Molecular theories of cell life and death:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New Brunswick u.a.
Rutgers Univ. Press
1991
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXXI, 508 S. |
| ISBN: | 0813516919 |
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Datensatz im Suchindex
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|---|---|
| adam_text | ^Molecular Theories of
Cell Life and Death
1 I
Edited by
Sungchul Ji
RUTGERS UMVERSITY PRESS • NEW BRUNSWICK • NEW JERSEY
CONTENTS
PREFACE xiii
ACKNOWLEDGMENTS xix
CONTRIBUTORS xxi
INTRODUCTION xxiii
I THEORIES
Chapter I
Biocybernetics: A Machine Theory of Biology
Sungchul Ji
1 1 Introduction 2
12A Bird s-Eye View of Biocybernetics S
1 3 The Table Theory: A New Method in Theoretical Biology 8
1 4 Cybernetics: A Theory of Machines 13
1 5 Biopolymers as Molecular Machines: The McClare Machine 29
1 6 Metabolic Pathways as Machines: The Holcombe-Welch Machines 44
1 7 Subcellular Organelles as Machines 49
1 8 The Cell as a Machine: The Bhopalator 62
1 9 The Biocybernetics Model of the Human Body: The Piscatawaytor 141
1 10 The Biocybernetics Model of the Human Society: Newbrunswickator 149
1 11 A Biological Model of the Universe: The Shillongator 1S2
1 12 Applications 163
1 13 Concluding Remarks 209
Acknowledgement 210
References 211
Appendix 1 A: The Law of Requisite Variety 221
Appendix l B: Nucleic Acid and Protein Communication Channels 222
Appendix l C: The Conformon-Based Model of the Origin of Life—The 224
Princelonator
Appendix I D: Cell Death Kinetics 225
Appendix I E: The Xenogene Hypothesis 228
Appendix I F: The Shillongator—the Abstract Version 230
Chapter 2 238
Schrodinger and the Riddle of Life
llya Prigogine
References 242
viii Contents
Chapter 3 243
A Note on Chiral Symmetry Breaking and the Origin of Biomolecular Chirality
Dilip K Kondepudi
3 1 Introduction 243
3 2 Chiral Symmetry Breaking in Non- Equilibrium Chemical Systems 244
3 3 Selection of Biomolecular Chirality by Extremely Small Parity 247
Non-Conserving Interactions
References 248
Chapter 4 250
Mathematical Models of Cell Biochemistry
W Mike L Holcombe
Chapter 5
Introduction
Windows on the Cell
A General Abstract Machine
The Topology of Death
References
Davydov s Soliton
AlwynC
Scott
Introduction
Davydov s Soliton Theory
Self-Trapping in Crystalline Acetanilide
The Quantum Theory of Self-Trapping
Biological Significance of Self-Trapping
References
Chapter 6 282
Cytosodology: A Field-Theoretic View of Cell Metabolism
Harry A Smith and G Rickey Welch
6 1 Introduction 282
6 2 Cytosociology of Cell Metabolism 284
6 3 Cytosociology of Enzyme Action in Vivo 285
6 4 Enzymes: Field-Effect Elements 290
65A Primer of Field Theory 294
6 6 Biological Space-Time 296
6 7 Cell Metabolism: An Affine Geometry 298
6 8 The Metabolic Microdomain: A Gauge Field 311
6 9 Concluding Remarks 318
Acknowledgements 320
References 320
Contents ix
Chapter 7 324
Non-Dichotomous, Relative and Hierarchical Aspects of life and Death
Jerome Rothstein
7 1 Introduction and Summary 325
7 2 On Whether Life and Death Are Mutually Exclusive and Exhaustive 327
Logical Alternatives
7 3 Why Dead and Alive Are Neither Molecular, Quantum Mechanical, Nor 331
Thermodynamic States
7 4 Toward a Definition of Living State 345
7 5 Concluding Discussion 355
References 358
Chapter 8 361
Emergent Properties in Neural Networks
Steven Finette
8 1 Introduction 361
8 2 The Netlet as a Paradigm for Neural Self-Organization 363
8 3 Reliability and Cooperative Computation 370
8 4 Conclusions 371
References 372
II EXPERIMENTS
Chapter 9
Molecular Mechanisms of Cell Death
Sten Orrenius
9 1 Introduction 373
9 2 Characteristics of Toxic Injury to Hepatocytes 374
9 3 Mechanisms of Glutathione Depletion 374
9 4 Role of Protein Thiol Modification 376
9 5 Appearance of Surface Blebs in Hepatocytes Exposed to Toxic Agents 376
9 6 Disruption of Intracellular Ca 2 + Homeostasis by Toxic Agents 378
9 7 Mechanisms of Ca2+-Mediated Toxicity 379
9 8 Future Perspectives 381
References 383
Chapter 10 384
Damage to the Nucleus and Acute Cell Death Produced by Alkylating Hepatotoxins
Sidhartha D Ray and George B Corcoran
10 1 Introduction - 384
10 2 Compartmentation of Molecular Damage Leading to Acute Cell Death 386
in the Liver
Introduction
Low-Level Chemiluminescence
Redox Cycling
Antioxidant Activities
DNA-Damage by Singlet Oxygen
Excited Carbonyls
Concluding Remarks
Acknowledgements
References
Contents
10 3 Cell Death and the Hepatocyte: Theories of Acute Cellular Necrosis 391
10 4 The Nucleus as a Critical Site of Lethal Cell Injury 392
10 5 Outlook 395
Acknowledgements 396
References 396
Chapter 11 401
Electronically Excited States in Cells and Organs: Relation to
Prooxidant/Antioxidant Balance
Helmut Sies
Chapter 12 414
Ilypoxia and Molecular Mechanisms of Cell Death
Herbert de Groot and Thomas Noll
12 1 Introduction 414
12 2 Oxygen Partial Pressures in Mammalian Tissues 416
12 3 Oxygen Dependence of Cell Functions 417
12 4 Hypoxic Cell Death 418
12 5 Pathological Cell Functions under Hypoxia 421
12 6 Conclusions 425
Abbreviations 426
Acknowledgements 426
References 426
Chapter 13 430
Population Dynamics of Tumors Attacked by
Immunocompetent Killer Cells
Jacques Hiernaux, Patricia Meyers and Ren£ Lefever
13 1 Introduction 430
13 2 The Cytolytic Reaction and the Switching Parameter P 432
13 3 Conclusion 440
Acknowledgements 440
References 440
Contents xi
Chapter 14 442
Organization of Histone Genes and Regulation and Control of Their
Expression in Early Development
Hans V Westerhoff, Johanna G Koster, and Olivier H J Destree
14 1 Introduction 443
14 2 The Histones and the Organization of Eukaryotic Genes in Chromatin 444
14 3 The Organization of Histone Genetic Information 448
14 4 Kinetics of Histone Synthesis in Xenopus Laevis: The Race Against Time 454
14 5 The Control of Histone-Gene Expression in Xenopus Laevis 459
14 6 Concluding Remarks 467
References 467
Chapter 15 473
How Fundamental Knowledge Can Help Solve Practical Problems in Toxicology
Robert A Neal
15 1 Introduction 473
15 2 Mechanisms of Toxicity 475
15 3 Toxic Response at Low Doses 476
15 4 Validity of Animal Models 477
15 5 Improved Methodology 477
15 6 Measurements of Human Exposure 478
15 7 Concluding Remarks 479
Glossary 481
Index 495
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| spelling | Molecular theories of cell life and death ed. by Sungchul Ji New Brunswick u.a. Rutgers Univ. Press 1991 XXXI, 508 S. txt rdacontent n rdamedia nc rdacarrier Biologie moléculaire - Congrès Cellules - Mort - Congrès Cytologie - Congrès Cell Death physiology Congresses Cell Physiological Phenomena Congresses Cell Survival physiology Congresses Cell death Congresses Cytology Congresses Molecular Biology Congresses Molecular biology Congresses Zelle (DE-588)4067537-3 gnd rswk-swf Zelltod (DE-588)4207415-0 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1986 Piscataway NJ gnd-content Zelle (DE-588)4067537-3 s Molekularbiologie (DE-588)4039983-7 s DE-604 Zelltod (DE-588)4207415-0 s Ji, Sungchul Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=003576295&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular theories of cell life and death Biologie moléculaire - Congrès Cellules - Mort - Congrès Cytologie - Congrès Cell Death physiology Congresses Cell Physiological Phenomena Congresses Cell Survival physiology Congresses Cell death Congresses Cytology Congresses Molecular Biology Congresses Molecular biology Congresses Zelle (DE-588)4067537-3 gnd Zelltod (DE-588)4207415-0 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4067537-3 (DE-588)4207415-0 (DE-588)4039983-7 (DE-588)1071861417 |
| title | Molecular theories of cell life and death |
| title_auth | Molecular theories of cell life and death |
| title_exact_search | Molecular theories of cell life and death |
| title_full | Molecular theories of cell life and death ed. by Sungchul Ji |
| title_fullStr | Molecular theories of cell life and death ed. by Sungchul Ji |
| title_full_unstemmed | Molecular theories of cell life and death ed. by Sungchul Ji |
| title_short | Molecular theories of cell life and death |
| title_sort | molecular theories of cell life and death |
| topic | Biologie moléculaire - Congrès Cellules - Mort - Congrès Cytologie - Congrès Cell Death physiology Congresses Cell Physiological Phenomena Congresses Cell Survival physiology Congresses Cell death Congresses Cytology Congresses Molecular Biology Congresses Molecular biology Congresses Zelle (DE-588)4067537-3 gnd Zelltod (DE-588)4207415-0 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Biologie moléculaire - Congrès Cellules - Mort - Congrès Cytologie - Congrès Cell Death physiology Congresses Cell Physiological Phenomena Congresses Cell Survival physiology Congresses Cell death Congresses Cytology Congresses Molecular Biology Congresses Molecular biology Congresses Zelle Zelltod Molekularbiologie Konferenzschrift 1986 Piscataway NJ |
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