The platelet amine storage granule:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton u.a.
CRC Press
1992
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV, 203 S. Ill., graph. Darst. |
| ISBN: | 0849388384 |
Internformat
MARC
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| 245 | 1 | 0 | |a The platelet amine storage granule |c ed. by Kenneth M. Meyers ... |
| 264 | 1 | |a Boca Raton u.a. |b CRC Press |c 1992 | |
| 300 | |a XV, 203 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Amines biogènes - Métabolisme | |
| 650 | 4 | |a Granulations cytoplasmiques | |
| 650 | 4 | |a Sang - Plaquettes | |
| 650 | 4 | |a Biogenic amines |x Metabolism | |
| 650 | 4 | |a Blood Platelets |x physiology | |
| 650 | 4 | |a Blood platelets | |
| 650 | 4 | |a Cytoplasmic Granules |x physiology | |
| 650 | 4 | |a Cytoplasmic granules | |
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Datensatz im Suchindex
| _version_ | 1804119794179375104 |
|---|---|
| adam_text | The
Platelet Amine
Storage Granule
Edited by
Kenneth M Meyers • Charles D Barnes
Department of Veterinary and Comparative Anatomy,
Pharmacology and Physiology
College of Veterinary Medicine
Pullman, Washington
, , _- „ i
CRC Press
Boca Raton Ann Arbor London Tokyo
The Platelet Amine Storage Granule
CONTENTS
About the Editors xi
Contributors xii
Preface xv
CHAPTER 1
THE DENSE BODIES OF HUMAN PLATELETS 1
James G White
Introduction 1
Discovery and Characterization of Dense Bodies 1
The Number of Dense Bodies in Human Platelets 6
Origin of Platelet Dense Bodies 7
Secretion of Platelet Dense Bodies 14
Inherited Disorders of Dense Bodies 19
Hermansky-Pudlak Syndrome (HPS) 19
Storage Pool Disease (SPD) 22
Chediak-Higashi Syndrome (CHS) 23
Other Dense Body Disorders 26
Summary 27
list of Abbreviations 27
References 27
CHAPTER 2
ULTRASTRUCTURE OF DENSE GRANULE PRECURSOR
DEVELOPMENT IN MEGAKARYOCYTES 31
Michile Menard and Kenneth M Meyers
Introduction 31
MK Classification with Transmission Electron Microscopy 33
Dense Granule Precursors in MK with Standard
Processing for Transmission Electron Microscopy 33
Uranaffin Cytochemical Reaction 36
Fixation in a Calcium-Supplemented Fixative 38
Studies with Extracellular Electron Dense Markers 41
Tannic Acid 41
Horseradish Peroxidase 41
Lanthanum and Ruthenium Red 41
Dense Granule Precursors in MK from Animal Models
of the Chediak-Higashi Syndrome (CHS) 44
CHS Cattle 44
CHS Cats 44
Beige (C57BU6JW) Mice 46
list of Abbreviations 48
References 48
vi The Platelet Amine Storage Granule
CHAPTER 3
NUCLEAR MAGNETIC RESONANCE STUDIES OF AMINE
AND NUCLEOTIDE STORAGE MECHANISMS IN
PLATELET DENSE GRANULES 51
Holm Holmsen and Kamil Ugurbil
Introduction 51
NMR Measurements: Some Basic Considerations 51
Compartmentation of Nucleotides in Platelets 53
Contents of Dense Granules in Human and Porcine Platelets 54
Use of 3IP-NMR to Study Nucleotides in Intact
Platelets and Isolated Granules 56
Studies on Intact Human Platelets and Their Extracts 56
Studies on Intact Porcine Platelets, Their Extracts
and Isolated Dense Granules 59
Differences Among Species Regarding the NMR
Resonances of Granule Constituents 61
H-NMR of Porcine Platelet Dense Granule Constituents 63
Spectra of Organdies 63
Uptake of Serotonin 65
Nuclear Overhauser Effects Between Adjacent
Nucleotides and Between Nucleotide and Serotonin
in Dense Granules 66
Tentative Molecular Model of Nucleotide Aggregate 67
Conclusions 69
Acknowledgments 70
References 70
CHAPTER 4
THE ROLE OF INOSITOL PHOSPHATE METABOLISM IN
PLATELET STIMULUS-RESPONSE COUPUNG 73
James L Daniel
Introduction 73
Inositol Phosphate Metabolism and Platelet Activation 73
Phosphatidylinositol (Ptdlns) Turnover 73
The Second Messenger Function of Ins 1,4,5-P3 75
Measurement of the Formation of Inositol Trisphosphate
(InsP3) in Platelets 76
Early Studies Employing p2P]-PO4-labeling 76
Studies Employing pH]-inositol-labeling 76
The Measurement of the InsP3 Mass in Resting and
Stimulated Platelets 78
The Platelet Amine Storage Granule vii
Improved Measurement of InsP3 Using P2P]-PO4
Labeling 79
Inositol l:2-cyclic, 4,5-trisphosphate 79
ADP-induced InsP3 Formation 81
The Metabolism of Ins 1,4,5-P3 82
Formation of Isomers and Other Polyphosphates 82
The Formation of Ins 1,4,5-P3 82
The Regulation of Inositol 13,4-trisphosphate3-kinase *
by Calcium 84
The Function of Ins 13,4,5-P4 85
A Possible Function of Ins 13,4,-P3 86
The Pathways in the Formation of Inositol from
Insl,4,5-P3 86
Other Inositol Polyphosphates 86
The Effect of Activation of Protein Kinase C on Inositol
Phosphate Metabolism 87
Concluding Remarks 88
List of Abbreviations 89
Acknowledgments 90
References 90
CHAPTER 5
POLYPHOSPHOINOSrriDE METABOLISM IN RESTING
AND STIMULATED PLATELETS 97
Holm Holmsen, Ole-Bj0rn Tysnes and Adrie J M Verhoeven
Platelet Activation 97
Polyphosphoinositide (PPI) Cycle and Radioisotopic Labeling 98
Time Courses of Changes in 32P-PPIs During Platelet
Stimulation 102
Turnover of PI in Resting and Stimulated Platelets 102
Turnover of PIP and PIP2 in Resting and Stimulated Platelets 105
Rapid Influx and Efflux of Inorganic Phosphate During
Platelet Stimulation 106
Rates of Production and Consumption of PA in Stimulated
Platelets—The Existence of a Non-equilibrium Condition 107
Metabolic Heterogeniety of PA in Resting and Stimulated
Platelets 108
Conversion Rates in the Individual Steps in the PPI Cycle
of Resting and Stimulated Platelets—Purpose of the
High Turnover Rates of the PPI Monoesters 109
Acknowledgments 114
List of Abbreviations 114
References 114
viii The Platelet Amine Storage Granule
CHAPTER 6
EPINEPHRINE-INDUCED PLATELET
MEMBRANE MODULATION 117
Gundu H R Rao and James G White
Introduction 117
Facilitating Influence of Epinephrine on Platelet Function 117
Alpha Adrenoceptors and Platelet Function 119
Discovery of Platelet Membrane Modulation 121
Irreversible Aggregation Independent of the Mediation
By Cyclooxygenase Products or Dense Granule Contents 122
Mechanism Involved in Epinephrine-induced Restoration
of Function in Aspirin-treated Platelets 123
Studies on Membrane Modulation in Various
Platelet Disorders 124
Epinephrine-induced Restoration of Function in Drug-induced
Refractory Platelets 125
Is Membrane Modulation Different from Synergism? 126
Mechanisms Involved in Epinephrine-induced Facilitation
of Platelet Function 126
Mechanisms Involved in Epinephrine-induced Membrane
Modulation in Drug-induced Refractory Platelets 133
Clinical Significance of Membrane Modulation 138
Summary 139
Acknowledgments
list of Abbreviations 141
References • 141
CHAPTER 7
PLATELET STORAGE POOL DEFICIENCY 149
Kenneth M Meyers and Michile Menard
Introduction 149
Congenital SPD 150
Storage Pool Disease 150
Dense Granule Deficiency 150
Combined Alpha Granule-Dense Granule Deficiency 153
Hermansky-Pudlak Syndrome (HPS) 154
HPS Variant 156
Suggested Animal Models of the HPS 156
The Platelet Amine Storage Granule ix
Chediak-Higashi Syndrome (CHS) 157
CHS Cattle 160
Resting and Secreted Granule Constituents 160
Ultrastructure 162
Basis for the SPD 164
Mepacrine Containing Granules in CHS Cattle 171
Beige Mice (bg/bg) 171
Rats, Foxes, Mink and Cats with the CHS 173
Fawn-Hooded Rat : 176
Miscellaneous Disorders Where Congenital SPD
has been Described 177
Thrombocytopenic Absent Radii (TAR) Syndrome 177
Wiskott-Aldrich Syndrome 177
Porcine SPD 177
Acquired SPD 178
Myeloproliferative Disorders 178
Immunologically Mediated Platelet SPD 180
Alcohol Abuse and SPD 181
Cardiopulmonary Bypass (CPB) and SPD 181
Miscellaneous Diseases Where Acquired SPD has been
Described 183
Treatment 184
Summary 185
List of Abbreviations 186
References 186
Index 197
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| spelling | The platelet amine storage granule ed. by Kenneth M. Meyers ... Boca Raton u.a. CRC Press 1992 XV, 203 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Amines biogènes - Métabolisme Granulations cytoplasmiques Sang - Plaquettes Biogenic amines Metabolism Blood Platelets physiology Blood platelets Cytoplasmic Granules physiology Cytoplasmic granules Thrombozyt (DE-588)4059964-4 gnd rswk-swf Amine (DE-588)4001705-9 gnd rswk-swf Granulum Cytologie (DE-588)4302848-2 gnd rswk-swf Speicherung (DE-588)4191504-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Thrombozyt (DE-588)4059964-4 s Granulum Cytologie (DE-588)4302848-2 s Amine (DE-588)4001705-9 s Speicherung (DE-588)4191504-5 s DE-604 Meyers, Kenneth M. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=003495682&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The platelet amine storage granule Amines biogènes - Métabolisme Granulations cytoplasmiques Sang - Plaquettes Biogenic amines Metabolism Blood Platelets physiology Blood platelets Cytoplasmic Granules physiology Cytoplasmic granules Thrombozyt (DE-588)4059964-4 gnd Amine (DE-588)4001705-9 gnd Granulum Cytologie (DE-588)4302848-2 gnd Speicherung (DE-588)4191504-5 gnd |
| subject_GND | (DE-588)4059964-4 (DE-588)4001705-9 (DE-588)4302848-2 (DE-588)4191504-5 (DE-588)4143413-4 |
| title | The platelet amine storage granule |
| title_auth | The platelet amine storage granule |
| title_exact_search | The platelet amine storage granule |
| title_full | The platelet amine storage granule ed. by Kenneth M. Meyers ... |
| title_fullStr | The platelet amine storage granule ed. by Kenneth M. Meyers ... |
| title_full_unstemmed | The platelet amine storage granule ed. by Kenneth M. Meyers ... |
| title_short | The platelet amine storage granule |
| title_sort | the platelet amine storage granule |
| topic | Amines biogènes - Métabolisme Granulations cytoplasmiques Sang - Plaquettes Biogenic amines Metabolism Blood Platelets physiology Blood platelets Cytoplasmic Granules physiology Cytoplasmic granules Thrombozyt (DE-588)4059964-4 gnd Amine (DE-588)4001705-9 gnd Granulum Cytologie (DE-588)4302848-2 gnd Speicherung (DE-588)4191504-5 gnd |
| topic_facet | Amines biogènes - Métabolisme Granulations cytoplasmiques Sang - Plaquettes Biogenic amines Metabolism Blood Platelets physiology Blood platelets Cytoplasmic Granules physiology Cytoplasmic granules Thrombozyt Amine Granulum Cytologie Speicherung Aufsatzsammlung |
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