Animal cell bioreactors:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boston u.a.
Butterworth-Heinemann
1991
|
| Schriftenreihe: | Biotechnology series
17 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XVI, 494 S. Ill., graph. Darst. |
| ISBN: | 0409901237 |
Internformat
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| 245 | 1 | 0 | |a Animal cell bioreactors |c ed. by Chester S. Ho ... |
| 264 | 1 | |a Boston u.a. |b Butterworth-Heinemann |c 1991 | |
| 300 | |a XVI, 494 S. |b Ill., graph. Darst. | ||
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| 490 | 1 | |a Biotechnology series |v 17 | |
| 500 | |a Literaturangaben | ||
| 650 | 7 | |a Bioreactoren |2 gtt | |
| 650 | 7 | |a Bioréacteurs |2 ram | |
| 650 | 7 | |a Biotechnologie |2 gtt | |
| 650 | 7 | |a Celkweek |2 gtt | |
| 650 | 7 | |a Cellules animales - Biotechnologie |2 ram | |
| 650 | 4 | |a Animal cell biotechnology | |
| 650 | 4 | |a Bioreactors | |
| 650 | 4 | |a Biotechnology | |
| 650 | 4 | |a Cells, Cultured | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-002863131 | ||
Datensatz im Suchindex
| _version_ | 1804118779467137024 |
|---|---|
| adam_text | Animal Cell Bioreactors
Edited by
Chester S Ho
Daniel I C Wang
Butterworth-Heinemann
Boston London Singapore Sydney Toronto Wellington
CONTENTS
Preface xv
PART I HISTORICAL DEVELOPMENT OF
ANIMAL CELL BIOREACTORS
1 An Overview of Animal Cell Biotechnology: The Conjoint
Application of Science, Art, and Engineering 3
R E Spier
1 1 Shear and Bubbles 6
1 2 High Cell Concentration Systems 10
1 3 Modern Bioprocess Engineering for Animal-Cell
Containing Systems 14
1 4 Conclusions 17
References 17
PART II IMPLICATIONS OF CELL BIOLOGY ON
BIOREACTOR OPERATION
2 Implications of Cell Biology in Animal Cell Biotechnology 21
Ales Prokop
2 1 Cell Status 21
2 2 Status of Extracellular Environment 42
ix
X Contents
2 3 Cell-Environment Interaction 47
2 4 Dynamics of Interaction of Cell and Environment 51
References 53
3 Protein Glycosylation: Function and Factors that Regulate
Oligosaccharide Structure 59
Joseph K Welply
3 1 Structure and Heterogeneity of the Protein-Bound
Oligosaccharides 61
3 2 Factors that Influence the Structure of Protein-Bound
Oligosaccharides 65
3 3 Conclusion 70
References 70
4 Serum-Free Media 73
Kazuaki Kitano
4 1 Chemically Denned Serum-Free Media 74
4 2 Serum-Free Media-Containing Serum-Substitutes 87
4 3 Production of Biologically Active Substances by
Serum-Free Cultures 92
4 4 Conclusion 97
References 98
5 Nuclear Magnetic Resonance Spectroscopy of Dense Cell
Populations for Metabolic Studies and Bioreactor
Engineering: A Synergistic Partnership 107
Bruce E Dale and Robert J Gillies
5 1 Phenomena that Can and Cannot be Measured by
NMR 107
5 2 Some Representative NMR Spectra 109
5 3 Current Limitations on Whole Cell NMR: Sensitivity
and the Need for Well-Defined Bioreactors 110
5 4 Bioreactor Engineering Considerations 112
5 5 Quantitative Measures of Diffusion and Reaction 112
5 6 Design Procedures Involving Weisz s Modulus 113
5 7 Experimental Confirmations of Reaction Rate
Control: Toward Gradientless Bioreactors 115
5 8 Uses of NMR in Bioreactor Analysis and Design 116
5 9 Summary 117
References 117
6 Regulation of Animal Cell Metabolism in Bioreactors 119
William M Miller and Harvey W Blanch
6 1 Metabolism of Cultured Cells 120
6 2 Methods for Obtaining Metabolic Information in
Bioreactors 129
Contents XI
6 3 Metabolic Results Obtained in Continuous
Suspension Bioreactors 135
6 4 Models of Cell Metabolism 150
References 157
PART III ANCHORAGE-DEPENDENT CELL SUPPORTS
7 Fixed Immobilized Beds for the Cultivation of Animal Cells 165
Bryan Griffiths and Denis Looby
7 1 General Principles 166
7 2 Historical Developments in Animal Cell
Immobilization 171
7 3 Fixed Beds in a Production Process 172
7 4 Optimization of Glass Sphere Reactors 177
7 5 Porous Packing Materials for High Cell Density
Culture 183
7 6 Conclusion 188
References 188
8 Microcarriers for Animal Cell Biotechnology: An Unfulfilled
Potential 191
R E Spier and N Maroudas
Times Past
Three-Dimensional Microcarriers
The Problems Expounded
Current Manifestations of Three-Dimensional
Microcarriers
Conclusions
References
9 Hydrodynamic Effects on Animal Cells in Microcarrier
Bioreactors 213
Matthew S Croughan and Daniel I C Wang
9 1 Methods of Investigation 214
9 2 Hydrodynamic Effects on Cell Growth 217
9 3 Hydrodynamic Effects on Cell Metabolism 222
9 4 Fluid-Lift, Airlift, and Stirred-Tank Bioreactors 223
9 5 Mechanisms of Hydrodynamic Cell Death 224
9 6 Cell Damage from Direct Sparging 239
9 7 Protective Polymers 241
9 8 Recommendations for Future Research 243
9 9 Nomenclature 245
References 247
XII Contents
PART IV ANIMAL CELL BIOREACTOR DESIGN,
OPERATION, AND CONTROL
10 Scaleup of Animal Cell Suspension Culture 253
Malcolm Rhodes, Simon Gardiner, and David Broad
10 1 Scaleup Principles 255
10 2 Bioreactor Scaleup 257
10 3 Process Scaleup 262
10 4 Conclusions 266
10 5 Nomenclature 266
References 267
11 Continuous Cell Culture 269
Mary L Nicholson, Brian S Hampson, Gordon G Pugh,
and Chester S Ho
11 1 Methods of Continuous Cell Culture 270
11 2 Automation 275
11 3 Assessing Cell Yield and Productivity in an
Immobilized System 279
11 4 Maintaining Steady-State Conditions 284
11 5 Maintenance Media 287
11 6 Cell Density in Perfusion Systems 290
11 7 Rapid Product Isolation and Nutrient Manipulation 293
11 8 Scalability 294
References 302
12 Optimization of the Microenvironment for Mammalian Cell
Culture in Flexible Collagen Microspheres in a Fluidized-Bed
Bioreactor 305
John N Vournakis and Peter W Runstadler, Jr
12 1 Verax Microspheres and Cell Viability 308
12 2 The Verax Fluidized Bed Reactor 311
12 3 Cell-Cell and Cell-Matrix Interactions 314
12 4 The Microenvironment 317
12 5 Bioreactor Productivity and Product Quality 322
12 6 Summary 323
References 325
13 High Density Cell Culture 327
Michiyuki Tokashiki
13 1 Development of a New Perfusion Culture Process 329
13 2 Perfusion Culture with Recycling of High Molecular
Weight Components 339
Contents xiii
13 3 High Density Culture Using Fluorocarbon to Supply
Oxygen 351
References 355
14 Diffusion and Convection in Membrane Bioreactors 357
Carole A Heath and Georges Belfort
14 1 Diffusive Mass Transfer 359
14 2 Convective Mass Transfer 365
14 3 Simultaneous Diffusive and Convective Mass
Transfer 368
14 4 Conclusions 370
References 370
15 Bioreactor Control and Optimization 373
Michael W Glacken
15 1 Process Goals 374
15 2 Process Control: Direct Control of Measured
Variables
Process Control from Inferred Measurements
Feed-Forward Control Using Empirically Derived
Mathematical Relations
Speculative Strategies for Manipulating Cellular
Metabolism to Improve Bioreactor Performance
Nomenclature
References
16 Instrumentation of Animal Cell Culture Reactors
Winfried Scheirer and Otto-W Merten
Theoretical Approaches
State of the Art
Future Developments
Conclusions
References
17 Large-Scale Process Purification of Clinical Product from
Animal Cell Cultures 445
Christopher P Prior
17 1 Potential Product Contaminants Derived from
Animal Cell Culture Processes 447
17 2 Discussion of a cGMP Ion Exchange Process
Purification Scheme for a Monoclonal IgG 450
17 3 Use of Protein A Affinity Chromatography for
Monoclonal IgG Purification 462
17 4 The Impact of Cell Culture Techniques on Product
Integrity 465
17 5 Summary of Key Points 474
References 477
Index 479
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| indexdate | 2024-07-09T16:15:43Z |
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| isbn | 0409901237 |
| language | English |
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| physical | XVI, 494 S. Ill., graph. Darst. |
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| publisher | Butterworth-Heinemann |
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| series | Biotechnology series |
| series2 | Biotechnology series |
| spelling | Animal cell bioreactors ed. by Chester S. Ho ... Boston u.a. Butterworth-Heinemann 1991 XVI, 494 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biotechnology series 17 Literaturangaben Bioreactoren gtt Bioréacteurs ram Biotechnologie gtt Celkweek gtt Cellules animales - Biotechnologie ram Animal cell biotechnology Bioreactors Biotechnology Cells, Cultured Zellkultur (DE-588)4067547-6 gnd rswk-swf Tierzelle (DE-588)4185509-7 gnd rswk-swf Bioreaktor (DE-588)4006780-4 gnd rswk-swf Zellkultur (DE-588)4067547-6 s Bioreaktor (DE-588)4006780-4 s DE-604 Tierzelle (DE-588)4185509-7 s Ho, Chester S. Sonstige oth Biotechnology series 17 (DE-604)BV000007885 17 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002863131&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Animal cell bioreactors Biotechnology series Bioreactoren gtt Bioréacteurs ram Biotechnologie gtt Celkweek gtt Cellules animales - Biotechnologie ram Animal cell biotechnology Bioreactors Biotechnology Cells, Cultured Zellkultur (DE-588)4067547-6 gnd Tierzelle (DE-588)4185509-7 gnd Bioreaktor (DE-588)4006780-4 gnd |
| subject_GND | (DE-588)4067547-6 (DE-588)4185509-7 (DE-588)4006780-4 |
| title | Animal cell bioreactors |
| title_auth | Animal cell bioreactors |
| title_exact_search | Animal cell bioreactors |
| title_full | Animal cell bioreactors ed. by Chester S. Ho ... |
| title_fullStr | Animal cell bioreactors ed. by Chester S. Ho ... |
| title_full_unstemmed | Animal cell bioreactors ed. by Chester S. Ho ... |
| title_short | Animal cell bioreactors |
| title_sort | animal cell bioreactors |
| topic | Bioreactoren gtt Bioréacteurs ram Biotechnologie gtt Celkweek gtt Cellules animales - Biotechnologie ram Animal cell biotechnology Bioreactors Biotechnology Cells, Cultured Zellkultur (DE-588)4067547-6 gnd Tierzelle (DE-588)4185509-7 gnd Bioreaktor (DE-588)4006780-4 gnd |
| topic_facet | Bioreactoren Bioréacteurs Biotechnologie Celkweek Cellules animales - Biotechnologie Animal cell biotechnology Bioreactors Biotechnology Cells, Cultured Zellkultur Tierzelle Bioreaktor |
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