyzing an Early Step in Asn-Linked
Glycosylation, in Chinese Hamster Ovary Cells Resistant to
Tunicamycin 233
Jane R Scocca and Sharon S Krag
19 Amplification of CAD Genes 243
George R Stark
20 A Reversible Selection System for UMP Synthase Gene Amplification and
Deamplification 255
D Parker Suttle and Mazin B Qumsiyeh
21 Amplification of the Genes Encoding the Rl and R2 Subunits of
Mammalian Ribonucleotide Reductase 265*
Lars Thelander
22 DNA Amplification in Histidinol-Resistant Chinese Hamster Ovary
Cells 275
Florence W L Tsui and Louis Siminovitch
23 Amplification of the P-Glycoprotein Gene Family and Multidrug
Resistance 287
Lela Veinot and Victor Ling
24 Glutamine Synthetase Gene Amplification in Chinese Hamster Ovary
Cells 301
Richard H Wilson
Part ID: Amplification of Transferred Genes
25 Amplification and Expression of Transfected Genes in Mammalian
Cells 315
Randal J Kaufman
26 Consequences of Coamplification of Adenosine Deaminase and
Nonselected Genes in a Heterodiploid Host 345
Sheila P Little, Edward M Johnstone, and Karen Ward
xviii Contents
27 Production of Proteins by Mammalian Cells Using Dominant Selectable
and Amplifiable Markers 355
Mitchell E Reff and David S Pfarr
Part IV: Gene Amplification and Cancer
28 Oncogene Amplification: Analysis of myc Oncoproteins 371
Kari Alitalo, Tomi P Mdkeld, Kalle Saksela, Harri Hirvonen,
and Pdivi J Koskinen
29 Biological and Clinical Significance of MYCN Amplification in Human
Neuroblastomas 383
Garrett M Brodeur
30 Amplification of the c-abl Oncogene in Chronic Myelogenous
Leukemia 397
Steven J Collins and Mark T Groudine
31 Gene Amplification in Small Cell Carcinoma of the Lung 405
Edward A Sausville
32 Amplification and Mutagenesis of the Acetylcholinesterase and
Butyrylcholinesterase Genes in Primary Human Tumors 417
Hermona Soreq, Gal Ehrlich, Yaron Lapidot-Lifson, Averell Gnatt,
Lewis Neville, Revital Ben-Aziz-Aloya, Shlomo Seidman, Dalia Ginzberg,
and Haim Zakut
33 Gene Amplification in Nontumorigenic and Tumorigenic Mammalian
Cells: Relationship to Carcinogenesis 429
Thea D Tlsty
Part V: The Mechanism of Gene Amplification
34 Mechanisms of Arsenic-Induced Gene Amplification 441
J Carl Barrett and Te-Chang Lee
35 Involvement of Inverted Duplications in the Generation of Gene
Amplification in Mammalian Cells 447
Mike Fried, Salvatore Feo, and Edith Heard
36 The Genetics of Amplification 461
Elena Giulotto and Mary Ellen Perry
37 U-Turn Replication at Arrested Forks Leads to the Generation
of Extrachromosomal Inverted Repeats 471
Sara Lavi, David Hassin, Mirit Aladjem, Zlil Ophir, and Shulamit Karby
Contents xix
38 The Stimulation of Gene Amplification in Mammalian Cells by HSAG
Middle Repetitive Elements 485
James G Me Arthur, Lenore K Beitel, and Clifford P Stanners
39 Amplisomes: Novel Submicroscopic Extrachromosomal Elements
Containing Amplified Genes 499
Giovanni Pauletti, Barry J Maurer, and Giuseppe Attardi
40 Cytogenetic and Molecular Dynamics of Mammalian Gene Amplification:
Evidence Supporting Chromosome Breakage as an Initiating Event 513
Geoffrey M Wahl, Susan M Carroll, and Bradford E Windle
Index 533
|
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| spellingShingle | Gene amplification in mammalian cells a comprehensive guide Gene amplification Gene amplification Research Methodology Genetik (DE-588)4071711-2 gnd Genamplifikation (DE-588)4333686-3 gnd Säugetiere (DE-588)4051253-8 gnd Zelle (DE-588)4067537-3 gnd |
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| title | Gene amplification in mammalian cells a comprehensive guide |
| title_auth | Gene amplification in mammalian cells a comprehensive guide |
| title_exact_search | Gene amplification in mammalian cells a comprehensive guide |
| title_full | Gene amplification in mammalian cells a comprehensive guide ed. by Rodney E. Kellems |
| title_fullStr | Gene amplification in mammalian cells a comprehensive guide ed. by Rodney E. Kellems |
| title_full_unstemmed | Gene amplification in mammalian cells a comprehensive guide ed. by Rodney E. Kellems |
| title_short | Gene amplification in mammalian cells |
| title_sort | gene amplification in mammalian cells a comprehensive guide |
| title_sub | a comprehensive guide |
| topic | Gene amplification Gene amplification Research Methodology Genetik (DE-588)4071711-2 gnd Genamplifikation (DE-588)4333686-3 gnd Säugetiere (DE-588)4051253-8 gnd Zelle (DE-588)4067537-3 gnd |
| topic_facet | Gene amplification Gene amplification Research Methodology Genetik Genamplifikation Säugetiere Zelle Aufsatzsammlung |
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