Mechanisms of eukaryotic DNA recombination:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego
Academic Press u.a.
1992
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 215 S. Ill., graph. Darst. |
| ISBN: | 0122934458 |
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Datensatz im Suchindex
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|---|---|
| adam_text | MECHANISMS OF EUKARYOTIC
DNA RECOMBINATION
Edited by
MAX E GOTTESMAN
HENRY J VOGEL
College of Physicians and Surgeons
Columbia University
New York, New York
ACADEMIC PRESS INC ij
Harcourt Brace Jovanovich, Publishers
San Diego New York Boston
London Sydney Tokyo Toronto
Contents
Preface xi
PART I TARGETED DNA INTEGRATION IN MAMMALIAN
CELLS
1 Chromatid Interactions during Intrachromosomal
Recombination in Mammalian Cells
RONI J BOLLAG AND R MICHAEL LISKAY
Introduction 3
Results and Discussion 5
Conclusion 12
References 13
Studies on Extrachromosomal Homologous
Recombination in Mammalian Cells: Implications for
Chromosomal Recombination and Gene Targeting
MICHAEL LIN, KAREN SPERLE, AND NAT STERNBERG
Introduction 15
Results 17
Discussion 25
References 27
Homologous Recombination in Embryonic Stem Cells
as a Means to Generate Mice with Defined Mutations
ANDREAS ZIMMER, ZHAO-QI WANG, ERWIN F
WAGNER, AND PETER GRUSS
Introduction 29
General Strategy 30
VI CONTENTS
Microinjection of Mutated tlox-1 1 Fragments into Embryonic Stem Cells 32
Cloning of Homologous Recombined Cell Lines 34
Generation of Chimeric Animals with Homologously Recombined Cells 36
Discussion 37
References 39
Identification and Targeted Mutation of
Developmental Genes in Mouse Embryonic Stem
Cells
J ROSSANT, A GOSSLER, C MOENS, VV C SKARNES,
AND A JOYNER
Introduction 41
Embryonic Stem Cell Technology 43
Identification of New Domains of Gene Action in Developing Embryos 43
Targeted Mutation of Cloned Genes 46
Problems and Prospects 49
References 50
PART H DNA INSERTION PHENOMENA
Developmental Mutations Generated by Retroviral
Insertional Mutagenesis
DOUGLAS A GRAY, HANS WEIHER, THOMAS
GRIDLEY, TETSUO NODA, ARLENE SHARPE,
AND RUDOLF JAENISCH
Introduction 55
Results and Discussion 56
Summary and Conclusion 57
References 58
6 Transfer of Yeast Artificial Chromosomes into
Cultured Cells: A New Method for Manipulating the
Mammalian Genome
VASSILIS PACHNIS, LARYSA PEVNY, RODNEY
ROTHSTEIN, AND FRANK COSTANTINI
Introduction 61
Results 62
Conclusions and Future Prospects 66
References 67
CONTENTS Vll
Sex-Dependent de Novo Methylation of the Transgene
and Its Insertional Locus on Mouse
Chromosome 13
X WU, M HADCHOUEL, H FARZA, L AMAR,
AND C POURCEL
Introduction 69
Results 70
References 73
8 A Role for Transcription in Antibody Switch
Recombination
JOHANNA A GRIFFIN AND MARY E REABAN
Introduction 75
Results and Discussion 77
Model for the Mechanism of Switch Recombination 81
References 82
PART HI GENETIC RECOMBINATION IN DROSOPHILA AND
CAENORHABDITIS
9 Genetic and Molecular Studies of a Simple Meiotic
System
R SCOTT HAWLEY AND ANNE E ZITRON
Introduction 87
Partner Choice and the Nature of Distributive Pairing 88
The Segregation of Nonexchange Chromosomes 94
Summary 96
References 97
10 Diversity among DrosophUa Transposable Elements
and in Their Effects on Gene Expression
STEPHEN M MOUNT
Introduction 99
Classes of Transposable Elements 100
Regulation of Element Activity 105
Alteration of Gene Expression 106
Summary 109
References 109
Vlll CONTENTS
11 Meiotic Recombination in Caenorhabditis elegans
A M ROSE AND K S McKIM
Introduction 113
Homolog Recognition / 113
Pairing and Recombination 115
Frequency of Recombination 117
Distribution of Recombination Events along the Chromosome 118
Disjunction 122
Summary 123
References 124
PART IV GENETIC RECOMBINATION IN YEASTS AND
VSTILAGO
12 Saccharomyces cerevisiae Proteins That Promote
Hybrid DNA Formation in Vitro
RICHARD D KOLODNER, ERIC ALANI,
WOLF D HEYER, ARLEN W JOHNSON,
~ DAVID N NORRIS, AND DAN TISHKOFF
Introduction 128
The Strand-Exchange Protein, SEP1, from Saccharomyces cerevisiae 130
Additional Factors Involved in Hybrid DNA Formation in Vitro 133
MT 34,000 Single-Stranded DNA-Binding Protein
[Fragment of yRPA (yRFA)] 133
Stimulatory Factor 1 136
Discussion 137
References 140
13 Gap Repair in Vitro Catalyzed by Cell-Free Extracts
from Yeast
LORRAINE S SYMINGTON
Introduction 143
Results and Discussion 145
References 153
14 Meiotic Recombination in Schizosaccharomyces pombe:
Genes, Enzymes, and Sites
GERALD R SMITH AND ALFRED S PONTICELLI
Introduction 155
Genes 156
CONTENTS IX
Enzymes 160
Sites 161
Summary ! 165
References 165
15 Genetics and Molecular Biology of Recombination
ROBIN HOLLIDAY
Introduction 167
Recombination and Heteroduplex DNA 168
Mutants Defective in Recombination 172
Recombination Proteins 173
Molecular Analysis 174
References 175
PART V GENETIC RECOMBINATION IN TRYPANOSOMES AND
PLASMODWM
16 Chromosome and Telomere Structure in Trypanosoma
brucei
LEX H T VAN DER PLOEG, KEITH GOTTESDIENER,
DORIS B TSE, HUI-MIN CHUNG, AND MICHAEL
WEIDEN
Introduction 179
Organization of the Trypanosoma brucei Genome; Presence of Chromosome
Homologs 180
Minichromosome Structure 183
Concluding Remarks 186
References 186
17 Use of DNA Sequence Homology and Pseudogenes for
the Construction of Active Variable Surface Antigen
Genes in Trypanosoma equiperdum: How Ordered
Expression Is Established
HARVEY EISEN
Introduction 189
Early- and Late-Appearing Variable Surface Glycoproteins 190
Early Genes Have Complete Silent Copies, whereas Late Silent Copy
Genes Are Defective 190
CONTENTS
The Use of DNA Sequence Homology to Generate Ordered Expression
of the Late-Appearing Variable Cell Surface Glycoprotein Genes 191
5-3 Joining 193
A Possible Molecular Mechanism for Late-Variable Surface Glycoprotein
Expression-Linked Copy Formation 194
Why Pseudogenes? 194
References 195
18 Chromosomal Size Variations in Plasmodium
falciparum
ALAN F COWMAN AND DAVID J KEMP
Introduction 197
Intragenic Recombination in a Major Antigen of Plasmodium falciparum 199
Size Polymorphisms in Plasmodium falciparum Chromosomes 199
Chromosome Size Polymorphisms Generated by Deletion of
Subtelomeric Repeats 201
Deletions Involving Coding Sequences 203
The Multidrug Resistance Gene of Plasmodium falciparum and Chromosome
Size Polymorphisms 204
Conclusion 206
References 207
Index 209
|
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| spelling | Mechanisms of eukaryotic DNA recombination ed. by Max E. Gottesman ... San Diego Academic Press u.a. 1992 XI, 215 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier ADN recombinant Recombinaison génétique DNA Replication Congresses Eukaryotic Cells Congresses Gene Rearrangement Congresses Genetic recombination Recombinant DNA Recombination, Genetic Congresses Rekombinante DNS (DE-588)4225578-8 gnd rswk-swf Rekombination (DE-588)4049338-6 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf Eukaryoten (DE-588)4070991-7 gnd rswk-swf DNS (DE-588)4070512-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content (DE-588)1071861417 Konferenzschrift gnd-content Eukaryoten (DE-588)4070991-7 s DNS (DE-588)4070512-2 s Rekombination (DE-588)4049338-6 s DE-604 Genetik (DE-588)4071711-2 s Rekombinante DNS (DE-588)4225578-8 s Gottesman, Max E. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004437507&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mechanisms of eukaryotic DNA recombination ADN recombinant Recombinaison génétique DNA Replication Congresses Eukaryotic Cells Congresses Gene Rearrangement Congresses Genetic recombination Recombinant DNA Recombination, Genetic Congresses Rekombinante DNS (DE-588)4225578-8 gnd Rekombination (DE-588)4049338-6 gnd Genetik (DE-588)4071711-2 gnd Eukaryoten (DE-588)4070991-7 gnd DNS (DE-588)4070512-2 gnd |
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| title | Mechanisms of eukaryotic DNA recombination |
| title_auth | Mechanisms of eukaryotic DNA recombination |
| title_exact_search | Mechanisms of eukaryotic DNA recombination |
| title_full | Mechanisms of eukaryotic DNA recombination ed. by Max E. Gottesman ... |
| title_fullStr | Mechanisms of eukaryotic DNA recombination ed. by Max E. Gottesman ... |
| title_full_unstemmed | Mechanisms of eukaryotic DNA recombination ed. by Max E. Gottesman ... |
| title_short | Mechanisms of eukaryotic DNA recombination |
| title_sort | mechanisms of eukaryotic dna recombination |
| topic | ADN recombinant Recombinaison génétique DNA Replication Congresses Eukaryotic Cells Congresses Gene Rearrangement Congresses Genetic recombination Recombinant DNA Recombination, Genetic Congresses Rekombinante DNS (DE-588)4225578-8 gnd Rekombination (DE-588)4049338-6 gnd Genetik (DE-588)4071711-2 gnd Eukaryoten (DE-588)4070991-7 gnd DNS (DE-588)4070512-2 gnd |
| topic_facet | ADN recombinant Recombinaison génétique DNA Replication Congresses Eukaryotic Cells Congresses Gene Rearrangement Congresses Genetic recombination Recombinant DNA Recombination, Genetic Congresses Rekombinante DNS Rekombination Genetik Eukaryoten DNS Aufsatzsammlung Konferenzschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004437507&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT gottesmanmaxe mechanismsofeukaryoticdnarecombination |