Nuclear trafficking:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego u.a.
Acad. Press
1992
|
| Schriftenreihe: | Cell biology
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 370 S. Ill., graph. Darst. |
| ISBN: | 0122520505 |
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Datensatz im Suchindex
| _version_ | 1804120682519330816 |
|---|---|
| adam_text | Nuclear Trafficking
Edited by
Carl M Feldherr
Department of Anatomy and Cell Biology
University of Florida College of Medicine
Gainesville, Florida
ACADEMIC PRESS, INC
Harcourt Brace Jovanovich, Publishers
San Diego New York Boston
London Sydney Tokyo Toronto
Contents
Contributors xi
Preface xiii
I Molecular Exchanges across the Nuclear Envelope
1 Diffusion between Nucleus and Cytoplasm
Philip L Paine
I Introduction 3
II Permeability of Nuclear Envelope 5
A Envelope and Pore Complex 5
B Diffusion of Exogenous Tracers across in Vivo Envelope 6
C Nucleocytoplasmic Trafficking of Endogenous Molecules 7
III Biophysical State of Transported Molecules 9
IV Kinetics and Equilibria of Diffusion 10
A Cell-Cycle Duration and Protein Half-Life 10
B Water Availability and Differential Binding Influence
Diffusional Transport 10
C Nondiffusional Transport Mechanisms 12
References 13
2 Overview of Signal-Mediated Transport
CarlM Feldherr
I Introduction 15
II Signal-Mediated Transport 16
A Evidence for Transport 16
B Identification of Transport Sites 18
III Composition of Pores 20
IV Regulation of Nucleocytoplasmic Exchange 21
A Methods of Regulation 21
B Possible Significance of Transport Changes 23
C Factors Influencing Transport 24
VI Contents
V Concluding Comments 25
References 25
II Structural Organization of Pores and Associated
Skeletal Elements
3 The Nuclear Pore Complex: A Macromolecular Transporter
Christopher W Akey
I Introduction and Background 31
A Nucleocytoplasmic Transport Pathway 32
B Morphology of the Pore Complex 34
II Triple Ring Model of the Nuclear Pore Complex 36
III Symmetry of the Nuclear Pore Complex: A Question of
Resolution and Semantics 41
IV Components of the Nuclear Pore Complex: Modality and Function 43
A Spokes 44
B Vertical Supports 45
C ThinRings 45
D Radial Arms 48
E Lamina, Fibers, and Peripheral Assemblies 51
V Nuclear Pore Complex and Transport 57
A Labeling Studies 57
B Visualization of the Nuclear Pore Complex Transporter 60
C Hypothesis: The Transporter as a Macromolecular Lock 62
VI Concluding Remarks 65
References 66
Regulation of Nucleocytoplasmic Transport by Mechanical
Forces Transmitted through the Cytoskeleton
Linda K Hanson and Donald E Ingber
I Introduction 71
II Nuclear Pore Complex 72
III Regulation of Nucleocytoplasmic Transport 72
A Biochemical Determinants 72
B Structural Determinants 73
IV Linkages between Nuclear Pore Complex and
Nuclear Matrix-Cytoskeletal Network 74
V Possible Use of a Tensegrity (Tensional Integrity) Mechanism
for Regulation of Nucleocytoplasmic Transport 78
VI Conclusion 83
References 83
Contents vii
III Molecular Aspects of Nuclear Trafficking
5 Structure and Regulation of Nuclear Localization Signals
Joel D Richter and David Standiford
I Introduction 90
II Suggestions of Nuclear Localization Signal 90
III Molecular Biology of Nuclear Localization Signals 91
A Yeast a2 91
B SV40 Large T Antigen 92
C SV40 Large T NLS as Model Probe for Selective Nuclear Import 93
D Other Simple Nuclear Localization Signals 93
IV Redundant Nuclear Localization Signals 96
A Polyoma Large T Antigen 96
B c-m vc 98
C Glucocorticoid Receptor 99
D Progesterone Receptor p53 100
E Tumor Suppressor Protein p53 100
V Complex Nuclear Localization Signals 101
A Nucleoplasmin 101
B Xenopus Nuclear Protein Nl 104
C Influenza Virus Polymerase Basic Protein 1 104
D Adenovirus DNA Binding Protein 105
E snRNP Proteins 105
VI Regulation of Nuclear Localization Signal Function 106
A NF-KB 106
B Drosophila dorsal Gene Product 107
C Adenovirus Type 5 El A 108
VII Concluding Remarks 113
References 116
6 Nuclear Transport Receptors: Specificity amid Diversity
Uli Yamasaki and Robert E Lanford
I Nuclear Transport: Overview 122
A Introduction 122
B Evidence for Receptor-Mediated Nuclear Transport 122
C Signal Complexity 124
D Import and Export Signals and Receptors 125
E Model Transport Systems for Receptor Identification 127
II Functional Characteristics of Nuclear Transport Receptors 131
A Recognition of Diversity 131
B Strategies for Receptors to Increase Transport Efficiency 134
C Species Specificity of Signal Recognition 137
D Saturability of Signal Recognition 137
E Kinetics of Transport 139
F Signal Accessibility 142
viii Contents
G Conditional Nuclear Transport 145
H Localization of Nuclear Transport Receptors 147
III Identification of Nuclear Transport Receptor Candidates 150
A Direct Involvement of Signal Binding 151
B Antibody-Mediated Inhibition of Transport 157
C In Wrro Reconstitution of Transport 159
D Genetic Isolation of Transport Mutants 161
IV Future Directions 162
References 165
7 Structure and Function of Nuclear Pore Glycoproteins
Christopher M StarrandJohnA Hanover
I Introduction 175
II Nuclear Pore Complex Proteins 176
A Integral Glycoprotein gp210 176
B Peripheral Proteins: Structure of O-Linked
GlcNAc-Modified Nucleoporins 177
C Gene Encoding Rat p62 Nucleoporin 185
D Yeast Genes Encoding Nuclear Pore Proteins 186
E Identification of Possible Signature Motifs for Nucleoporins 187
F Location and Assembly of Nucleoporins 191
III Functional Studies of Nucleoporins 194
A Nuclear Transport in Cultured Cells 194
B Nuclear Reconstitution Experiments 196
C Morphological Studies of Nucleoporin Function 197
IV Conclusions 198
References 198
8 Nuclear Pore Complex-Associated ATPase
Miguel Berrios
I Introduction: Nuclear Envelope 203
II Nuclear Pore Complex 204
A Histochemical Localization of Pore Complex-Associated ATPase 204
B ATP Hydrolysis and in Vitro Transport 204
C Polypeptide Structure 206
D Nuclear Envelope-Associated NTPases 207
III Myosin-like ATPase Associated with Nuclear Pore Complex 209
A Photoaffinity Labeling and Biochemical Identification 209
B Immunocytochemical Localization 212
C Myosin and Nuclear Pore Complex 215
IV Conclusions and Prospects for Future Research 218
References 222
Contents IX
IV RNA Transport
9 Role of mRNA Transport in Posttranscriptional
Control of Gene Expression
Norbert Riedel and Hugo Fasold
I Overview 231
II Roleof Posttranscriptional Control in Regulation of Gene Expression 233
III Posttranscriptional Processing of Primary Transcript 236
A Heterogeneous Nuclear RNA 236
B Cap Structure Formation 239
C Role of Polyadenylation 240
D Splicing 242
IV Nuclear Matrix 243
V Relationship between Pre-mRNA Splicing and mRNA Transport 247
VI Transport across Nuclear Envelope 251
A Nuclear Pore Complex 252
B Translation of mRNA 254
VII Conclusions and Future Prospects 269
References 272
10 Transport of Ribosomal Proteins and rRNA,
tRNA, and snRNA
Howard M Fried
I Introduction 291
II Overview of Ribosome Assembly in Nucleated Cells 293
A Ribosome Structure 293
B Nucleolus as Site of Ribosome Assembly 293
C Division of Labor in Nucleolus 294
D Ribosome Biosynthesis and Nuclear Transport 298
III Nuclear Localization of Ribosomal Proteins 298
A Nuclear Protein Transport in General 298
B Nuclear Transport of Ribosomal Proteins 299
IV Nuclear Export of Ribosomal Subunits 305
A Generalized Mechanism 307
B Specific Transport Signal 308
V Transport of 5 S rRNA 309
VI Transport of tRNA 312
VII Trafficking of snRNPs 314
A Import of snRNA into Nucleus 315
B Export of snRNA from Nucleus 317
VIII Export of Other Small RNAs 318
IX Concluding Remarks 321
References 322
X Contents
V Biophysical Considerations
11 B iophysics of Nucleocytoplasmic Transport
Robert J Cohen and Philip L Paine
I Introduction 334
II Cytoplasm 334
A Diffusion in Cytoplasm 334
B Two-Phase Model of Cytoplasm 335
C Diffusion of Exogenous Tracers in Cytoplasm 336
D Diffusion of Endogenous Molecules in Cytoplasm 338
III Near Nuclear Envelope 339
A PoreDensity 339
B Recognition of Nuclear Localization Signal 341
IV Nuclear Pore Complex 342
A Nuclear Envelope Transit by Size-Restricted Diffusion 342
B Specific Nuclear Envelope Transport Mechanisms 344
C Physical Models for Envelope Transport Mechanisms 346
D Coupling of Transport to Metabolic Energy 349
V Nuclear Interior 350
A Intranuclear Binding 350
B Nucleocytoplasmic Partition Coefficients 352
C Measurement of Binding from Diffusion Coefficients 353
VI Kinetics and Steady State of Transport 355
A Permeability and Partition Coefficients 355
B Experimental Resolution of Mechanisms 355
References 358
Index 363
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| spelling | Nuclear trafficking ed. by Carl M. Feldherr San Diego u.a. Acad. Press 1992 XIII, 370 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cell biology Biological Transport physiology Biological transport Regulations Cell Communication physiology Cell Nucleus physiology Cell Nucleus ultrastructure Nuclear membranes Signal Transduction physiology Membran (DE-588)4038571-1 gnd rswk-swf Kernhülle (DE-588)4309987-7 gnd rswk-swf Stofftransport Biologie (DE-588)4443397-9 gnd rswk-swf Zellkern (DE-588)4067544-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Kernhülle (DE-588)4309987-7 s Stofftransport Biologie (DE-588)4443397-9 s DE-604 Zellkern (DE-588)4067544-0 s Membran (DE-588)4038571-1 s Feldherr, Carl M. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004076054&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nuclear trafficking Biological Transport physiology Biological transport Regulations Cell Communication physiology Cell Nucleus physiology Cell Nucleus ultrastructure Nuclear membranes Signal Transduction physiology Membran (DE-588)4038571-1 gnd Kernhülle (DE-588)4309987-7 gnd Stofftransport Biologie (DE-588)4443397-9 gnd Zellkern (DE-588)4067544-0 gnd |
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| title | Nuclear trafficking |
| title_auth | Nuclear trafficking |
| title_exact_search | Nuclear trafficking |
| title_full | Nuclear trafficking ed. by Carl M. Feldherr |
| title_fullStr | Nuclear trafficking ed. by Carl M. Feldherr |
| title_full_unstemmed | Nuclear trafficking ed. by Carl M. Feldherr |
| title_short | Nuclear trafficking |
| title_sort | nuclear trafficking |
| topic | Biological Transport physiology Biological transport Regulations Cell Communication physiology Cell Nucleus physiology Cell Nucleus ultrastructure Nuclear membranes Signal Transduction physiology Membran (DE-588)4038571-1 gnd Kernhülle (DE-588)4309987-7 gnd Stofftransport Biologie (DE-588)4443397-9 gnd Zellkern (DE-588)4067544-0 gnd |
| topic_facet | Biological Transport physiology Biological transport Regulations Cell Communication physiology Cell Nucleus physiology Cell Nucleus ultrastructure Nuclear membranes Signal Transduction physiology Membran Kernhülle Stofftransport Biologie Zellkern Aufsatzsammlung |
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