Structure and stability of biological macromolecules:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York
Dekker
1969
|
| Schriftenreihe: | Biological macromolecules
2 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VIII, 694 S. graph. Darst. |
Internformat
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Datensatz im Suchindex
| _version_ | 1804121296554950656 |
|---|---|
| adam_text | STRUCTURE AND STABILITY
OF BIOLOGICAL MACROMOLECULES
Edited by
Serge N Timasheff and Gerald D Fasman
Graduate Department of Biochemistry
Brandeis University
Waltham, Massachusetts
MARCEL DEKKER, INC , New York
CONTENTS
Introduction to the Series V
Contributors to This Volume vi
1 Theory of the Conformations of Biological Macromolecules in
Solution 2
HOWARD DEVOE
I Introduction 2
II Statistical Mechanics Theory 3
III Independent Free-Energy Change Contributions 14
IV Theoretical Energy Functions 25
V Model Systems 30
VI Helix-Coil Transitions of Regular Macromolecules 34
VII Polypeptides 38
VIII Polynucleotides 45
IX Concluding Remarks 58
References 59
2 Thermodynamic and Kinetic Aspects of Protein Conformations in
Relation to Physiological Function 65
RUFUS LUMRY AND RODNEY BILTONEN
Introduction 67
I Definitions and Details 69
II Factors Determining the Conformational Stability of Proteins 96
III Conformational Thermodynamic Analysis by the Approach with
Models 116
IV Conformational Variation in the Chymotrypsinogen Family 139
V Protein Function in Relation to Protein Conformation 146
VI Proposal of a Rack Mechanism for a-Chymotrypsin 154
VII An Abrupt Change in Orientation 178
VIII General Role of Protein Conformation in Physiological Functions:
A Hypothesis 187
Appendix: State Diagrams for Proteins 202
References 205
v i i
viii CONTENTS
3 Conformational Transitions of Proteins in Water and in Aqueous
Mixtures 213
JOHN F BRANDTS
I Introduction 213
II Some Factors Involved in Protein Stability 215
III Two-State Theory and the Mechanism of Conformational
Transitions 223
IV Structural Factors of Importance in Determining the Extent of
Cooperativity 232
V Thermodynamics of Protein Denaturation 240
VI Kinetics of Denaturation 275
VII Structural Variations with Solvent Conditions 277
Appendix A: Treatment of Three-Dimensional Model Protein System 280
Appendix B: Description of Model for the Treatment of the Thermo
dynamics of Nonpolar Solutes in Aqueous Mixtures 285
References 287
4 The Comparison of Protein Structure in the Crystal and in Solution 291
J A RUPLEY
I Introduction 292
II Special Characteristics of Protein Crystals 293
III Interpretation and Comparison of Reactions in the Crystal and in
Solution 302
IV Comparisons of Kinetic Properties 304
V Comparisons of Equilibrium Properties 328
VI Solution Properties 341
VII Conclusions 345
References 348
5 Conformations of Hexose Polysaccharides in Solution 353
A L STONE
I Introduction 353
II Hexose Units and Their Modes of Linkage in Relation to Polymer
Structure 355
III Physical Properties of Polysaccharides in Solution: Size and Shape 369
IV Optical Properties of Polysaccharides and Polysaccharide Com
plexes 381
V Concluding Remarks 405
Appendix: Comments on the Metachromatic Reaction 407
References 411
CONTENTS i x
6 The Effects of Neutral Salts on the Structure and Conformational
Stability of Macromolecules in Solution 417
PETER H VON HIPPEL AND THOMAS SCHLEICH
I Introduction 418
II Effccts of Neutral Salts on Macromolecuiar Structure, Interactions,
and Transconformation Rates 426
III Studies of Neutral Salt Effects on Model Compounds 483
IV Effects of Neutral Salts on the Structure and Properties of Water 505
V Summary, Correlations, and Conclusions 559
References 569
7 Infrared Spectra of Biological Macromolecules and Related
Systems 575
H Susi
I Introduction 576
II Characteristic Vibrations of Secondary Amides: A Brief Review 578
III Infrared Spectra and Conformation of Polypeptides and Proteins 593
IV Hydrogen Bonding 613
V Infrared Dichroism and Molecular Structure 626
VI Infrared Spectroscopy as an Analytical Tool 635
VII Spectra and Structure of Nucleosides, Nucleotides, and Nucleic
Acids 641
References 659
Author Index 665
Subject Index 684
|
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| spelling | Structure and stability of biological macromolecules ed. by Serge N. Timasheff ... New York Dekker 1969 VIII, 694 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biological macromolecules 2 Biochimie Macromolécules Biochemistry Macromolecules Polymers Molekülstruktur (DE-588)4170383-2 gnd rswk-swf Biomolekül (DE-588)4135124-1 gnd rswk-swf Biomolekül (DE-588)4135124-1 s Molekülstruktur (DE-588)4170383-2 s DE-604 Timasheff, Serge N. edt Biological macromolecules 2 (DE-604)BV001889175 2 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004526924&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Structure and stability of biological macromolecules Biological macromolecules Biochimie Macromolécules Biochemistry Macromolecules Polymers Molekülstruktur (DE-588)4170383-2 gnd Biomolekül (DE-588)4135124-1 gnd |
| subject_GND | (DE-588)4170383-2 (DE-588)4135124-1 |
| title | Structure and stability of biological macromolecules |
| title_auth | Structure and stability of biological macromolecules |
| title_exact_search | Structure and stability of biological macromolecules |
| title_full | Structure and stability of biological macromolecules ed. by Serge N. Timasheff ... |
| title_fullStr | Structure and stability of biological macromolecules ed. by Serge N. Timasheff ... |
| title_full_unstemmed | Structure and stability of biological macromolecules ed. by Serge N. Timasheff ... |
| title_short | Structure and stability of biological macromolecules |
| title_sort | structure and stability of biological macromolecules |
| topic | Biochimie Macromolécules Biochemistry Macromolecules Polymers Molekülstruktur (DE-588)4170383-2 gnd Biomolekül (DE-588)4135124-1 gnd |
| topic_facet | Biochimie Macromolécules Biochemistry Macromolecules Polymers Molekülstruktur Biomolekül |
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