Transgenic animals: proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture ... held at the National Institutes of Health, Bethesda, Maryland, December 12 - 15, 1988
Gespeichert in:
| Format: | Tagungsbericht Buch |
|---|---|
| Sprache: | Undetermined |
| Veröffentlicht: |
Boston u.a.
Butterworth-Heinemann
1991
|
| Schriftenreihe: | Biotechnology series
16 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXV, 358 S. Ill., graph. Darst. |
| ISBN: | 040990189X |
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| 245 | 1 | 0 | |a Transgenic animals |b proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture ... held at the National Institutes of Health, Bethesda, Maryland, December 12 - 15, 1988 |c ed. by Neal L. First ... |
| 264 | 1 | |a Boston u.a. |b Butterworth-Heinemann |c 1991 | |
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Datensatz im Suchindex
| _version_ | 1804118839268474880 |
|---|---|
| adam_text | CONTENTS
Preface
PART I. GENE TRANSFER: APPROACHES, METHODS,
AND TOOLS
1.
Transgenic Animals: A New Era in Developmental Biology
and Medicine
3
Luis M.
Isola
and Jon W. Gordon
1.1
Integration of Microinjected Sequences into the
Embryo
5
1.2
Expression of Foreign Genes in Transgenic Mice
7
1.3
Specific Applications of Transgenic Mice
10
1.4
Transgenic Mice in Developmental Genetics
16
1.5
Summary and Conclusions
17
References
18
XV
xvi Contents
2. Determination
of Retroviral
Mutation Rates
Using
Spleen
Necrosis Virus-Based Vectors and Helper Cells
21
Joseph P. Dougherty and Howard M. Temin
2.1
Materials and Methods
22
2.2
Results
23
2.3
Discussion
30
References
32
3.
Steroid Hormone Receptors as Transactivators of Gene
Expression
35
Bert W. O Malley
References
41
PARTII.
GENE EXPRESSION
43
4.
Targeted Mutagenesis in Embryo-Derived Stem Cells
45
Kirk Thomas
4.1
Homologous Recombination in Cultured Mouse
Fibroblasts
46
4.2
Targeted Mutagenesis of the HPRT Locus in Mouse
ES
Cells
47
4.3
Targeted Mutagenesis of Nonselectable Genes
49
4.4
Conclusion
53
References
53
5.
Application of Germline Transformation to the Study of
Myogenesis
55
Moshe Shani
5.1
Expression of Rat Muscle-Specific Genes in
Transgenic Mice
56
5.2
Expression of Muscle-Specific Genes Introduced into
ES
Cells
59
5.3
Gene Transfer Mediated by Retroviral Vectors:
Expression of an Internal Muscle-Specific Promoter
61
References
63
6.
Regulation of Expression of Genes for Milk Proteins
65
Lothar
H
ennighausen,
Christoph Westphal,
Lakshmanan Sankaran, and
Christoph
W.
Pittius
6.1
Expression of the WAP and /3-Casem Genes During
Mammary Development
66
6.2
Tissue-Specific Expression of the Genes for WAP and
/3-Casein
68
6.3
Hormone-Induced Accumulation of WAP and
/3-Casein
RNA
in Mammary Glands of Pregnant
Mice
71
Contents
XVii
6.4
Summary
71
References
73
7.
Expression of a Silent
MUP Gene
in Transgenic Mice
75
H. Jin Son, Kate Shahan, Eva Derman, and Frank Costantini
7.1
Results
76
7.2
Discussion
77
References
80
8.
The Activation and Silencing of Gene Transcription in the
Liver
81
Sally A. Camper and Shirley M. Tilghman
8.1
Function of Multiple AFP Enhancer Elements in
Tissue Specificity and Gene Activation
83
8.2
Role of the AFP Promoter-Proximal Region
84
8.3
Regulatory Elements of the Albumin Gene
84
8.4
Developmental Regulation of Expression of AFP and
Albumin Genes
85
References
86
9.
Gene Targeting in Embryonic Stem Cells
89
Thomas
С
Doetschman
9.1 ES
Cells In Vitro
90
9.2 ES
Cells In Vivo
93
9.3
Gene Targeting
95
9.4
Future Prospects for Animal Modeling via Gene
Targeting
100
References
100
10.
Expression of a Human Multidrug-Resistance cDNA (MDR1)
under the Control of
a
ß-Actin
Promoter in Transgenic Mice
103
Hanan
Galski,
Glenn T.
Merlino,
Michael
M. Gottesman,
and
Ira
Pastan
10.1
Construction and Transfection of
ß-Actin
Promoter-
MDRÌ
Plasmids
104
10.2
Production of Mice that Carry the
ßAP-MDRl
Transgene
108
10.3
Transmission of
MDRÌ
to Progeny
109
10.4
Expression Studies in MDR
1
Transgenic Mice
110
10.5
Expression of P-Glycoprotein Detected by Immuno-
fluorescence
115
10.6
Studies In Vivo
115
10.7
Expression of the
Transgene: No
Obvious Phenotypic
Effects
119
10.8
Discussion
П9
xviii Contents
References
123
11.
Insertion of a Disease Resistance Gene into the Chicken
Germline
125
Donald W.
Salter
and Lyman B. Crittenden
11.1
Materials and Methods
126
11.2
Results and Discussion
126
11.3
Conclusions
130
References
131
PART III. USE OF TRANSGENICS IN
UNDERSTANDING BIOLOGY
133
12.
Analysis of Regulatory Genes Using the Transgenic Mouse
System
135
Guerard W. Byrne, Claudia
Kappen,
Klaus Schughart,
Manuel Utset, Leonard
Bogarad,
and Frank
H.
Ruddle
12.1
Discovery of the Homeobox
136
12.2
Evolution of Homeobox Genes
137
12.3
Expression of Homeobox Genes
139
12.4
Regulation of Homeobox Genes
143
12.5
Transgenic Mice and the Function of Homeobox
Genes
144
12.6
Multiplex Gene Regulation
145
12.7
Future Prospects
150
References
151
13.
Regulation of Expression of a Class I MHC
Transgene
153
Dinah S. Singer, William I. Frels, and Rachel
Ehrlich
References
158
14.
Generation of Transgenic Mice with Major Histocompatibility
Class II Genes
161
Javier Martin,
Bing-
Yuan Wei, Roger Little,
Suresh Savarirayan, and
Chelia S.
David
14.1
Materials and Methods
163
14.2
Results
165
14.3
Discussion
171
References
173
15.
Mice Transgenic for a Gene That Encodes a Soluble,
Polymorphic Class I MHC Antigen
175
Rosemarie
Hunziker and David H. Margulies
15.1
Experimental Procedures
177
15.2
Results and Discussion
178
15.3
Conclusions
182
Contents xix
References
184
PART IV. USE OF TRANSGENICS IN MEDICINE
187
16.
Principles of Gene Transfer and the Treatment of Disease
189
Evelyn M.
Karson
16.1
Which Diseases are Candidates for Treatment?
190
16.2
Bone Marrow-Mediated Gene Transfer in the Mouse
198
16.3
Gene Transfer via Autologous Bone Marrow
Transplantation in the Adult Primate
198
16.4
Protocol for Gene Transfer into Fetal Lambs In
Utero
201
16.5
Gene Transfer into Fetal Human and Nonhuman
Primate Hematopoietic Cells
206
16.6
Gene Transfer into Tumor-Infiltrating Lymphocytes
(TIL)
209
References
210
17.
Transgenic Mice Carrying
HIV
Proviral
DNA 213
David S.
Pezen,
John M. Leonard, Jan W. Abramczuk, and
Malcolm A. Martin
References
226
18.
Apolipoprotein
А
-I
Gene Expression in Transgenic Mice
227
Annemarie
Walsh, Yasushi
Ito,
and Jan L. Breslow
18.1
Materials and Methods
228
18.2
Results
229
18.3
Discussion
234
References
235
19.
Eifects of Human Growth Hormone on Reproductive and
Neuroendocrine
Functions in Transgenic Mice
237
A. Bartke, J.G.M. Shire, V.
Chandr
ashekar, R. W.
Steger,
A. Mayerhofer, A.G.
Amador,
P. Bain, K. Tang, J.S. Yun, and
Т.Е.
Wagner
19.1
Production of Transgenic Mice and Their
Characteristics
238
19.2
Reproductive and
Neuroendocrine
Functions in
Transgenic Females
240
19.3
Reproductive and
Neuroendocrine
Functions in
Transgenic Males
241
19.4
Conclusions
246
References
247
XX
Contents
PART V. USE OF TRANSGENICS IN ANIMAL
AGRICULTURE AND OTHER ANIMALS USED
AS RESEARCH MODELS
249
20.
Enhanced Growth Performance in Transgenic Swine
251
Carl A. Pinkert, David L. Kooyman, and Timothy J. Dyer
20.1
Discussion
253
20.2
Prospects
255
20.3
Conclusion
256
References
256
21.
Production of Sheep Transgenic for Growth Hormone Genes
259
Caird E. Rexroad, Jr.
21.1
Insertion of Genes
259
21.2
Growth-Related Genes for Insertion into Ova
261
21.3
Expression of
Transgenes
261
21.4
Physiology of Integrated Genes
262
21.5
Transmission of
Transgenes
262
21.6
Conclusion
263
References
263
22.
Production of Transgenic Cattle by Pronuclear Injection
265
Kenneth R. Bondioli, Karen A. Biery, Keith G. Hill,
Karen B. Jones, and
Franko
J.
De Mayo
22.1
Materials
and Methods
266
22.2
Results and Discussion
269
References
272
23.
Methods for the Introduction of
Recombinant
DNA
into
Chicken Embryos
275
John J. Kopchick, Ed Mills, Charles
Rosenblum,
Joyce Taylor,
F. Macken, F.
Leung, Jim Smith, and Howard Chen
23.1
Materials and Methods
276
23.2
Results
280
23.3
Discussion
289
References
293
24.
Gene Transfer in Fish
295
Kevin S. Guise,
Anne A.R.
Kapuscinski, Perry B. Hackett, Jr.,
and Anthony J.
Faras
24.1
Gene Transfer by Microinjection
298
24.2
Success of Transfer and Expression of
Transgenes
301
24.3
Production of Sterile Transgenic Fish
302
24.4
Future of Gene Transfer Technology in Fish
303
References
305
Contents XXJ
25.
Studies on Transgenic Fish: Gene Transfer, Expression, and
Inheritance
307
Dennis A. Powers, Lucia Irene Gonzalez-Villasenor,
Peijun Zhang, Thomas T. Chen, and Rex A. Dunham
25.1
Materials and Methods
308
25.2
Construction of Transgenic Fish
312
25.3
Transgenic Fish Containing Genes for Growth
Hormones
320
References
323
26.
Transgenic Rats: A Discussion
325
Jan Heideman
26.1
Need for Transgenic Rats
326
26.2
Rats Versus Mice
327
26.3
Collection and Transfer of Embryos
328
26.4
Transfer of Embryos to Rat Oviducts
328
26.5
Technique for
Microinjection
of Rat Embryos
329
26.6
Increasing the Yield of Embryos
331
26.7
Increasing the Size of Litters
331
References
332
PART VI. TRANSGENICS: SOCIETY, COMMERCE,
AND THE ENVIRONMENT
333
27.
The Mouse That Roared
335
Lisa J. Raines
27.1
An Abundance of Uses
336
27.2
The Rules Change, Slowly
337
27.3
The Nature of Patents
338
27.4
Animals as Tennis Balls?
340
27.5
Down on the Farm
342
27.6
Time to Decide
344
Recommended Reading
345
Index
347
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| series2 | Biotechnology series |
| spelling | Transgenic animals proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture ... held at the National Institutes of Health, Bethesda, Maryland, December 12 - 15, 1988 ed. by Neal L. First ... Boston u.a. Butterworth-Heinemann 1991 XXV, 358 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biotechnology series 16 Gentechnologie (DE-588)4071722-7 gnd rswk-swf Transgene Tiere (DE-588)4279021-9 gnd rswk-swf Gentransfer (DE-588)4194102-0 gnd rswk-swf Tiere (DE-588)4060087-7 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1988 Bethesda Md. gnd-content Transgene Tiere (DE-588)4279021-9 s DE-604 Tiere (DE-588)4060087-7 s Gentransfer (DE-588)4194102-0 s Gentechnologie (DE-588)4071722-7 s 1\p DE-604 First, Neal L. Sonstige oth Symposium on Transgenetic Technology in Medicine and Agriculture 1988 Bethesda, Md. Sonstige (DE-588)3014383-4 oth Biotechnology series 16 (DE-604)BV000007885 16 Digitalisierung TU Muenchen application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002902243&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Transgenic animals proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture ... held at the National Institutes of Health, Bethesda, Maryland, December 12 - 15, 1988 Biotechnology series Gentechnologie (DE-588)4071722-7 gnd Transgene Tiere (DE-588)4279021-9 gnd Gentransfer (DE-588)4194102-0 gnd Tiere (DE-588)4060087-7 gnd |
| subject_GND | (DE-588)4071722-7 (DE-588)4279021-9 (DE-588)4194102-0 (DE-588)4060087-7 (DE-588)1071861417 |
| title | Transgenic animals proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture ... held at the National Institutes of Health, Bethesda, Maryland, December 12 - 15, 1988 |
| title_auth | Transgenic animals proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture ... held at the National Institutes of Health, Bethesda, Maryland, December 12 - 15, 1988 |
| title_exact_search | Transgenic animals proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture ... held at the National Institutes of Health, Bethesda, Maryland, December 12 - 15, 1988 |
| title_full | Transgenic animals proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture ... held at the National Institutes of Health, Bethesda, Maryland, December 12 - 15, 1988 ed. by Neal L. First ... |
| title_fullStr | Transgenic animals proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture ... held at the National Institutes of Health, Bethesda, Maryland, December 12 - 15, 1988 ed. by Neal L. First ... |
| title_full_unstemmed | Transgenic animals proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture ... held at the National Institutes of Health, Bethesda, Maryland, December 12 - 15, 1988 ed. by Neal L. First ... |
| title_short | Transgenic animals |
| title_sort | transgenic animals proceedings of the symposium on transgenic technology in medicine and agriculture held at the national institutes of health bethesda maryland december 12 15 1988 |
| title_sub | proceedings of the Symposium on Transgenic Technology in Medicine and Agriculture ... held at the National Institutes of Health, Bethesda, Maryland, December 12 - 15, 1988 |
| topic | Gentechnologie (DE-588)4071722-7 gnd Transgene Tiere (DE-588)4279021-9 gnd Gentransfer (DE-588)4194102-0 gnd Tiere (DE-588)4060087-7 gnd |
| topic_facet | Gentechnologie Transgene Tiere Gentransfer Tiere Konferenzschrift 1988 Bethesda Md. |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002902243&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000007885 |
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