Aging, sex, and DNA repair:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
San Diego u.a.
Academic Press
1991
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 382 S. |
| ISBN: | 0120928604 |
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Datensatz im Suchindex
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|---|---|
| adam_text | Aging, Sex, and DNA Repair
Carol Bernstein
Department of Microbiology and Immunology
College of Medicine
University of Arizona
Tucson, Arizona
Harris Bernstein
Department of Microbiology and Immunology
College of Medicine
University of Arizona
Tucson, Arizona
Academic Press, Inc
Harcourt Brace Jovanovich, Publishers
San Diego New York Boston
London Sydney Tokyo Toronto
Contents
Preface xi
1 Introduction: Major Ideas and Historical Perspectives
I Definitions of Aging and Sex 1
II DNA Damage as the Basic Cause of Aging
and Sex 2
III Historical Background 4
References 11
2 DNA Damage
I DNA Damages as Physically Distinct Alterations in
Polynucleotide Chains 15
II Kinds of DNA Damage Prevalent in Nature 18
References 25
3 Immediate Consequences of DNA Damage
I Transcription Termination 27
II Impairment of Replication 29
III Decreased Cell Survival 32
References 34
4 Accumulation of DNA Damage in Somatic Cells
I Cell Types Based on Rate of Division 37
II Low DNA Repair in Postmitotic Muscle and
Neuronal Tissue 38
III Accumulation of DNA Damage in Adult Muscle and
Neuronal Tissue 46
IV Accumulation of DNA Damage in Liver 52
V Accumulation of DNA Damage in Other Tissues 59
Vll
viii I Contents
VI Conclusions 60
References 60
5 The DNA Damage Hypothesis of Aging Applied
to Mammals
I Theoretical Considerations in Support of DNA Damage
as the Cause of Aging in Mammals 66
II Experimental Evidence in Support of the Hypothesis
that DNA Damage is the Cause of
Aging in Mammals 68
III Mechanisms of Compensating for DNA Damage 82
IV Summary of the Stages of Aging Leading to Death
in Mammals 84
References 85
6 Oxidative DNA Damage as a Potential Major Cause
of Aging
I The Nature and Cause of Oxidative DNA
Damage 91
II Accumulation of Oxidative DNA Damages
with Age 95
III Inverse Correlation between Incidence of Oxidative
DNA Damage and Life Span 96
IV Premature Aging in Down s Syndrome Correlated with
Increased Oxidative Damage 99
V Conclusions 102
References 103
7 Additional Evidence Bearing on the DNA Damage
Hypothesis of Aging
I Positive Correlation of Life Span with
DNA Repair Capacity 108
II Experimental Acceleration of Aging by
DNA-Damaging Agents 116
III Genetic Syndromes in Humans with Features of
Premature Aging 121
IV Conclusions 139
References 139
8 Aging in Nonmammalian Organisms, with Comparisons
to Aspects of Aging in Mammals
I Aging and DNA Damage in Single-Celled
Organisms 152
Contents I ix
II Aging in Multicellular Organisms 157
III Similarities of Aging in Nonmammalian Organisms and
in Mammals 164
IV Aging of Mammals Viewed in a Broad Evolutionary
Context 167
References 168
9 DNA Repair with Emphasis on Single-Strand Damages
I Repair Depends on Redundant Information 173
II Repair of Single-Strand DNA Damages 175
III Relationship of DNA Repair Levels to Aging 189
IV Repair of Double-Strand Damages 196
References 198
10 DNA Repair with Emphasis on Recombinational Repair
I Viruses 209
II Bacteria 213
III Eukaryotes 219
IV Overview 226
References 227
11 Meiosis and Meiotic Recombination
I Events of Meiosis and of Meiotic
Recombination 235
II Evidence Bearing on the Double-Strand Break Repair
Model of Meiotic Recombination 240
III Implications 245
References 246
12 Meiosis Viewed as an Adaptation for DNA Repair
I DNA Repair during Meiosis 248
II Premeiotic Replication 252
III Role of Mitotic Recombination Compared With
Meiotic Recombination 255
IV Organisms Not Using Meiosis or Having Reduced
Meiotic Recombination in Males 262
V Immortality of the Germ Line: Aging of the
Somatic Line 265
VI Summary 265
References 267
x I Contents
13 The Selective Advantage of Outcrossing
I Prevalence of Sexual Reproduction 272
II Sex Has Two Basic Features: Recombination
and Outcrossing 274
III Outcrossing 277
IV Conclusions 287
References 288
14 Evolutionary Aspects of Sex
I The Likely Continuous Evolutionary History of Sex:
Evidence that Sex Arose prior to the Divergence
of Prokaryotes and Eukaryotes 290
II Possible Origin of Sex in the Earliest Cells 293
III Selective Forces Leading to the Origin of
Enzyme-Mediated Recombinational Repair 297
IV Advantage of Sex in Unicellular
Haploid Organisms 299
V Emergence of Diploid Organisms 300
VI Sex and the Emergence of Species 303
VII Summary and Conclusions 308
References 309
15 Other Theories of Aging and Sex
I Aging Theories 314
II Theories of Sex 327
References 339
16 Overview, Future Directions, and Implications
I General Overview 346
II Medical Implications 360
III Future Research Directions 366
IV General Implications 369
References 370
Index 373
|
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| spelling | Bernstein, Carol Verfasser aut Aging, sex, and DNA repair Carol Bernstein ; Harris Bernstein San Diego u.a. Academic Press 1991 XII, 382 S. txt rdacontent n rdamedia nc rdacarrier ADN - Lésions ADN - Réparation ADN ram Lésion Adn Jussieu Méiose Jussieu Réparation Adn Jussieu Sexe Jussieu Sexualité (Biologie) Sénescence Jussieu Vieillissement - Aspect moléculaire Aging Molecular aspects Aging genetics DNA Damage DNA Repair DNA damage DNA repair Reproduction genetics Sex (Biology) DNS-Schädigung (DE-588)4150350-8 gnd rswk-swf Sexualität (DE-588)4054684-6 gnd rswk-swf Altern (DE-588)4068596-2 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Meiose (DE-588)4169347-4 gnd rswk-swf DNS-Reparatur (DE-588)4150347-8 gnd rswk-swf DNS-Reparatur (DE-588)4150347-8 s Meiose (DE-588)4169347-4 s DE-604 DNS-Schädigung (DE-588)4150350-8 s Altern (DE-588)4068596-2 s Sexualität (DE-588)4054684-6 s Molekularbiologie (DE-588)4039983-7 s Bernstein, Harris Verfasser aut HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002903381&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bernstein, Carol Bernstein, Harris Aging, sex, and DNA repair ADN - Lésions ADN - Réparation ADN ram Lésion Adn Jussieu Méiose Jussieu Réparation Adn Jussieu Sexe Jussieu Sexualité (Biologie) Sénescence Jussieu Vieillissement - Aspect moléculaire Aging Molecular aspects Aging genetics DNA Damage DNA Repair DNA damage DNA repair Reproduction genetics Sex (Biology) DNS-Schädigung (DE-588)4150350-8 gnd Sexualität (DE-588)4054684-6 gnd Altern (DE-588)4068596-2 gnd Molekularbiologie (DE-588)4039983-7 gnd Meiose (DE-588)4169347-4 gnd DNS-Reparatur (DE-588)4150347-8 gnd |
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| title | Aging, sex, and DNA repair |
| title_auth | Aging, sex, and DNA repair |
| title_exact_search | Aging, sex, and DNA repair |
| title_full | Aging, sex, and DNA repair Carol Bernstein ; Harris Bernstein |
| title_fullStr | Aging, sex, and DNA repair Carol Bernstein ; Harris Bernstein |
| title_full_unstemmed | Aging, sex, and DNA repair Carol Bernstein ; Harris Bernstein |
| title_short | Aging, sex, and DNA repair |
| title_sort | aging sex and dna repair |
| topic | ADN - Lésions ADN - Réparation ADN ram Lésion Adn Jussieu Méiose Jussieu Réparation Adn Jussieu Sexe Jussieu Sexualité (Biologie) Sénescence Jussieu Vieillissement - Aspect moléculaire Aging Molecular aspects Aging genetics DNA Damage DNA Repair DNA damage DNA repair Reproduction genetics Sex (Biology) DNS-Schädigung (DE-588)4150350-8 gnd Sexualität (DE-588)4054684-6 gnd Altern (DE-588)4068596-2 gnd Molekularbiologie (DE-588)4039983-7 gnd Meiose (DE-588)4169347-4 gnd DNS-Reparatur (DE-588)4150347-8 gnd |
| topic_facet | ADN - Lésions ADN - Réparation ADN Lésion Adn Méiose Réparation Adn Sexe Sexualité (Biologie) Sénescence Vieillissement - Aspect moléculaire Aging Molecular aspects Aging genetics DNA Damage DNA Repair DNA damage DNA repair Reproduction genetics Sex (Biology) DNS-Schädigung Sexualität Altern Molekularbiologie Meiose DNS-Reparatur |
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| work_keys_str_mv | AT bernsteincarol agingsexanddnarepair AT bernsteinharris agingsexanddnarepair |