Stable isotope pharmaceuticals: for clinical research and diagnosis
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Jena
Fischer
1991
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| Schriftenreihe: | Drug development and evaluation
18 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | IX, 149 S. graph. Darst. |
| ISBN: | 333460358X |
Internformat
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Datensatz im Suchindex
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| adam_text | STABLE ISOTOPE PHARMACEUTICALS FOR CLINICAL RESEARCH AND DIAGNOSIS PETER
KRUMBIEGEL PREFACE: H. HUNDESHAGEN, HANNOVER 52 FIGURES AND 8 TABLES
SEMPER M GUSTAV FISCHER VERLAG * JENA * STUTTGART * NEW YORK * 1991
CONTENTS 1. INTRODUCTION 1 2. FUNDAMENTALS 3 2.1. ISOTOPES IN
BIOCHEMISTRY AND MEDICINE. A SHORT REVIEW OF THE HISTORY 3 2.2. STABLE
ISOTOPES 6 2.2.1. TERMINOLOGY 6 2.2.2. NOMENCLATURE OF STABLE ISOTOPE
LABELED SUBSTANCES 13 2.2.3. EVALUATION PRINCIPLES IN TRACER TECHNIQUES
15 2.2.3.1. SYMBOLS IN THE FORMULA LANGUAGE 15 2.2.3.2. ISOTOPE DILUTION
ANALYSIS 17 2.2.3.3. TRACER KINETICS IN VIVO 19 2.2.4. MEASUREMENT
PRINCIPLES 24 2.2.4.1. MASS SPECTROMETRY 24 2.2.4.2. OPTICAL
SPECTROSCOPY 26 2.2.4.3. NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY
28 2.2.4.4. NEUTRON ACTIVATION 29 2.3. STABLE ISOTOPES IN MEDICINE 30
2.3.1. INSERTION OF STABLE ISOTOPE PHARMACEUTICALS IN NUCLEAR MEDICAL
NOMENCLATURE 30 2.3.2. APPLICATION RISK; LICENSE 31 2.3.3. APPLICATION
FIELD 37 2.4. PRACTICAL USE OF STABLE ISOTOPE PHARMACEUTICALS 38 2.4.1.
AVAILABILITY 38 2.4.2. ANALYTICAL METHODS 40 2.4.3. CLINICAL WORK 43 VIM
CONTENTS 3. APPLICATIONS 49 3.1. DEUTERATED PHARMACEUTICALS FOR
DIAGNOSIS 51 3.1.1. ESTIMATION OF AMOUNTS OF BODY FLUIDS WITH H2O (HEAVY
WATER) 51 3.1.2. INVESTIGATION OF METABOLIC PATHWAYS IN VIVO 53 3.1.3.
IN VITRO ASSAYS 56 3.2. 13 C PHARMACEUTICALS 57 3.2.1. 13 CO 2 BREATH
TEST SUBSTRATES 58 3.2.1.1. MEASUREMENT OF HEPATIC MICROSOMAL
BIOTRANSFORMATION CAPACITY USING [ 13 C 2 ]AMINOPYRINE, [L,3,7-METHYL-
13 C3]CAFFEINE, [ETHYL- 13 C]PHENACETIN, [METHYL- 13 C]METHACETIN, AND [
13 C]GALACTOSE 60 3.2.1.2. MEASUREMENT OF ENTEROHEPATIC CIRUCLATION OF
BILE ACIDS USING [ 13 C]GLYCOCHOLIC ACID .*: 64 3.2.1.3. DETECTION OF
GASTRIC HELICOBACTER PYLORI INFECTION USING [ 13 C]UREA 65 3.2.1.4.
DETECTION OF FAT MALABSORPTION USING [ 13 C]TRIGLYCERIDES 65 3.2.1.5.
DETECTION OF DISACCHARIDE MALABSORPTION USING [ C]LACTOSE AND [ 13
C]SUCROSE 66 3.2.1.6. DETECTION OF HEXOSE ABSORPTION AND UTILIZATION
USING [ 13 C]GLUCOSE AND [ 13 C]FRUCTOSE 67 3.2.1.7. ESTIMATION OF FATTY
ACID OXIDATION USING [L- 13 C]OCTANOATE ... 68 3.2.1.8. ESTIMATION OF
AMINO ACID OXIDATION USING L-[L- 13 C]LEUCINE, [ 13 C 2 ]GLYCINE, AND
DL- [L- 13 C]PHENYLALANINE 68 3.2.1.9. OTHER BREATH TEST SUBSTRATES 68
3.2.2. 13 C-LABELED SUBSTRATES NOT RECOVERED AS 13 CO 2 * * * * 69
3.2.3. NATURALLY LABELED 13 C SUBSTRATES 70 3;2.4. LIMITATIONS OF 13 CO
2 BREATH TESTS 72 3.3. 15 N PHARMACEUTICALS 73 3.3.1. 1S N URINE TEST
SUBSTRATES 74 3.3.1.1. FUNDAMENTAL AND METHODOLOGICAL WORK TO ASSESS
NORMAL AND CHANGED PROTEIN TURNOVER USING 15 N ... 76 3.3.1.2. [ 15
N]GLYCINE TO TEST LIVER FUNCTION AND PARTICULAR EXOGENOUS OR ENDOGENOUS
INFLUENCES ON PROTEIN TURNOVER 78 3.3.1.3. [ N] AMMONIUM TEST TO ASSESS
HEPATIC AMMONIA DETOXIFICATION CAPACITY 82 3.3.1.4. [ 15 N]METHACETIN
TEST TO ASSESS HEPATIC MICROSOMAL BIOTRANSFORMATION CAPACITY 83 3.3.1.5.
[ 5 N 2 ]UREA TEST TO DETECT GASTRIC HELICOBACTER PYLORI INFECTION 89
CONTENTS IX 3.3.1.6. 15 N-LABELED BILE ACIDS TO DETECT FAILURES IN THEIR
ENTEROHEPATIC CIRCULATION 91 3.3.2. 15 N PHARMACEUTICALS TO BE RECOVERED
IN BODY POOLS OTHER THAN URINE 92 3.3.3. 1S N IN VITRO ASSAYS 94 3.4.
DIAGNOSTIC AGENTS WITH STABLE ISOTOPES OTHER THAN 2 H, 13 C, AND 15 N 94
3.5. MIXED LABELED SUBSTANCES FOR DIAGNOSIS 98 3.5.1. DOUBLY LABELED
WATER, 2 H 218 O 98 3.5.2. 15 N- N X- AND OTHER MIXED LABELED SUBSTANCES
100 3.5.3. MULTIPLE LABELING WITH ONE ISOTOPE 104 3.6. STABLE ISOTOPE
PHARMACEUTICALS FOR THERAPY . . . 105 3.6.1. DEUTERATED DRUGS 106
3.6.2. 10 B-ENRICHED SUBSTANCES 110 REFERENCES ILL COMPOUND INDEX 147
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| illustrated | Illustrated |
| indexdate | 2024-07-09T16:14:37Z |
| institution | BVB |
| isbn | 333460358X |
| language | English |
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| physical | IX, 149 S. graph. Darst. |
| publishDate | 1991 |
| publishDateSearch | 1991 |
| publishDateSort | 1991 |
| publisher | Fischer |
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| series | Drug development and evaluation |
| series2 | Drug development and evaluation |
| spelling | Krumbiegel, Peter Verfasser aut Stable isotope pharmaceuticals for clinical research and diagnosis Peter Krumbiegel Jena Fischer 1991 IX, 149 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Drug development and evaluation 18 Radiopharmakon (DE-588)4048223-6 gnd rswk-swf Radiopharmakon (DE-588)4048223-6 s DE-604 Drug development and evaluation 18 (DE-604)BV000000949 18 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002818749&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Krumbiegel, Peter Stable isotope pharmaceuticals for clinical research and diagnosis Drug development and evaluation Radiopharmakon (DE-588)4048223-6 gnd |
| subject_GND | (DE-588)4048223-6 |
| title | Stable isotope pharmaceuticals for clinical research and diagnosis |
| title_auth | Stable isotope pharmaceuticals for clinical research and diagnosis |
| title_exact_search | Stable isotope pharmaceuticals for clinical research and diagnosis |
| title_full | Stable isotope pharmaceuticals for clinical research and diagnosis Peter Krumbiegel |
| title_fullStr | Stable isotope pharmaceuticals for clinical research and diagnosis Peter Krumbiegel |
| title_full_unstemmed | Stable isotope pharmaceuticals for clinical research and diagnosis Peter Krumbiegel |
| title_short | Stable isotope pharmaceuticals |
| title_sort | stable isotope pharmaceuticals for clinical research and diagnosis |
| title_sub | for clinical research and diagnosis |
| topic | Radiopharmakon (DE-588)4048223-6 gnd |
| topic_facet | Radiopharmakon |
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