Transdifferentiation: flexibility in cell differentiation
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford
Clarendon Press
1991
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 238 S. Ill. |
| ISBN: | 019854281X |
Internformat
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Datensatz im Suchindex
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| adam_text | Transdifferentiation
Flexibility in Cell Differentiation
T S OKADA
Okazaki National Research Institutes, Aichi,)japan
(formerly University of Kyoto)
CLARENDON PRESS • OXFORD
Contents
Introduction
1 1 The scope of the monograph
1 2 Historical survey
1 3 Terminology
131 Metaplasia and related terminology
132 Transdifferentiation
133 Transdetermination
134 Some other terms
Are dormant genes in differentiated cells
activated?
2 1 Nuclear transplantation
2 2 Heterokaryons
2 3 Possible re-activation ofVdormant genes by
hypomethylation $/:
2 4 Does transdifferentiation occur in differentiated
plant cells?
2 5 Transdetermination in Drosophila imaginal
discs
Does change in differentiated cell phenotypes
occur in normal development?
3 1 Examples from invertebrate development
3 2 Developmental shift of molecular markers
Examples of transdifferentiation among single
or related cell classes
4 1 Flexibility of differentiation phenotypes of
neurons
4 2 Transdifferentiation among different subclasses
ofchromatophores
4 3 Transdifferentiation of endocrine cells to
neurons
431 Chromaffin cells can change to neuronal
cells
viii Contents
432 Factors influencing transdifferentiation
of chromaffin cells into neuronal cells 53
5 Re-evaluation of classical examples of
metaplasia and some related systems 56
5 1 Epithelial metaplasia 56
511 Skin metaplasia 57
512 Endodermal derivatives 58
513 Corneal epithelium 64
5 2 Pancreatic hepatocytes 66
5 3 Bone metaplasia: myocytes transdifferentiate
into cartilage cells 72
5 4 Other systems 78
6 Does transdifferentiation occur in
regeneration? 80
6 1 Regeneration in representative invertebrates 80
611 Regeneration in planarians 80
612 Other invertebrate systems 85
6 2 Regeneration of imphibian limbs 88
621 Nuclear transplantation and cell
culture 89
622 Cell differentiation of blastema cells in
situ 91
623 Regeneration from putative reserve
cells 95
624 Summary of studies on limb
regeneration 96
6 3 Lens regeneration by transdifferentiation 99
631A short historical note 99
632 Regenerated lens is derived from iris
pigmented epithelium (IPE) by
transdifferentiation 100
633 Retinal pigmented epithelium
transdifferentiates into lens 105
634 Lens regeneration from cornea 105
635 Possible lens transdifferentiation from
neural retina in vivo 107
6 4 Regeneration of neural retina by
transdifferentiation 111
6 5 Summary of studies on regeneration of eyes 116
Contents ix
7 Transdifferentiation in cell culture conditions 119
7 1 Transdifferentiation from pigmented cells of
eyes 119
711 Retinal pigmented epithelial cells
transdifferentiate into lens 119
712 Retinal pigmented epithelial cells
transdifferentiate into neural retina 125
713 Iris pigmented epithelial cells
transdifferentiate into lens 127
714 Other pigment cells 129
7 2 Transdifferentiation from neural retina 130
721 General features of transdifferentiating
cultures of neural retina 132
722 Molecular events 134
723 Progenitor cell type in
transdifferentiated lens 138
724 Extrinsic factors affecting
transdifferentiation of neural retina 140
7 3 The pineal body as,a/multipotentia] system in
cell differentiation * * - 143
7 4 The unusually wide differentiation repertoire
of isolated striated muscle of medusa 146
741 Birth of new cell types from isolated
striated muscle 147
742 Organ regeneration from isolated
striated muscle 150
8 Factors influencing transdifferentiation 155
8 1 Are preceding mitotic cycles obligatory for
transdifferentiation? 155
8 2 Is a loss of the pre-existing phenotype a
necessary condition for transdifferentiation? 161
83A possible cue to trigger the process of
transdifferentiation 163
8 4 Does disruption of contact-mediated cell
interaction control phenotypic modification? 165
8 5 Do specific molecules induce new pathways in
transdifferentiation systems? 170
8 6 Is molecular memory a possible prerequisite
for transdifferention? 173
x Contents
9 Characteristics of the transdifferentiation
process 178
9 1 Transdifferentiation is basically a
unidirectional process 178
9 2 Can the dichotomy of transdifferentiation
(metaplasia) versus differentiation of stem cells
be reconciled? 182
9 3 Speculation on the mechanisms of
transdifferentiation 186
References 193
Index 230
|
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| indexdate | 2024-07-09T16:21:12Z |
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| isbn | 019854281X |
| language | English |
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| physical | X, 238 S. Ill. |
| publishDate | 1991 |
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| publishDateSort | 1991 |
| publisher | Clarendon Press |
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| spelling | Okada, T. S. Verfasser aut Transdifferentiation flexibility in cell differentiation T. S. Okada Oxford Clarendon Press 1991 X, 238 S. Ill. txt rdacontent n rdamedia nc rdacarrier Différenciation cellulaire Cell Differentiation physiology Cell differentiation Zelldifferenzierung (DE-588)4067536-1 gnd rswk-swf Zelldifferenzierung (DE-588)4067536-1 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=003071607&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Okada, T. S. Transdifferentiation flexibility in cell differentiation Différenciation cellulaire Cell Differentiation physiology Cell differentiation Zelldifferenzierung (DE-588)4067536-1 gnd |
| subject_GND | (DE-588)4067536-1 |
| title | Transdifferentiation flexibility in cell differentiation |
| title_auth | Transdifferentiation flexibility in cell differentiation |
| title_exact_search | Transdifferentiation flexibility in cell differentiation |
| title_full | Transdifferentiation flexibility in cell differentiation T. S. Okada |
| title_fullStr | Transdifferentiation flexibility in cell differentiation T. S. Okada |
| title_full_unstemmed | Transdifferentiation flexibility in cell differentiation T. S. Okada |
| title_short | Transdifferentiation |
| title_sort | transdifferentiation flexibility in cell differentiation |
| title_sub | flexibility in cell differentiation |
| topic | Différenciation cellulaire Cell Differentiation physiology Cell differentiation Zelldifferenzierung (DE-588)4067536-1 gnd |
| topic_facet | Différenciation cellulaire Cell Differentiation physiology Cell differentiation Zelldifferenzierung |
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