Antimetabolites of nucleic acid metabolism: the biochemical basis of their action, with special reference to their application in cancer therapy. Transl. from the German by Thomas A. Scott
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Gordon and Breach
1975
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 273 S. Ill. u. graph. Darst. |
| ISBN: | 0677307608 |
Internformat
MARC
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| 240 | 1 | 0 | |a Antimetabolite des Nucleinsäure-Stoffwechsels |
| 245 | 1 | 0 | |a Antimetabolites of nucleic acid metabolism |b the biochemical basis of their action, with special reference to their application in cancer therapy. Transl. from the German by Thomas A. Scott |c Peter Langen |
| 264 | 1 | |a New York, NY [u.a.] |b Gordon and Breach |c 1975 | |
| 300 | |a XII, 273 S. |b Ill. u. graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-004801568 | ||
Datensatz im Suchindex
| _version_ | 1804121679235907584 |
|---|---|
| adam_text | Content
I General 1
1 General comments on the properties of antimetabolites 3
1 1 Definition, history and differentiation from other cyto-
static agents 3
1 2 The structural similarities between antimetabolite and
metabolite 6
1 3 Lethal Synthesis 8
2 Mode of action 13
2 1 Inhibition of enzyme reactions 13
211 Blockage of the catalytically active centre of an enzyme 15
2111 The kinetic basis of the binding of substrate and in-
hibitor to the catalytically active centre 15
2112 Antimetabolites that act as substrate analogues 23
212 The reaction of antimetabolites with the regulative
centre of the enzyme 32
2121 The feedback control of enzymic reactions 32
2122 Feedback inhibition by antimetabolites 34
2 2 The incorporation of antimetabolites into nucleic acids 38
221 The incorporation of antimetabolites into DNA and
its consequences 38
2211 5-Bromouracil and 5-iodouracil (mutations p 52;
irradiation sensitivity p 57; inhibition of differen-
tiation p 54) 38
2212 5-Trifluoromethyluracil 70
2213 5-Ethyluracil 70
2214 5-Fluorouracil 71
2215 6-Azathymine 71
2216 5-Azacytosine 71
2217 Cytosine-arabinoside 71
2218 3 -Deoxy thymidine; S -deoxy-S -fluorothymidine and
2/,3/-dideoxyadenosine 72
2219 2-Aminopurine 72
221 10 6-Thioguanine 74
222 The incorporation of antimetabolites into RNA and
its consequences 74
2221 5-Fluorouracil 79
2222 8-Azaguanosine 86
IX
2223 2-ThiouraciI 87
2224 Tubercidin (7-deazaadenosine) and Toyocamycin (7-
cyano-7-deazaadenosine) 89
222 Ö 7-Deazanebularin (7-Deazapurine riboside) 89
2226 Formycin(7-Amino-pyrazolo[4 3-d]pyrimidine riboside) 89
2227 5-Azacytosine 90
2228 6-Azacytosine 90
2229 5-Chlorouracil 90
222 10 5-Bromouracil and 5-bromocytosine 90
222 11 Cytosine arabinoside 91
222 12 3 -Deoxyadenosine 91
3 The biochemical basis of aquired resistance 93
3 1 Loss of lethal synthesis 96
3 2 Change in the affinity between enzyme and anti-
metabolite 103
3 3 Compensatory increase in enzyme synthesis 104
3 4 Decreased permeability of the cell membrane to anti-
metabolites 106
3 5 Increased degradation of antimetabolites 107
4 The degradation of antimetabolites 109
4 1 The deamination of purines 110
4 2 The degradation of hypoxanthine, xanthine and their
analogues 112
4 3 The deamination of pyrimidines 113
4 4 The degradation of thymine, uracil and 5-halogenated
uracils 114
4 5 The cleavage of nucleosides 116
4 6 The degradation of folic acid antagonists 118
4 7 The degradation of azaserine 118
5 Biochemical problems associated with the use of anti-
metabolites of nucleic acid metabolism in the chemo-
therapy of cancer 119
II Special 141
1 Pyrimidine analogues and their nucleosides 143
1 1 5-Fluorouracil, its riboside and 2 -deoxyriboside 143
1 2 5-Fluorocytosine and its 2 -deoxyriboside 145
1 3 5-Fluoroorotate 146
1 4 5-Trifluoromethyl-2 -deoxyuridine 146
1 5 5-Bromo-2 -deoxyuridine and 5-iodo-2 -deoxyuridine 147
1 6 5-Chloro-2/-deoxyuridine 148
1 7 5-Aminouracil, its riboside and 2 -deoxyriboside 149
185 -Me thy 1am ino - 27 - deo xy uridine 149
1 9 5-Nitrouracil and its 2 -deoxyriboside 149
1 10 5-Diazouracil (5-diazopyrimidin-2 4(3H)dione) 150
1 11 5-Cyanouracil 150
1 12 5-Hydroxyuracil, its riboside and 2/-deoxyriboside 150
1 13 5-Mercaptouracil, its riboside and 2/-deoxyriboside 151
1 14 5-EthyluraciI and its 2 -deoxyriboside 151
1 15 5-Allyl-2 -deoxyuridine 152
1 16 Uracil 6-sulphonic acid 152
1 17 6-Aminothymine 152
1 18 N-Methyl uridine 153
1 19 4-N-Hydroxy-2 -deoxycytidine 153
1 20 2-Thiouracil, 2-Thiouridine; 2 4-Dithiouridine 154
1 21 4-Thiothymidine 154
1 22 Pyrimidine-ones, their ribosides and 2 -deoxyribosides 155
1 23 6-Azauracil and its riboside 155
1 24 5-Azauracil 157
1 25 6-Azacytidine 157
1 26 5-Azacytidine and 5-Aza-2 -deoxycytidine 157
1 27 6-Azathymidine and its 2/-deoxyriboside 158
1 28 5-Azaorotate 159
1 29 3-Deazauridine, 3-Deazacytidine 159
2 Purine analogues and their nucleosides 161
2 1 6-Mercaptopurine 161
2 2 6-Methylmercaptopurine riboside 163
2 3 6-Thioguanine 164
2 4 6-Chloropurine 165
2 5 6-Methylpurine 165
2 6 6-N-Hydroxyaminopurine 166
2 7 N6-(A2-Isopentenyl)adenosine 166
2 8 6-N-Allyladenosine 166
2 9 2-FIuoroadenine, its riboside and 2 -deoxyriboside 167
2 10 2-Aminopurine 167
2 11 2,6-Diaminopurine 168
2 12 Pyrazolo[3 4-d]pyrimidines 168
2 13 Formycin(7-Amino-pyrazolo[4 3-d]pyrimidine riboside) 169
2 14 Tubercidin (7-Deazaadenosine) 170
2 15 Toyocamycin (7-Cyano-7-deaza-adenosine) 170
2 16 7-Deazanebularin (7-Deazapurine riboside) 171
2 17 8-Azaguanine 171
2 18 3-Isoadenosine (3-ß-D-Ribofuranosyl-adenine) 172
3 Nucleoside analogues with modified sugar components 173
3 1 Arabinosyl-nucleosides 173
3 2 Xylosyl-nucleosides 175
3 3 3 -Deoxyadenosine, 3 -Deoxy-3 -aminoadenosine 176
3 4 2,,3/-Dideoxyadenosine 177
3 5 3 -Deoxy-3 -fluorothymidine 177
3 6 ö -Deoxy-ö -fluorothymidine 178
3 7 4 -Thioadenosine 179
3 8 Cyclopentanyl analogue of adenosine 179
3 9 Homoribose-nucleosides 180
XI
3 10 Pyranoid thymine^ -deoxymicleosides 180
3 11 2 - or S -C-methyl-nucleosides 181
3 12 Psicofuranine (Angustmycin C) 181
3 13 Decoyinine (Angustmycin A) 182
3 14 Puromycin 182
3 15 L-Nucleosides (L-adenosine) 183
4 Nucleotide analogues with modified phosphate groups 184
4 1 Uridine phosphonates 184
4 2 Nucleoside 5 -phosphites 184
4 3 Nucleoside thiophosphates 185
4 4 S -Fluorophosphates 186
4 5 Hypophosphate analogues of adenosine 5 -di- and 5 -
triphosphates 186
4 6 The ö -tmethylenediphosphonyljphosphates of adeno-
sine and guanosine 187
4 7 Adenosine 5 -sulphato-pyrophosphate 187
5 Polic acid antagonists (Aminopterin, Amethopterin;
Homofolic acid) 188
6 Glutamine antagonists (Azaserine and 6-Diazo-5-oxo-
L-norleucine (DON)) 191
7 Other Compounds 192
7 1 N-substituted biuret derivatives 192
7 2 Antagonists of carbamoyl-aspartate 192
7 3 Hadacidin, Alanosin 193
III Appendix 195
IV References 203
|
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| discipline | Biologie |
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| id | DE-604.BV007416975 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:01:49Z |
| institution | BVB |
| isbn | 0677307608 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-004801568 |
| oclc_num | 633047860 |
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| owner | DE-355 DE-BY-UBR DE-188 |
| owner_facet | DE-355 DE-BY-UBR DE-188 |
| physical | XII, 273 S. Ill. u. graph. Darst. |
| publishDate | 1975 |
| publishDateSearch | 1975 |
| publishDateSort | 1975 |
| publisher | Gordon and Breach |
| record_format | marc |
| spelling | Langen, Peter Verfasser aut Antimetabolite des Nucleinsäure-Stoffwechsels Antimetabolites of nucleic acid metabolism the biochemical basis of their action, with special reference to their application in cancer therapy. Transl. from the German by Thomas A. Scott Peter Langen New York, NY [u.a.] Gordon and Breach 1975 XII, 273 S. Ill. u. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nucleinsäurestoffwechsel (DE-588)4172118-4 gnd rswk-swf Antimetabolit (DE-588)4142687-3 gnd rswk-swf Nucleinsäurestoffwechsel (DE-588)4172118-4 s Antimetabolit (DE-588)4142687-3 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004801568&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Langen, Peter Antimetabolites of nucleic acid metabolism the biochemical basis of their action, with special reference to their application in cancer therapy. Transl. from the German by Thomas A. Scott Nucleinsäurestoffwechsel (DE-588)4172118-4 gnd Antimetabolit (DE-588)4142687-3 gnd |
| subject_GND | (DE-588)4172118-4 (DE-588)4142687-3 |
| title | Antimetabolites of nucleic acid metabolism the biochemical basis of their action, with special reference to their application in cancer therapy. Transl. from the German by Thomas A. Scott |
| title_alt | Antimetabolite des Nucleinsäure-Stoffwechsels |
| title_auth | Antimetabolites of nucleic acid metabolism the biochemical basis of their action, with special reference to their application in cancer therapy. Transl. from the German by Thomas A. Scott |
| title_exact_search | Antimetabolites of nucleic acid metabolism the biochemical basis of their action, with special reference to their application in cancer therapy. Transl. from the German by Thomas A. Scott |
| title_full | Antimetabolites of nucleic acid metabolism the biochemical basis of their action, with special reference to their application in cancer therapy. Transl. from the German by Thomas A. Scott Peter Langen |
| title_fullStr | Antimetabolites of nucleic acid metabolism the biochemical basis of their action, with special reference to their application in cancer therapy. Transl. from the German by Thomas A. Scott Peter Langen |
| title_full_unstemmed | Antimetabolites of nucleic acid metabolism the biochemical basis of their action, with special reference to their application in cancer therapy. Transl. from the German by Thomas A. Scott Peter Langen |
| title_short | Antimetabolites of nucleic acid metabolism |
| title_sort | antimetabolites of nucleic acid metabolism the biochemical basis of their action with special reference to their application in cancer therapy transl from the german by thomas a scott |
| title_sub | the biochemical basis of their action, with special reference to their application in cancer therapy. Transl. from the German by Thomas A. Scott |
| topic | Nucleinsäurestoffwechsel (DE-588)4172118-4 gnd Antimetabolit (DE-588)4142687-3 gnd |
| topic_facet | Nucleinsäurestoffwechsel Antimetabolit |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004801568&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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