Targeted drug delivery:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1991
|
| Schriftenreihe: | Handbook of experimental pharmacology
100 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XIV, 364 S. Ill., graph. Darst. |
| ISBN: | 3540528431 0387528431 |
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Datensatz im Suchindex
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| adam_text | LS 2 PH- TARGETED DRUG DELIVERY CONTRIBUTORS K.L. AUDUS, N. BODOR, R.T.
BORCHARDT, M.E. BREWSTER, Y.W. CHIEN G. DEGOLS, R.L. JULIANO, A.S.
KEARNEY, J. KOPECEK, N.L. KRINICK B. LEBLEU, J.-P. LEONETTI, F.R.
MAXFIELD, T.E. MCGRAW, G.L. SCHERPHOF V.J. STELLA EDITOR RUDOLPH L.
JULIANO WITH 112 FIGURES SPRINGER-VERLAG BERLIN HEIDELBERG NEW YORK
LONDON PARIS TOKYO HONG KONG BARCELONA BUDAPEST CONTENTS CHAPTER 1 A NEW
PERSPECTIVE FOR DRUG DELIVERY RESEARCH R.L. JULIANO 1 A. PROMISES
REALIZED: A RECENT HISTORY OF CONTROLLED DRUG DELIVERY .. 1 I. SUSTAINED
DELIVERY SYSTEMS: A CLINICAL AND COMMERCIAL SUCCESS 1 1. IMPLANTABLE
SYSTEMS 2 2. TRANSDERMAL SYSTEMS 2 II. MICROPARTICULATE DELIVERY SYSTEMS
3 1. SOLVING OLD PROBLEMS 3 2. CLINICAL EVALUATION 4 B. THE OPENING
DOOR: MOLECULAR BIOLOGY GENERATES NEW OPPORTUNITIES AND CHALLENGES FOR
DRUG DELIVERY RESEARCH 5 I. USING THE BODY S OWN PHARMACEUTICALS 5 II.
ENDOCRINE VS PARACRINE: A DRUG TARGETING PROBLEM 5 C. AN OVERVIEW OF
THIS VOLUME: BUILDING ON THE PAST AND LOOKING TOWARD THE FUTURE 6 D.
DRUG TARGETING RESEARCH IN THE TWENTY-FIRST CENTURY: A NEW PERSPECTIVE 7
REFERENCES : 8 CHAPTER 2 INTERNALIZATION AND SORTING OF MACROMOLECULES:
ENDOCYTOSIS T.E. MCGRAW AND F.R. MAXFIELD. WITH 3 FIGURES 11 A.
INTRODUCTION 11 B. PATHWAYS OF ENDOCYTOSIS IN NONPOLARIZED CELLS 13 I.
ENDOSOMES/ 15 II. PROPERTIES OF ENDOSOMES 17 1. ACIDIFICATION 17 2.
ENDOSOME FUSION AND SORTING 20 3. MATURATION OF ENDOSOMES 23 C.
MOLECULAR BASIS OF ENDOCYTOSIS 24 X . CONTENTS I. INTERNALIZATION 24 1.
REQUIRED RECEPTOR SEQUENCES 24 2. CLATHRIN-COATED PIT CLUSTERING
PROTEINS 28 3. FORMATION OF ENDOCYTIC VESICLES 28 II. INTRACELLULAR
ROUTING 29 D. NONCOATED PIT INTERNALIZATION 31 E. ENDOCYTOSIS IN
POLARIZED CELLS 32 F. SUMMARY 34 REFERENCES 34 CHAPTER 3 TRANSPORT OF
MACROMOLECULES ACROSS THE CAPILLARY ENDOTHELIUM K.L. AUDUS AND R.T.
BORCHARDT. WITH 3 FIGURES 43 A. INTRODUCTION 43 B. PATHWAYS FOR THE
PASSAGE OF MACROMOLECULES ACROSS CAPILLARY ENDOTHELIUM 43 I. CAPILLARY
ENDOTHELIUM 43 II. FENESTRATIONS 45 III. LARGE PORES 45 IV.
INTERCELLULAR JUNCTIONS 46 V. ENDOCYTOSIS AND PHAGOCYTOSIS 46 C. THE
BLOOD-BRAIN BARRIER 48 D. EXPERIMENTAL MODEL SYSTEMS 49 I. BRAIN
PERFUSION MODEL 50 II. ISOLATED CAPILLARIES 50 III. TISSUE CULTURE
SYSTEMS 51 E. APPLICATIONS OF TISSUE CULTURE MODELS IN THE STUDY OF
CAPILLARY ENDOTHELIAL CELL TRANSPORT OF MACROMOLECULES 53 I. KINETICS OF
MARKER MOLECULES 53 1. LUCIFER YELLOW 54 2. LECTINS 54 II. LARGE
PEPTIDES 55 1. TRANSFERRIN 55 2. INSULIN AND INSULIN-LIKE GROWTH FACTOR
56 3. ATRIAL NATRIURETIC FACTOR 57 4. MODIFIED ALBUMINS 57 III. SMALL
PEPTIDES 58 IV. REGULATION OF THE PERMEABILITY OF CAPILLARY ENDOTHELIUM
59 1. ASTROCYTES 59 2. VASOACTIVE PEPTIDES 61 F: SUMMARY 63 REFERENCES
64 CONTENTS XI CHAPTER 4 PHARMACOKINETICS OF DRUG TARGETING: SPECIFIC
IMPLICATIONS FOR TARGETING VIA PRODRUGS V.J. STELLA AND A.S. KEARNEY.
WITH 18 FIGURES 71 A. INTRODUCTION 71 B. PHARMACOKINETIC MODELS AND DRUG
TARGETING 72 I. DEFINING DRUG TARGETING 72 II. TESTING TARGETING
HYPOTHESES USING CLASSICAL OR COMPARTMENTAL PHARMACOKINETIC MODELS 73
III. TESTING TARGETING HYPOTHESES USING PHYSIOLOGICAL PHARMACOKINETIC
MODELS 78 1. PERFUSION MODELS 78 2. TRAFFICKING AND CELLULAR UPTAKE
LIMITATIONS 81 3. SPECIFIC EXAMPLES OF MODELS USED TO EVALUATE AND
PREDICT TARGETING STRATEGIES 82 C. PRODRUG-MEDIATED TARGETED DRUG
DELIVERY 85 I. PRODRUGS IN GENERAL 85 II. SITE-SPECIFIC DRUG DELIVERY
VIA PRODRUGS 87 1. INDIRECT DRUG TARGETING VIA PRODRUGS 88 2. DIRECT
DRUG TARGETING VIA PRODRUGS 93 REFERENCES 100 CHAPTER 5 SOLUBLE POLYMERS
AS TARGETABLE DRUG CARRIERS N.L. KRINICK AND J. KOPECEK. WITH 13 FIGURES
105 A. INTRODUCTION 105 B. CONSEQUENCES OF DRUG BINDING TO
MACROMOLECULAR CARRIERS: CELLULAR LEVEL 106 I. PINOCYTOSIS 106 1.
RECEPTOR-MEDIATED ENDOCYTOSIS 108 II. ENDOSOMES ILL III. LYSOSOMES 113
C. FATE OF MACROMOLECULAR CARRIERS IN VIVO 116 I. PRINCIPLES OF
BIODEGRADABILITY 117 II. INFLUENCE OF SUBSTITUTION ON THE DEGRADABILITY
OF NATURAL POLYMERS 118 1. POLYSACCHARIDES 118 2. POLYAMINO ACIDS 119
III. ELIMINATION OF MACROMOLECULAR CARRIERS FROM THE ORGANISM.... 121 1.
STRUCTURAL FACTORS INFLUENCING THE FATE OF MACROMOLECULES .. 122 D.
RELEASE OF DRUGS 124 I. RELEASE OF DRUGS BY HYDROLYSIS 124 XII CONTENTS
II. DISULFIDE SPACERS 125 III. RELEASE OF DRUGS BY ENZYMES 125 1.
RELEASE OF DRUG MODELS FROM HPMA COPOLYMERS BY CHYMOTRYPSIN 126 2.
CLEAVAGE BY LYSOSOMAL ENZYMES 128 IV. RELATIONSHIP BETWEEN
SUSCEPTIBILITY TO ENZYMATICALLY CATALYZED HYDROLYSIS AND BIOLOGICAL
ACTIVITY 131 E. TARGETING 134 I. PRINCIPLES OF TARGETING 134 II.
OBSTACLES TO TARGETED DRUG DELIVERY 135 1. MULTIDRUG RESISTANCE 137 III.
TARGETING LYSOSOMES WITH CARBOHYDRATE MOIETIES 137 1.
ASIALOGLYCOPROTEINS 138 2. LYSOSOMAL HYDROLASES 138 3. GLYCOCONJUGATES
139 4. SYNTHETIC AND NATURAL POLYMERS 140 IV. ANTIBODIES 143 1.
ANTIBODY-DRUG CONJUGATES 143 2. ANTIBODY-SYNTHETIC POLYMER-DRUG
CONJUGATES 149 3. ANTIBODY-NATURAL POLYMER-DRUG CONJUGATES 152 V.
HORMONES 154 VI. OTHER TARGETING SYSTEMS 155 F. PHOTOSENSITIZATION:
ACTIVATION BY LIGHT 156 I. PHOTODYNAMIC THERAPY 157 1. DOUBLE TARGETING
158 2. UPTAKE OF PHOTOSENSITIZER CONJUGATES 160 G. DECREASED TOXICITY
AND IMMUNOGENICITY OF DRUG-POLYMER CONJUGATES 161 I. TOXICITY OF
DRUG-POLYMER CONJUGATES 161 II. IMMUNOGENICITY OF POLYMER-DRUG
CONJUGATES 162 H. SOLUBLE POLYMERS FOR SITE SPECIFIC ORAL DRUG DELIVERY
163 I. ENZYME CONTROLLED SITE SPECIFIC DRUG RELEASE 163 II. BIOADHESION
OF POLYMERIC CARRIERS . 164 III. TWO FOLD SPECIFICITY IN ORAL DRUG
DELIVERY 165 I. CONCLUDING REMARKS 166 REFERENCES 166 CHAPTER 6 SYSTEMIC
DELIVERY OF PHARMACOLOGICALLY ACTIVE MOLECULES ACROSS THE SKIN Y.W.
CHIEN. WITH 33 FIGURES 181 A. BIOMEDICAL LOGIC OF TRANSDERMAL DRUG
DELIVERY 181 I. INTRODUCTION 181 II. THE SKIN SITE FOR PERCUTANEOUS OR
TRANSDERMAL DRUG DELIVERY.. 182 III. MECHANISMS AND KINETICS OF TDD 184
CONTENTS XIII B. HISTORIC DEVELOPMENT OF TDD 187 C. TRANSDERMAL DELIVERY
OF PHARMACOLOGICALLY ACTIVE ORGANIC MOLECULES 191 I.
NITROGLYCERIN-RELEASING TDD SYSTEM 193 1. MEMBRANE PERMEATION-CONTROLLED
DRUG DELIVERY 193 2. MATRIX DIFFUSION-CONTROLLED DRUG DELIVERY 196 3.
INTERFACIAL PARTITIONING-CONTROLLED DRUG DELIVERY 198 II.
SCOPOLAMINE-RELEASING TDD SYSTEM 201 III. CLONIDINE-RELEASING TDD SYSTEM
201 IV. ESTRADIOL-RELEASING TDD SYSTEM 202 V. DETERMINATION OF TDD
KINETICS 205 1. IN VITRO DRUG RELEASE KINETICS 206 2. IN VITRO
TRANSDERMAL PERMEATION KINETICS 208 3. IN VIVO TRANSDERMAL PERMEATION
KINETICS 210 4. IN VITRO AND IN VIVO CORRELATIONS OF TRANSDERMAL
PERMEATION KINETICS 213 VI. OPTIMIZATION OF TRANSDERMAL CONTROLLED DRUG
DELIVERY ... 214 D. TRANSDERMAL DELIVERY OF PHARMACOLOGICALLY ACTIVE
PEPTIDE/PROTEIN MOLECULES 217 E. CONCLUSION 226 REFERENCES 227 CHAPTER 7
CHEMICAL DELIVERY SYSTEMS N. BODOR AND M.E. BREWSTER. WITH 40 FIGURES
231 A. INTRODUCTION 231 B. SITE AND STEREOSPECIFIC DRUG DELIVERY TO THE
EYE 231 C. BRAIN-TARGETING DRUG DELIVERY 236 I. BACKGROUND 237 II.
DIHYDRONICOTINATE CDSS 239 1. BRAIN-TARGETING OF NEUROTRANSMITTERS AND
AMINO ACIDS 241 2. BRAIN-ENHANCED DELIVERY OF ANTIVIRAL AGENTS 248 3.
APPLICATION OF THE BRAIN-TARGETING CDS TO ESTROGENS 260 4. CONCLUSION
278 REFERENCES 279 CHAPTER 8 IN VIVO BEHAVIOR OF LIPOSOMES: INTERACTIONS
WITH THE MONONUCLEAR PHAGOCYTE SYSTEM AND IMPLICATIONS FOR DRUG
TARGETING G.L. SCHERPHOF 285 A. INTRODUCTION 285 B. INTERACTIONS WITH
BODY FLUIDS 286 XIV CONTENTS C. INTERACTIONS WITH CELLS 288 D.
ANATOMICAL BARRIERS 290 E. FACTORS INFLUENCING LIPOSOME UPTAKE BY CELLS
293 I. LIPOSOME SIZE 295 II. LIPOSOME COMPOSITION 296 III. CHOLESTEROL
AND OPSONIZATION 297 IV. PROLONGED CIRCULATION TIME 300 F. SURFACE
MODIFICATION 302 G. INTRACELLULAR PROCESSING OF LIPOSOMES 305 H.
IMPLICATIONS FOR DRUG TARGETING 307 I. CONCLUDING REMARKS 312 REFERENCES
313 CHAPTER 9 ANTISENSE OLIGONUCLEOTIDES AS PHARMACOLOGICAL MODULATORS
OF GENE EXPRESSION G. DEGOLS, J.-P. LEONETTI, AND B. LEBLEU. WITH 2
FIGURES 329 A. GENERAL PRINCIPLES AND HISTORICAL BACKGROUND 329 B.
ARTIFICIAL CONTROL OF GENE EXPRESSION BY SYNTHETIC OLIGONUCLEOTIDES: AN
OVERVIEW OF PROBLEMS AND POTENTIAL 331 C. OLIGONUCLEOTIDE CHEMISTRY AND
MODIFICATIONS 332 I. MODIFICATIONS OF THE PHOSPHODIESTER BACKBONE 332 1.
NONIONIC OLIGONUCLEOTIDES 332 2. ISOELECTRIC OLIGONUCLEOTIDES 333 3.
PHOSPHORAMIDATE OLIGONUCLEOTIDES 334 II. MODIFICATIONS OF THE SUGAR
MOIETY 334 1. SUGAR-MODIFIED OLIGONUCLEOTIDES 334 2. OLIGORIBONUCLEOTIDE
ANALOGUES 335 III. FUNCTIONALIZATION OF OLIGONUCLEOTIDE ENDS 336 D.
INTERNALIZATION PATHWAY OF ANTISENSE OLIGONUCLEOTIDES AND ALTERNATIVE
METHODS TO INCREASED CELLULAR UPTAKE 337 I. MECHANISM OF UPTAKE OF
OLIGONUCLEOTIDES IN CELLS 337 II. MODIFICATIONS OF OLIGONUCLEOTIDES TO
INCREASE CELL UPTAKE 338 E. MECHANISM OF ACTION OF ANTISENSE
OLIGONUCLEOTIDES 340 F. BIOLOGICAL POTENTIAL OF SYNTHETIC
OLIGONUCLEOTIDES 342 G. PROSPECTIVES OF IN VIVO UTILIZATION OF ANTISENSE
OLIGONUCLEOTIDES ... 345 REFERENCES 348 SUBJECT INDEX 355
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| id | DE-604.BV004455009 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T16:13:16Z |
| institution | BVB |
| isbn | 3540528431 0387528431 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-002762525 |
| oclc_num | 23650773 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-12 DE-355 DE-BY-UBR DE-29T DE-20 DE-11 DE-188 DE-578 |
| owner_facet | DE-19 DE-BY-UBM DE-12 DE-355 DE-BY-UBR DE-29T DE-20 DE-11 DE-188 DE-578 |
| physical | XIV, 364 S. Ill., graph. Darst. |
| publishDate | 1991 |
| publishDateSearch | 1991 |
| publishDateSort | 1991 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | Targeted drug delivery contributors K. L. Audus ... Ed. Rudolph L. Juliano Berlin [u.a.] Springer 1991 XIV, 364 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 100 Literaturangaben Drug Delivery Systems cabt Drug targeting gtt Farmacotherapie gtt Médicaments - Ciblage Drug Delivery Systems Drug targeting Pharmakokinetik (DE-588)4115557-9 gnd rswk-swf Targeted drug delivery (DE-588)4302415-4 gnd rswk-swf Wirkstofffreisetzung (DE-588)4190018-2 gnd rswk-swf Zielorgan (DE-588)4205824-7 gnd rswk-swf Pharmakokinetik (DE-588)4115557-9 s DE-604 Targeted drug delivery (DE-588)4302415-4 s Wirkstofffreisetzung (DE-588)4190018-2 s Zielorgan (DE-588)4205824-7 s Juliano, Rudolph L. Sonstige oth Audus, Kenneth L. Sonstige oth Handbook of experimental pharmacology 100 (DE-604)BV002390716 100 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002762525&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Targeted drug delivery Handbook of experimental pharmacology Drug Delivery Systems cabt Drug targeting gtt Farmacotherapie gtt Médicaments - Ciblage Drug Delivery Systems Drug targeting Pharmakokinetik (DE-588)4115557-9 gnd Targeted drug delivery (DE-588)4302415-4 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd Zielorgan (DE-588)4205824-7 gnd |
| subject_GND | (DE-588)4115557-9 (DE-588)4302415-4 (DE-588)4190018-2 (DE-588)4205824-7 |
| title | Targeted drug delivery |
| title_auth | Targeted drug delivery |
| title_exact_search | Targeted drug delivery |
| title_full | Targeted drug delivery contributors K. L. Audus ... Ed. Rudolph L. Juliano |
| title_fullStr | Targeted drug delivery contributors K. L. Audus ... Ed. Rudolph L. Juliano |
| title_full_unstemmed | Targeted drug delivery contributors K. L. Audus ... Ed. Rudolph L. Juliano |
| title_short | Targeted drug delivery |
| title_sort | targeted drug delivery |
| topic | Drug Delivery Systems cabt Drug targeting gtt Farmacotherapie gtt Médicaments - Ciblage Drug Delivery Systems Drug targeting Pharmakokinetik (DE-588)4115557-9 gnd Targeted drug delivery (DE-588)4302415-4 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd Zielorgan (DE-588)4205824-7 gnd |
| topic_facet | Drug Delivery Systems Drug targeting Farmacotherapie Médicaments - Ciblage Pharmakokinetik Targeted drug delivery Wirkstofffreisetzung Zielorgan |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002762525&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002390716 |
| work_keys_str_mv | AT julianorudolphl targeteddrugdelivery AT auduskennethl targeteddrugdelivery |