The biosynthesis of secondary metabolites:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Chapman & Hall
1989
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 231 S. graph. Darst. |
| ISBN: | 0412277204 0412275406 |
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Datensatz im Suchindex
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|---|---|
| adam_text | IMAGE 1
THE BIOSYNTHESIS OF
SECONDARY METABOLITES
R. B.JHERBERT SENIOR LECTURER SCHOOL OF CHEMISTRY UNIVERSITY OF LEEDS
SECOND EDITION
LONDON NEW YORK CHAPMAN AND HALL
IMAGE 2
CONTENTS
PREFACE * XIPREFACE TO THE FIRST EDITION XIII
1 INTRODUCTION 1
1.1 PRIMARY AND SECONDARY METABOLISM 1
1.1.1 INTRODUCTION 1
1.1.2 FATTY ACID BIOSYNTHESIS 2
1.1.3 THE BIOSYNTHESIS OF POLYACETYLENES AND PROSTAGLANDINS 5 1.2
STEREOCHEMISTRY AND BIOSYNTHESIS 6
1.2.1 CHIRALITY AND PROCHIRALITY 6
1.2.2 CHIRAL METHYL GROUPS 7
1.2.3 HYDROXYLATION AT SATURATED CARBON ATOMS 10
1.3 SOME REACTIONS OF GENERAL IMPORTANCE IN SECONDARY METABOLISM 10
1.3.1 OXIDATIVE COUPLING OF PHENOLS 10
1.3.2 HYDROXYLATION OF AROMATIC SUBSTRATES 12
1.3.3 METHYLATION 12
REFERENCES - 14
2 TECHNIQUES FOR BIOSYNTHESIS 16
16 18 18 21 28 29
31
31
2.1 2.2
2.3
3
3.1
INTRODUCTION ISOTOPIC LABELLING 2.2.1 RADIOACTIVE ISOTDPES 2.2.2 STABLE
ISOTOPES ENZYMES AND MUTANTS
REFERENCES
POLYKETIDES
INTRODUCTION
IMAGE 3
VIII CONTENTS
3.2 FORMATION OF POLY-/3-KETO-ACYL-COA S 33
3.2.1 ACETATE AND MALONATE 33
3.2.2 ASSEMBLY OF POLY-0-KETO-ACYL-COA S 34
3.3 TETRAKETIDES 38
3.4 PENTAKETIDES 42
3.5 HEXAKETIDES 45
3.6 HEPTAKETIDES * 47
3.7 OCTAKETIDES 49
3.8 NONA-AND DECA-KETIDES 51
3.9 POLYKETIDES WITH MIXED ORIGINS AND LARGE RING POLYKETIDES 55
REFERENCES 58
4 TERPENES AND STEROIDS 63
4.1 INTRODUCTION 63
4.2 STEROIDS 66
4.3 PENTACYCLIC TRITERPENES 72
4.4 SQUALENE 73
4.5 MONOTERPENES 76
4.6 SESQUITERPENES 79
4.7 DITERPENES 86
4.8 SESTERPENES 89
4.9 CAROTENOIDS AND VITAMIN A 89
REFERENCES 92
5 THE SHIKIMIC ACID PATHWAY 96
5.1 INTRODUCTION 96
5.2 QUINONES 104
5.3 COUMARINS 110
5.4 FLAVONOIDS 111
REFERENCES 116
6 ALKALOIDS 120
6.1 INTRODUCTION 120
6.2 PIPERIDINE AND PYRROLIDINE ALKALOIDS 121
6.2.1 PIPERIDINE ALKALOIDS 121
6.2.2 PYRROLIDINE ALKALOIDS 133
6.3 ISOQUINOLINE AND RELATED ALKALOIDS 141
6.3.1 PHENETHYLAMINES AND SIMPLE ISOQUINOLINES 141
6.3.2 APORPHINES 146
6.3.3 ERYTHRINA ALKALOIDS 149
6.3.4 MORPHINE AND RELATED ALKALOIDS 150
6.3.5 HASUBANONINE AND PROTOSTEPHANINE 151
IMAGE 4
CONTENTS IX
6.3.6 PROTOBERBERINE AND RELATED ALKALOIDS 151
6.3.7 PHENETHYLISOQUINOLINE ALKALOIDS 154
6.4 AMARYLLIDACEAE AND MESEMBRINE ALKALOIDS 156
6.4.1 AMARYLLIDACEAE ALKALOIDS 156
6.4.2 MESEMBRINE ALKALOIDS 160
6.5 QUINOLINE AND RELATED ALKALOIDS 162
6.6 INDOLE ALKALOIDS ^ 164
6.6.1 SIMPLE INDOLE DERIVATIVES 164
6.6.2 TERPENOID INDOLE AND RELATED ALKALOIDS 165
6.7 IPECAC ALKALOIDS 173
6.8 MISCELLANEOUS ALKALOIDS 174
REFERENCES 175
7 MICROBIAL METABOLITES CONTAINING NITROGEN 182
Q
7.1 INTRODUCTION 182,
7.2 PIPERIDINE AND PYRIDINE METABOLITES 182
7.3 DIKETOPIPERAZINES 186
7.4 BENZODIAZEPINES 189
7.5 METABOLITES DERIVED FROM THE TRYPTOPHAN PATHWAY 191
7.5.1 ERGOT ALKALOIDS 191
7.5.2 CYCLOPIAZONIC ACIDS AND CARBAZOMYCIN B 194
7.5.3 INDOLMYCIN 195
7.5.4 STREPTONIGRIN AND PYRROLNITRIN 195
7.6 METABOLITES DERIVED FROM THE SHIKIMATE PATHWAY 197
7.6.1 PSEUDANS, PHENOXAZINONES, PHENAZINES, AND CHLORAMPHENICOL 197
7.6.2 ANSAMYCINS, MITOMYCINS AND ANTIBIOTIC A23187 199 7.6.3
CYTOCHALASINS AND PSEUROTIN A 203
7.6.4 NYBOMYCIN 204
7.6.5 NAPHTHYRIDINOMYCIN, SAFRAMYCIN A AND CC-1065 204 7.6.6 ISOCYANIDES
AND TUBERIN 205
7.6.7 SARUBICINA 207
7.6.8 ARPHAMENINES 207
7.7 /3-LACTAMS 208
7.7.1 PENICILLINS AND CEPHALOSPORINS 208
7.7.2 CLAVULANIC ACID 211
7.7.3 NOCARDICINS 211
7.7.4 THIENAMYCIN AFTD TABTOXIN 212
7.8 MISCELLANEOUS METABOLITES 213
7.8.1 PRODIGININES 213
7.8.2 ELAIOMYCIN AND VALINIMYCIN 213
7.8.3 STREPTOTHRICIN, ACIVICIN, REDUCTIOMYCIN AND ASUKAMYCIN 214
IMAGE 5
CONTENTS
7.8.4 MYXOPYRONIN A, MYXOTHIAZOL, ANGIOLAM A, RHIZOXIN AND MALONIMYCIN
215
7.8.5 VIRGINIAMYCIN ANTIBIOTICS - 215
7.8.6 CYCLIZIDINE 217
REFERENCES 217
INDEX 222
|
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| author | Herbert, Richard B. |
| author_facet | Herbert, Richard B. |
| author_role | aut |
| author_sort | Herbert, Richard B. |
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| bvnumber | BV004445053 |
| classification_rvk | VK 8500 VK 8501 |
| classification_tum | CHE 870f CHE 801f |
| ctrlnum | (OCoLC)603928618 (DE-599)BVBBV004445053 |
| discipline | Chemie / Pharmazie Chemie |
| edition | 2. ed. |
| format | Book |
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| isbn | 0412277204 0412275406 |
| language | English |
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| spelling | Herbert, Richard B. Verfasser aut The biosynthesis of secondary metabolites R. B. Herbert 2. ed. London [u.a.] Chapman & Hall 1989 X, 231 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Naturstoff (DE-588)4041418-8 gnd rswk-swf Biosynthese (DE-588)4006902-3 gnd rswk-swf Chemische Synthese (DE-588)4133806-6 gnd rswk-swf Sekundärstoffwechsel (DE-588)4126827-1 gnd rswk-swf Sekundärstoffwechsel (DE-588)4126827-1 s DE-604 Naturstoff (DE-588)4041418-8 s Biosynthese (DE-588)4006902-3 s Chemische Synthese (DE-588)4133806-6 s 1\p DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002757496&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Herbert, Richard B. The biosynthesis of secondary metabolites Naturstoff (DE-588)4041418-8 gnd Biosynthese (DE-588)4006902-3 gnd Chemische Synthese (DE-588)4133806-6 gnd Sekundärstoffwechsel (DE-588)4126827-1 gnd |
| subject_GND | (DE-588)4041418-8 (DE-588)4006902-3 (DE-588)4133806-6 (DE-588)4126827-1 |
| title | The biosynthesis of secondary metabolites |
| title_auth | The biosynthesis of secondary metabolites |
| title_exact_search | The biosynthesis of secondary metabolites |
| title_full | The biosynthesis of secondary metabolites R. B. Herbert |
| title_fullStr | The biosynthesis of secondary metabolites R. B. Herbert |
| title_full_unstemmed | The biosynthesis of secondary metabolites R. B. Herbert |
| title_short | The biosynthesis of secondary metabolites |
| title_sort | the biosynthesis of secondary metabolites |
| topic | Naturstoff (DE-588)4041418-8 gnd Biosynthese (DE-588)4006902-3 gnd Chemische Synthese (DE-588)4133806-6 gnd Sekundärstoffwechsel (DE-588)4126827-1 gnd |
| topic_facet | Naturstoff Biosynthese Chemische Synthese Sekundärstoffwechsel |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002757496&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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