Proceedings of the first International Conference on Stable Isotopes in Chemistry, Biology, and Medicine: May 9 - 11, 1973, Argonne National Laboratory, Argonne, Ill.
Gespeichert in:
| Körperschaft: | |
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| Format: | Tagungsbericht Buch |
| Sprache: | English |
| Veröffentlicht: |
Oak Ridge, Penn.
USAEC Techn. Inform. Center
1973
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VII, 477 S. Ill. |
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CONF-730525
PROCEEDINGS OF THE
FIRST INTERNATIONAL
CONFERENCE ON
STABLE ISOTOPES IN
CHEMISTRY, BIOLOGY,
AND MEDICINE MAY 9-11R 1973
ARGONNE NATIONAL LABORATORY ARGONNE, ILLINOIS
EDITED BY
PETER D. KLEIN
AND
SHIRLEY V. PETERSON
UNIVER8ITATSBIBLIOTHEK HANNOVER TECHNISCHE INFORMATIQNSBIBLIOTHEK ». -
-
SPONSORED BY
ARGONNE NATIONAL LABORATORY
AND SUPPORTED BY
MERCK, SHARP AND DOHME, CANADA, LTD.
G, D. SEARLE & COMPANY
THE UNIVERSITY OF CHICAGO
UNITED STATES ATOMIC ENERGY COMMISSION TIB/UB HANNOVER 89 129 946 29X
IMAGE 2
TABLE OF CONTENTS
INTRODUCTION 1
SESSION I
SYNTHESES WITH STABLE ISOTOPES
ORGANIC SYNTHESIS WITH STABLE ISOTOPES T. W. WHALEY, V. N. KERR* AND D.
G. OTT 5
ACID-CATALYZED DEUTERIUM EXCHANGE N. E, WERSTIUK AND TONY KADAI 13
CARBON-13 IN BIOSYNTHETIC STUDIES OF ANTIBIOTICS K. L. RINEHART, JR., W.
M. J. KN&LL, B. MILAVETZ, AND K. KAKINVMA . . 20
LARGE-SCALE PHOTOSYNTHETIC PRODUCTION OF CARBON-13 LABELED SUGARS V. H,
KOLLMAN, C. T. GREGG, J. L, BANNERS, T. W, WHALEY, AND D. G. OTT 30
THE CULTURE OF THERMOPHILIC ALGAE AND OTHER MICROORGANISMS IN HEAVY
WATER H. L. CRESPI, E. F. DABOLL, R. G. MRTEK, AND J. J. KATZ 41
LARGE SCALE CULTIVATION OF HIGHLY ENRICHED OR DEPLETED 13C-PLANTS R. A.
UPHAUA 48
SESSION II
NMR SPECTROSCOPY-!
13C FOURIER TRANSFORM NUCLEAR MAGNETIC RESONANCE OF LARGE MOLECULES A.
ALLERHAND 55
CARBON-13 MAGNETIC RESONANCE STUDIES OF CARBOHYDRATE INTERACTIONS WITH
CONCANAVALIN A C. F. BREWER, D. M. MARCUS, A. P. GROLLMAN, AND H.
STERNLIAHT .... 56
A CARBON-13 NUCLEAR MAGNETIC RESONANCE STUDY OF THE CONFORMATIONS OF
NEUROHYPOPHYSIAL HORMONES: OXYTOCIN, VASOPRESSIN AND ARGININE VASOTOCIN
R. DESLAUVIERS, R. WALTER, AND I. C. P. SMITH 64
CARBON-13 NUCLEAR MAGNETIC RESONANCE SPECTRA OF PROSTAGLANDINS AND SOME
PROSTAGLANDIN ANALOGS G. F. COOPER AND J. FRIED . 72
IMPLICATION ON STRUCTURE AND CONFORMATION OF NUCLEIC ACID COMPONENTS
FROM VICINAL 13C-1H COUPLING CONSTANTS P. DEA, G. P. RREISHMAN, M. P.
SOHWEIZER, J. T, WITKOSWKI, R. NUNLIST, AND M. BRAMUIELL 84
ILL
IMAGE 3
THE USE OF XH AND 13C NMR FOR THE ELUCIDATION OF THE STRUCTURE AND
BIOSYNTHETIC PATHWAY OF MALEIMYCIN, AND ANTIBIOTIC ISOLATED FROM
STREPTOMYCES SHOWDOENSIS E. F. ELSTNER, D. M. CARNES, R. J. SUHADOLNIK,
G. P. KREISHMAN,
M. P. SOHWEIZER, AND R. K. ROBINS 89
CARBON-13 NMR SPECTROSCOPY OF CARBON-13 LABELED BIOLOGICAL SYSTEMS N. A.
MATTFIYOFF 95
SESSION III
NMR SPECTR0SC0PY-2
STABLE ISOTOPES IN PROTEIN NMR 0. JARDETZKY 99
DIFFERENTIAL EXCHANGE OF THE C2-HYDROGENS OF HISTIDINE SIDE CHAINS IN
NATIVE PROTEINS: PROPOSED GENERAL TECHNIQUE FOR THE ASSIGNMENT OF
HISTIDINE NMR PEAKS IN PROTEINS J. L, MARKLEY AND S. M. CHEUNG 103
SYNTHESIS AND NMR SPECTROSCOPY OF SELECTIVELY DEUTERATED NUCLEIC ACIDS
N. S. KONDO AND S. S. DANYLUK 119 THE PREPARATION, ANALYSIS AND *5N-NMR
OF 15N-LABELLED BIOLOGICAL MOLECULES A. LAPIDOT, C. S. IRVING, AND Z.
MALIK 127
SESSION IV
ESR AND ENDOR SPECTROSCOPY
ELECTRON NUCLEAR DOUBLE RESONANCE (ENDOR) ON ISOTOPICALLY ENRICHED
PROTEINS R. H. SANDS 141
ESR AND ENDOR OF ORGANISMS OF UNUSUAL ISOTOPIC COMPOSITION J. R. NORRIS
AND M. E. DRUYAN 164
ESR STUDIES WITH 2H-FLAVIN AND 2H-FLAV0PR0TEIN E. L. CRESPI AND J. R.
NORRIS 171
COPPER-LIGAND HYPERFINE INTERACTION IN DEUTERIUM LABELED AMINO ACID AND
PEPTIDE CRYSTALS M. FUJIMOTO 177
SESSION V
BIOLOGICAL ISOTOPE EFFECTS
DEUTERIUM ISOTOPE EFFECTS IN LIVING ORGANISMS A. J. FINKEL 187
STABLE ISOTOPES AND THE STUDY OF THE BRAIN AND BEHAVIOR D. SAMUEL 196
PRELIMINARY EXPERIMENTAL RESULTS ON THE EFFECT OF OXYGEN-18 ON MICE D.
SAMUEL, D. WOLF, A. MESHORER, AND J. WASSERMAN 203
IV
IMAGE 4
DEUTERIUM OXIDE ADMINISTRATION TO COTURNIX JAPONICA: BIOLOGICAL EFFECTS
AND INCORPORATION OF DEUTERIUM INTO NON-ESSENTIAL AMINO ACIDS OF EGG
WHITE C. C. TORRES, S. P. SUTTON, AND R. BARN 210
A NEW APPROACH TO THE STUDY OF AQUEOUS SOLUTIONS OF C02 R. E. GERSTER,
T. H. MAREN, AND D. N. SILVERMAN 219
USE OF 180 IN STUDIES OF THE MECHANISMS OF ACTION OF ALDOLASES R. M.
CAPRIOLI AND E. J. EERON 229
NITROGEN ISOTOPE EFFECTS ON PAPAIN CATALYZED AMIDE HYDROLYSIS M. E. 0
LEARY AND M. URBERG 235
THE KINETICS AND DETECTION OF CARBONIC ANHYDRASE BY OXYGEN-18 EXCHANGE
TECHNIQUES D. N. SILVERMAN 239
THE MEASUREMENT OF THE EFFECTS OF ISOTOPIC DISCRIMINATION WHERE L5N IS
USED AS A TRACER IN A COMPLEX SYSTEM A. P. EDWARDS 246
SESSION VI
INSTRUMENTATION FOR STABLE ISOTOPES
STABLE ISOTOPE DISTRIBUTIONS BY NMR ZEUGMATOGRAPHY P. C. LAUTERHUR 255
THE APPROACHES FOR THE ANALYSIS OF THE MASS SPECTRA OF ISOTOPICALLY
ENRICHED NATURAL PRODUCTS W. E. BUDDENBAUM, B. S. EARL, AND G. D. DAVES,
JR 261
UTILIZATION OF MASS CHROMATOGRAPHY FOR THE ESTIMATION OF STABLE ISOTOPIC
ABUNDANCE BY COMBINED GAS CHROMATOGRAPHY-MASS SPECTROMETRY C. C.
SWEELEY, N. D. YOUNG, M. A. BIEBER, AND J. F. HOLLAND 273
NONRADIOACTIVE MULTILABELED MOLECULAR TRACERS IN BIOMEDICAL RESEARCH M,
ANBAR, J. H. MOREYNOLDS, W. H. ABERT, AND G. A. ST. JOHN 274
SESSION VII
PANEL DISCUSSION
DISCUSSION W. SHREEVE 287
J. MACLOSKEY 287
K. BIEMANN 287
D, J. JENDEN 287
SESSION VIII
DRUG QUANTITATION BY MASS FRAGMENTOGRAPHY
QUANTITATIVE MEASUREMENTS OF ENDOGENOUS AND 2H-TRACER VARIANTS OF DRUGS
AND METABOLITES USING A MULTIPLEXED GC/QUADRUPOLE MASS SPECTROMETER
SYSTEM D. J. JENDEN, A. K. CHO, AND R. W. SILVERMAN 291
V
I
IMAGE 5
THE USE OF STABLE ISOTOPES IN STUDIES OF DRUG METABOLISM M. G. HORNING,
W. G. STILLWELL, J. NOWLIN, K. LERTRATANANGKOON, D. CARROLL, I. DZIDIE,
R. N. STILLWELL, E. C. EORNING, AND R. M. HILL 299
QUADRUPOLE MASS FRAGMENTOGRAPHY IN DRUG RESEARCH J. M. STRONG, W. J.
FIES, AND A. J. ATKINSON, JR 310
QUANTITATIVE MASS SPECTRAL DETERMINATION OF MORPHINE IN BODY FLUID
EXTRACTS P. A. CLARKE AND R. L. FOLTZ 321
THE IMPORTANCE OF STABLE ISOTOPE LAGELLED DRUGS IN CLINICAL PHARMACOLOGY
WITH ILLUSTRATIONS FROM STUDIES ON THE DISPOSITION OF PROPRANOLOL AND
*NORTRIPTYLINE IN MAN T. E. GAFFNEY, D. KNAPP, T. WALLE, P. PRIVITERA,
AND D. SAELENS. . . . 326
UTILIZATION OF DEUTERIUM LABELING IN THE STUDY OF THE BIOTRANSFORMATION
OF (+)-PROPOXYPHENE IN MAN H. R. SULLIVAN, S. L. DUE, F. J. MARSHALL,
AND R. E. MCMAHON 345
STABLE ISOTOPE-MASS SPECTROMETRY IN DRUG METABOLISM AND PHARMACOKINETICS
W. SAD&E, C. FINN, N. CASTAGNOLI, AND W. GARLAND 346
SYNTHESIS AND PHYSICAL PROPERTIES OF CARBON-13 LABELLED DRUGS J. A.
KEPLER, N. M. CHUNG, J, W. LYTLE, M. E. WALL, AND
F. I. CARROLL 353
STUDIES WITH DEUTERATED DRUGS M. L. BLAKE 359
SESSION IX
CLINICAL APPLICATIONS OF STABLE ISOTOPES
STUDIES ON THE CAUSE AND TREATMENT OF GALLSTONES USING DEUTERIUM LABELED
BILE ACIDS A. F. HOFMANN, P. D. KLEIN, J. L. THISTLE, D. L. EAAHEY, N.
E. HOFFMAN, N. F. LA RUSSO, P. J. THOMAS, AND P. A. SZOZEPANIK 369
MATHEMATICAL ANALYSIS OF KINETIC DATA FOLLOWING THE INTRAVENOUS
INJECTION OF A BILE ACID INTERMEDIATE IN MAN R. F. HANSON, P. D. KLEIN,
AND G. C. WILLIAMS 380
BILE SALT KINETICS IN THE NEWBORN INFANT: ANALYSIS BY STABLE ISOTOPE
TECHNIQUE J. B. WATKINS, P. SZAZEPANIK, J. GOULD, P. D. KLEIN, AND R.
LESTER. . 385
POTENTIAL USES OF 13C-LABELED CARBOHYDRATES IN THE STUDY AND DIAGNOSIS
OF DIABETES MELLITUS W. W. SHREEVE 390
THE IN VIVO MEASUREMENT OF ALANINE AND GLUCOSE TURNOVER WITH DETUERIUM
LABELLED METABOLITES D. M. BIER, W. R. SHERMAN, W. H. EOLLAND, AND D. M.
KIPNIS 397
GLYCINE 1,2-13C IN THE INVESTIGATION OF CHILDREN WITH INBORN ERRORS OF
METABOLISM L. SWEETMAN, W. L. NYHAN, P. D. KLEIN, AND P. A. SZAZEPANIK
404
VI
IMAGE 6
MEDICAL AUTORADIOGRAPHY WITH STABLE ISOTOPE THYMIDINE: THEORY AND
PRELIMINARY EXPERIMENTS D. N. SLATKIN, H. W. JONES, F. H. GEISLER, A. P.
WOLF, J. S. FOWLER, H. W. KRONER, AND E. P. CRONKITE 410
DEUTERIUM LABELED FOLIC ACID: SYNTHESIS AND APPLICATIONS TO STUDIES IN
MAN I. H. ROSENBERG, D. L. EAEHEY, D. E. BEER, AND P. D. KLEIN 421
DEUTERIUM-LABELED CHOLESTEROL: VALIDATION OF A STABLE ISOTOPIC LABEL FOR
CHOLESTEROL KINETICS D. L. EAEHEY, N. E. HOFFMAN, A. F. EOFMANN, P. A.
SZAZEPANIK, AND P. D. KLEIN . 428
PAPERS READ BY TITLE
LANTHANIDE - INDUCED SHIFTS IN THE CMR SPECTRA OF AMINES A. K. BOSE AND
R. BRAMBILLA . 431
SURVEY OF PRODUCTION AND STUDIES OF CARBON-13 C. F. EAK 436
ELECTRON PARAMAGNETIC RESONANCE ABSORPTION STUDY OF A GASEOUS MIXTURE OF
N160, N170, AND N180 F. H. JARKE, I. J. SOLOMON, AND N. A. ASHFORD 442
THE APPLICATION OF 15N IN STUDYING THE HETEROGENEOUS REDUCTION OF NO K.
OTTO AND M. SHELEF 448
DETERMINATION OF NITRIC OXIDE IN BLOOD BY ISOTOPE DILUTION ANALYSIS M.
ANBAR, R. L. DYER, AND G. A. ST. JOHN 452
LIST OF PARTICIPANTS 461
AUTHOR INDEX 476
VLI
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| publisher | USAEC Techn. Inform. Center |
| record_format | marc |
| spelling | International Conference on Stable Isotopes in Chemistry, Biology, and Medicine 1 1973 Argonne, Ill. Verfasser (DE-588)1304430-8 aut Proceedings of the first International Conference on Stable Isotopes in Chemistry, Biology, and Medicine May 9 - 11, 1973, Argonne National Laboratory, Argonne, Ill. ed. by Peter D. Klein ... Oak Ridge, Penn. USAEC Techn. Inform. Center 1973 VII, 477 S. Ill. txt rdacontent n rdamedia nc rdacarrier Isotopes congresses Isotop (DE-588)4027801-3 gnd rswk-swf Chemie (DE-588)4009816-3 gnd rswk-swf Biologie (DE-588)4006851-1 gnd rswk-swf Medizin (DE-588)4038243-6 gnd rswk-swf (DE-588)1071861417 Konferenzschrift gnd-content Stable isotopes gnd rswk-swf Isotop (DE-588)4027801-3 s Chemie (DE-588)4009816-3 s DE-604 Medizin (DE-588)4038243-6 s Biologie (DE-588)4006851-1 s Stable isotopes f Klein, Peter D. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004698002&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Proceedings of the first International Conference on Stable Isotopes in Chemistry, Biology, and Medicine May 9 - 11, 1973, Argonne National Laboratory, Argonne, Ill. Isotopes congresses Isotop (DE-588)4027801-3 gnd Chemie (DE-588)4009816-3 gnd Biologie (DE-588)4006851-1 gnd Medizin (DE-588)4038243-6 gnd |
| subject_GND | (DE-588)4027801-3 (DE-588)4009816-3 (DE-588)4006851-1 (DE-588)4038243-6 (DE-588)1071861417 |
| title | Proceedings of the first International Conference on Stable Isotopes in Chemistry, Biology, and Medicine May 9 - 11, 1973, Argonne National Laboratory, Argonne, Ill. |
| title_auth | Proceedings of the first International Conference on Stable Isotopes in Chemistry, Biology, and Medicine May 9 - 11, 1973, Argonne National Laboratory, Argonne, Ill. |
| title_exact_search | Proceedings of the first International Conference on Stable Isotopes in Chemistry, Biology, and Medicine May 9 - 11, 1973, Argonne National Laboratory, Argonne, Ill. |
| title_full | Proceedings of the first International Conference on Stable Isotopes in Chemistry, Biology, and Medicine May 9 - 11, 1973, Argonne National Laboratory, Argonne, Ill. ed. by Peter D. Klein ... |
| title_fullStr | Proceedings of the first International Conference on Stable Isotopes in Chemistry, Biology, and Medicine May 9 - 11, 1973, Argonne National Laboratory, Argonne, Ill. ed. by Peter D. Klein ... |
| title_full_unstemmed | Proceedings of the first International Conference on Stable Isotopes in Chemistry, Biology, and Medicine May 9 - 11, 1973, Argonne National Laboratory, Argonne, Ill. ed. by Peter D. Klein ... |
| title_short | Proceedings of the first International Conference on Stable Isotopes in Chemistry, Biology, and Medicine |
| title_sort | proceedings of the first international conference on stable isotopes in chemistry biology and medicine may 9 11 1973 argonne national laboratory argonne ill |
| title_sub | May 9 - 11, 1973, Argonne National Laboratory, Argonne, Ill. |
| topic | Isotopes congresses Isotop (DE-588)4027801-3 gnd Chemie (DE-588)4009816-3 gnd Biologie (DE-588)4006851-1 gnd Medizin (DE-588)4038243-6 gnd |
| topic_facet | Isotopes congresses Isotop Chemie Biologie Medizin Konferenzschrift Stable isotopes |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004698002&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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