Biochemistry of lipids, lipoproteins and membranes:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
1991
|
| Ausgabe: | [2. ed.] |
| Schriftenreihe: | New comprehensive biochemistry
20 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XXI, 596 S. Ill., graph. Darst. |
| ISBN: | 0444893210 0444893849 0444803033 |
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Datensatz im Suchindex
| _version_ | 1804118884771430400 |
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| adam_text | BIOCHEMISTRY OF LIPIDS, LIPOPROTEINS AND MEMBRANES EDITORS DENNIS E.
VANCE AND JEAN E. VANCE LIPID AND LIPOPROTEIN RESEARCH GROUP, FACULTY OF
MEDICINE, 328 HERITAGE MEDICAL RESEARCH CENTRE, EDMONTON, AHA., CANADA,
T6G 2S2 1991 ELSEVIER AMSTERDAM * LONDON * NEW YORK * TOKYO IX CONTENTS
PREFACE V LIST OF CONTRIBUTORS VII CHAPTER 1. PHYSICAL PROPERTIES AND
FUNCTIONAL ROLES OF LIPIDS IN MEMBRANES PIETER R. CULLIS AND MICHAEL J.
HOPE L 1. INTRODUCTION AND OVERVIEW 1 2. LIPID DIVERSITY AND
DISTRIBUTION 3 2.1. CHEMICAL DIVERSITY OF LIPIDS 3 2.2. MEMBRANE LIPID
COMPOSITIONS 5 2.3. TRANSBILAYER LIPID ASYMMETRY 7 3. MODEL MEMBRANE
SYSTEMS 8 3.1. LIPID ISOLATION AND PURIFICATION 9 3.2. TECHNIQUES FOR
MAKING MODEL MEMBRANE VESICLES 9 3.3. TECHNIQUES FOR MAKING PLANAR
BILAYERS AND MONOLAYERS 13 3.4. RECONSTITUTION OF INTEGRAL MEMBRANE
PROTEIN INTO VESICLES 13 4. PHYSICAL PROPERTIES OF LIPIDS 15 4.1.
GEL-LIQUID-CRYSTALLINE PHASE BEHAVIOUR 15 4.2. LIPID POLYMORPHISM 19
4.3. FACTORS WHICH MODULATE LIPID POLYMORPHISM 24 4.4. THE PHYSICAL
BASIS OF LIPID POLYMORPHISM 26 5. LIPIDS AND THE PERMEABILITY PROPERTIES
OF MEMBRANES 28 5.1. THEORETICAL CONSIDERATIONS 28 5.2. PERMEABILITY OF
WATER AND NON-ELECTROLYTES 29 5.3. PERMEABILITY OF IONS 30 6.
LIPID-PROTEIN INTERACTIONS 31 6.1. EXTRINSIC PROTEINS 32 6.2. INTRINSIC
PROTEINS 33 7. LIPIDS AND MEMBRANE FUSION 34 7.1. FUSION OF MODEL
SYSTEMS 34 7.2. FUSION OF BIOLOGICAL MEMBRANES 36 8. MODEL MEMBRANES AND
DRUG DELIVERY 38 9. FUTURE DIRECTIONS 40 REFERENCES 40 CHAPTER 2. LIPID
METABOLISM IN PROCARYOTES S. JACKOWSKI, J.E. CRONAN JR. AND CO. ROCK 43
1. THE STUDY OF BACTERIAL LIPID METABOLISM 43 2. HISTORICAL INTRODUCTION
43 3. AN OVERVIEW OF PHOSPHOLIPID METABOLISM IN E. COLI 44 4. GENETIC
ANALYSIS OF LIPID METABOLISM 44 5. MEMBRANE SYSTEMS OF E. COLI 48 6.
LIPID BIOSYNTHETIC PATHWAYS IN E. COLI 50 6.1. INITIATION OF FATTY ACID
BIOSYNTHESIS 50 6.2. ELONGATION OF ACYL CHAINS 51 6.3. PRODUCT
DIVERSIFICATION 52 6.4. TRANSFER TO THE MEMBRANE 53 6.5. DIVERSIFICATION
OF POLAR HEAD GROUPS 54 6.6. CENTRAL ROLE OF ACYL CARRIER PROTEIN 54 7.
LIPOPOLYSACCHARIDE BIOSYNTHESIS 58 8. DEGRADATIVE PATHWAYS 59 8.1.
PHOSPHOLIPASES 59 8.2. THIOESTERASES 62 8.3. FATTY ACID OXIDATION IN
BACTERIA 63 9. PHOSPHOLIPID TURNOVER 63 9.1. THE DIACYLGLYCEROL CYCLE 63
9.2. THE 2-ACYLGLYCEROLPHOSPHOETHANOLAMINE CYCLE 65 10. INHIBITORS OF
LIPID METABOLISM 66 10.1. 3-DECYNOYL-YV-ACETYLCYSTEAMINE 66 10.2.
CERULENIN 66 10.3. THIOLACTOMYCIN 67 11. REGULATION OF FATTY ACID
COMPOSITION IN E. COLI 68 11.1. ROLE OF 3-HYDROXYDECANOYL-ACP DEHYDRASE
68 11.2. ROLE OF 3-KETOACYL-ACP SYNTHASE I 69 11.3. ROLE OF
3-KETOACYL-ACP SYNTHASE II 70 11.4. FACTORS AFFECTING FATTY ACID
CHAIN-LENGTH DISTRIBUTION 72 11.5. SYNTHESIS OF CYCLOPROPANE FATTY ACIDS
72 11.6. IMPORTANCE OF THE FATTY ACID COMPOSITION OF THE MEMBRANE
PHOSPHOLIPIDS . . . 73 12. REGULATION OF PHOSPHOLIPID BIOSYNTHESIS IN E.
COLI 74 12.1. CONTROL OF FATTY ACID POSITIONAL DISTRIBUTION 74 12.2.
REGULATION OF TOTAL PHOSPHOLIPID SYNTHESIS 76 12.3. COORDINATION OF
PHOSPHOLIPID SYNTHESIS WITH CELLULAR METABOLISM 77 12.4. REGULATION OF
PHOSPHOLIPID HEAD GROUP COMPOSITION 77 12.5. E. COLI TOLERATES
VARIATIONS IN PHOSPHOLIPID COMPOSITION 78 12.6. OUTER MEMBRANE
LIPOPROTEIN 79 13. LIPID METABOLISM IN BACTERIA OTHER THAN E. COLI 80
13.1. BACTERIA LACKING UNSATURATED FATTY ACIDS 80 13.2. BACTERIA
CONTAINING PHOSPHATIDYLCHOLINE 81 13.3. BACTERIA SYNTHESIZING
UNSATURATED FATTY ACIDS BY AN AEROBIC PATHWAY 81 13.4. BACTERIA WITH A
MULTIFUNCTIONAL FATTY ACID SYNTHASE 81 13.5. BACTERIA WITH
INTRACYTOPLASMIC MEMBRANES 82 13.6. OTHER BACTERIAL ODDITIES 82 13.7.
LIPIDS OF NONBACTERIAL (BUT RELATED) ORGANISMS 83 14. FUTURE DIRECTIONS
83 REFERENCES 84 CHAPTER 3. OXIDATION OF FATTY ACIDS HORST SCHULZ 87 1.
THE PATHWAY OF ^-OXIDATION: A HISTORICAL ACCOUNT 87 2. UPTAKE AND
ACTIVATION OF FATTY ACIDS IN ANIMAL CELLS 89 XI 3. ^-OXIDATION IN
MITOCHONDRIA 91 3.1. MITOCHONDRIAL UPTAKE OF FATTY ACIDS 91 3.2. ENZYMES
OF /J-OXIDATION IN MITOCHONDRIA 93 3.3. /^-OXIDATION OF UNSATURATED AND
ODD-CHAIN FATTY ACIDS 96 3.4. REGULATION OF MITOCHONDRIAL /J-OXIDATION
98 3.5. INHIBITORS OF MITOCHONDRIAL /7-OXIDATION 100 4. /J-OXIDATION IN
PEROXISOMES 101 5. FATTY ACID OXIDATION IN E. COLI 104 6. INHERITED
DISEASES OF FATTY ACID OXIDATION 106 7. FUTURE DIRECTIONS 108 REFERENCES
109 CHAPTER 4. FATTY ACID SYNTHESIS IN EUCARYOTES ALAN G. GOODRIDGE ILL
1. INTRODUCTION ILL 2. SIGNALS IN BLOOD THAT MEDIATE THE EFFECTS OF DIET
112 3. WHICH ENZYMES REGULATE FATTY ACID SYNTHESIS? 114 4. REGULATION OF
SUBSTRATE SUPPLY 115 4.1. PRODUCTION OF PYRUVATE FROM GLUCOSE 115 4.2.
PRODUCTION OF CITRATE FROM PYRUVATE 115 4.3. PRODUCTION OF NADPH 117 5.
REGULATION OF THE CATALYTIC EFFICIENCY OF ACETYL-COA CARBOXYLASE 117
5.1. A KEY REGULATORY REACTION 117 5.2. STRUCTURE AND REACTION MECHANISM
118 5.3. REGULATION BY CITRATE 118 5.4. REGULATION BY LONG-CHAIN FATTY
ACYL-COA 119 5.5. REGULATION BY COVALENT MODIFICATION 121 6. FATTY ACID
SYNTHASE 125 6.1. ANIMAL FATTY ACID SYNTHASE: THE COMPONENT REACTIONS
125 6.2. ANIMAL FATTY ACID SYNTHASE: THE SUBUNITS ARE IDENTICAL 127 6.3.
ANIMAL FATTY ACID SYNTHASE: STRUCTURAL ORGANIZATION 128 6.4. COMPARISON
OF YEAST AND ANIMAL FATTY ACID SYNTHASES 129 7. REGULATION OF ENZYME
CONCENTRATION 130 7.1. MESSENGER RNA LEVELS REGULATE ENZYME SYNTHESIS
RATES 130 7.2. TRANSCRIPTION IS USUALLY THE REGULATED STEP 131 7.3.
REGULATION IN CELLS IN CULTURE 134 7.3.1. 3T3-L1 CELLS *A PRE-ADIPOCYTE
CELL LINE 134 7.3.2. HEPATOCYTES IN MAINTENANCE CULTURE 135 8. FUTURE
DIRECTIONS 137 REFERENCES 138 CHAPTER 5. FATTY ACID DESATURATION AND
CHAIN ELONGATION IN EUCARYOTES HAROLD W. COOK 141 1. INTRODUCTION 141 2.
HISTORICAL BACKGROUND 143 3. CHAIN ELONGATION OF LONG CHAIN FATTY ACIDS
144 XLL 3.1. THE MICROSOMAL ELONGATION SYSTEM 146 3.2. THE MITOCHONDRIAL
ELONGATION SYSTEM 147 3.3. FUNCTIONS OF THE TWO ELONGATION SYSTEMS 148
4. FORMATION OF MONOUNSATURATED FATTY ACIDS BY OXIDATIVE DESATURATION
148 4.1. NOMENCLATURE TO DESCRIBE DOUBLE BONDS 148 4.2. CHARACTERISTICS
OF THE MONOENE-FORMING DESATURATION ENZYMES 149 4.3. MODIFICATION OF ZL9
DESATURASE ACTIVITIES IN VITRO 151 4.4. DIETARY AND HORMONAL REGULATION
OF J9 DESATURASE 152 4.5. FORMATION OF MONOUNSATURATED FATTY ACIDS IN
PLANTS 154 5. FORMATION OF POLYUNSATURATED FATTY ACIDS 154 5.1.
CHARACTERISTICS AND RESTRICTIONS IN ANIMAL SYSTEMS 154 5.2. ESSENTIAL
FATTY ACIDS*A CONTRIBUTION OF PLANT SYSTEMS 155 5.3. FAMILIES OF FATTY
ACIDS AND THEIR METABOLISM 157 5.3.1. THE (N-6) FAMILY 157 5.3.2. THE
(N-3) FAMILY 159 5.3.3. COMPETITION BETWEEN THE (N-6) AND (N-3) FAMILIES
160 5.3.4. THE (N-9) FAMILY 161 5.3.5. THE (N-7) FAMILY 161 5.4. DIETARY
AND HORMONAL ALTERATIONS OF POLYUNSATURATED ACID SYNTHESIS 161 5.5. TWO
OR MORE DOUBLE BONDS IN PLANTS 163 6. UNSATURATED FATTY ACIDS WITH TRANS
DOUBLE BONDS 164 7. ABNORMAL PATTERNS OF DISTRIBUTION AND METABOLISM OF
LONG CHAIN SATURATED AND UNSATURATED FATTY ACIDS 165 7.1. ESSENTIAL
FATTY ACID DEFICIENCY 165 7.2. ZINC DEFICIENCY 166 7.3. OTHER CLINICAL
DISORDERS 166 7.4. RELATIONSHIP TO PLASMA CHOLESTEROL 166 8. FUTURE
DIRECTIONS 167 REFERENCES 168 CHAPTER 6. METABOLISM OF TRIACYLGLYCEROLS
DAVID N. BRINDLEY 171 1. INTRODUCTION 171 2. BIOSYNTHESIS OF
TRIACYLGLYCEROLS 173 2.1. BIOSYNTHESIS OF PHOSPHATIDATE 173 2.2.
CONVERSION OF PHOSPHATIDATE TO TRIACYLGLYCEROL 178 2.3. CONVERSION OF
MONOACYLGLYCEROL TO TRIACYLGLYCEROL 179 3. DIGESTION, ABSORPTION AND
TRANSPORT OF LIPIDS 181 3.1. DIGESTION OF LIPIDS 181 3.2. ABSORPTION OF
LIPIDS FROM THE SMALL INTESTINE 183 3.3. FORMATION OF CHYLOMICRONS AND
VLDL 184 3.4. PARTITIONING OF FATTY ACIDS BETWEEN THE PORTAL BLOOD AND
THE LYMPHATIC SYSTEM . . 186 4. CONTROL OF TRIACYLGLYCEROL SYNTHESIS 187
4.1. CONTROL OF PHOSPHATIDATE SYNTHESIS IN THE LIVER 188 4.2. CONTROL OF
THE CONVERSION OF PHOSPHATIDATE TO TRIACYLGLYCEROL IN LIVER 189 4.3.
DIACYLGLYCEROL AS A PRECURSOR OF TRIACYLGLYCEROL, PHOSPHATIDYLCHOLINE
AND PHOSPHATI- DYLETHANOLAMINE 193 5. METABOLISM OF TRIACYLGLYCEROLS
WHEN THE ACTION OF INSULIN IS HIGH 195 6. TRIACYLGLYCEROL METABOLISM IN
CONDITIONS OF METABOLIC STRESS 198 XLLL 7. FUTURE DIRECTIONS 200
REFERENCES 201 CHAPTER 7. PHOSPHOLIPID METABOLISM AND CELL SIGNALLING IN
EUCARYOTES DENNIS E. VANCE 205 1. INTRODUCTION 205 2.
PHOSPHATIDYLCHOLINE BIOSYNTHESIS 206 2.1. HISTORICAL BACKGROUND 206 2.2.
CHOLINE TRANSPORT AND OXIDATION 207 2.3. ENZYMES OF THE CDP-CHOLINE
PATHWAY 207 2.4. PHOSPHATIDYLETHANOLAMINE-JV-METHYLTRANSFERASE 208 3.
REGULATION OF PHOSPHATIDYLCHOLINE BIOSYNTHESIS 209 3.1. THE
RATE-LIMITING REACTION 209 3.2. THE TRANSLOCATION HYPOTHESIS 210 3.3.
REGULATORY MECHANISMS 210 3.3.1. FATTY ACIDS ARE IMPORTANT REGULATORS OF
PHOSPHATIDYLCHOLINE BIOSYNTHESIS IN CULTURED CELLS 211 3.3.2.
DIACYLGLYCEROL MAY ALSO REGULATE PHOSPHATIDYLCHOLINE BIOSYNTHESIS . . .
211 3.3.3. PHOSPHORYLATION-DEPHOSPHORYLATION REACTIONS 212 3.3.4.
FEEDBACK REGULATION 212 3.3.5. CHOLINEPHOSPHOTRANSFERASE 213 3.4.
SUBSTRATE CHANNELING 213 4. SPHINGOMYELIN BIOSYNTHESIS 214 5.
PHOSPHATIDYLSERINE BIOSYNTHESIS 215 5.1. HISTORICAL DEVELOPMENTS AND
BIOSYNTHESIS 215 5.2. CHO MUTANTS AND REGULATION 217 6.
PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS 218 6.1. HISTORICAL BACKGROUND 218
6.2. ENZYMES OF THE CDP-ETHANOLAMINE PATHWAY 218 6.3. REGULATION OF THE
CDP-ETHANOLAMINE PATHWAY 219 6.3.1. REGULATION AT THE
CYTIDYLYLTRANSFERASE REACTION 219 6.3.2. DIACYLGLYCEROL 220 6.4.
PHOSPHATIDYLSERINE DECARBOXYLATION AND THE RELATIVE IMPORTANCE OF THE
VARIOUS PATHWAYS FOR PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS 221 6.5.
JV-ACYL-PHOSPHATIDYLETHANOLAMINE 221 7. POLYGLYCEROPHOSPHOLIPIDS 222
7.1. HISTORICAL DEVELOPMENTS AND BIOSYNTHETIC PATHWAYS 222 7.2. ENZYMES
AND SUBCELLULAR LOCATION 224 8. INOSITOL PHOSPHOLIPIDS 224 8.1.
HISTORICAL DEVELOPMENTS 224 8.2. BIOSYNTHETIC ENZYMES 225 9.
PHOSPHOLIPIDS AS PRECURSORS OF CELLULAR SECOND MESSENGERS 226 9.1.
DISCOVERY OF THE PHOSPHATIDYLINOSITOL CYCLE 226 9.2. DEGRADATION OF
PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE BY PHOSPHOLIPASEC . . . 227 9.3.
METABOLISM OF THE INOSITOL PHOSPHATES 228 9.4. FUNCTION OF INOSITOL
PHOSPHATES 229 9.5. DIACYLGLYCEROL AND PROTEIN KINASE C 230 9.6.
PHOSPHATIDYLCHOLINE CYCLES AND FORMATION OF DIACYLGLYCEROL 231 XIV 10.
PHOSPHOLIPID CATABOLISM AND REMODELING OF THE ACYL SUBSTITUENTS 231 11.
PHOSPHOLIPID BIOSYNTHESIS IN YEAST 233 12. PHOSPHONOLIPIDS 234 12.1.
HISTORICAL PERSPECTIVE 234 12.2. BIOSYNTHESIS 235 13. GLYCOSYL
PHOSPHATIDYLINOSITOLS FOR ATTACHMENT OF CELL SURFACE PROTEINS 236 14.
FUTURE DIRECTIONS 238 REFERENCES 238 CHAPTER 8. METABOLISM, REGULATION,
AND FUNCTION OF ETHER-LINKED GLYCEROLIPIDS AND THEIR BIOACTIVE SPECIES
FREDSNYDER 241 1. INTRODUCTION 241 2. NOMENCLATURE 241 3. HISTORICAL
EVENTS 243 4. ANALYTICAL APPROACHES 245 5. PHYSICAL PROPERTIES 247 6.
OCCURRENCES IN NATURE 248 7. BIOLOGICALLY ACTIVE ETHER LIPIDS 249 8.
BIOSYNTHESIS 250 8.1. ETHER LIPID PRECURSORS 250 8.1.1. ACYL-COA
REDUCTASE 250 8.1.2. DIHYDROXYACETONE-P ACYLTRANSFERASE 250 8.2. ETHER
LIPIDS IN MEMBRANES 252 8.2.1. BIOSYNTHESIS OF THE ETHER BOND 252 8.2.2.
BIOSYNTHESIS OF THE ALKYL ANALOGUE OF PHOSPHATIDIC ACID 254 8.2.3.
BIOSYNTHESIS OF COMPLEX NEUTRAL GLYCEROLIPIDS AND PHOSPHOLIPIDS WITH
0-ALKYL BONDS 254 8.2.4. BIOSYNTHESIS OF PLASMALOGENS 255 8.3. BIOACTIVE
ETHER LIPIDS 256 9. CATABOLISM 258 9.1. ETHER LIPID PRECURSORS 258
9.1.1. LONG-CHAIN FATTY ALCOHOLS 258 9.1.2. DIHYDROXYACETONE-P AND
ACYLDIHYDROXYACETONE-P 258 9.2. ETHER LIPIDS IN MEMBRANES 259 9.2.1.
ALKYL CLEAVAGE ENZYME 259 9.2.2. PLASMALOGENASES 260 9.2.3.
PHOSPHOLIPASES AND LIPASES 260 9.3. BIOACTIVE ETHER LIPIDS 262 10.
REGULATORY CONTROLS 263 11. FUNCTIONAL ROLES 264 11.1. MEMBRANE
COMPONENTS 264 11.2. CELL MEDIATORS (ACTIVITIES AND MECHANISMS OF
ACTION) 265 12. FUTURE DIRECTIONS 266 REFERENCES 267 XV CHAPTER 9.
PHOSPHOLIPASES MOSELEY WAITE 269 1. OVERVIEW 269 1.1. DEFINITION OF
PHOSPHOLIPASES 269 1.2. ASSAY OF PHOSPHOLIPASES 271 1.3. INTERACTION OF
PHOSPHOLIPASES WITH INTERFACES 272 2. THE PHOSPHOLIPASES 276 2.1.
PHOSPHOLIPASE A 2 276 2.2. PHOSPHOLIPASE B AND LYSOPHOSPHOLIPASES 278
2.3. PHOSPHOLIPASE A 2 280 2.4. PHOSPHOLIPASE C 287 2.5. PHOSPHOLIPASE D
290 2.6. PHOSPHOLIPASES IN SIGNAL TRANSDUCTION 292 3. FUTURE DIRECTIONS
292 REFERENCES 294 CHAPTER 10. THE EICOSANOIDS: CYCLOOXYGENASE,
LIPOXYGENASE, AND EPOXYGENASE PATHWAYS WILLIAM L. SMITH, PIERRE BORGEAT
AND FRANK A. FITZPATRICK 297 1. INTRODUCTION 297 2. PROSTANOIDS 298 2.1.
STRUCTURES AND NOMENCLATURE 298 2.2. PROSTANOID CHEMISTRY 299 2.3.
PROSTANOID BIOSYNTHESIS 299 2.4. ARACHIDONATE RELEASE 299 2.5.
PROSTAGLANDIN ENDOPEROXIDE FORMATION 300 2.6. PHYSICO-CHEMICAL
PROPERTIES OF PGH SYNTHASE 302 2.7. PGH SYNTHASE AND NONSTEROIDAL
ANTI-INFLAMMATORY DRUGS 302 2.8. ANTI-INFLAMMATORY STEROIDS 303 2.9. PGH
SYNTHASE ACTIVE SITE 304 2.10. REGULATION OF PGH SYNTHASE GENE
EXPRESSION 304 2.11. PGH 2 METABOLISM 305 2.12. CATABOLISM: PROSTANOIDS
AS LOCAL HORMONES 306 3. HYDROXY- AND HYDROPEROXY-EICOSAENOIC ACIDS AND
LEUKOTRIENES 308 3.1. INTRODUCTION AND OVERVIEW 308 3.2. MECHANISM OF
LEUKOTRIENE BIOSYNTHESIS IN HUMAN NEUTROPHILS 309 3.3. THE ENZYMES OF
THE 5-LIPOXYGENASE PATHWAY 312 3.4. REGULATION OF LEUKOTRIENE SYNTHESIS
313 3.5. THE METABOLISM OF LIPOXYGENASE PRODUCTS 315 3.6. BIOLOGICAL
ACTIVITIES OF LEUKOTRIENES 317 4. EPOXYGENASE PRODUCTS 318 4.1.
INTRODUCTION 318 4.2. STRUCTURES, NOMENCLATURE, AND BIOSYNTHESIS 318
4.3. OCCURRENCE OF EPOXYEICOSATRIENOIC ACIDS 321 4.4. METABOLISM OF
EPOXYGENASE METABOLITES OF ARACHIDONIC ACID 321 4.5. BIOLOGICAL ACTIONS
OF EPOXYGENASE DERIVED EPETRES AND HETRES 322 XVI 5. FUTURE DIRECTIONS
322 5.1. CYCLOOXYGENASE METABOLITES 322 5.2. LIPOXYGENASE METABOLITES
323 5.3. EPOXYGENASE METABOLITES 323 REFERENCES 323 CHAPTER 11.
SPHINGOLIPIDS CHARLES C. SWEELEY 327 1. INTRODUCTION 327 2. CHEMISTRY
AND DISTRIBUTION 330 2.1. SPHINGOID BASES 330 2.2. CERAMIDES 332 2.3.
GLYCOSPHINGOLIPIDS 333 2.3.1. NEUTRAL GLYCOSPHINGOLIPIDS 333 2.3.2.
ACIDIC GLYCOSPHINGOLIPIDS 334 2.3.2.1. GANGLIOSIDES 334 2.3.2.2.
PHOSPHORUS-CONTAINING GLYCOSPHINGOLIPIDS 336 2.3.2.3.
SULFATOGLYCOSPHINGOLIPIDS 337 3. BIOSYNTHESIS OF SPHINGOLIPIDS 337 3.1.
SPHINGOID BASES AND CERAMIDE 338 3.2. SPHINGOMYELIN 340 3.3.
SULFATOGLYCOSPHINGOLIPIDS 340 3.4. NEUTRAL GLYCOSPHINGOLIPIDS 341 3.4.1.
CELL SURFACE GLYCOSYLTRANSFERASES 345 3.5. GANGLIOSIDES 345 4. TURNOVER
OF SPHINGOLIPIDS 347 4.1. LYSOSOMAL METABOLISM OF SPHINGOLIPIDS 348
4.1.1. SPHINGOMYELIN 348 4.1.2. CERAMIDE 349 4.1.3. GLYCOSPHINGOLIPIDS
349 4.2. GLYCOSPHINGOLIPID STORAGE DISEASES 350 4.2.1. TAY-SACHS DISEASE
AND RELATED DISORDERS 351 4.2.1.1. A-SUBUNIT MUTATIONS 352 4.2.1.2.
/?-SUBUNIT MUTATIONS 353 4.2.1.3. DEFECTIVE G M2 ACTIVATOR PROTEIN 353
4.2.2. FABRY S DISEASE AND SCHINDLER S DISEASE 353 5. REGULATION OF
GLYCOSPHINGOLIPID METABOLISM 354 5.1. DEVELOPMENTAL CHANGES 355 5.1.1.
GLYCOSPHINGOLIPID MARKERS IN LEUKOCYTE DIFFERENTIATION 355 5.1.2. EARLY
EMBRYONIC MARKERS 356 5.2. ONCOGENIC TRANSFORMATION AND IMMUNOMODULATION
BY SHED GANGLIOSIDES . . . . 356 6. BIOLOGICAL ACTIVITIES AND FUNCTIONAL
ROLES OF SPHINGOLIPIDS 357 6.1. ADHERENCE OF MICROORGANISMS TO CELL
SURFACE GLYCOSPHINGOLIPIDS 357 6.2. MODULATION OF SIGNAL TRANSDUCTION
358 6.2.1. GLYCOSPHINGOLIPIDS 358 6.2.2. SPHINGOID BASES 359 7. FUTURE
DIRECTIONS 359 REFERENCES 360 XVII CHAPTER 12. CHOLESTEROL: EVOLUTION OF
STRUCTURE AND FUNCTION KONRAD BLOCH 363 1. NATURAL OCCURRENCE OF STEROLS
363 2. METABOLIC AND PRECURSOR FUNCTIONS OF THE STEROL MOLECULE 364 3.
STEROL PATTERNS 366 4. STEROLS AND MEMBRANE FUNCTION 368 4.1. FUNCTION
OF STEROLS IN ANIMAL MEMBRANES 368 4.2. STEROL AUXOTROPHS 369 4.3.
METABOLIC REGULATION IN THE MEMBRANE ENVIRONMENT 370 4.4. FLUIDITY
CONTROL 371 5. REGULATORY ROLES FOR STEROLS IN MEMBRANES 372 5.1. FUNGI
AND INVERTEBRATES 372 5.2. STEROL EFFECTS ON HORMONE AND
NEUROTRANSMITTER RECEPTORS 373 5.3. STEROLS AND FUSION OF VIRAL
MEMBRANES 374 5.4. CAPPING OF SURFACE IMMUNOGLOBULIN 375 5.5. STEROL
EFFECTS ON ENZYME ACTIVITIES 375 5.6. EFFECTS OF CHOLESTEROL ON
PHOSPHOLIPID SYNTHESIS 376 6. EVOLUTION OF THE STEROL STRUCTURE 377 7.
FUTURE DIRECTIONS 380 REFERENCES 381 CHAPTER 13. REGULATION OF STEROL
BIOSYNTHESIS AND ISOPRENYLATION OF PROTEINS PETER A. EDWARDS 383 1.
INTRODUCTION 383 2. REGULATION OF CHOLESTEROL SYNTHESIS 385 3.
REGULATION OF CHOLESTERYL ESTER SYNTHESIS 387 4. TRANSCRIPTIONAL CONTROL
OF CHOLESTEROL SYNTHESIS 389 5. POSTTRANSCRIPTIONAL REGULATION 6.
IDENTIFICATION OF THE PHYSIOLOGICAL REGULATORS 1. REGULATION OF BILE
ACID SYNTHESIS 8. ISOPRENYLATION OF PROTEINS 9. FUTURE DIRECTIONS
REFERENCES 400 CHAPTER 14. LIPOPROTEIN STRUCTURE AND SECRETION ROGER A.
DAVIS 403 1- INTRODUCTION 2. STRUCTURE AND FUNCTION OF PLASMA
LIPOPROTEINS 2.1. CHYLOMICRONS AND VERY LOW DENSITY LIPOPROTEINS 2.2.
STRUCTURE: SURFACE COMPONENTS *. 2.3. CORE COMPONENTS 4Q S 2.4. LOW
DENSITY LIPOPROTEINS: STRUCTURE ^ 2.4.1. ORIGIN OF LOW DENSITY
LIPOPROTEINS ^ 2.4.2. HIGH DENSITY LIPOPROTEINS: STRUCTURE AND FUNCTION
^ 2.4.3. DISCOIDAL HIGH DENSITY LIPOPROTEINS XV111 3. ASSEMBLY OF
NASCENT LIPOPROTEINS 411 3.1. TRIACYLGLYCEROL-RICH LIPOPROTEINS 411
3.1.1. ROLE OF LIPIDS 412 3.2. CORE LIPIDS 412 3.2.1. ROLE OF
APOLIPOPROTEINS 413 3.2.2. APOLIPOPROTEIN B STRUCTURE 413 3.3.
VITELLOGENIN: THE PRIMORDIAL APOLIPOPROTEIN 415 3.4. VERY LOW DENSITY
LIPOPROTEIN ASSEMBLY: EJECTION OF A BALL OF FAT OUT OF THE ENDOPLASMIC
RETICULUM * 3.5. FILLING THE HYDROPHOBIC CORE: A THERMODYNAMIC
DILEMMA 422 3.6. HIGH DENSITY LIPOPROTEIN SYNTHESIS AND SECRETION 422 4.
FUTURE DIRECTIONS 423 REFERENCES 424 CHAPTER 15. DYNAMICS OF LIPOPROTEIN
TRANSPORT IN THE CIRCULATORY SYSTEM PHOEBE E. FIELDING AND CHRISTOPHER
J. FIELDING 42 7 1. OVERVIEW 427 2. LIPOPROTEIN LIPASE AND THE INITIAL
METABOLISM OF LIPOPROTEIN TRIACYLGLYCEROL 430 2.1. INITIAL EVENTS 430
2.2. LIPOPROTEIN LIPASE STRUCTURE 431 2.3. SYNTHESIS AND TRANSPORT OF
LIPOPROTEIN LIPASE 431 2.4. THE LIPOPROTEIN LIPASE REACTION AND THE ROLE
OF APOLIPOPROTEIN C-2 432 2.5. LIPOPROTEIN LIPASE ACTIVITY AT THE
VASCULAR SURFACE 434 2.6. REGULATION OF LIPOPROTEIN LIPASE ACTIVITY BY
PRODUCTS OF LIPOLYSIS 435 2.7. PHYSIOLOGICAL REGULATION OF LIPOPROTEIN
LIPASE 436 2.8. CONGENITAL LIPOPROTEIN LIPASE DEFICIENCY 437 3. HEPATIC
TRIACYLGLYCEROL LIPASE AND THE LATER METABOLISM OF LIPOPROTEIN
TRIACYLGLYCEROL. . . 437 3.1. INTRODUCTION 437 3.2. STRUCTURE OF HEPATIC
TRIACYLGLYCEROL LIPASE 437 3.3. ACYL GROUP HYDROLYSIS AND EXCHANGE
CATALYZED BY HEPATIC TRIACYLGLYCEROL LIPASE . . 438 3.4. HEPATIC
TRIACYLGLYCEROL LIPASE AND THE HYDROLYSIS OF LIPOPROTEIN LIPIDS 438 3.5.
REGULATION OF HEPATIC TRIACYLGLYCEROL LIPASE ACTIVITY 439 3.6. HUMAN
HEPATIC TRIACYLGLYCEROL LIPASE DEFICIENCY 440 3.7. PHOSPHOLIPID EXCHANGE
PROTEIN AND ITS ACTIVITY 440 4. LECITHIN:CHOLESTEROL ACYLTRANSFERASE AND
THE INITIAL METABOLISM OF LIPOPROTEIN CHOLESTEROL . 440 4.1.
INTRODUCTION 440 4.2. FORWARD CHOLESTEROL TRANSPORT BY VERY LOW
DENSITY LIPOPROTEIN AND ITS PRODUCT, LOW DENSITY LIPOPROTEIN 444 4.3.
ORIGIN OF THE MAJOR HIGH DENSITY LIPOPROTEIN PROTEINS 445 4.4.
CLASSIFICATION OF PLASMA AND LYMPH HIGH DENSITY LIPOPROTEIN 446 4.5.
APOPROTEIN TRANSFERS IN HIGH DENSITY LIPOPROTEIN 446 4.6. ORIGIN OF
PLASMA LECITHIN:CHOLESTEROL ACYLTRANSFERASE 447 4.7. STRUCTURE OF PLASMA
LECITHIN:CHOLESTEROL ACYLTRANSFERASE 447 4.8. MECHANISM OF PLASMA
LECITHINXHOLESTEROL ACYLTRANSFERASE ACTIVITY 448 4.9. ROLE OF APO A-L IN
THE PLASMA LECITHIN:CHOLESTEROL ACYLTRANSFERASE REACTION . . . 449 4.10.
TRANSFER OF CHOLESTEROL AMONG HIGH DENSITY LIPOPROTEIN SPECIES 450 4.11.
PHYSIOLOGICAL REGULATION OF PLASMA LECITHINXHOLESTEROL ACYLTRANSFERASE
ACTIVITY . . 452 4.12. STUDIES OF PLASMA LECITHINXHOLESTEROL
ACYLTRANSFERASE DEFICIENCY 452 XIX 5. CHOLESTERYL ESTER TRANSFER PROTEIN
AND THE LATER METABOLISM OF LIPOPROTEIN CHOLESTEROL . . 452 5.1.
INTRODUCTION 452 5.2. STRUCTURE OF CHOLESTERYL ESTER TRANSFER PROTEIN
454 5.3. MECHANISM OF CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY 454
5.4. QUANTITATION OF CHOLESTERYL ESTER TRANSFER 456 5.5. PHYSIOLOGICAL
REGULATION OF CHOLESTERYL ESTER TRANSFER PROTEIN 456 5.6. CONGENITAL
CHOLESTERYL ESTER TRANSFER PROTEIN DEFICIENCY 457 5.7. CHOLESTERYL ESTER
TRANSFER PROTEIN INHIBITOR PROTEIN 457 6. SUMMARY AND FUTURE DIRECTIONS
457 REFERENCES 458 CHAPTER 16. REMOVAL OF LIPOPROTEINS FROM PLASMA
WOLFGANG J. SCHNEIDER 461 1. INTRODUCTION 461 2. REMOVAL OF LOW DENSITY
LIPOPROTEIN FROM THE CIRCULATION 464 2.1. RECEPTOR-MEDIATED ENDOCYTOSIS
464 2.2. THE LOW DENSITY LIPOPROTEIN RECEPTOR PATHWAY 465 2.2.1.
FAMILIAL HYPERCHOLESTEROLEMIA: CLINICAL CONSEQUENCES OF LOW DENSITY
LIPO- PROTEIN RECEPTOR DYSFUNCTION 466 2.2.2. BIOCHEMICAL FINDINGS IN
CULTURED FIBROBLASTS FROM FAMILIAL HYPERCHOLEST- EROLEMIA HOMOZYGOTES
467 2.3. BIOSYNTHESIS AND STRUCTURE OF THE LOW DENSITY LIPOPROTEIN
RECEPTOR 467 2.3.1. THE LOW DENSITY LIPOPROTEIN RECEPTOR PROTEIN 468
2.3.2. THE LIGAND BINDING DOMAIN 469 2.3.3. THE EGF PRECURSOR HOMOLOGY
DOMAIN 470 2.3.4. THE THIRD DOMAIN 470 2.3.5. THE MEMBRANE ANCHORING
DOMAIN 470 2.3.6. THE CYTOPLASMIC TAIL 471 2.4. MOLECULAR DEFECTS IN LOW
DENSITY LIPOPROTEIN RECEPTORS OF PATIENTS WITH FAMILIAL HYPER-
CHOLESTEROLEMIA 471 2.4.1. THE GENE FOR THE HUMAN LOW DENSITY
LIPOPROTEIN RECEPTOR 471 2.4.2. FOUR GROUPS OF LOW DENSITY LIPOPROTEIN
RECEPTOR MUTATIONS 472 2.4.2.1. CLASS 1: NO DETECTABLE PRECURSOR 472
2.4.2.2. CLASS 2: SLOW OR ABSENT PROCESSING OF PRECURSOR 472 2.4.2.3.
CLASS 3: ABNORMAL LIGAND BINDING 473 2.4.2.4. CLASS 4: INTERNALIZATION
DEFECTIVE 474 3. CATABOLISM OF CHYLOMICRONS 475 4. HIGH DENSITY
LIPOPROTEIN AS A TRANSPORT VEHICLE 477 5. ATHEROSCLEROSIS 478 5.1.
UPTAKE AND MODIFICATION OF LOW DENSITY LIPOPROTEIN IN THE INTIMA 478
5.2. SCAVENGER RECEPTORS 480 6. LIPOPROTEIN TRANSPORT IN THE LAYING HEN
481 7. LOW DENSITY LIPOPROTEIN METABOLISM BY RAT SEROSAL MAST CELLS 483
8. FUTURE DIRECTIONS 485 REFERENCES 485 XX CHAPTER 17. LIPID ASSEMBLY
INTO CELL MEMBRANES DENNIS R. VOELKER 48 9 1. INTRODUCTION 489 2. THE
DIVERSITY OF LIPIDS 489 3. METHODS TO STUDY INTRA- AND INTER-MEMBRANE
LIPID TRANSPORT 492 3.1. FLUORESCENT PROBES 494 3.2. SPIN LABELED
ANALOGS 494 3.3. ASYMMETRIC CHEMICAL MODIFICATION OF MEMBRANES 495 3.4.
PHOSPHOLIPID TRANSFER PROTEINS 496 3.5. RAPID PLASMA MEMBRANE ISOLATION
497 3.6. ORGANELLE SPECIFIC LIPID METABOLISM 498 4. LIPID TRANSPORT
PROCESSES 498 4.1. INTRAMEMBRANE LIPID TRANSLOCATION AND MODEL MEMBRANES
498 4.2. INTRAMEMBRANE LIPID TRANSLOCATION AND BIOLOGICAL MEMBRANES 502
4.2.1. PROCARYOTES 502 4.2.2. EUCARYOTES 503 4.2.2.1. TRANSBILAYER
MOVEMENT AT THE ENDOPLASMIC RETICULUM 503 4.2.2.2. TRANSBILAYER MOVEMENT
OF PHOSPHATIDYLCHOLINE IN ERYTHROCYTES . . . . 504 4.2.2.3. TRANSBILAYER
MOVEMENT OF PHOSPHATIDYLCHOLINE IN NUCLEATED CELLS . . . 505 4.2.2.4.
ATP DEPENDENT TRANSBILAYER MOVEMENT OF AMINOPHOSPHOLIPIDS AT THE PLASMA
MEMBRANE OF EUKARYOTIC CELLS 506 4.3. INTERMEMBRANE LIPID TRANSPORT 507
4.3.1. TRANSPORT IN PROCARYOTES 507 4.3.2. TRANSPORT IN EUCARYOTES 510
4.3.2.1. PHOSPHATIDYLCHOLINE 510 4.3.2.2. PHOSPHATIDYLETHANOLAMINE 512
4.3.2.3. PHOSPHATIDYLSERINE 513 4.3.2.4. SPHINGOLIPIDS 515 4.3.2.5.
CHOLESTEROL 517 4.3.2.6. PHOSPHOLIPID TRANSFER PROTEINS AND
PHOSPHATIDYLINOSITOL TRANSPORT . . . 518 5. FUTURE DIRECTIONS 521
REFERENCES 522 CHAPTER 18. ASSEMBLY OF PROTEINS INTO MEMBRANES REINHART
A.F. REITHMEIER 525 1. ORGANIZATION OF MEMBRANE PROTEINS 525 1.1.
CLASSIFICATION OF MEMBRANE PROTEINS 525 1.2. MEMBRANE PROTEIN STRUCTURE
AND ENERGETICS 528 1.3. ASSEMBLY OF MEMBRANE PROTEINS 530 2. SECRETION
OF PROTEINS AND THE SIGNAL HYPOTHESIS 532 2.1. THE PALADE SECRETION
PATHWAY 533 2.2. THE BLOBEL SIGNAL HYPOTHESIS 533 2.3. IN VITRO
TRANSLATION AND TRANSLOCATION SYSTEMS 535 2.4. THE MILSTEIN EXPERIMENT:
SECRETED PROTEINS ARE MADE WITH AN AMINO TERMINAL SIGNAL SEQUENCE 538
2.5. SIGNAL SEQUENCES 540 XXI 3. THE TARGETING AND TRANSLOCATION
MACHINERY 541 3.1. THE SIGNAL RECOGNITION PARTICLE 542 3.2. THE SIGNAL
RECOGNITION PARTICLE RECEPTOR 543 3.3. TRANSLOCATION COMPONENTS 544 3.4.
RIBOSOME-BINDING PROTEINS 545 3.5. SIGNAL PEPTIDASE 546 4. BIOSYNTHESIS
OF TYPE I SIMPLE MEMBRANE PROTEINS 546 4.1. IGM AND THE RELATIONSHIP
BETWEEN THE BIOSYNTHESIS OF SECRETED PROTEINS AND SIMPLE MEMBRANE
PROTEINS 546 4.2. VESICULAR STOMATITIS VIRUS GLYCOPROTEIN AND
HEMAGGLUTININ 549 4.3. LOOP MODELS AND INSERTION INTO THE LIPID BILAYER
551 4.4. EVIDENCE FOR A LOOP STRUCTURE FOR INSERTION OF SIGNAL SEQUENCES
553 5. BIOSYNTHESIS OF TYPE II SIMPLE MEMBRANE PROTEINS 554 5.1.
OVALBUMIN, A SECRETED PROTEIN MADE WITHOUT A CLEAVED SIGNAL SEQUENCE . .
. . 556 5.2. ASIALOGLYCOPROTEIN RECEPTOR 557 5.3. SUCRASE-ISOMALTASE 557
6. BIOSYNTHESIS OF CYTOCHROME P-450 AND CYTOCHROME B 5 558 6.1.
CYTOCHROME P-450 558 6.2. CYTOCHROME B 5 559 7. BIOSYNTHESIS OF COMPLEX
MEMBRANE PROTEINS 559 7.1. ARTIFICIAL MEMBRANE PROTEINS 559 7.2. BAND 3,
THE ANION TRANSPORT PROTEIN OF THE ERYTHROCYTE MEMBRANE 561 7.3. GLUCOSE
CARRIER 561 7.4. RHODOPSIN 561 7.5. CA 2+ ATPASE AND CALSEQUESTRIN 562
8. GLYCOSYLATION OF PROTEINS 562 8.1. JV-GLYCOSYLATION 562 8.2.
PROCESSING OF THE OLIGOSACCHARIDE CHAIN 563 8.3. O-GLYCOSYLATION 566 9.
ATTACHMENT OF LIPID TO PROTEINS 566 9.1. FATTY ACYLATION 566 9.2.
PHOSPHATIDYLINOSITOL ANCHORS 567 10. PROTEIN FOLDING AND EXIT FROM THE
ENDOPLASMIC RETICULUM 567 10.1. PROTEIN FOLDING 567 10.2. DISULFIDE
FORMATION 568 10.3. ASSEMBLY OF MULTISUBUNIT SYSTEMS 569 10.4. EXIT FROM
THE ENDOPLASMIC RETICULUM 570 10.5. KDEL, AN ENDOPLASMIC RETICULUM
RETENTION SIGNAL 570 11. TRANSPORT AND TARGETING OF PROTEINS 571 11.1.
VESICLES MOVE PROTEINS BETWEEN ORGANELLES 571 11.2. ROLE OF GTP-BINDING
PROTEINS 573 11.3. LYSOSOMAL TARGETING 575 11.4. PROTEIN SORTING IN
EPITHELIAL CELLS 576 12. FUTURE DIRECTIONS -^ REFERENCES 577 INDEX 579
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV004766324 |
| classification_rvk | WD 4000 |
| classification_tum | CHE 887f CHE 820f CHE 840f |
| ctrlnum | (OCoLC)214312864 (DE-599)BVBBV004766324 |
| discipline | Biologie Chemie |
| edition | [2. ed.] |
| format | Book |
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| genre | 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV004766324 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T16:17:24Z |
| institution | BVB |
| isbn | 0444893210 0444893849 0444803033 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-002934242 |
| oclc_num | 214312864 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-12 DE-703 DE-355 DE-BY-UBR DE-29 DE-20 DE-83 DE-188 |
| owner_facet | DE-19 DE-BY-UBM DE-12 DE-703 DE-355 DE-BY-UBR DE-29 DE-20 DE-83 DE-188 |
| physical | XXI, 596 S. Ill., graph. Darst. |
| publishDate | 1991 |
| publishDateSearch | 1991 |
| publishDateSort | 1991 |
| publisher | Elsevier |
| record_format | marc |
| series | New comprehensive biochemistry |
| series2 | New comprehensive biochemistry |
| spelling | Biochemistry of lipids, lipoproteins and membranes ed. Dennis E. Vance ... [2. ed.] Amsterdam [u.a.] Elsevier 1991 XXI, 596 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier New comprehensive biochemistry 20 Literaturangaben Lipids cabt Lipoproteins cabt Cell Membranes cabt Biochemistry cabt Lipide (DE-588)4035873-2 gnd rswk-swf Lipoproteide (DE-588)4074259-3 gnd rswk-swf Biomembran (DE-588)4006884-5 gnd rswk-swf Membranlipide (DE-588)4203814-5 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Lipidmembran (DE-588)4167790-0 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Lipidmembran (DE-588)4167790-0 s DE-604 Lipide (DE-588)4035873-2 s Lipoproteide (DE-588)4074259-3 s Biomembran (DE-588)4006884-5 s Biochemie (DE-588)4006777-4 s 2\p DE-604 Membranlipide (DE-588)4203814-5 s 3\p DE-604 DE-188 Vance, Dennis E. Sonstige oth New comprehensive biochemistry 20 (DE-604)BV000003914 20 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002934242&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Biochemistry of lipids, lipoproteins and membranes New comprehensive biochemistry Lipids cabt Lipoproteins cabt Cell Membranes cabt Biochemistry cabt Lipide (DE-588)4035873-2 gnd Lipoproteide (DE-588)4074259-3 gnd Biomembran (DE-588)4006884-5 gnd Membranlipide (DE-588)4203814-5 gnd Biochemie (DE-588)4006777-4 gnd Lipidmembran (DE-588)4167790-0 gnd |
| subject_GND | (DE-588)4035873-2 (DE-588)4074259-3 (DE-588)4006884-5 (DE-588)4203814-5 (DE-588)4006777-4 (DE-588)4167790-0 (DE-588)4143413-4 |
| title | Biochemistry of lipids, lipoproteins and membranes |
| title_auth | Biochemistry of lipids, lipoproteins and membranes |
| title_exact_search | Biochemistry of lipids, lipoproteins and membranes |
| title_full | Biochemistry of lipids, lipoproteins and membranes ed. Dennis E. Vance ... |
| title_fullStr | Biochemistry of lipids, lipoproteins and membranes ed. Dennis E. Vance ... |
| title_full_unstemmed | Biochemistry of lipids, lipoproteins and membranes ed. Dennis E. Vance ... |
| title_short | Biochemistry of lipids, lipoproteins and membranes |
| title_sort | biochemistry of lipids lipoproteins and membranes |
| topic | Lipids cabt Lipoproteins cabt Cell Membranes cabt Biochemistry cabt Lipide (DE-588)4035873-2 gnd Lipoproteide (DE-588)4074259-3 gnd Biomembran (DE-588)4006884-5 gnd Membranlipide (DE-588)4203814-5 gnd Biochemie (DE-588)4006777-4 gnd Lipidmembran (DE-588)4167790-0 gnd |
| topic_facet | Lipids Lipoproteins Cell Membranes Biochemistry Lipide Lipoproteide Biomembran Membranlipide Biochemie Lipidmembran Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002934242&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003914 |
| work_keys_str_mv | AT vancedennise biochemistryoflipidslipoproteinsandmembranes |